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Paediatric Non-Invasive Respiratory Support

FIRST ABC Trial - Step Down

The FIRST ABC trial (Step Down) compares high-flow nasal oxygen with continuous positive airway pressure for non-invasive respiratory support in extubated critically ill children. The results of the Step Up trial will be presented at CCR22.

Thursday, April 7th

19:30 UTC + 1

Previous Livestreams


2022

2021

PLUS Trial and Balanced Solutions Systematic Review


PLUS Trial Results Presentation

Prof Simon Finfer (Sydney, Australia)

Balanced Crystalloids Systematic Review Results Presentation

Assoc Prof Naomi Hammond (Sydney, Australia)

Editorial

Prof Deborah Cook (Hamilton, Canada)

Viewer's Questions

Dr Murali Shyamsundar (Belfast, Northern Ireland)

Answers from Prof Simon Finfer & Assoc Prof Naomi Hammond (both Sydney, Australia)

Panel Discussion

Rob Mac Sweeney hosts a panel discussion on the results of the PLUS trial, including Prof John Kellum (Pittsburgh, USA), Prof Gordon Guyatt (Hamilton, Canada), Dr Tomoko Fujii (Tokyo, Japan) & Prof Jeff Drazen (Boston, USA)


BOUGIE Trial


BOUGIE Trial Results Presentation

Drs Jon Casey (Nashville, USA), Stacy Trent (Denver, USA) and Brian Driver (Minneapolis, USA)

Editorial

Prof Sheila Nainan Myatra (Mumbai, India).

Replies from Dr Brian Driver (Minneapolis, USA) & Dr Matt Semler (Nasville, USA), plus comments from Prof Jonathan Benger (Bristol, England).

Viewer's Questions

Dr Chris Nutt (Bellfast, Northern Ireland).

Replies from Dr Brian Driver (Minneapolis, USA) & Dr Matt Semler (Nasville, USA)

Panel Discussion

Prof Jonathan Benger (Bristol, England), Dr Jean-Baptiste Lascarrou (Nantes, France), George Kovacs (Halifax, Canada), Dr Jon Casey (Nasville, USA), Dr Stacy Trent (Denver, USA), Dr Brian Driver (Minneapolis, USA) & Dr Matt Semler (Nasville, USA). Chaired by Dr Rob Mac Sweeney (Bellfast, Northern Ireland).


COCA Trial


COCA Trial Results Presentation

Dr Mikael Fink Vallentin and Lars Andersen (Aarhus, Denmark)

Editorial

Prof Gavin Perkins (Coventry, England)

Viewer's Questions

Dr Chris Nutt (Belfast, Northern Ireland)

Panel Discussion

Prof Theresa Olasveengen (Oslo, Norway), Dr Victoria Cornelius (London, England), Prof Christopher Seymour (Pittsburgh, USA), Prof Gavin Perkins (Coventry, England), Dr Mikael Fink Vallentin & Prof Lars Andersen (Aarhus, Denmark)


COVID-STEROID 2 Trial


COVID STEROID 2 Trial Results Presentation

Prof Sheila Nainan Myatra (Mumbai, India), Prof Bala Ventakesh (Brisbane, Australia), Prof Anders Perner (Copenhagen, Denmark)

Editorial

Prof Marion Campbell (Aberdeen, Scotland)

Viewer's Questions

Dr Chris Nutt (Belfast, Northern Ireland)

Panel Discussion

Prof Bram Rochwerg (Hamilton, Canada), Dr Paul Mouncey (London, England) & Prof Colin McArthur (Auckland, New Zealand), Prof Sheila Nainan Myatra (Mumbai, India), Prof Bala Ventakesh (Brisbane, Australia), Prof Anders Perner (Copenhagen, Denmark), Prof Marion Campbell (Aberdeen, Scotland).

The HOPE Trial
Research Challenges during a Pandemic

Dr Bharath Kumar (Chennai, India)


VAM-IHCA Trial


VAM-IHCA Trial Results Presentation

Asger Granfeldt and Lars Wiuff Andersen (both Aarhus, Denmark)

Editorial

Prof Spyros Mentzelopoulos (Athens)

Viewer's Questions

Dr Chris Nutt (Belfast, Northern Ireland)

Panel Discussion

Katherine Berg (Boston), Bernd Böttiger (Cologne), Ranjit Lall (Coventry), Louise Morrison (Toronto), Spyros Mentzelopoulos (Athens), Lars Wiuff Andersen & Asger Granfeldt (Aarhus), Spyros Mentzelopoulos (Athens). Hosted by Rob Mac Sweeney (Belfast)


COVID-19 Anticoagulation Multi-Platform Trial


VAM-IHCA Trial Results Presentation

Drs Patrick Lawler (Toronto), Lindsay Berry (Austin) & Ewan Goligher (Toronto)

Editorial

Charlotte Summers (Cambridge)

Viewer's Questions

Dr Peter McGuigan (Belfast)

Panel Discussion

An international panel of experts discuss the robustness and implications of the COVID-19 Anticoagulation Trial at a livestreamed Critical Care Reviews Trial Results Meeting, on August 4th, 2021.The panel include Profs Judith Hochman (New York), Saskia Middledorp (Nijmegen) and James Douketis (Hamilton).


RECOVERY-RS Trial


RECOVERY-RS Trial Results Presentation

Drs Bronwen Connolly (Belfast) and Keith Couper (Coventry)

Editorial

Prof Manu Shankar-Hari (London)

Viewer's Questions

Dr Chris Nutt (Belfast)

Panel Discussion

Dr Rob Mac Sweeney (Belfast) hosts a panel discussion on the RECOVERY-RS trial. The panelists include Profs Leticia Kawano-Dourado (Sao Paulo), Janet Diaz (San Francisco) & John Norrie (Edinburgh), plus Dr Stephen Webb (Cambridge).


BaSICS Trial


BaSICS Trial Results Presentation

Dr Fernando Zampieri & Alexandre Biasi Cavalcante (São Paulo)

Editorial

Prof Simon Finfer (Sydney)

Viewer's Questions

Dr Bronwen Connolly (Belfast)

Panel Discussion

Rob Mac Sweeney hosts an international panel discussion on the results of the BaSICS trial. The panelists are Prof Kathryn Maitland (Kenya), Dr Tine Sylvest Meyhoff (Denmark), Assoc Prof Christopher Seymour (USA) & Asst. Prof Andrew Althouse (USA). They are joined by the lead trialists Drs Fernando Zampieri & Alexandre Biasi Cavalcante (both Brazil), as well Simon Finfer (Australia), who delivered an editorial on the trial.

Learnings from the BaSICS Trial

Dr Fernando Zampieri (São Paulo)


TTM2 Trial


Livestreamed June 16th, 2021

TTM2 Trial Results Presentation

Niklas Nielsen, Josef Dankiewicz and Gisela Lilja (all Lund)

Editorial

Stephen Bernard (Melbourne)

Viewer's Questions

Phil Gillen (Belfast)

Panel Discussion

Jerry Nolan (Bath), Kathy Rowan (London) and Terri Hough (Portland), join Stephen Bernard plus the TTM2 trial team of Niklas Nielsen, Josef Dankiewicz and Gisela Lilja (all Lund). Hosted by Rob Mac Sweeney (Belfast)


REMAP-CAP IL-6 Receptor Antagonist Domain Results Livestream


Livestreamed February 26th, 2021

This is the REMAP-CAP IL-6 receptor antagonist domain results presentation, recorded February 25th. The presentation was accompanied by a simultaneous publication in the New England Journal of Medicine.

Prof Derek Angus (Pittsburgh, USA) & Dr Liz Lorenzi (Berry Consultants, Austin, USA), set the scene with talks on the adaptive platform design of REMAP-CAP, and its underlying Bayesian framework, respectively. Next, Dr Lennie Derde (Utrecht, The Netherlands) presents the full results of the IL-6 receptor antagonist domain, followed by an independent editorial by Prof Tim Walsh (Edinburgh, Scotland). Lennie and her co-investigators reply to the editorial and questions from viewers. The session ends with a panel discussion, including external experts Dr David Harrison (Chief Statistician, ICNARC, London), Prof Anders Perner (Copenhagen, Denmark), and Prof Anthony Gordon (London, England), the lead investigator for the IL-6 RA domain at REMAP-CAP.

Session Timings

  • 1:37 - Derek Angus - The Beauty of Adaptive Designs

  • 19:22 - Liz Lorenzi -.The Statistical Framework of REMAP-CAP

  • 42:50 - Lennie Derde - The Results

  • 1:09:05 - Tim Walsh - The Editorial

  • 1:35:40 - Lennie Derde et al - Reply to the Editorial

  • 1:43:52 - Questions va Chris Nutt

  • 1:54:10 - Panel Discussion

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