Welcome to the 428th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. It's been a quiet week for research publications, but there are still loads of great articles to read, including a guideline on assessment of sublingual microcirculation, narrative reviews on paediatric traumatic brain injury, anaphylaxis, cerebral venous thrombosis and integration of bedside ultrasound into the ICU; editorials on nutritional management during noninvasive ventilation and maternal sepsis; commentaries on acute-on-chronic liver failure and cardiac output monitoring; plus correspondence on the long overdue banning of hydroxyethyl starch solutions.
This week's Topic of the Week is a selection of recent sepsis guidelines, starting with the Japanese guidelines for the management of sepsis and septic shock 2016 in tomorrow's Paper of the Day.
Welcome to the 428th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. I'm going to restart with this week's newsletter and catch up with the missing newsletters as I can, so their numbering will reflect the week they cover, rather than the order they will be published in.
The highlights of this week's edition are randomised controlled trials on a driving pressure-limited strategy for ARDS & intrapulmonary concentrations of meropenem administered by continuous infusion; systematic reviews and meta analyses on neuromuscular blocking agent use in ARDS & the effect of continuous epinephrine infusion on survival in critically ill patients; and observational studies on the association of low baseline diaphragm muscle mass with prolonged mechanical ventilation and mortality among critically ill adults & a post hoc analysis of ANDROMEDA-SHOCK trial - capillary refill time status could identify different clinical phenotypes among septic shock patients fulfilling Sepsis-3 criteria.
There are also two guidelines on nutrition, in critically ill children & in acute pancreatitis, as well as a guideline on the management of adult acute and acute-on-chronic liver failure in the ICU. There are narrative reviews on airway pressure release ventilation & community-acquired pneumonia in critically ill very old patients; editorials on stress ulcer prophylaxis & intensive care during the coronavirus epidemic; and commentaries on ECMO for COVID-19-induced respiratory failure & what has been learned in responding to emerging zoonotic viruses; as well as correspondence on Immune biomarker-based enrichment in sepsis trials & plasma-first resuscitation to treat haemorrhagic shock in urban areas.
This week's Topic of the Week will be out in the morning.
If you only have time to read one paper this week, try this one on Coronavirus disease 2019 (covid-19): a (radiological) perspective from china.
- Abstract: Campbell. Effect of Intravenous Tenecteplase Dose on Cerebral Reperfusion Before Thrombectomy in Patients With Large Vessel Occlusion Ischemic StrokeThe EXTEND-IA TNK Part 2 Randomized Clinical Trial. JAMA 2020;epublished February 20th
- Abstract: Romano. Driving Pressure-Limited Strategy for Patients with Acute Respiratory Distress Syndrome (ARDS): A Pilot Randomized Clinical Trial. Am J Respir Crit Care Med 2020;epublished February 18thAm J Respir Crit Care Med 2020;epublished February 18th
- Full Text: Benítez-Cano. Intrapulmonary concentrations of meropenem administered by continuous infusion in critically ill patients with nosocomial pneumonia: a randomized pharmacokinetic trial. Critical Care 2020;24:55
- Abstract: Heyland. Promotion of Regular Oesophageal Motility to Prevent Regurgitation and Enhance Nutrition Intake in Long-Stay ICU Patients. A Multicenter, Phase II, Sham-Controlled, Randomized Trial: The PROPEL Study. Crit Care Med 2020;48(3):e219-e226
- Abstract: Timal. Effect of No Prehydration vs Sodium Bicarbonate Prehydration Prior to Contrast-Enhanced Computed Tomography in the Prevention of Postcontrast Acute Kidney Injury in Adults With Chronic Kidney Disease: The Kompas Randomized Clinical Trial. JAMA Intern Med 2020;epublished February 17th
- Abstract: Cameron. Intraoperative Ketamine for Analgesia Post-Coronary Artery Bypass Surgery: A Randomized, Controlled, Double-Blind Clinical Trial. J Cardiothorac Vasc Anesth 2020;34(3):586–591
- Abstract: Lomivorotov. Sustained High-dose Thiamine Supplementation in High-risk Cardiac Patients Undergoing Cardiopulmonary Bypass: A Pilot Feasibility Study (The APPLY trial). J Cardiothorac Vasc Anesth 2020;34(3):594–600
- Full Text: Chang. Validation of neuromuscular blocking agent use in acute respiratory distress syndrome: a meta-analysis of randomized trials. Critical Care 2020;24:54
- Abstract: Belletti. Effect of Continuous Epinephrine Infusion on Survival in Critically Ill Patients: A Meta-Analysis of Randomized Trials. Crit Care Med 2020;48(3):398-405
- Full Text: Luo. Effect of combined parenteral and enteral nutrition for patients with a critical illness: A meta-analysis of randomized controlled trials. Medicine 2020;99(3):e18778
- Full Text: Yan. The global survival rate among adult out-of-hospital cardiac arrest patients who received cardiopulmonary resuscitation: a systematic review and meta-analysis. Critical Care 2020;24:61
- Full Text: Buchman. Sepsis Among Medicare Beneficiaries: 1. The Burdens of Sepsis, 2012–2018. Crit Care Med 2020;48(3):276-288
- Full Text: Buchman. Sepsis Among Medicare Beneficiaries: 2. The Trajectories of Sepsis, 2012–2018. Crit Care Med 2020;48(3):289-301
- Full Text: Buchman. Sepsis Among Medicare Beneficiaries: 3. The Methods, Models, and Forecasts of Sepsis, 2012–2018. Crit Care Med 2020;48(3):302-318
- Editorial: Rhee. The Eye-Popping Costs Associated With Sepsis Diagnoses Among Medicare Beneficiaries. Crit Care Med 2020;48(3):420-422
- Editorial: Levy. Identifying the Burden of Sepsis With Big Data. Crit Care Med 2020;48(3):422-423
- Editorial: Busch. Predicting Sepsis Mortality and Costs Using Medicare Claims: A Method to the Madness. Crit Care Med 2020;48(3):424-426
- Abstract: Lasica. Haematological features, transfusion management and outcomes of massive obstetric haemorrhage: findings from the Australian and New Zealand Massive Transfusion Registry. Br J Haematol 2020;epublished February 16th
- Full Text: Sklar. Association of Low Baseline Diaphragm Muscle Mass With Prolonged Mechanical Ventilation and Mortality Among Critically Ill Adults. JAMA Netw Open 2020;3(2):e1921520
- Full Text: Blount. Vitamin E Acetate in Bronchoalveolar-Lavage Fluid Associated with EVALI. N Engl J Med 2020;382:697-705
- Full Text: Writing Group for the BASILAR Group. Assessment of Endovascular Treatment for Acute Basilar Artery Occlusion via a Nationwide Prospective Registry. JAMA Neurol 2020;epublished February 20th
- Abstract: Olivier. Renin aldosterone vasopressin and copeptin kinetics in patients with septic shock, a post-hoc Hyper2S randomized trial analysis. Intensive Care Med 2020;epublished February 19th
- Abstract: Hernández. Capillary refill time status could identify different clinical phenotypes among septic shock patients fulfilling Sepsis-3 criteria: a post hoc analysis of ANDROMEDA-SHOCK trial. Intensive Care Med 2020;epublished February 19th
- Nutritional support for children during critical illness: European Society of Pediatric and Neonatal Intensive Care (ESPNIC) metabolism, endocrine and nutrition section position statement and clinical recommendations. Intensive Care Med 2020;epublished February 20th
- ESPEN guideline on clinical nutrition in acute and chronic pancreatitis. Clinical Nutrition 2020;39:612-631
- Nanchal. Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU: Cardiovascular, Endocrine, Hematologic, Pulmonary, and Renal Considerations. Crit Care Med 2020;48(3):e173-e191
- Gurney. The Prehospital Evaluation and Care of Moderate/Severe TBI in the Austere Environment. Military Medicine 2020;185(Suppl 1):148–153
- Fredericks. Airway Pressure Release Ventilation: A Review of the Evidence, Theoretical Benefits, and Alternative Titration Strategies. Clin Med Insights Circ Respir Pulm Med 2020;14:1179548420903297
- Zu. Coronavirus Disease 2019 (COVID-19): A Perspective from China. Radiology 2020;epublished February 21st
- Cillóniz. Community-acquired pneumonia in critically ill very old patients: a growing problem. Eur Respir Rev 2020;29:190126
- Saran. New and promising anti-bacterials: Can this promise be sustained?. J Anaesthesiol Clin Pharmacol 2020;36:13-9
- Kroesen. The ABCs of Ocular Trauma: Adapting a Familiar Mnemonic for Rapid Eye Exam in the Pre-Ophthalmic Zone of Care. Military Medicine 2020;185(Suppl 1):448–453
- Kaufman. Beyond Band-Aids for Bullet Holes: Firearm Violence As a Public Health Priority. Crit Care Med 2020;48(3):391-397
- Jain. Ultrasonographic assessment of airway. J Anaesthesiol Clin Pharmacol 2020;36:5-12
- Nin Vaeza. Humanizing Intensive Care: Toward a Human-Centered Care ICU Model. Crit Care Med 2020;48(3):385-390
- Harhay. Could stress ulcer prophylaxis increase mortality in high-acuity patients? Intensive Care Med 2020;epublished February 20th
- Liu. Critical care response to a hospital outbreak of the 2019-nCoV infection in Shenzhen, China. Critical Care 2020;24:56
- Anonymous. COVID-19: fighting panic with information. Lancet 2020;395(10224):537
- Qiu. Intensive care during the coronavirus epidemic. Intensive Care Med 2020;epublished February 20th
- Timsit. Antimicrobial de-escalation is part of appropriate antibiotic usage in ICU. Intensive Care Med 2020;epublished February 20th
- Wilcox. Understanding gender disparities in outcomes after sepsis. Intensive Care Med 2020;epublished February 18th
- Pan. How to face the novel coronavirus infection during the 2019–2020 epidemic: the experience of Sichuan Provincial People’s Hospital. Intensive Care Med 2020;epublished February 18th
- Gelman. Is goal-directed haemodynamic therapy dead? Eur J Anaesthesiol 2020;37(3):159-161
- Chew. Improving peri-operative outcome: Time once more to update protocols. Eur J Anaesthesiol 2020;epublished February 18th
- Schier. Prehabilitation. The next challenge for anaesthesia teams. Eur J Anaesthesiol 2020;epublished February 18th
- MacLaren. Preparing for the Most Critically Ill Patients With COVID-19The Potential Role of Extracorporeal Membrane Oxygenation. JAMA 2020;epublished February 19th
- Wong. COVID-19 in Singapore—Current ExperienceCritical Global Issues That Require Attention and Action. JAMA 2020;epublished February 20th
- Desai. Discussing the ABCs of Health Security—Antibiotic Resistance, Biothreats, and Coronavirus. JAMA 2020;epublished February 19th
- Kaplan. Imagine…(A Common Language for ICU Data Inquiry and Analysis). Crit Care Med 2020;48(3):273-275
- Wang. From Hendra to Wuhan: what has been learned in responding to emerging zoonotic viruses. Lancet 2020;395(10224):e33-e34
- Spinetti. Immune biomarker-based enrichment in sepsis trials. Critical Care 2020;24:58
- Zumla. Reducing mortality from 2019-nCoV: host-directed therapies should be an option. Lancet 2020;395(10224):e35-e36
- Plasma-first resuscitation to treat haemorrhagic shock in urban areas. Lancet 2020;395(10224):562
Registration is open!
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board