CCR-Newsletter-BannerNewsletter 445  |  June 21st 2020

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Welcome to the 445th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.

The highlights of this week's edition are a randomised controlled trial investigating a high-dose 24-h infusion of tranexamic acid in patients with acute gastrointestinal bleeding; systematic reviews and meta analyses on the incidence of acute kidney injury in COVID-19 infection & clinical outcomes of piperacillin-tazobactam administration and dosage strategies in critically ill adults; and observational studies on prone positioning in awake, nonintubated patients with covid-19 hypoxemic respiratory failure & the genetics of severe Covid-19 with respiratory failure. There is also a guideline on reporting randomised trials that use an adaptive design; narrative reviews on neuromuscular blockade management in the critically Ill patient & hyponatremia in the neurologically ill patient; an editorial on endothelial cell dysfunction in SARS-CoV-2 infection; as well as commentaries on delivering evidence-based critical care for mechanically ventilated patients with COVID-19 & a visual guide to the SARS-CoV-2 coronavirus.

Following on from his week's big news from the RECOVERY trial investigators, that dexamethasone reduces death by up to one third in hospitalised patients with severe respiratory complications of COVID-19, this week's Topic of the Week is corticosteroids in COVID-19 & ARDS. I'll have this out in the morning.

If you only have time to read one review article this week, try this one on Bayesian analysis.



Review Articles













CCR21 Meeting

Due to the phenomenal success of CCR20, the Critical Care Reviews Meeting 2021 has been expanded to 3 days, allowing more time for major trial results presentations, as well as understanding the best clinical trials published during 2020. We aim to decide whether these trials are sufficiently robust to support their findings and if we should consider changing practice on the basis of them. To help in this endeavour we invite world leading experts to provide independent editorial overviews and have panel discussions to delve deep into the specifics of each trial. In addition, we also have detailed discussions on research methodology, to encourage critical thinking about the scientific findings which form the basis of our clinical practice.

CCH Journal

Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive.  If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.

COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.

I hope you find these links useful.

Until next week


Supported by the Health Research Board

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