Just over two weeks to CCR20...
Happy New Year
Welcome to the 420th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are a randomised controlled trial on timing of staged nonculprit artery revascularization in patients with ST-segment elevation myocardial infarction; systematic reviews and meta analyses investigating terlipressin vs norepinephrine in septic shock & ketamine sedation in mechanically ventilated patients; and an observational study on a post hoc analysis of the ADRENAL trial. There are also guidelines on central venous access & management of the child's airway under anaesthesia; narrative reviews on neuroimaging in traumatic brain injury & the microcirculation; editorials on adjuvant vitamin C for sepsis & transcranial doppler; and commentaries on the responsibility of physicians to maintain competency & when could human challenge trials be deployed to combat emerging infectious diseases; as well as correspondence on global warming “heating up” the ICU through Candida auris infections & dynamic hyperinflation and intrinsic PEEP in ARDS patients.
This week's Topic of the Week is the COACT trial, starting with a paper on new perspectives for the management of non-ST elevation myocardial infarction after the COACT trial in tomorrow's Paper of the Day.
If you only have time to read one review article this week, try this one on organ dysfunction in sepsis.
- Abstract: Wood. Timing of Staged Nonculprit Artery Revascularization in Patients With ST-Segment Elevation Myocardial Infarction: COMPLETE Trial. J Am Coll Cardiol 2019;74(22):2713-2723
- Abstract: Mahmoodpoor. A clinical trial of silver-coated and tapered cuff plus supraglottic suctioning endotracheal tubes in preventing ventilator-associated pneumonia. J Crit Care 2019;epublished December 28th
- Abstract: Lipcsey. Endotoxin Removal in Septic Shock with the Alteco® LPS Adsorber was Safe But Showed No Benefit Compared to Placebo in the Double-Blind Randomized Controlled Trial - the Asset Study. Shock 2019;epublished December 26th
- Full Text: Huang. Terlipressin Versus Norepinephrine for Septic Shock: A Systematic Review and Meta-Analysis. Front Pharmacol 2019;10:1492
- Abstract: Manasco. Ketamine sedation in mechanically ventilated patients: A systematic review and meta-analysis. J Crit Care 2019;56:80-88
- Abstract: Wei. Efficacy of vitamin C in patients with sepsis: A updated meta-analysis. Eur J Pharmacol. 2019 Dec 20:172889
- Full Text: Fernando. Pre-arrest and intra-arrest prognostic factors associated with survival after in-hospital cardiac arrest: systematic review and meta-analysis. BMJ 2019;367:l6373
- Full Text: Wang. Open-chest cardiopulmonary resuscitation versus closed-chest cardiopulmonary resuscitation in patients with cardiac arrest: a systematic review and meta-analysis. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2019;27:116
- Abstract: Anto. Severity of hemorrhage and the survival benefit associated with plasma. Results from a randomized prehospital plasma trial. J Trauma Acute Care Surg 2020;88(1):141–147
- Full Text: Bouadma. Influence of dyskalemia at admission and early dyskalemia correction on survival and cardiac events of critically ill patients. Critical Care 2019;23:415
- Full Text: Venkatesh. Hydrocortisone Compared with Placebo in Patients with Septic Shock Satisfying the Sepsis-3 Diagnostic Criteria and APROCCHSS Study Inclusion Criteria: A Post Hoc Analysis of the ADRENAL Trial. Anesthesiology 2019;131(12):1292-1300
- Gaudry. The Artificial Kidney Initiation in Kidney Injury 2 (AKIKI2): study protocol for a randomized controlled trial. Trials 2019;20:726
- Waldauf. Functional electrical stimulation-assisted cycle ergometry in the critically ill: protocol for a randomized controlled trial. Trials 2019;20:724
- Mondardini. Efficacy and safety of dexmedetomidine for prevention of withdrawal syndrome in the pediatric intensive care unit: protocol for an adaptive, multicenter, randomized, double-blind, placebo-controlled, non-profit clinical trial. Trials 2019;20:710
- Roggeveen. Right Dose Right Now: bedside data-driven personalized antibiotic dosing in severe sepsis and septic shock — rationale and design of a multicenter randomized controlled superiority trial. Trials 2019;20:745
- Practice Guidelines for Central Venous Access 2020: An Updated Report by the American Society of Anesthesiologists Task Force on Central Venous Access. Anesthesiology 2020;132:8-43
- Duodeno-pancreatic and extrahepatic biliary tree trauma: WSES-AAST guidelines. World J Emerg Surg 2019;14:56
- Management of the child's airway under anaesthesia: The French guidelines. Anaesth Crit Care Pain Med 2019;38(6):681-693
- Bonow. Transcranial Doppler ultrasonography in neurological surgery and neurocritical care. Neurosurg Focus 2019;47(6):E2
- Smith. Advanced neuroimaging in traumatic brain injury: an overview. Neurosurg Focus 2019;47(6):E17
- Howard. Comprehensive review of imaging of intracranial aneurysms and angiographically negative subarachnoid hemorrhage. Neurosurg Focus 2019;47 (6):E20
- Rayner. Brain Death Criteria: Medical Dogma and Outliers. Yale J Biol Med 2019;92(4):751–755
- Junna. Practice Variability in Determination of Death by Neurologic Criteria for Adult Patients. Yale J Biol Med 2019;92(4):719–724
- Hahn. Understanding volume kinetics. Acta Anaesthesiol Scand 2019;epublished December 20th
- van der Sande. Using Bioimpedance Spectroscopy to Assess Volume Status in Dialysis Patients. Blood Purif 2019;epublished December 18th
- Guven. Microcirculation: Physiology, Pathophysiology, and Clinical Application. Blood Purif 2019;epublished December 18th
- Kamboj. Left Ventricular Assist Device and the Kidney: Getting to the Heart of the Matter. Blood Purif 2019;48:289–298
- Gumbert. Perioperative Acute Kidney Injury. Anesthesiology 2020;132:180-204
- Rondon-Berrios. Urea for Chronic Hyponatremia. Blood Purif 2019;epublished December 18th
- Fulop. Are We Ill Because We Age? Front Physiol 2019;10:1508
- Clark. Uremic Toxins and their Relation to Dialysis Efficacy. Blood Purif 2019;48:299–314
- Sars. Intradialytic Hypotension: Mechanisms and Outcome. Blood Purif 2019;epublished December 18th
- Claxton. The challenge of recognising sepsis: Future nanotechnology solutions. JICS 2019;epublished December 13th
- Caraballo. Organ Dysfunction in Sepsis: An Ominous Trajectory From Infection To Death. Yale J Biol Med 2019;92(4):629–640
- Ramesh. Fluid resuscitation in trauma: what are the best strategies and fluids? Int J Emerg Med 2019;12:38
- Garibaldi. Reinvigorating the clinical examination for the 21st century. Pol Arch Intern Med 2019;129:907‑911
- Capron. Looking Back at Withdrawal of Life-Support Law and Policy to See What Lies Ahead for Medical Aid-in-Dying. Yale J Biol Med 2019;92(4):781–791
- Spoelstra–de Man. Adjuvant vitamin C for sepsis: mono or triple? Crit Care 2019;23:425
- Ostermann. How much centralization of critical care services in the era of telemedicine? Crit Care 2019;23:423
- Robba. How I use Transcranial Doppler. Critical Care 2019;23:420
- van der Graaf. Ethics of alternative trial designs and methods in low-resource settings. Trials 2019;20:705
- Kazory. Emergence of Chloride as an Overlooked Cardiorenal Connector in Heart Failure. Blood Purif 2019;epublished December 18th
- Joag. Ethical issues in the design and conduct of stepped-wedge cluster randomized trials in low-resource settings. Trials 2019;20:703
- Palacio. When could human challenge trials be deployed to combat emerging infectious diseases? Lessons from the case of a Zika virus human challenge trial. Trials 2019;20:702
- Santen. The Responsibility of Physicians to Maintain Competency. JAMA 2019;epublished December 26th
- Misseri. Global warming “heating up” the ICU through Candida auris infections: the climate changes theory. Critical Care 2019;23:416
- Gutsche. Echocardiography: Do We Need New Standards for ECMO Patients? J Cardiothorac Vasc Anesth. 2019 Aug;33(8):2356-2357
- Civantos. Outcomes of hospitalized hematologic oncology patients receiving rapid response system activation for acute deterioration: another time, another way. Critical Care 2019;23:419
- Stahl. “Better be awake”—a role for awake extracorporeal membrane oxygenation in acute respiratory distress syndrome due to Pneumocystis pneumonia. Critical Care 2019;23:418
- Wang. Dynamic hyperinflation and intrinsic PEEP in ARDS patients: who, when, and how needs more focus? Critical Care 2019;23:422
Now in it's 8th year, the Critical Care Reviews Meeting brings the chief investigators for the best critical care trials of the previous year to Titanic, Belfast, to discuss their studies. We aim to decide whether these trials are sufficiently robust to support their findings and if we should consider changing practice on the basis of them. To help in this endeavour we invite world leading experts to provide independent editorial overviews and have panel discussions to delve deep into the specifics of each trial. In addition, we also have detailed discussions on research methodology, to encourage critical thinking about the scientific findings which form the basis of our clinical practice. It's not just about specific trials though; for 2020, we have a distinguished panel of trialists, methodologists, statisticians and clinicians provide insight into the mysteries of clinical trial interpretation, as well as a panel discission on the proposed MEGA-ROX trial, potentially a game changer for critical care trials. We are delighted to have the opportunity to conduct a one-on-one interview with the editor-in-chief of JAMA, Prof Howard Bauchner, in discussion with Prof Marion Campbell. As usual, we eound off the formal programme with the annual honorary John Hinds Lecture, to be delivered by Prof Kathryn Maitland, entitled "A Higher Calling: Two Decades of Emergency Research in Africa", and finish the meeting with the incredibly popular "Informal Chat", where the faculty and delegates congregate in the bar and an enormous, meandering discussion about all things critical care takes place.
For CCR20, we are hosting 3 major trial results presentations, PEPTIC, 65 & VITAMINS, plus the IHME Sepsis Study results, as well as discussing 9 of the best trials from 2019 - COACT, TRACT, ICU-ROX, SPICE III, BiRDS, ROSE, CITRIS-ALI, SEPSIS-ACT & HYPERION.
Based on our feedback from last year, we've reverted to keeping everyone on the same floor during breaks. In addition, we will also provide a sleeping area for those post-call to rest for a few hours as needed. As before, we are offering free childcare and a baby feeding area, where the meeting will live streamed. All dietary requirements are catered for also. Please get in touch if you have any specific needs. We sold out last year, so please don't delay if you want to attend. As usual, CPD points will be applied for in due course.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board