CCR-Newsletter-BannerNewsletter 447  |  July 5th 2020

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 Newsletter 447

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Welcome to the 447th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. It's a massive newsletter and I'm unable to fit it all into the emailed version. There are 45 full text narrative reviews on COVID-19 related topics alone this week. The additional articles can be found in the desktop version instead. Apologies for any misformatted links - I have poor internet access this week and it's been difficult to check everything.

The highlights of this week's edition are two randomised controlled trials evaluating antibiotics in non-critically ill paediatric patients with pneumonia, including a fascinating trial comparing antibiotics with placebo, as well as two RCTs investigating vitamic C, thiamine and steroids in sepsis; systematic reviews and meta analyses on glucocorticoids in patients with ARDS (pre RECOVERY) & the use of a checklist for endotracheal intubation; and observational studies on multisystem inflammatory syndrome in U.S. children & the association of premorbid blood pressure with vasopressor infusion duration in patients with shock. There are also guidelines & recommendations on critical care ultrasound competencies & extracorporeal blood purification and organ support in the critically ill patient during the COVID-19 pandemic; narrative reviews on acute ischemic stroke & the treatment of nosocomial pneumonia in the ICU; editorials on anti-NMDA receptor encephalitis & chloroquine: to use or not to use in COVID‐19 (see the news section below); commentaries on accelerating the development of SARS-CoV-2 vaccines & the PREVENT study; as well as correspondence on COVID-19 phenotypes & rethinking the post-COVID-19 pandemic hospital: more ICU beds or smart monitoring on the wards?.

Although this newsletter focuses almost exclusively on the published literature, this week's recommended article come from outside this sphere, with an outstanding statistical review, by four experienced trial statisticians, on the RECOVERY trial

I'm out of time tonight, so this week's Topic of the Week will be out in the morning.

Sadly, it's already 5 years since our colleague Dr John Hinds died prematurely, providing medical cover to a motorbike race in Dublin. He may be gone but his impact and legacy remain.

Finally, in case you missed the news last week, the Critical Care Reviews Meeting 2021 will be held virtually. More information about our free, 3 day online conference is available here.



Review Articles












I hope you find these links useful.

Until next week


Supported by the Health Research Board

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