CCR-Newsletter-BannerNewsletter 409  |  October 14th 2019

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The latest trial added to the CCR20 programme is SEPSIS-ACT


Welcome to the 409th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.

The highlights of this week's edition are randomised controlled trials on melatonin for prevention of post-operative delirium & an ultrasound-driven diagnostic protocol in ICU; systematic reviews and meta analyses on systemic corticosteroids and the incidence of gastrointestinal bleeding in critically ill adults & extracorporeal liver support in patients with liver failure; and observational studies on invasive pulmonary aspergillosis in critically ill patients with hematological malignancies & national trends in timing of death among patients with septic shock. There is also a French guideline on severe asthma exacerbation; narrative reviews on central pontine myelinosis and osmotic demyelination syndrome, intraoperative fraction of inspired oxygen & stepped wedge trials; commentaies on oxygen toxicity in major emergency surgery & alveolar recruitment in ARDS; as well as correspondence on venous and arterial base excess difference & ‘the pause’.

This week's Topic of the Week is the ICU-ROX trial (see below), starting with a paper on oxygen treatment in intensive care and emergency medicine in today's Paper of the Day.

If you only have time to read one review article this week, try this one on the role of speech and language therapists in the intensive care unit.

Critical Care Reviews Meeting 2020

The latest trial to be added to the CCR20 programme is SEPSIS-ACT, the largest randomised controlled yet of a vasopressin analogue in septic shock. This will be presented by Prof Anders Perner from Copenhagen. Also, tonight (or tomorrow, depending on where you are), Dr Paul Young will present the results of the much anticipated ICU-ROX trial, comparing a conservative oxygenation strategy with standard care in 1,000 mechanically ventilated patients, at the World Congress Meeting in Melbourne. This presentation is timed with a simultaneous major journal publication. I previously chatted with Paul about ICU-ROX in an early CCR podcast, which is worth checking out in anticipation of the results presentation. The results of CRASH-3, investigating tranexamic acid in traumatic brain injury, are due out in the same session.



Review Articles











CCR20 Meeting

CCR20 010819 Widget

Now in it's 8th year, the Critical Care Reviews Meeting brings the chief investigators for the best critical care trials of the previous year to Titanic, Belfast, to discuss their studies. We aim to decide whether these trials are sufficiently robust to support their findings and if we should consider changing practice on the basis of them. To help in this endeavour we invite world leading experts to provide independent editorial overviews and have panel discussions to delve deep into the specifics of each trial. In addition, we also have detailed discussions on research methodology, to encourage critical thinking about the scientific findings which form the basis of our clinical practice. It's not just about specific trials though; for 2020, we have a distinguished panel of trialists, methodologists, statisticians and clinicians provide insight into the mysteries of clinical trial interpretation. We also have the annual honorary John Hinds Lecture, to be delivered by Prof Kathryn Maitland, entitled "A Higher Calling: Two Decades of Emergency Research in Africa", and finish the meeting with the incredibly popular "Informal Chat", where the faculty and delegates congregate in the bar and an enormous, meandering discussion about all things critical care takes place.

Based on our feedback from last year, we've reverted to keeping everyone on the same floor during breaks. In addition, we will also provide a sleeping area for those post-call to rest for a few hours as needed. As before, we are offering free childcare and a baby feeding area, where the meeting will live streamed. All dietary requirements are catered for also. Please get in touch if you have any specific needs. We sold out last year, so please don't delay if you want to attend. As usual, CPD points will be applied for in due course.

CCH Journal

Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive.  If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.

COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.

I hope you find these links useful.

Until next week


Supported by the Health Research Board

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