Newsletter 149 / October 12th 2014



Welcome to the 149th Critical Care Reviews Newsletter, bringing you the best critical care research published in the past week, plus a wide range of free full text review articles, guidelines, commentaries, editorials, study critiques, correspondence and case reports from hundreds of clinical and scientific journals. This week's newsletter is dominated by the escalating Ebola Virus Disease outbreak, which has spread to North American and Europe. I have created an EVD resource, containing the main research, guidelines, review articles and commentaries published over the past several months.

The highlights this week include the stunning CHEER study, new guidance on when to consider "do-not-attempt CPR" orders, and review articles on mechanical support in acute heart failure and acute-on-chronic liver failure. In news, the Ebola Virus Disease epidemic threatens to spread globally, with new patient-to-patient transmission in both Europe and the USA. I have put together a complete resource on Ebola Virus Disease, compiling the best published literature available at present. Current guidelines from the WHO, Europe, USA, Canada, Australia, UK, Spain and France are also available.

The Topic of the Week is cardiogenic shock, starting with a general paper in tomorrow's Paper of the Day.

I'm delighted to announce Dr Karin Amrein (Graz, Austria), chief investigator for the VITdAL-ICU study is a late addition to the Critical Care Reviews Meeting in January. See below for further details of this cutting edge meeting.


Upcoming Meetings

Critical Care Reviews Meeting 2015

Registration for the 2015 Critical Care Reviews Meeting has now opened, with early bookings already rolling in. The event theme is to review the top papers of 2014, aiming to decide whether we should implement the results of these studies. On hand to provide genuine expert opinion will be the chief investigators for several of these trials, including TTM, VITdAL-ICU, CALORIES, ProMISE and HARP 2. In addition, another 8 major randomized controlled trials will be critiqued. Further talks include early mobilisation, ECMO, airway management, and neuroprognostication post cardiac arrest. Amazingly, if the embargo has lifted in time, we will also have the inside line on, and be one of the first worldwide to discuss, the new sepsis definitions. With chief investigators for three of the major RCTs presented at ESICM just two weeks ago, the chief investigator for the biggest critical care study of 2013, and the chief investigator for the third of the 2014 early goal-directed therapy sepsis studies, it's one of the most contemporary, focused meetings around - you won't want to miss it.

The meeting is on Friday January 23rd, at the Galgorm Resort and Spa, outside Belfast, Northern Ireland, and is held in association with the Northern Ireland Intensive Care Society.  The impressive list of speakers includes Clifford Deutschman (USA), past president of the Society of Critical Care Medicine, Niklas Nielsen (Sweden), Eddy Fan (Canada), Kathy Rowan (England), Karin Amrein, (Austria), Danny McAuley, Eamon McCoy, and John Hinds (Northern Ireland), plus a host of local intensivists. In keeping with a FOAMed event, this is a not-for-profit meeting, with all talks being recorded and made freely available online shortly after. The programme will be released in the next few days.

SMACC Chicago

The next SMACC conference will be held June 23rd to 26th, in Chicago, USA. Just like the Critical Care Reviews Meeting, this is a not-for-profit event, run by a team interested in sharing knowledge in a fun, modern way. It's a conference like no other. Further details, including a truly incredible programme and registration, will be out very soon on the SMACC website.


Critical Care Horizons

Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. A call for papers has been issued, so if you have something interesting to say, and can say it in an engaging manner, please get in touch. The first issue will be released on January 1st 2015.

COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.



Randomized Controlled Trials

Meta Analyses

Observational Studies


Guidelines & Position Statements











Case Report




Clinical Review Articles












Non-Clinical Review Articles



I hope you find these links useful.

Until next week