CCR-Newsletter-BannerNewsletter 403  |  September 1st 2019

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The latest trial added to the CCR20 programme is VITAMINS


Welcome to the 403rd Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.

The highlights of this week's edition are randomised controlled trials on the effects of vasopressin on transfusion requirements in trauma & complete vs culprit only PCI revascularization for myocardial infarction; a systematic review and meta analysis on IV immunoglobulin in sepsis; and an observational study looking at the association between acute kidney injury and neurological outcome or death at 6 months in out-of-hospital cardiac arrest. There is also a guideline on laboratory testing in the diagnosis of fungal infections; plus narrative reviews on hyperventilation in neurological patients & early brain injury after poor-grade subarachnoid hemorrhage; commentaries on death by organ donation & artificial intelligence in perioperative medicine; and correspondence on managing ICP-CPP & tidal volume.

This week's Topic of the Week is the second of a two part series looking at alcoholic liver disease, this week focusing on the complications of cirrhosis. We start with a paper on hepatorenal syndrome in tomorrow's Paper of the Day.

If you only have time to read one article this week, try this editorial from Prof Howard Bauchner, the Editor-in-Chief of JAMA, about the reporting and interpretation of randomized clinical trials. This topic, and others, will be advanced in more depth at the Critical Care Reviews Meeting 2020, where Prof Marion Campbell will interview Prof Bauchner over an hour in "The Editor's View".

Two sets of presentations from CCR19, POPPI & MIND-USA, were released this week. These are available in both video and podcast format. The full set to date, and our previous year's talks, are available here.



Review Articles










CCR20 Meeting

CCR20 290819 Widget

Now in it's 8th year, the Critical Care Reviews Meeting brings the chief investigators for the best critical care trials of the previous year to Titanic, Belfast, to discuss their studies. We aim to decide whether these trials are sufficiently robust to support their findings and if we should consider changing practice on the basis of them. To help in this endeavour we invite world leading experts to provide independent editorial overviews and have panel discussions to delve deep into the specifics of each trial. In addition, we also have detailed discussions on research methodology, to encourage critical thinking about the scientific findings which form the basis of our clinical practice. It's not just about specific trials though; for 2020, we have a distinguished panel of trialists, methodologists, statisticians and clinicians provide insight into the mysteries of clinical trial interpretation. We also have the annual honorary John Hinds Lecture, to be delivered by Prof Kathryn Maitland, entitled "A Higher Calling: Two Decades of Emergency Research in Africa", and finish the meeting with the incredibly popular "Informal Chat", where the faculty and delegates congregate in the bar and an enormous, meandering discussion about all things critical care takes place.

Based on our feedback from last year, we've reverted to keeping everyone on the same floor during breaks. In addition, we will also provide a sleeping area for those post-call to rest for a few hours as needed. As before, we are offering free childcare and a baby feeding area, where the meeting will live streamed. All dietary requirements are catered for also. Please get in touch if you have any specific needs. We sold out last year, so please don't delay if you want to attend. As usual, CPD points will be applied for in due course.

CCH Journal

Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive.  If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.

COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.

I hope you find these links useful.

Until next week


Supported by the Health Research Board

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Bauchner. Reporting and Interpretation of Randomized Clinical Trials. JAMA 2019;322(8):732-735