Welcome to the 397th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are randomised controlled trials on the effects of flexible family visitation on delirium & ICU diaries on posttraumatic stress disorder; systematic reviews and meta analyses on driving pressure for ventilated ARDS patients & procalcitonin-guided antibiotic treatment in patients with positive blood cultures; and observational studies on the association between state-mandated protocolized sepsis care and in-hospital mortality in sepsis & time to treatment with endovascular reperfusion therapy and outcomes in patients with acute ischemic stroke.
There are also guidelines on advanced training in echocardiography & key data elements and definitions for transthoracic echocardiography; narrative reviews on renal replacement therapy & biomarkers in ICU infections, as well as an entire series on CO2-derived variables for haemodynamic management in critically ill patients; editorials on ventilator-associated pneumonia & critical care nephrology; and commentaries on evidence vs consensus in clinical practice guidelines & the legacy of project Apollo. If you only have time to read one review article this week, try this one on invasive fungal infections.
After my unexpected loss of internet connectivity whilst travelling last month, I've finally caught up!
- Abstract: Rosa. Effect of Flexible Family Visitation on Delirium Among Patients in the Intensive Care Unit. The ICU Visits Randomized Clinical Trial. JAMA 2019;322(3):216-228
- Abstract: Garrouste-Orgeas. Effect of an ICU Diary on Posttraumatic Stress Disorder Symptoms Among Patients Receiving Mechanical Ventilation. A Randomized Clinical Trial. JAMA 2019;322(3):229-239
- Abstract: Deletombe. Dexmedetomidine to facilitate non-invasive ventilation after blunt chest trauma: a randomised, double-blind, crossover, placebo-controlled pilot study. Anaesth Crit Care Pain Med 2019;epublished July 15th
- Full Text: Min. Randomized Trial Comparing Early and Late Administration of Rocuronium Before and After Checking Mask Ventilation in Patients With Normal Airways. Anesthesia & Analgesia 2019;129(2):380-386
- Abstract: Bornstein. An injectable implant to stimulate the sphenopalatine ganglion for treatment of acute ischaemic stroke up to 24 h from onset (ImpACT-24B): an international, randomised, double-blind, sham-controlled, pivotal trial. Lancet 2019;394(10194):219-229
- Abstract: Rissanen. Drug-coated balloon for treatment of de-novo coronary artery lesions in patients with high bleeding risk (DEBUT): a single-blind, randomised, non-inferiority trial. Lancet 2019;394(10194):230-239
- Abstract: Chen. Higher vs. Lower DP for Ventilated Patients with Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis. Emergency Medicine International 2019;4654705
- Full Text: Bibas. Association of Surrogate Decision-making Interventions for Critically Ill Adults With Patient, Family, and Resource Use OutcomesA Systematic Review and Meta-analysis. JAMA Netw Open 2019;2(7):e197229
- Full Text: Wilcox. Cost-Effectiveness Studies in the ICU: A Systematic Review. Crit Care Med 2019;47(8):1011-1017
- Abstract: Storm. Impact of Structured Pathways for Postcardiac Arrest Care: A Systematic Review and Meta-Analysis. Crit Care Med 2019;47(8):e710-e716
- Abstract: Meier. Procalcitonin-guided Antibiotic Treatment in Patients With Positive Blood Cultures: A Patient-level Meta-analysis of Randomized Trials. Clinical Infectious Diseases 2019;69(3):388–396
- Abstract: Litton. Safety and efficacy of erythropoiesis-stimulating agents in critically ill patients admitted to the intensive care unit: a systematic review and meta-analysis. Intensive Care Med 2019;epublished July 11th
- Abstract: Kahn. Association Between State-Mandated Protocolized Sepsis Care and In-hospital Mortality Among Adults With Sepsis. JAMA 2019;322(3):240-250
- Abstract: Jahan. Association Between Time to Treatment With Endovascular Reperfusion Therapy and Outcomes in Patients With Acute Ischemic Stroke Treated in Clinical Practice. JAMA 2019;322(3):252-263
- Full Text: Bergez. PEEP titration in moderate to severe ARDS: plateau versus transpulmonary pressure. Ann Intensive Care 2019;9(1):81
- Abstract: Anadani. Blood Pressure and Outcome After Mechanical Thrombectomy With Successful Revascularization. Stroke 2019;epublished July 18th
- Abstract: Sadaka. Ascorbic Acid, Thiamine, and Steroids in Septic Shock: Propensity Matched Analysis. J Intensive Care Med 2019;epublished July 17th
- Abstract: Branch-Elliman. Association of Duration and Type of Surgical Prophylaxis With Antimicrobial-Associated Adverse Events. JAMA Surg 2019;154(7):590-598
- Abstract: Jaquet. Functional outcomes in adult patients with herpes simplex encephalitis admitted to the ICU: a multicenter cohort study. Intensive Care Med 2019;epublished July 11th
- Martín. Buffered solutions versus 0.9% saline for resuscitation in critically ill adults and children.Cochrane Database of Systematic Reviews 2019, Issue 7. Art. No.: CD012247
- Barry. Community first responders for out-of-hospital cardiac arrestin adults and children.Cochrane Database of Systematic Reviews 2019, Issue 7. Art. No.: CD012764
- 2019 ACC/AHA/ASE advanced training statement on echocardiography (revision of the 2003 ACC/AHA clinical competence statement on echocardiography): a report of the ACC Competency Management Committee. Cardiovascular Imaging 2019;12:e000026
- 2019 ACC/AHA/ASE key data elements and definitions for transthoracic echocardiography: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Data Standards (Writing Committee to Develop Cardiovascular Endpoints Data Standards) and the American Society of Echocardiography. Circ Cardiovasc Imaging 2019;12:e000027
- Bigdon. Spinal injury in alpine winter sports: a review. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2019;27:69
- Tezcan. Current Use of Neuromuscular Blocking Agents in Intensive Care Units. Turk J Anaesthesiol Reanim 2019;47(4):273-281
- Colebourn. Field guide to critical care echocardiography: the UK view. J Emerg Crit Care Med 2019;3:29
- Spadaccio. Recent advances in aortic valve replacement. F1000Research 2019, 8(F1000 Faculty Rev):1159
- Welte. Pleural Effusion in Adults—Etiology, Diagnosis, and Treatment. Dtsch Arztebl Int 2019;116(21):377-86
- Ahmed. Renal Replacement Therapy in the Critical Care Setting. Critical Care Research and Practice 2019;6948710
- Kalil. Influenza virus-related critical illness: pathophysiology and epidemiology. Critical Care 2019;23:258
- Xu. Biomarkers in intensive care unit infections, friend or foe? J Emerg Crit Care Med 2019;3:27
- von Lilienfeld-Toal. Invasive Fungal Infection. New treatments to meet new challenges. Dtsch Arztebl Int 2019;116(16):271-8
- Gavelli. How can CO2-derived indices guide resuscitation in critically ill patients? J Thorac Dis 2019;11(Suppl 11):S1528-S1537
- Yuan. Interpretation of venous-to-arterial carbon dioxide difference in the resuscitation of septic shock patients. J Thorac Dis 2019;11(Suppl 11):S1538-S1543
- Ospina-Tascón. Combination of O2 and CO2-derived variables to detect tissue hypoxia in the critically ill patient. J Thorac Dis 2019;11(Suppl 11):S1544-S1550
- Huette. Venous-to-arterial pCO2 difference in high-risk surgical patients. J Thorac Dis 2019;11(Suppl 11):S1551-S1557
- Mari. Transcutaneous PCO2 monitoring in critically ill patients: update and perspectives. J Thorac Dis 2019;11(Suppl 11):S1558-S1567
- Bar. Regional capnometry to evaluate the adequacy of tissue perfusion. J Thorac Dis 2019;11(Suppl 11):S1568-S1573
- Nassar. Usefulness of venous-to-arterial partial pressure of CO2 difference to assess oxygen supply to demand adequacy: effects of dobutamine. J Thorac Dis 2019;11(Suppl 11):S1574-S1578
- Vallabhajosyula. Multidisciplinary teams for cardiogenic shock. Aging 2019;epublished July 17th
- Bos. Changes in lung microbiome do not explain the development of ventilator-associated pneumonia. Intensive Care Med 2019;epublished July 17th
- Darmon. Focus on critical care nephrology. Intensive Care Med 2019;epublished July 11th
- Johnston. A New Supreme Court Ruling on Drug Liability. JAMA 2019;epublished July 11th
- Djulbegovic. Evidence vs Consensus in Clinical Practice Guidelines. JAMA 2019;epublished July 19th
- Leaf. IDEAL-ICU in Context. Clin J Am Soc Nephrol 2019;epublished July 17th
- Fong. Moon landing: space medicine and the legacy of Project Apollo. Lancet 2019;394(10194):205-207
- Nundy. Promoting Trust Between Patients and Physicians in the Era of Artificial Intelligence. JAMA 2019;epublished July 15th
- Molero-Díez. Fourth universal definition of myocardial infarction. Perioperative anesthetic considerations. Colombian Journal of Anesthesiology 2019;47(3):175–177
- Muratsu. Gastric emphysema with portal emphysema due to superior mesenteric artery syndrome developing septic shock: a case report. Acute Med Surg 2019;epublished July 11th
- Ogura. A case of hypoxic encephalopathy induced by the inhalation of helium that resolved with no neurological complications: a case report and analysis of similar cases. Acute Med Surg 2019;6:308–311
- Odagiri. Elderly‐onset acute necrotizing encephalopathy mimicking severe heat stroke: a case report and review of the literature. Acute Med Surg 2019;6:316–320
- Kakizaki. Takotsubo cardiomyopathy developed during rewarming of accidental hypothermia with extracorporeal membrane oxygenation. Acute Med Surg 2019;6:201–205
- Shih. Focused ultrasound assists in diagnosis and management of difficult airway in Ludwig's angina. J Med Ultrasound 2019;27:101-3
- Moreira. Whole-lung lavage for severe pulmonary alveolar proteinosis assisted by veno-venous extracorporeal membrane oxygenation: a case report. Can J Respir Ther 2019;55:10.29390/cjrt-2018-019
- Kugasia. An unorthodox way to confirm an uncommon complication of central venous catheter placement. J Emerg Crit Care Med 2019;3:28
- Khanna. Wellens syndrome. left anterior descending coronary T-wave syndrome. Colombian Journal of Anesthesiology 2019;47(3):178–179
Now in it's 8th year, the Critical Care Reviews Meeting brings the chief investigators for the best critical care trials of the previous year to Titanic, Belfast, to discuss their studies. We aim to decide whether these trials are sufficiently robust to support their findings and if we should consider changing practice on the basis of them. To help in this endeavour we invite world leading experts to provide independent editorial overviews and have panel discussions to delve deep into the specifics of each trial. In addition, we also have detailed discussions on research methodology, to encourage critical thinking about the scientific findings which form the basis of our clinical practice. It's not just about specific trials though; for 2020, we have a distinguished panel of trialists, methodologists, statisticians and clinicians provide insight into the mysteries of clinical trial interpretation. We also have the annual honorary John Hinds Trauma Lecture, and finish the meeting with the incredibly popular "Informal Chat", where the faculty and delegates congregate in the bar and an enormous, meandering discussion about all things critical care takes place.
Based on our feedback from last year, we've reverted to keeping everyone on the same floor during breaks. In addition, we will also provide a sleeping area for those post-call to rest for a few hours as needed. As before, we are offering free childcare and a baby feeding area, where the meeting will live streamed. All dietary requirements are catered for also. Please get in touch if you have any specific needs. We sold out last year, so please don't delay if you want to attend. As usual, CPD points will be applied for in due course.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board