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Critical Care Reviews Newsletter

June 3rd 2012





Welcome to the 26th Critical Care Reviews Newsletter. Every week over two hundred clinical and scientific journals are monitored and the most important and interesting research publications in critical care are highlighted. These studies are added to the Current Articles section of the website on a daily basis, as publication occurs. A link to either the full text or abstract, depending on the publishers degree of open access, is attached. Links to free review articles are also included.

It's a mixed newsletter this week as there appears to be just 1 major study published over the past 7 days. There are a number of review articles covered, including clinical, basic science and non-clinical papers.

In addition, the Hot Articles section has now been completed, and includes some of the most important papers published in critical care over the past 6 months. If you feel I've missed something important, please let me know at It's hoped this will be a useful resource for anyone wanting to find the major recent studies in critical care.

The topic for This Week's Papers is electrolyte disorders, starting with sodium in tomorrow's Paper of the Day. It's a free and easy way to stay up-to-date with your reading.



Lancet:     Subarachnoid Haemorrhage

In an international multi-centre randomised, placebo-controlled trial of 1204 patients within 4 days of onset of SAH, the addition of 64 mmol/day of MgSO4 intravenously had no effect on the primary outcome of a score of 4—5 on the modified Rankin Scale—3 months after subarachnoid haemorrhage, or death {magnesium group 158 patients (26·2%) vs placebo group 151 (25·3%) (RR 1·03, 95% CI 0·85—1·25).

Abstract: Dorhout Mees. Magnesium for aneurysmal subarachnoid haemorrhage (MASH-2): a randomised placebo-controlled trial. Lancet 2012; epublished ahead of print


Clinical Infectious Disease:     Candidiasis

In an analysis of 257 patients undergoing a treatment trial of andilafungin for invasive candidiasis, 203 patients had paired (1,3)-β-D-Glucan levels measured, which were as a prognostic marker of treatment response. Successfully treated patients, had initial and post-treatment (1,3)-β-D-Glucan levels (mean/SD) of 573 ± 681 pg/mL and 499 ± 635 pg/mL (P = .03). The 15% of patients who failed treatment had pre- and post- therapy levels of 1224 ± 1585 pg/mL and 1293 ± 1283 pg/mL (P = .29). A pre-treatment (1,3)-β-D-Glucan levels <416 pg/mL had a positive predictive value of 89% for treatment success.

Abstract: Jaijakul. (1,3)-β-D-Glucan as a Prognostic Marker of Treatment Response in Invasive Candidiasis. Clin Infect Dis 2012 epublished 31 May 2012.


British Medical Journal.     Sepsis Outcomes

To evaluate whether a relationship exists between volume and outcome for admissions with severe sepsis to adult general critical care units in the United Kingdom, Shashin et al examined data from 30,727 patients managed in 2008 - 2009. No significant relationships were identified, including when allowing for the effects of severity of illness and mechanical ventilation.

Full Text: Shashin. Relation between volume and outcome for patients with severe sepsis in United Kingdom: retrospective cohort study. BMJ 2012;344:e3394


Advanced Materials:     Synthetic Platelets

A laboratory in Santa Barbara has successfully created synthetic platelets, although further pre-clinical and clinical work means it will be a long time, if ever, before they reach a patient. The advancement of tissue engineering and organogenesis continues.

Abstract: Doshi. Platelet Mimetic Particles for Targeting Thrombi in Flowing Blood. Advanced Materials 2012; epublished ahead of print May 29 2012


Review - Clinical

Journal of Neurotrauma:     Traumatic Brain Injury


Singapore Medical Journal:     Opioid-Induced Hyperalgesia


Cleveland Clinic Journal of Medicine:     Bacterial Menigitis


Cleveland Clinic Journal of Medicine:     Fat Embolism Syndrome


Respiratory Research:     Drug-Induced Interstitial Lung Disease


BMC Medicine:     ALI Biomarkers


Clinical Cardiology:    Implanted Cardiac Devices


Review - Basic Science

Nephrology Dialysis Transplantation:     Pericyte Physiology


 Journal of Cerebral Blood Flow & Metabolism:     Cerebrovascular System


Review - Non-Clinical

Canadian Medical Association Journal:     Professionalism


Clinical Cardiology:     Evidence Based Medicine


Cleveland Clinic Journal of Medicine:     Cost-Effectiveness



I hope you find these brief summaries and links useful. Please feel free to forward this newsletter to a colleague who may find it helpful.

Until next week