Newsletter 405 | September 17th 2019
Journal Watch | Newsletters | CCR Meeting 2020 | CCR18 Book | Podcast | Hot Articles | Topic of the Week | Reviews | Top 100 Studies | Guidelines | Journals
Welcome to the 405th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are randomised controlled trials on supplementation of vitamin D in neurocritical care patients & high-flow nasal cannulae versus non-invasive ventilation for preoxygenation of obese patients; systematic reviews and meta analyses on airway pressure release ventilation & selective digestive decontamination vs. selective oropharyngeal decontamination; and observational studies on prolonged versus brief ICU stay & the association between supra-physiologic arterial oxygen levels and mortality. There are also guidelines on acute and chronic heart failure & immune checkpoint inhibitor–related pneumonitis; narrative reviews on malignant hyperthermia & oral anticoagulant reversal strategies; editorials on crystalloids in sepsis & nasal high‐flow therapy; and commentaries on heart recovery after circulatory determination of death & perioperative hemodynamic monitoring; as well as a study critique on the EOLIA trial.
If you only have time to read one review article this week, try this one on new perspectives for the management of non-ST elevation myocardial infarction after the COACT trial - another great trial being discussed at CCR20!
The latest presentations from the Critical Care Reviews Meeting 2019 released this week are SMART & its editorial and SUP-ICU & its editorial. The previously released talks are available here.
Celebrating 25 years of the UK Intensive Care National Audit and Research Centre, this week's Topic of the Week focuses on some of the major trials ICNARC has undertaken (CALORIES, ProMISe & POPPI - all previously discussed at CCR) and some currently running (65 - being discussed at CCR20) or being assisting with (PEPTIC - results being presented at CCR20; & REST, hopefully being discussed at CCR20something). We started yesterday with their landmark trial PAC-Man and finish on Sunday with the protocol for 65.
Research
- Abstract: Karsy. The effect of supplementation of vitamin D in neurocritical care patients: RandomizEd Clinical TrIal oF hYpovitaminosis D (RECTIFY). J Neurosurg 2019:1-10
- Full Text: Vourc'h. High-flow nasal cannulae versus non-invasive ventilation for preoxygenation of obese patients: the PREOPTIPOP randomized trial. EClinicalMedicine 2019;13:112-119
- Abstract: Madan. The Cricothyroid versus Spray-As-You-Go Method for Topical Anesthesia during Flexible Bronchoscopy: The CRISP Randomized Clinical Trial. Respiration 2019;epublished August 28th
- Abstract: Czarnecki. A Pilot Randomized Controlled Trial of Outcomes Associated with Parent-Nurse Controlled Analgesia vs. Continuous Opioid Infusion in the Neonatal Intensive Care Unit. Pain Manag Nurs 2019;epublished September 4th
- Full Text: Hausenloy. Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial. Lancet 2019;epublished September 6th
- Abstract: Lim. Airway Pressure Release Ventilation in Adult Patients With Acute Hypoxemic Respiratory Failure: A Systematic Review and Meta-Analysis. Crit Care Med 2019;epublished September 10th
- Abstract: Dushianthan. Immunonutrition for Adults With ARDS: Results From a Cochrane Systematic Review and Meta-Analysis. Respir Care 2019;epublished Septemebr 10th
- Full Text: van Hout. Cost-effectiveness of selective digestive decontamination (SDD) versus selective oropharyngeal decontamination (SOD) in intensive care units with low levels of antimicrobial resistance: an individual patient data meta-analysis. BMJ Open 2019;9(9):e028876
- Abstract: Pei. Meta-Analysis of Catheter Directed Ultrasound-Assisted Thrombolysis in Pulmonary Embolism. Am J Cardiol 2019;epublished August 7th
- Abstract: Wijntjens. Prognostic implications of microcirculatory perfusion versus macrocirculatory perfusion in cardiogenic shock: a CULPRIT-SHOCK substudy. Eur Heart J Acute Cardiovasc Care 2019;epublished September 13th
- Abstract: Hermans. Five-year mortality and morbidity impact of prolonged versus brief ICU stay: a propensity score matched cohort study. Thorax 2019;epublished September 3rd
- Abstract: Palmer. The Association Between Supra-Physiologic Arterial Oxygen Levels and Mortality in Critically Ill Patients: A Multi-Centre Observational Cohort Study. Am J Respir Crit Care Med 2019;epublished September 12th
- Chabanne. Sedation versus general anaesthesia in endovascular therapy for anterior circulation acute ischaemic stroke: the multicentre randomised controlled AMETIS trial study protocol. BMJ Open 2019;9(9):e027561
- Zhou. The effect of recombinant human thrombopoietin (rhTPO) on sepsis patients with acute severe thrombocytopenia: a study protocol for a multicentre randomised controlled trial (RESCUE trial). BMC Infect Dis 2019;19(1):780
Guidelines
- JCS 2017/JHFS 2017 Guideline on Diagnosis and Treatment of Acute and Chronic Heart Failure - Digest Version. Circ J 2019;epublished September 10th
- Recommendations and guidelines for the treatment of pneumonia in Taiwan. J Microbiol Immunol Infect 2019;52(1):172-199
- Knowledge Gaps and Research Priorities in Immune Checkpoint Inhibitor–related Pneumonitis. An Official American Thoracic Society Research Statement. Am J Respir Crit Care Med 2019;200(6):e31–e43
Review Articles
Neurological
Circulatory
- Gabr. The importance of nontechnical skills in leading cardiopulmonary resuscitation teams. J R Coll Physicians Edinb 2019;49:112-6
- Hoe. Hurdles to Cardioprotection in the Critically Ill. Int J Mol Sci 2019;20(15):3823
- Reto. The Human Coronary Collateral Circulation, Its Extracardiac Anastomoses and Their Therapeutic Promotion. Int J Mol Sci 2019;20(15):3726
- Schima. Complications of central venous port systems: a pictorial review. Insights Imaging 2019;10:86
- Bryce. Pathophysiology of right ventricular failure in acute pulmonary embolism and chronic thromboembolic pulmonary hypertension: a pictorial essay for the interventional radiologist. Insights Imaging 2019;10:18
Respiratory
- Chalmers. Diagnosis and treatment of acute pulmonary inflammation in critically ill patients: The role of inflammatory biomarkers. World J Crit Care Medl 2019;8(5):59-71
- Severiche-Bueno. Hot topics and current controversies in community-acquired pneumonia. Breathe 2019;15(3):216-225
- Hunton. Updated concepts in the diagnosis and management of community-acquired pneumonia. JAAPA 2019;epublished September 10th
Gastrointestinal
- Blaser. Citrulline and intestinal fatty acid-binding protein as biomarkers for gastrointestinal dysfunction in the critically ill. Anaesthesiol Intensive Ther 2019; 512):230–239
- Bodnar. Polycompartment syndrome – intra-abdominal pressure measurement. Anaesthesiol Intensive Ther 2019;51:3
Nutrition
Metabolic
Sepsis
Trauma
Perioperative
Miscellaneous
- Marin-Acevedo. Immune Checkpoint Inhibitor Toxicities. Mayo Clin Proc 2019;94(7):1321–1329
- Ozeke. Second victims in health care: current perspectives. Adv Med Educ Pract 2019;10:593–603
- Van Groenendael. The Human Chorionic Gonadotropin Derivate EA-230 Modulates the Immune Response and Exerts Renal Protective Properties: Therapeutic Potential in Humans. Seminars in Nephrology 2019;39(5):496-504
- Shah. Mesenchymal stem cells-derived extracellular vesicles in acute respiratory distress syndrome: a review of current literature and potential future treatment options. Clin Transl Med 2019;8(1):25
- Jagadish. Post-operative atrial fibrillation: should we anticoagulate? Ann Transl Med 2019;7(17):407
- Bhattad. Intravenous cangrelor as a peri-procedural bridge with applied uses in ischemic events. Ann Transl Med 2019;7(17):408
- Cave. Targeting ticagrelor: a novel therapy for emergency reversal. Ann Transl Med 2019;7(17):410
- Rawal. Current status of oral anticoagulant reversal strategies: a review. Ann Transl Med 2019;7(17):411
- Raja. Is early invasive management as ST elevation myocardial infarction warranted in de Winter’s sign?—a “peak” into the widow-maker. Ann Transl Med 2019;7(17):412
- Maturana. After COACT trial—new perspectives for the management of non-ST elevation myocardial infarction: early versus late cardiac catheterization post cardiac arrest. Ann Transl Med 2019;7(17):413
- Rawal. Is there an optimal “door to cath time” in the treatment of acute pulmonary embolism with catheter-directed thrombolysis? Ann Transl Med 2019;7(17):419
- Pour-Ghaz. Accuracy of non-invasive and minimally invasive hemodynamic monitoring: where do we stand? Ann Transl Med 2019;7(17):421
Editorials
- Young. Balanced crystalloids or 0.9% saline in sepsis: beyond reasonable doubt? Am J Respir Crit Care Med 2019;epublished September 12th
- Rubin. Changing Principals, Keeping Principles. N Engl J Med 2019;381:1069-1070
- Miller. Pediatric solid organ injury management: the role of initial hematocrit in lean times. J Emerg Crit Care Med 2019;3:39
- Mansfield. Nasal high‐flow therapy: Established roles and emerging opportunities. Respirology 2019;epublished September 5th
Commentaries
- Ball. Heart recovery after circulatory determination of death: time for public engagement. Can J Anaesth 2019;66(10):1147-1150
- Bernardo. Updates in pulmonary hypertension and other pulmonary vascular diseases. Breathe 2019;15(3):241-243
- Michard. Shedding light on perioperative hemodynamic monitoring. J Clin Monit Comput 2019;epublished September 10th
Miscellaneous
- Diop. Remote cerebellar hemorrhage with acute hydrocephalus after supratentorial surgery. J Emerg Crit Care Med 2019;3:41
- Limchareon. Idiopathic intrahepatic arterioportal shunt rupture. J Emerg Crit Care Med 2019;3:42
- Mishra. Tuberculosis septic shock, an elusive pathophysiology and hurdles in management: A case report and review of literature. World J Crit Care Med 2019;8(5):72-81
- Harfouche. Gunshot wound to big blue. Trauma Surgery & Acute Care Open 2019;4:e000368
- Diop. Remote cerebellar hemorrhage with acute hydrocephalus after supratentorial surgery. J Emerg Crit Care Med 2019;3:41
- Limchareon. Idiopathic intrahepatic arterioportal shunt rupture. J Emerg Crit Care Med 2019;3:42
CCR20 Meeting
Now in it's 8th year, the Critical Care Reviews Meeting brings the chief investigators for the best critical care trials of the previous year to Titanic, Belfast, to discuss their studies. We aim to decide whether these trials are sufficiently robust to support their findings and if we should consider changing practice on the basis of them. To help in this endeavour we invite world leading experts to provide independent editorial overviews and have panel discussions to delve deep into the specifics of each trial. In addition, we also have detailed discussions on research methodology, to encourage critical thinking about the scientific findings which form the basis of our clinical practice. It's not just about specific trials though; for 2020, we have a distinguished panel of trialists, methodologists, statisticians and clinicians provide insight into the mysteries of clinical trial interpretation. We also have the annual honorary John Hinds Lecture, to be delivered by Prof Kathryn Maitland, entitled "A Higher Calling: Two Decades of Emergency Research in Africa", and finish the meeting with the incredibly popular "Informal Chat", where the faculty and delegates congregate in the bar and an enormous, meandering discussion about all things critical care takes place.
Based on our feedback from last year, we've reverted to keeping everyone on the same floor during breaks. In addition, we will also provide a sleeping area for those post-call to rest for a few hours as needed. As before, we are offering free childcare and a baby feeding area, where the meeting will live streamed. All dietary requirements are catered for also. Please get in touch if you have any specific needs. We sold out last year, so please don't delay if you want to attend. As usual, CPD points will be applied for in due course.
CCH Journal
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Rob
Supported by the Health Research Board