Newsletter 149 / October 12th 2014
Welcome to the 149th Critical Care Reviews Newsletter, bringing you the best critical care research published in the past week, plus a wide range of free full text review articles, guidelines, commentaries, editorials, study critiques, correspondence and case reports from hundreds of clinical and scientific journals. This week's newsletter is dominated by the escalating Ebola Virus Disease outbreak, which has spread to North American and Europe. I have created an EVD resource, containing the main research, guidelines, review articles and commentaries published over the past several months.
The highlights this week include the stunning CHEER study, new guidance on when to consider "do-not-attempt CPR" orders, and review articles on mechanical support in acute heart failure and acute-on-chronic liver failure. In news, the Ebola Virus Disease epidemic threatens to spread globally, with new patient-to-patient transmission in both Europe and the USA. I have put together a complete resource on Ebola Virus Disease, compiling the best published literature available at present. Current guidelines from the WHO, Europe, USA, Canada, Australia, UK, Spain and France are also available.
The Topic of the Week is cardiogenic shock, starting with a general paper in tomorrow's Paper of the Day.
I'm delighted to announce Dr Karin Amrein (Graz, Austria), chief investigator for the VITdAL-ICU study is a late addition to the Critical Care Reviews Meeting in January. See below for further details of this cutting edge meeting.
Upcoming Meetings
Critical Care Reviews Meeting 2015
Registration for the 2015 Critical Care Reviews Meeting has now opened, with early bookings already rolling in. The event theme is to review the top papers of 2014, aiming to decide whether we should implement the results of these studies. On hand to provide genuine expert opinion will be the chief investigators for several of these trials, including TTM, VITdAL-ICU, CALORIES, ProMISE and HARP 2. In addition, another 8 major randomized controlled trials will be critiqued. Further talks include early mobilisation, ECMO, airway management, and neuroprognostication post cardiac arrest. Amazingly, if the embargo has lifted in time, we will also have the inside line on, and be one of the first worldwide to discuss, the new sepsis definitions. With chief investigators for three of the major RCTs presented at ESICM just two weeks ago, the chief investigator for the biggest critical care study of 2013, and the chief investigator for the third of the 2014 early goal-directed therapy sepsis studies, it's one of the most contemporary, focused meetings around - you won't want to miss it.
The meeting is on Friday January 23rd, at the Galgorm Resort and Spa, outside Belfast, Northern Ireland, and is held in association with the Northern Ireland Intensive Care Society. The impressive list of speakers includes Clifford Deutschman (USA), past president of the Society of Critical Care Medicine, Niklas Nielsen (Sweden), Eddy Fan (Canada), Kathy Rowan (England), Karin Amrein, (Austria), Danny McAuley, Eamon McCoy, and John Hinds (Northern Ireland), plus a host of local intensivists. In keeping with a FOAMed event, this is a not-for-profit meeting, with all talks being recorded and made freely available online shortly after. The programme will be released in the next few days.
SMACC Chicago
The next SMACC conference will be held June 23rd to 26th, in Chicago, USA. Just like the Critical Care Reviews Meeting, this is a not-for-profit event, run by a team interested in sharing knowledge in a fun, modern way. It's a conference like no other. Further details, including a truly incredible programme and registration, will be out very soon on the SMACC website.
Critical Care Horizons
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. A call for papers has been issued, so if you have something interesting to say, and can say it in an engaging manner, please get in touch. The first issue will be released on January 1st 2015.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
Research
Randomized Controlled Trials
- Abstract: Shehabi. Procalcitonin Algorithm in Critically Ill Adults with Undifferentiated Infection or Suspected Sepsis: A Randomized Controlled Trial (ProGUARD Study). Am J Respir Crit Care Med 2014;epublished October 8th
- Abstract: Coreya. Single-dose Oritavancin Compared to 7-10 days of Vancomycin in the Treatment of Gram-Positive Acute Bacterial Skin and Skin Structure Infections; the SOLO II Non-inferiority Study. Clin Infect Dis 2014;epublished October 6th
- Full Text: Chawla. Intravenous angiotensin II for the treatment of high-output shock (ATHOS trial): a pilot study. Critical Care 2014;18:534
- Abstract: Hacke. Transcranial Laser Therapy in Acute Stroke Treatment. Results of Neurothera Effectiveness and Safety Trial 3, a Phase III Clinical End Point Device Trial. Stroke 2014;epublished October 7th
- Abstract: Struik. Nocturnal non-invasive ventilation in COPD patients with prolonged hypercapnia after ventilatory support for acute respiratory failure: a randomised, controlled, parallel-group study. Thorax 2014;69(9):826-34
- Abstract: Voors . Renal Hemodynamic Effects of Serelaxin in Patients With Chronic Heart Failure: A Randomized, Placebo-Controlled Study. Circ Heart Fail 2014;epublished October 6th
- Abstract: Munro. Pre-Intubation application of oral chlorhexidine does not provide additional benefit in prevention of early onset ventilator-associated pneumonia. Chest 2014;epublished October 9th
Meta Analyses
- Abstract: McIlvennan. Clinical Outcomes Following Continuous-Flow Left Ventricular Assist Device: A Systematic Review. Circ Heart Failure 2014;epublished October 7th
- Abstract: Tsoi. Meta-analysis: comparison of oral vs. intravenous proton pump inhibitors in patients with peptic ulcer bleeding. Aliment Pharmacol Ther 2013;38(7):721-8
- Abstract: Bai. Lidocaine Patch for Acute Pain Management: A Meta-analysis of Prospective Controlled Trials. Current Medical Research and Opinion 2014;epublished October 7th
- Abstract: Chen. Thrombolysis Versus Anticoagulation for the Initial Treatment of Moderate Pulmonary Embolism: A Meta-Analysis of Randomized Controlled Trials. Respir Care 2014;epublished September 30th
- Abstract: Hughes. Analgesia After Open Abdominal Surgery in the Setting of Enhanced Recovery Surgery: A Systematic Review and Meta-analysis JAMA Surg 2014;epublished October 8th
- Full Text: Kalil. Association Between Vancomycin Minimum Inhibitory Concentration and Mortality Among Patients With Staphylococcus aureus Bloodstream Infections: A Systematic Review and Meta-analysis. JAMA 2014;epublished October 9th
- Abstract: Kohn. Prognostic Accuracy of Clinical Prediction Rules for Early Post-Pulmonary Embolism All-Cause Mortality: A Bivariate Meta-Analysis. Chest 2014;epublished October 9th
- Full Text: Luo. Can non-invasive positive pressure ventilation prevent endotracheal intubation in acute lung injury/acute respiratory distress syndrome? A meta-analysis. Respirology 2014;19:1149–1157
Observational Studies
- Abstract: Stub. Refractory Cardiac Arrest Treated with Mechanical CPR, Hypothermia, ECMO and Early Reperfusion (the CHEER Trial). Resuscitation 2014;epublished September 30th
- Full Text: Shaw. Association between intravenous chloride load during resuscitation and in-hospital mortality among patients with SIRS. Intensive Care Med 2014;epublished October 8th
- Abstract: Smekal. CPR-related injuries after manual or mechanical chest compressions with the LUCAS™ device: A multicentre study of victims after unsuccessful resuscitation. Resuscitation 2014;epublished September 29th
- Full Text: Magill. Prevalence of Antimicrobial Use in US Acute Care Hospitals, May-September 2011. JAMA 2014;312(14):1438
- Abstract: Kashefi. Does a Nebulized Heparin/N-acetylcysteine Protocol Improve Outcomes in Adult Smoke Inhalation?. Plast Reconstr Surg Glob Open. 2014 Jul 9;2(6):e165
- Abstract: Bro-Jeppesen. Targeted Temperature Management at 33°C Versus 36°C and Impact on Systemic Vascular Resistance and Myocardial Function After Out-of-Hospital Cardiac Arrest: A Sub-Study of the Target Temperature Management Trial. Circ Cardiovasc Interv 2014;epublished September 30th
- Abstract: Stammet. Bispectral Index to Predict Neurological Outcome Early After Cardiac Arrest. Resuscitation 2014;epublished September 24th
- Abstract: Hellyer. Diagnostic accuracy of pulmonary host inflammatory mediators in the exclusion of ventilator-acquired pneumonia. Thorax 2014;epublished October 8th
- Abstract: Rampa . Outcomes of Invasive Mechanical Ventilation in Children and Adolescents Hospitalized due to Status Asthmaticus in United States: A Population based Study. J Asthma 2014;8:1-27
- Abstract: Francesco. Intrapleural tPA and DNase for Pleural Infection: an effective and safe alternative to surgery. Annals ATS 2014;epublished October 8th
- Full Text: Hincker. Rotational thromboelastometry predicts thromboembolic complications after major non-cardiac surgery. Critical Care 2014;18:549
- Abstract: Hellyer. Diagnostic accuracy of pulmonary host inflammatory mediators in the exclusion of ventilator-acquired pneumonia. Thorax 2014;epublished October 8th
- Abstract: Rampa. Outcomes of Invasive Mechanical Ventilation in Children and Adolescents Hospitalized due to Status Asthmaticus in United States: A Population based Study. J Asthma 2014;8:1-27
- Abstract: Francesco. Intrapleural tPA and DNase for Pleural Infection: an effective and safe alternative to surgery. Annals ATS 2014;epublished October 8th
- Full Text: Hincker. Rotational thromboelastometry predicts thromboembolic complications after major non-cardiac surgery. Critical Care 2014;18:549
Guidelines & Position Statements
- NICE. Acute heart failure: diagnosing and managing acute heart failure in adults. NICE 2014;epublished October
- Canadian Critical Care Society. Ebola Clinical Care Guidelines. Epublished August 29th 2014
- Decisions relating to Cardiopulmonary Resuscitation (3rd edition). Guidance from the British Medical Association, the Resuscitation Council (UK), and the Royal College of Nursing. Epublished October 7th (ht @LJMottram)
- St-onge. Treatment for calcium channel blocker poisoning: A systematic review. Clinical Toxicology 2014;epublished October 6th
- Kübler. Guidelines regarding the ineffective maintenance of organ functions (futile therapy) in ICU patients incapable of giving informed statements of will. Anaesthesiology Intensive Therapy 2014;46(4):215-220
- Misiołek. The 2014 guidelines for post-operative pain management. Anaesthesiology Intensive Therapy 2014;46(4):221-244
- Bruhin. Systematic review and evidence based recommendations for the use of Negative Pressure Wound Therapy in the open abdomen. International Journal of Surgery 2014;12(10):1105–1114
Editorials
Clinical
- McLean. Echography is mandatory for the initial management of critically ill patients: Yes. Intensive Care Med 2014;epublished October 7th
- Volpicelli. Echography is mandatory for the initial management of critically ill patients: No. Intensive Care Med 2014;epublished October 7th
- Feinman. Hemodynamic Transesophageal Echocardiography in Left Ventricular Assist Device Care: A Complementary Technology. Journal of Cardiothoracic and Vascular Anesthesia 2014;28(5):1181-1183
- Baden. Ebola — An Ongoing Crisis. N Engl J Med 2014;371:1458-1459
- The Lancet. Ebola: what lessons for the International Health Regulations? Lancet 2014;384(9951):1321
- Anonymous. Out of Africa. Nature 2014;514:139
Non-Clinical
- Rosen. History of anaesthesia: The conception and birth of the European Academy of Anaesthesiology. European Journal of Anaesthesiology 2014;31(11):586-588
- Carreiro. Ethics in the digital age. Rev Col Bras Cir 2014;41(4):234-235
Commentaries
Clinical
- Kaiser Family Foundation. The 2014 Ebola Outbreak. JAMA 2014;312(14):1388
- Kanapathipillai. Ebola Vaccine — An Urgent International Priority. N Eng J Med 2014;epublished October 7th
- Hayden. Ebola outbreak shuts down malaria-control efforts. Nature 2014;514:15–16
- Gostin. Ebola: towards an International Health Systems Fund. Lancet 2014;384(9951):e49-e51 (Free Registration Required)
- Boozary. The Ebola Outbreak, Fragile Health Systems, and Quality as a Cure. JAMA 2014;epublished October 6th
- Strauss. Ebola research fueled by bioterrorism threat. CMAJ 2014;epublished October 6th
- Lancet Respiratory Medicine. Antibiotic resistance—poised at a pivotal point in time. Lancet Respiratory Medicine 2014;2(10):775
- Hampton. Efforts Mount to Curb Carbapenem-Resistant Infections. JAMA 2014;312(14):1386-1387
- Akkermans. 2014 annual congress of the European Respiratory Society. Lancet Respiratory Medicine 2014;2(10):788-790
- Jalan. Toward an Improved Definition of Acute-on-Chronic Liver Failure. Gastroenterology 2014;147(1):4–10
- Roelandt. An arcane cardiomyopathy. Neth Heart J 2014;22:477–479
Correspondence
Case Report
News
- Gulland. Spanish authorities investigate how nurse contracted Ebola. BMJ 2014;349:g6120
- Garza. Texas health worker becomes 2nd person diagnosed in U.S. with Ebola. Reuters 2014;epublished October 12th
Clinical Review Articles
Neurological
- Wijayatilake. What's new in the management of traumatic brain injury on neuro ICU? Curr Opin Anaesth 2014;27(5):569-564
- Mazurkiewicz-Bełdzińska. Current treatment of convulsive status epilepticus — a therapeutic protocol and review. Anaesthesiology Intensive Therapy 2014;46(4):293-300
- Chaudhry. Sepsis Associated Encephalopathy. Advances in Medicine 2014;2014:762320
- Lirk. Local anaesthetics: 10 essentials. Eur J Anaesthesiology 2014;31(11):575-585
- Idris. Early experience in endoscopic management of massive intraventricular hemorrhage with literature review. Asian J Neurosurg 2014;9:124-9
Circulatory
- Szymanski. Cardiogenic shock — diagnostic and therapeutic options in the light of new scientific data. Anaesthesiology Intensive Therapy 2014;46(4):301–306
- Khan. Mechanical circulatory support in acute cardiogenic shock. F1000Prime Reports 2014;6:(91)
- Frost. Perioperative Fluids: An Evidence-Based Review. Anesthesiology News 2014;40:10S
- Oliemy. Transcatheter aortic valve implantation. F1000Prime Reports 2014;6:(92)
- Mathew. Assessing the Risk of Aortic Valve Replacement for Severe Aortic Stenosis in the Transcatheter Valve Era. Mayo Clin Proc 2014;89(10):1427–1435
- Taegtmeyer. Rethinking cardiac metabolism: metabolic cycles to refuel and rebuild the failing heart. F1000Prime Reports 2014 6:(90)
- Shah. Pheochromocytoma. A Devious Opponent in a Game of Hide-and-Seek. Circulation 2014;130:1295-1298
- Wijnker. Troponin I phosphorylation in human myocardium in health and disease. Neth Heart J 2014;22:463–460
Respiratory
- Lee. Imaging adults on extracorporeal membrane oxygenation (ECMO). Insights into Imaging 2014;epublished October 9th
- Carlucci. Effective management of ARDS. Nurse Pract 2014;epublished October 8th
Gastrointestinal
Hepatobiliary
- Moreau. Acute-on-Chronic Liver Failure: Recent Concepts. Journal of Clinical and Experimental Hepatology 2014;epublished October 3rd
- Sauerbruch. Future therapy of portal hypertension in liver cirrhosis – a guess. F1000Prime Reports 2014;6:(95)
Renal
Endocrine
Haematological
- Anderson. When patients on target-specific oral anticoagulants need surgery. Cleveland Clinic Journal of Medicine 2014; 81(10):629-639
- Weitz. Expanding use of new oral anticoagulants. F1000Prime Reports 2014;6:(93)
- Brieger. Anticoagulation: a GP primer on the new oral anticoagulants. Aust Fam Physician 2014;43(5):254-9
- Gusmão. Transoperative refusion: a simple and safe method in emergency surgery. Rev Col Bras Cir 2014;41(4):292-296
Sepsis
- Ansari. Clinical features and pathobiology of Ebolavirus infection. J Autoimmun 2014;epublished September 26th
- Tan. Ebola virus disease: Potential use of melatonin as a treatment. Journal of Pineal Research 2014;epublished September 30th
- Zhang. Forty years of the war against Ebola. J Zhejiang Univ Sci B 2014;15(9):761–765
- Lyle. Barriers to the effective treatment of sepsis: antimicrobial agents, sepsis definitions, and host-directed therapies. Annals of the New York Academy of Sciences 2014;1323:101–114
- Fowler. The risk/benefit of predicting a post-antibiotic era: Is the alarm working?. Annals of the New York Academy of Sciences 2014;1323:1–10
- Temkin. Carbapenem-resistant Enterobacteriaceae: biology, epidemiology, and management. Annals of the New York Academy of Sciences 2014;1323:22–42
- Mdluli. Tuberculosis drug discovery and emerging targets. Annals of the New York Academy of Sciences 2014;1323:56–75
- Riccardi. Trends in discovery of new drugs for tuberculosis therapy. The Journal of Antibiotics 2014;67:655–659
- Allen. Finding alternatives to antibiotics. Annals of the New York Academy of Sciences 2014;1323:91–100
- Webster. Continuing challenges in influenza. Annals of the New York Academy of Sciences 2014;1323:115–139
- Al-Dorzi. Antibiotic therapy of pneumonia in the obese patient: dosing and delivery. Current Opinion in Infectious Diseases 2014;27(2):165-173
- Iturriza-Gómara. Norovirus in healthcare settings. Curr Opin Infect Dis 2014;27:437–443
- Amin. Hospitalist Perspective on the Treatment of Skin and Soft Tissue Infections. Mayo Clin Proc 2014;89(10):1436-1451
- Fooks. Current status of rabies and prospects for elimination. Lancet 2014;384(9951):1389-1399 (Free Registration Required)
Perioperative
Non-Clinical Review Articles
- Kumar. Knowing and avoiding plagiarism during scientific writing. Ann Med Health Sci Res 2014;4(Suppl S3):193-8
- Winter. Clinical trial design in the era of comparative effectiveness research. Open Access Journal of Clinical Trials 2014;6:101-110
I hope you find these links useful.
Until next week
Rob