CCR-Newsletter-BannerNewsletter 449  |  July 20th 2020

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Welcome to the 449th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.

The highlights of this week's edition are the peer reviewed preliminary results from the dexamethasone arm of the RECOVERY trial, the eagerly anticipated results from the STARRT-AKI trial, and health-related quality of life - a 6-month follow-up from the ADRENAL trial; systematic reviews and meta analyses on tranexamic acid administration in traumatic brain injury & the association of delirium with long-term cognitive decline; and observational studies on the association between universal masking in a health care system and SARS-CoV-2 positivity among health care workers & another preliminary report of an mRNA vaccine against SARS-CoV-2. There are also narrative reviews on temporary circulatory support for cardiogenic shock, continuous‐flow left ventricular assist devices & the evaluation and management of shock in patients with COVID-19; editorials on the Covid-19 vaccine-development multiverse & the United States and the World Health Organization; and commentaries on airborne transmission of SARS-CoV-2, communicating science in the time of a pandemic & improving clinical trial enrollment - in the Covid-19 era and beyond. Finally, correspondence has been published on CRASH 3 & remdesivir for Covid-19.

If you only have time to read one review article this week, try this one on bedside assessment and clinical utility of mean systemic filling pressure in acute care.

With the publication of the RECOVERY trial, this week's Topic of the Week is immunomodulation in COVID-19, starting with the paper "Cytokine Storms: understanding COVID-19".


Review Articles






Raffay. Challenges in procedural sedation and analgesia in the emergency department. J Emerg Crit Care Med 2020;4:27



CCR21 Meeting

Due to the phenomenal success of CCR20, the Critical Care Reviews Meeting 2021 has been expanded to 3 days, allowing more time for major trial results presentations, as well as understanding the best clinical trials published during 2020. As the coronavirus pandemic precludes physical meetings at present, we have moved to an online platform - eCCR21. We aim to decide whether these trials are sufficiently robust to support their findings and if we should consider changing practice on the basis of them. To help in this endeavour we invite world leading experts to provide independent editorial overviews and have panel discussions to delve deep into the specifics of each trial. In addition, we also have detailed discussions on research methodology, to encourage critical thinking about the scientific findings which form the basis of our clinical practice.

CCH Journal

Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive.  If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.

COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.

I hope you find these links useful.

Until next week


Supported by the Health Research Board

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