The latest trial added to the CCR20 programme is CITRIS-ALI
Welcome to the 407th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are two randomised controlled trials on antibiotics for pneumonia; lefamulin vs moxifloxacin in community-acquired pneumonia & ceftolozane–tazobactam vs meropenem for nosocomial pneumonia; systematic reviews and meta analyses on intensity of renal replacement treatment for acute kidney injury & meta-analyses in critical care; and observational studies on plasma-to–red blood cell transfusion ratio in adults with severe traumatic bleeding & lung ultrasound for early diagnosis of postoperative need for ventilatory support.
There are also guidelines on withholding and withdrawing life-support in adults in emergency care & fluid resuscitation in the peri-acute kidney injury period; narrative reviews on psychopathology after admission to ICU & present and future of carbapenem-resistant enterobacteriaceae infections; editorials on recruiting the microcirculation in septic shock & clinical trial data sharing (read the correspondence section below too...); and commentaries on post-traumatic stress in the intensive care unit & advances in fluid assessment and kidney injury prediction.
This week's Topic of the Week is influenza, starting with a paper on a year of terror and a century of reflection: perspectives on the great influenza pandemic of 1918–1919 in tomorrow's Paper of the Day. If you only have time to read one review article this week, try this one on fluid management in the perioperative setting.
- Abstract: Patel. Phase 3 Pilot Randomized Controlled Trial Comparing Early Trophic Enteral Nutrition With “No Enteral Nutrition” in Mechanically Ventilated Patients With Septic Shock. JPEN J Parenter Enteral Nutr 2019;epublished September 19th
- Full Text: McCollum. Bubble continuous positive airway pressure for children with high-risk conditions and severe pneumonia in Malawi: an open label, randomised, controlled trial. Lancet Respir Med 2019;epublished September 24th
- Full Text: Alexander. Oral Lefamulin vs Moxifloxacin for Early Clinical Response Among Adults With Community-Acquired Bacterial Pneumonia. The LEAP 2 Randomized Clinical Trial. JAMA 2019;epublished September 27th
- Abstract: Mehran. Ticagrelor with or without Aspirin in High-Risk Patients after PCI. N Engl J Med 2019;epublished September 26th
- Abstract: Brandmeir. A Randomized Trial of Complications of Peripherally and Centrally Inserted Central Lines in the Neuro-Intensive Care Unit: Results of the NSPVC Trial. Neurocrit Care 2019;epublished September 25th
- Abstract: Nee. Elimination of Glutamate using CRRT for 72 hours in patients with post-cardiac arrest syndrome: a randomized clinical pilot trial. Resuscitation 2019;epublished September 23rd
- Abstract: Kollef. Ceftolozane–tazobactam versus meropenem for treatment of nosocomial pneumonia (ASPECT-NP): a randomised, controlled, double-blind, phase 3, non-inferiority trial. Lancet Infect Dis 2019;epublished September 25th
- Abstract: Kumar. Treatment with carvedilol improves survival of patients with acute-on-chronic liver failure: a randomized controlled trial. Hepatol Int 2019;epublished September 20th
- Full Text: Lin. Impact and Beneficial Critical Points of Clinical Outcome in Corticosteroid Management of Adult Patients With Sepsis: Meta-Analysis and GRADE Assessment. Front Pharmacol 2019;10:1101
- Full Text: Wang. The Intensity of Renal Replacement Treatment for Acute Kidney Injury: A Systematic Review and Network Meta-Analysis. J Transl Crit Care Med 2019;1:61-8
- Abstract: Koster. Apparently conclusive meta-analyses on interventions in critical care may be inconclusive—a meta-epidemiological study. J Clin Epidemiol 2019;114:1-10
- Abstract: Carrier. Restrictive fluid management strategies and outcomes in liver transplantation: a systematic review. Can J Anaesth 2019;epublished September 25th
- Full Text: Roquet. Association of Early, High Plasma-to–Red Blood Cell Transfusion Ratio With Mortality in Adults With Severe Bleeding After Trauma. JAMA Netw Open 2019;2(9):e1912076
- Abstract: Kundi. Association of Frailty With 30-Day Outcomes for Acute Myocardial Infarction, Heart Failure, and Pneumonia Among Elderly Adults. JAMA Cardiol 2019;epublished September 25th
- Abstract: Gauss. Association of Prehospital Time to In-Hospital Trauma Mortality in a Physician-Staffed Emergency Medicine System. JAMA Surg 2019;epublished September 25th
- Abstract: Dransart-Rayé. Lung ultrasound for early diagnosis of postoperative need for ventilatory support: a prospective observational study. Anaesthesia 2019;epublished September 23rd
- Abstract: Richard. Feasibility and safety of ultra-low tidal volume ventilation without extracorporeal circulation in moderately severe and severe ARDS patients. Intensive Care Med 2019;epublished September 23rd
- Abstract: Das. Optic nerve sheath diameter in children with acute liver failure: a prospective observational pilot study. Liver Int 2019;epublished September 24th
- Lewis. Bispectral index for improving intraoperative awareness and early postoperative recovery in adults. Cochrane Database of Systematic Reviews 2019, Issue 9. Art. No.: CD003843
- Blessberger. Perioperative beta-blockers for preventing surgery-related mortality and morbidity in adults undergoing non-cardiac surgery.Cochrane Database of Systematic Reviews2019, Issue 9. Art. No.: CD013438
- Blessberger. Perioperative beta-blockers for preventing surgery-related mortality and morbidity in adults undergoing cardiac surgery.Cochrane Database of Systematic Reviews2019, Issue 9. Art. No.: CD013435
- Merriel. The effects of interactive training of healthcare providers onthe management of life-threatening emergencies in hospital.Cochrane Database of Systematic Reviews2019, Issue 9. Art. No.: CD012177
- Guirgis. LIPid Intensive Drug therapy for Sepsis Pilot (LIPIDS-P): Phase I/II clinical trial protocol of lipid emulsion therapy for stabilising cholesterol levels in sepsis and septicshock. BMJ Open 2019;9:e029348
- Beqiri. Feasibility of individualised severe traumatic brain injury management using an automated assessment of optimal cerebral perfusion pressure: the COGiTATE phase II study protocol. BMJ Open. 2019;9(9):e030727
- Prowle. Pragmatic Studies for Acute Kidney Injury in China: Renal Replacement Therapy for Acute Kidney Injury and Sepsis Consensus Report of Acute Disease Quality Initiative XIX. J Transl Crit Care Med 2019;1:48-51
- Murugan. Pragmatic Studies for Acute Kidney Injury: Fluid Resuscitation in the Peri-Acute Kidney Injury Period. J Transl Crit Care Med 2019;1:52-6
- Ostermann. Is there a Role for Systematic Tools to Improve the Clinical Management of Patients with Acute Kidney Injury? Consensus Report of Acute Disease Quality Initiative XIX. J Transl Crit Care Med 2019;1:57-60
- Withholding and withdrawing life-support in adults in emergency care: joint position paper from the French Intensive Care Society and French Society of Emergency Medicine. Annals of Intensive Care 2019;epublished September 23rd
- Shao. Pathophysiological Mechanisms and Potential Therapeutic Targets in Intracerebral Hemorrhage. Front Pharmacol 2019;10:1079
- Kok. Psychopathology after admission to the intensive care unit. Neth J Crit Care 2019;5(5):186-9
- Pan. Multiorgan Drug Action of Levosimendan in Critical Illnesses. BioMed Research International 2019;9731467
- Cucci. Blood pressure variability in the management of hypertensive emergency: A narrative review. J Clin Hypertens 2019;epublished September 25th
- Smit-Fun. Heart Failure in Adult Patients with Congenital Heart Disease. Anesthesiology Clin 2019;epublished September September 27th
- Meesters. Optimizing Perioperative Blood and Coagulation Management During Cardiac Surgery. Anesthesiology Clin 2019;epublished September September 27th
- Jacob. Prevention of Cardiac Surgery-Associated Acute Kidney Injury. A Review of Current Strategies. Anesthesiology Clin 2019;epublished September 21st
- Bridwell. Sepsis in Pregnancy: Recognition and Resuscitation. West J Emerg Med 2019;20(5):822–832
- Bersani. Antifungal Drugs for Invasive Candida Infections (ICI) in Neonates: Future Perspectives. Front Pediatr 2019;7:375
- Suay-García. Present and Future of Carbapenem-resistant Enterobacteriaceae (CRE) Infections. Antibiotics 2019;8(3):122
- Al-Hasan. Direct Measurement of Performance: A New Era in Antimicrobial Stewardship. Antibiotics 2019;8(3):127
- Romero-Calle. Bacteriophages as Alternatives to Antibiotics in Clinical Care. Antibiotics 2019;8(3):138
- Fernández. The Perfect Bacteriophage for Therapeutic Applications—A Quick Guide. Antibiotics 2019;8(3):126
- Raffaeli. Drug Disposition and Pharmacotherapy in Neonatal ECMO: From Fragmented Data to Integrated Knowledge. Front Pediatr 2019;7:360
- Cashen. Anticoagulation in Neonatal ECMO: An Enigma Despite a Lot of Effort! Front Pediatr 2019;7:366
- Zatloukal. Perioperative goal directed therapy—current view. J Emerg Crit Care Med 2019;3:49
- Favaron. Fluid management in the perioperative setting: mind the kidney. J Emerg Crit Care Med 2019;3:50
- Braithwaite. New Techniques for Optimization of Donor Lungs/Hearts. Anesthesiology Clin 2019;epublished September September 27th
- Alhazzani. Intensive care medicine rapid practice guidelines (ICM-RPG): paving the road of the future. Intensive Care Med 2019;epublished September 24th
- Legrand. Recruiting the microcirculation in septic shock. Ann Intensive Care 2019;9:102
- Briggs. Clinical Trial Data Sharing: The Time Is Now. JASN 2019;30(9):1556-1558
- Arabi. The journey to zero deep-vein thrombosis in critically ill patients. Ann Thorac Med 2019;14:223-5
- Kesecioglu. Ethics and End-of-Life Care. J Transl Crit Care Med 2019;1:45-7
- Burki. Post-traumatic stress in the intensive care unit. Lancet Respir Med 2019;7(10):P843-844
- Urban. What are the results of venoarterial extracorporeal membrane oxygenation bridging to heart transplantation? Interactive CardioVascular and Thoracic Surgery 2019;29(4):632–634
- Abbasi. Advances in Fluid Assessment and Kidney Injury Prediction. JAMA 2019;322(10):918
- Moscote-Salazar. Management of Simultaneously Occurring Multiple Massive Intracerebral Hemorrhages. J Transl Crit Care Med 2019;1:69-71
- van der Ende. New Year’s Eve - an unintentional oral cocaine intoxication in an octogenarian. Neth J Crit Care 2019;5(5):200-03
- Veneman. Fatal, progressive dyspnoea with an unusual cause. Neth J Crit Care 2019;5(5): 204-06
- Lokhorst. The clinical approach to a patient with suspected autoimmune encephalitis. Neth J Crit Care 2019;5(5):207-11
Now in it's 8th year, the Critical Care Reviews Meeting brings the chief investigators for the best critical care trials of the previous year to Titanic, Belfast, to discuss their studies. We aim to decide whether these trials are sufficiently robust to support their findings and if we should consider changing practice on the basis of them. To help in this endeavour we invite world leading experts to provide independent editorial overviews and have panel discussions to delve deep into the specifics of each trial. In addition, we also have detailed discussions on research methodology, to encourage critical thinking about the scientific findings which form the basis of our clinical practice. It's not just about specific trials though; for 2020, we have a distinguished panel of trialists, methodologists, statisticians and clinicians provide insight into the mysteries of clinical trial interpretation. We also have the annual honorary John Hinds Lecture, to be delivered by Prof Kathryn Maitland, entitled "A Higher Calling: Two Decades of Emergency Research in Africa", and finish the meeting with the incredibly popular "Informal Chat", where the faculty and delegates congregate in the bar and an enormous, meandering discussion about all things critical care takes place.
Based on our feedback from last year, we've reverted to keeping everyone on the same floor during breaks. In addition, we will also provide a sleeping area for those post-call to rest for a few hours as needed. As before, we are offering free childcare and a baby feeding area, where the meeting will live streamed. All dietary requirements are catered for also. Please get in touch if you have any specific needs. We sold out last year, so please don't delay if you want to attend. As usual, CPD points will be applied for in due course.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board