Topic of the Week November 3rd to 9th Research Over-Interpretation - part II Monday Collins. Reliable assessment of the effects of treatment on mortality and major morbidity. I. Clinical trials. Lancet 2001;357:373-380 Tuesday MacMahon. Reliable assessment of the effects of treatment on mortality and major morbidity, II: observational studies. Lancet 2014;357(9254):455-462 Wednesday Concato. Study Design and “Evidence” in Patient-oriented Research. Am J Respir Crit Care Med 2013;187(11):1167-1172 Thursday Albert. “Lies, Damned Lies …” and Observational Studies in Comparative Effectiveness Research". Am J Respir Crit Care Med 2013;187(11):1173-1177 Friday Wallace. Solving the challenges of large multicenter trials in anesthesia. HSR Proc Intensive Care Cardiovasc Anesth 2009;1(3):46-53 Saturday Delaney. Bench-to-bedside review: the evaluation of complex interventions in critical care. Crit Care 2008;12(2):210 Sunday Lewis. How to spot bias and other potential problems in randomised controlled trials. J Neurol Neurosurg Psychiatry 2004;75(2):181-7