Latest REMAP-CAP podcast series episode on ivermectin with Prof Alistair Nichol
Welcome to the 509th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are randomised controlled trials on convalescent plasma for hospitalized patients with COVID-19 & cyclophosphamide added to glucocorticoids in acute exacerbation of idiopathic pulmonary fibrosis; systematic reviews and meta analyses on the effect of vitamin C on mortality in patients with sepsis & timing of tracheostomy in acute traumatic spinal cord injury; and observational studies on oxygenation targets in ICU patients with COVID-19 & the association of hyperoxaemia and hypoxaemia with harm in patients with ARDS.
There are also guidelines on the management of septic shock and sepsis-associated organ dysfunction in children & mass critical care surge response during COVID-19; narrative reviews on oxygen therapy for critically ill and post-operative patients & what intensive care registries can teach us about outcomes; commentaries on whether it's time to abandon ARDS & the management of multi-morbidity in elderly patients; as well as correspondence on the effect of vaccination on transmission of SARS-CoV-2 & opioids for sedation. If you only have time to read one review article this week, try this one on extracorporeal cardiopulmonary resuscitation in adults.
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Research
Randomised Controlled Trials
- Bégin. Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial. Nat Med 2021;epublished September 9th
- Jacquier. Effect of a Musical Intervention During the Implantation of a Central Venous Catheter or a Dialysis Catheter in the Intensive Care Unit: A Prospective Randomized Pilot Study. Anesth Analg 2021;epublished September 9th
- Page. Prolonged Prone Positioning for COVID-19-induced Acute Respiratory Distress Syndrome: A Randomized Pilot Study. Ann Am Thorac Soc 2021;epublished September 7th
- Naccache. Cyclophosphamide added to glucocorticoids in acute exacerbation of idiopathic pulmonary fibrosis (EXAFIP): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Respir Med 2021;epublished September 7th
- The effect of peri-operative dexmedetomidine on the incidence of postoperative delirium in cardiac and non-cardiac surgical patients: a randomised, double-blind placebo-controlled trial. Anaesthesia 2021;76(10):1342-1351
Systematic Reviews & Meta Analyses
- Sato. Effect of IV High-Dose Vitamin C on Mortality in Patients With Sepsis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Crit Care Med 2021;epublished Septemebr 8th
- Foran. Timing of tracheostomy in acute traumatic spinal cord injury: a systematic review and meta-analysis. J Trauma Acute Care Surg 2021;epublished September 9th
Observational Studies
- Rasmussen. Oxygenation targets in ICU patients with COVID-19: a post-hoc sub-group analysis of the HOT-ICU trial. Acta Anaesthesiol Scand 2021;;epublished August 23rd
- Falvey. Association of Social Isolation With Disability Burden and 1-Year Mortality Among Older Adults With Critical Illness. JAMA Intern Med 2021;epublished online September 7th
- Pugh. Long-term trends in critical care admissions in Wales. Anaesthesia 2021;76(10):1316–25
- Ergün. Aspergillus test profiles and mortality in critically-ill COVID-19 patients. J Clin Microbiol 2021;epublished September 8th
- Riera. Increased mortality in patients with COVID-19 receiving extracorporeal respiratory support during the second wave of the pandemic. Intensive Care Med 2021;epublished September 8th
- Nadig. Psychological Outcomes in Family Members of Patients With Acute Respiratory Failure. Does Inter-ICU Transfer Play a Role? Chest 2021;160(3):890-898
- Han. Effect of Early High-Dose Vitamin D3 Repletion on Cognitive Outcomes in Critically Ill Adults. Chest 2021;160(3):909-918
- Hirshberg. Performance of an Electronic Decision Support System as a Therapeutic Intervention During a Multicenter PICU Clinical Trial. Heart and Lung Failure-Pediatric Insulin Titration Trial (HALF-PINT). Chest 2021;160(3):919-928
- Vasquez. Identification of Distinct Clinical Subphenotypes in Critically Ill Patients With COVID-19. Chest 2021;160(3):929-943
- Azoulay. Symptoms of Mental Health Disorders in Critical Care Physicians Facing the Second COVID-19 Wave. A Cross-Sectional Study. Chest 2021;160(3):944-955
- Schwager. Utilizing machine learning to improve clinical trial design for acute respiratory distress syndrome. NPJ Digit Med 2021;4(1):133
- Garcia. Association between Troponin I Levels during Sepsis and Postsepsis Cardiovascular Complications. Am J Respir Crit Care Med 2021;204(5):557–565
- Rouzé. Early Bacterial Identification among Intubated Patients with COVID-19 or Influenza Pneumonia: A European Multicenter Comparative Clinical Trial. Am J Respir Crit Care Med 2021;204(5):546–556
- Duprey. Opioid Use Increases the Risk of Delirium in Critically Ill Adults Independently of Pain. Am J Respir Crit Care Med 2021;204(5):566–572
- Östlund. Neuron-Specific Enolase and long-term neurological outcome after OHCA - a validation study. Resuscitation 2021;epublished September 8th
- Boyle. Hyperoxaemia and hypoxaemia are associated with harm in patients with ARDS. BMC Pulm Med 2021;21:285
- Weiner-Lastinger. The impact of coronavirus disease 2019 (COVID-19) on healthcare-associated infections in 2020: A summary of data reported to the National Healthcare Safety Network. Infection Control & Hospital Epidemiology 2021;epublished September 3rd
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Guidelines
- Clinical practice guideline on the management of septic shock and sepsis-associated organ dysfunction in children: Endorsement by the Scandinavian Society of Anaesthesiology and Intensive Care Medicine.
Acta Anaesthesiol Scand 2021;epublished July 26th - Clinician Well-Being—addressing global needs for improvements in the health care field: a joint opinion from the American College of Cardiology, American Heart Association, European Society of Cardiology, World Heart Federation. Eur Heart J 2021;42(33):3122–3126
- Clinical Practice Guideline by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA): 2021 Focused Update Guidelines on Management of Clostridioides difficile Infection in Adults. Clin Infect Dis 2021;73(5):755–757
- Mass Critical Care Surge Response during COVID-19: Implementation of Contingency Strategies A Preliminary Report of findings from the Task Force for Mass Critical Care. Chest 2021;epublished September 6th
- Wang. Expert consensus of perioperative intensive care and management of critically ill cancer patients (2021). Ann Palliat Med 2021;epublished September 4th
- Circulating Heart Failure Biomarkers beyond Natriuretic Peptides: updated review from the Biomarker Study Group of the Heart Failure Association (HFA), European Society of Cardiology (ESC). Eur J Heart Fail 2021;epublished September 8th
- Fire safety and emergency evacuation guidelines for intensive care units and operating theatres: for use in the event of fire, flood, power cut, oxygen supply failure, noxious gas, structural collapse or other critical incidents. Guidelines from the Association of Anaesthetists and the Intensive Care Society. Anaesthesia 2021;76(10):1377-1391
- Clinical practice guideline on the management of septic shock and sepsis-associated organ dysfunction in children: Endorsement by the Scandinavian Society of Anaesthesiology and Intensive Care Medicine.
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Reviews
Clinical
COVID-19
- Nakanishi. Post-Intensive Care Syndrome and Its New Challenges in Coronavirus Disease 2019 (COVID-19) Pandemic: A Review of Recent Advances and Perspectives. J Clin Med 2021;10(17):3870
- Nana. COVID-19 in pregnancy. Clin Med 2021;21(5):e446-e450
- Mung. Interplay between endocrinology, metabolism and COVID-19 infection. Clin Med 2021;21(5):e499-e504
Neurological
- Peng. Blood Pressure Management After Endovascular Thrombectomy. Front Neurol 2021;12:723461
- Rubiano. Management of severe traumatic brain injury in regions with limited resources. Brain Inj 2021;epublished September 7th
- Washington. Acute Ischemic Stroke. Am J Nurs 2021;121(9):26-33
Circulatory
- Abrams. Extracorporeal cardiopulmonary resuscitation in adults: evidence and implications. Intensive Care Med 2021;epublished September 10th
- Lampejo. Acute myocarditis: aetiology, diagnosis and management. Clin Med 2021;21(5):e505-e510
Respiratory
- Young. Oxygen therapy for critically Ill and post-operative patients. J Anesth 2021;epublished September 6th
- Coppadoro. The use of head helmets to deliver noninvasive ventilatory support: a comprehensive review of technical aspects and clinical findings. Crit Care 2021;25:327
- Livingstone. Coagulation Dysfunction in Acute Respiratory Distress Syndrome and Its Potential Impact in Inflammatory Subphenotypes. Front Med 2021;8:723217
- Beasley. Acute lung injury-from cannabis to COVID. Mod Pathol 2021;epublished September 9th
Hepatobiliary
- Zanetto. Recent Advances in the Management of Acute Variceal Hemorrhage. J Clin Med 2021;10(17):3818
- Mangini. New Therapies of Liver Diseases: Hepatic Encephalopathy. J Clin Med 2021;10(17):4050
Renal
- Li. Targeting Mitochondria and Metabolism in Acute Kidney Injury. J Clin Med 2021;10(17):3991
- Ergin. Kidney Microcirculation as a Target for Innovative Therapies in AKI. J Clin Med 2021;10(17):4041
- Menè. Acute Kidney Injury in Monoclonal Gammopathies. J Clin Med 2021;10(17):3871
- Ow. Targeting Oxidative Stress in Septic Acute Kidney Injury: From Theory to Practice. J Clin Med 2021;10(17):3798
Haematological
Trauma
Paediatrics
- Giorni. Pediatric Mechanical Circulatory Support: Pathophysiology of Pediatric Hemostasis and Available Options. Front Cardiovasc Med 2021;8:671241
- Giacalone. Multisystem inflammatory syndrome in children (MIS-C): a mini-review. Int J Emerg Med 2021;14:50
- Laho. Invasive Group A Streptococcal Infections: Benefit of Clindamycin, Intravenous Immunoglobulins and Secondary Prophylaxis. Front Pediatr 2021;9:697938
- Veldscholte. Intermittent fasting in paediatric critical illness: The properties and potential beneficial effects of an overnight fast in the PICU. Clin Nutrition 2021;40(9):5122-5132
Obstetrics
- Wiles. Severe hypertension in pregnancy. Clin Med 2021;21(5):e451-e456
- Mohan. Metabolic emergencies in pregnancy. Clin Med 2021;21(5):e438-e440
- Lim. Liver diseases in pregnancy. Clin Med 2021;21(5):e441-e445
- Liew-Spilger. Viscoelastic Hemostatic Assays for Postpartum Hemorrhage. J Clin Med 2021;10(17):3946
Miscellaneous
Non-Clinical
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Editorials
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Commentaries
- Gattinoni. Isn’t it time to abandon ARDS? The COVID-19 lesson. Crit Care 2021;25:326
- Beil. The management of multi-morbidity in elderly patients: Ready yet for precision medicine in intensive care?. Crit Care 2021;25:330
- Siddiqui. Pathological disease in the lung periphery after acute COVID-19. Lancet Respir Med 2021;epublished September 7th
- Alam. The dominant left ventricular assist device: lessons from an era. ESC Heart Fail 2021;epublished September 10th
- Zaidi. Family Calls and Visitation in the COVID-19 Era. Chest 2021;160(3):1147-1148
- Ely. Medicine at Its Finest. Chest 2021;160(3):1149-1150
- Montrucchio. When Words Are Not Enough (First Anniversary of Pandemic in the Words of a Doctor to a Patient). Chest 2021;160(3):1145-1146
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Correspondence
- Shah. Effect of Vaccination on Transmission of SARS-CoV-2. N Engl J Med 2021;epublished September 8th
- Schönborn. Decline in Pathogenic Antibodies over Time in VITT. N Engl J Med 2021;epublished September 8th
- Normark. Heterologous ChAdOx1 nCoV-19 and mRNA-1273 Vaccination. N Engl J Med 2021;385:1049-1051
- Murray. Opioids for Sedation: Has the Pendulum Swung Too Far? Am J Respir Crit Care Med 2021;204(5):611
- Yasuma. No Strong Evidence for Ruling Out the Role of Coagulation in Long-Term Disability after Critical Illness. Am J Respir Crit Care Med 2021;204(5):613
- Dugar. Defining Right Ventricular Dysfunction in Acute Respiratory Distress Syndrome. J Cardiothorac Vasc Anesth 2021;epublished September 7th
- Perez-Vizcaino. Interleukin-6 and intrapulmonary shunt. Eur Respir J 2021;58:2101292
- Riera. Increased mortality in patients with COVID-19 receiving extracorporeal respiratory support during the second wave of the pandemic. Intensive Care Med 2021;epublished September 9th
- Rouzé,. High Incidence of Nosocomial Infections in COVID-19 Patients. Chest 2021;160(3):e315
- Zuin. Right Ventricular Dysfunction in Early Sepsis and Septic Shock. Chest 2021;160(3):e318-e319
- Xiao. The Linkage Between Intraabdominal Hypertension and Acute Kidney Injury Remains To Be Confirmed. Chest 2021;160(3):e320-e321
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Case Reports
- Chakraborty. The Tricky Trachea. Chest 2021;160(3):e255-e258
- Manoukian. A 70-Year-Old Woman With Refractory Hypoxemia. Chest 2021;160(3):e265-e268
- Alnabulsi. A 60-Year-Old Man With Acute Chest Pain. A Common Presentation, But Unusual Diagnosis. Chest 2021;160(3):e269-e272
- Karime. A 49-Year-Old Woman With Persistent Bilateral Pleural Effusions.Chest 2021;160(3):273-e278
- Winston. A 24-Year-Old Woman Presenting With Altered Mental Status and Multiorgan Failure. Chest 2021;160(3):e279-e283
- Tzilas. A 58-Year-Old Woman With Lung Nodules and Chronic Cough. Chest 2021;160(3):e285-e288
- Gable. A 24-Year-Old Man With Hemoptysis Found to Have a Chest Mass and Contralateral Axillary Lymphadenopathy. Chest 2021;160(3):e289-e293
- Qureshi. Dyspnea, Elevated Jugular Venous Pulse, and Lower Extremity Edema in the Setting of Interstitial Lung Disease in a Patient Who Has Undergone Liver and Kidney Transplantation. Chest 2021;160(3):e295-e298
- Fanget. Intestinal Air in the Mediastinum. Chest 2021;160(3):e299-e303
- Kourouni. A Hydropneumothorax That Never Was! Chest 2021;160(3):e305-e309
- Haloot. 60-Year-Old Man With Liver Lesions and a Subcutaneous Nodule. Chest 2021;160(3):e311-e313
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Multimedia
I hope you find this newsletter useful.
Until next week
Rob
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