Welcome to the 444th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. After 3 newsletters last week, it's a small edition today.
The highlights are randomised controlled trials on a bundle of coated devices to reduce nosocomial infections in the ICU & hypertonic saline for fluid resuscitation in ICU patients post-cardiac surgery; systematic reviews and meta analyses on mucoactive agents for acute respiratory failure & oropharyngeal dysphagia; and observational studies on the interaction between arterial oxygenation and carbon dioxide and hospital mortality following out of hospital cardiac arrest & pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2.
There are also guidelines on managing the ICU surge during the COVID‑19 crisis & one from the European Resuscitation Council on COVID-19; narrative reviews on drug dosing in the critically ill obese patient & damage control resuscitation; editorials on how likely are COVID-19 interventions to benefit the sickest patients & weaning from venoarterial ECMO; and commentaries on pharmacological approaches for managing cytokine storm in COVID-19 patients & false negative tests for SARS-CoV-2 infection.
If you only have time to read one review article this week, try this one on Coronavirus Disease 2019 coagulopathy.
Finally, congratulations to the Intensive Care Society on 50 years of service to the critical care community.
- Abstract: Zampieri. Bundle of Coated Devices to Reduce Nosocomial Infections in the Intensive Care Unit: CRITIC Pilot Randomized Controlled Trial. Annals ATS 2020;epublished June 11thAnnals ATS 2020;epublished June 11th
- Abstract: Martins. Thrombectomy for Stroke in the Public Health Care System of Brazil. N Engl J Med 2020;382:2316-2326
- Full Text: Pfortmueller. Hypertonic saline for fluid resuscitation in ICU patients post-cardiac surgery (HERACLES): a double-blind randomized controlled clinical trial. Intensive Care Med 2020;epublished June 9th
- Full Text: Anand. Mucoactive agents for acute respiratory failure in the critically ill: a systematic review and meta-analysis. Thorax 2020;epublished June 8th
- Full Text: Duncan. Interventions for oropharyngeal dysphagia in acute and critical care: a systematic review and meta-analysis. Intensive Care Med 2020;epublished June 8th
- Abstract: Robert. Sedation practice and discomfort during withdrawal of mechanical ventilation in critically ill patients at end-of-life: a post-hoc analysis of a multicenter study. Intensive Care Med 2020;46:1194–1203
- Full Text: McGuigan. The interaction between arterial oxygenation and carbon dioxide and hospital mortality following out of hospital cardiac arrest: a cohort study. Crit Care 2020;24:336
- Full Text: Whittaker. Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2. JAMA 2020;epublished June 8th
- Full Text: De Bus. Antimicrobial de-escalation in the critically ill patient and assessment of clinical cure: the DIANA study. Intensive Care Med 2020;epublished June 9th
- Full Text: Li. Extracorporeal membrane oxygenation programs for COVID-19 in China. Crit Care 2020;24:317
- Full Text: Chernevskaya. Serum and fecal profiles of aromatic microbial metabolites reflect gut microbiota disruption in critically ill patients: a prospective observational pilot study. Crit Care 2020;24:312
- Full Text: Wang. Multiple cross displacement amplification-a more applicable technique in detecting Pseudomonas aeruginosa of ventilator-associated pneumonia (VAP). Crit Care 2020;24:306
- Faqihi. A pilot study of therapeutic plasma exchange for serious SARS CoV-2 disease (COVID-19): A structured summary of a randomized controlled trial study protocol. Trials 2020;21:506
- Eckhardt. Evaluating the efficacy and safety of human anti-SARS-CoV-2 convalescent plasma in severely ill adults with COVID-19: A structured summary of a study protocol for a randomized controlled trial. Trials 2020;21:499Trials 2020;21:499
- Zhang. Efficacy and safety of Anluohuaxian in the treatment of patients with severe Coronavirus disease 2019- a multicenter, open label, randomized controlled study: a structured summary of a study protocol for a randomised controlled trial. Trials 2020;21:495Trials 2020;21:495
- Chen. Cardiac injuries in coronavirus disease 2019 (COVID-19). J Mol Cell Cardiol 2020;145:25-29
- Imazio. COVID-19 pandemic and troponin: indirect myocardial injury, myocardial inflammation or myocarditis? Heart 2020;epublished June 4th
- Levi. Coronavirus Disease 2019 Coagulopathy: Disseminated Intravascular Coagulation and Thrombotic Microangiopathy—Either, Neither, or Both. Semin Thromb Hemost 2020;epublished June 8th
- Erstad. Drug dosing in the critically ill obese patient—a focus on sedation, analgesia, and delirium. Crit Care 2020;24:315
- Perner. How likely are COVID-19 interventions to benefit the sickest patients?. Intensive Care Med 2020;epublished June 9th
- Tan. Intra-hospital preventive principles to protect frontline healthcare workers to overcome pandemic COVID-19 in Taiwan. Crit Care 2020;24:328
- Ronco. Coronavirus Epidemic and Extracorporeal Therapies in Intensive Care: si vis pacem para bellum. Blood Purif 2020;49:255–258
- Taylor. Sometimes more is not always better: ScvO2 monitoring in pediatric sepsis. Intensive Care Med 2020;46:1264–1266
- Evans. Diagnosing and Treating Systemic Racism. N Engl J Med 2020;epublished June 10th
- Ye. Infection prevention and control in nursing severe coronavirus disease (COVID-19) patients during the pandemic. Crit Care 2020;24:338
- Weiss. Focus on gastrointestinal system in critically ill patients. Intensive Care Med 2020;epublished June 8th
- Mohamed. Neutrophil Elastase Inhibitors: A potential prophylactic treatment option for SARS-CoV-2-induced respiratory complications?. Crit Care 2020;24:311
- Fried. How I approach weaning from venoarterial ECMO. Crit Care 2020;24:307
- Anonymous. The future of critical care: lessons from the COVID-19 crisis. Lancet Respir Med 2020;8(6):527
- Gill. The Importance of Proper Death Certification During the COVID-19 Pandemic. JAMA 2020;epublished June 10th
- Villarreal-Fernandez. A plea for avoiding systematic intubation in severely hypoxemic patients with COVID-19-associated respiratory failure. Crit Care 2020;24:337
- Convertino. Exploring pharmacological approaches for managing cytokine storm associated with pneumonia and acute respiratory distress syndrome in COVID-19 patients. Crit Care 2020;24:331
- Fuchs. Health Care Policy After the COVID-19 Pandemic. JAMA 2020;epublished June 12th
- Galea. COVID-19 Pandemic, Unemployment, and Civil Unrest. Underlying Deep Racial and Socioeconomic Divides. JAMA 2020;epublished June 12th
- Berwick. The Moral Determinants of Health. JAMA 2020;epublished June 12th
- Jalkanen. Interferon beta-1a for COVID-19: critical importance of the administration route. Crit Care 2020;24:335
- Gossen. The Isolation Communication Management System. A Telemedicine Platform to Care for Patients in a Biocontainment Unit. Annals ATS 2020;17(6):673–678
- Gostin. The Dual Epidemics of COVID-19 and Influenza. Vaccine Acceptance, Coverage, and Mandates. JAMA 2020;epublished June 11th
- Allen. Medicaid and COVID-19At the Center of Both Health and Economic Crises. JAMA 2020;epublished June 11th
- Woloshin. False Negative Tests for SARS-CoV-2 Infection — Challenges and Implications. N Engl J Med 2020;epublished June 5th
- Weinstein. Waiting for Certainty on Covid-19 Antibody Tests — At What Cost? N Engl J Med 2020;epublished June 5th
- Chan. Putting the Public Back in Public Health — Surveying Symptoms of Covid-19. N Engl J Med 2020;epublished June 5th
- Morse. Creating Real Change at Academic Medical Centers — How Social Movements Can Be Timely Catalysts. N Engl J Med 2020;epublished June 10th
- Hardeman. Stolen Breaths. N Engl J Med 2020;epublished June 10th
- Sjöberg. Health-related quality of life after critical care—the emperor’s new clothes. Crit Care 2020;24:308
- Curley. Alone, the hardest part. Intensive Care Med 2020;epublished June 8th
- Jeannet. Severe COVID-19 is associated with deep and sustained multifaceted cellular immunosuppression. Intensive Care Med 2020;epublished June 9th
- Painvin. Hydroxychloroquine pharmacokinetic in COVID-19 critically ill patients: an observational cohort study. Intensive Care Med 2020;epublished June 8th
- Liaudet. Blocking mineralocorticoid receptor with spironolactone may have a wide range of therapeutic actions in severe COVID-19 disease. Crit Care 2020;24:318
- Vargas. Three-step checklist for tracheostomy in critically ill COVID-19 patients. Crit Care 2020;24:316
- Bösel. Critical care physicians treating COVID-19: mind the nervous system!. Crit Care 2020;24:310
- Nagatomo. Peritoneal dialysis for COVID-19-associated acute kidney injury. Crit Care 2020;24:309
- Alfano. The Role of the Renin-Angiotensin System in Severe Acute Respiratory Syndrome-CoV-2 Infection. Blood Purif 2020;epublished April 28th
- Hoshino. Early versus late tracheostomy in patients with traumatic brain injury. Intensive Care Med 2020;46:1286–1287
- Kreitmann. Cyclosporine A prevents cardiac arrest-induced acute respiratory failure: a post-hoc analysis of the CYRUS trial. Intensive Care Med 2020;46:1281–1283
- Sakurai. Natural History of Asymptomatic SARS-CoV-2 Infection. N Engl J Med 2020;epulished June 12th
- Soloman. Neuropathological Features of Covid-19. N Engl J Med 2020;epulished June 12th
- Ferrandis. COVID-19: opening a new paradigm in thromboprophylaxis for critically ill patients? Crit Care 2020;24:332
- Mahjoub. Severe Covid-19 disease: rather AVDS than ARDS? Crit Care 2020;24:327
Due to the phenomenal success of CCR20, the Critical Care Reviews Meeting 2021 has been expanded to 3 days, allowing more time for major trial results presentations, as well as understanding the best clinical trials published during 2020. We aim to decide whether these trials are sufficiently robust to support their findings and if we should consider changing practice on the basis of them. To help in this endeavour we invite world leading experts to provide independent editorial overviews and have panel discussions to delve deep into the specifics of each trial. In addition, we also have detailed discussions on research methodology, to encourage critical thinking about the scientific findings which form the basis of our clinical practice.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board