Newsletter 331  |  April 15^th 2018

Journal Watch  |  Newsletters  |  CCR Meeting 2018  |  CCR18 Book |  Podcast  |  Hot Articles  |  Topic of the Week  |  Reviews  |  Top 100 Studies  |  Guidelines  |  Journals

Welcome to the 331^st Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. The highlights of this week's newsletter are randomised controlled trials on APRV in paediatric ARDS  & a polyclonal antibody preparation in patients with severe community-acquired pneumonia; observational studies on Karoshi and cerebral autoregulation in the prediction of delayed cerebral ischemia; guidelines on acute non-invasive ventilation & right-sided heart failure; narrative reviews on chloride levels in critical illness, antibiotic therapy in ventilator-associated tracheobronchitis & reversal agents for non-vitamin K antagonist oral anticoagulants. If you only have time for one review paper this week, try this one on immune therapy in sepsis. 

This week's Topic of the Week is Group A Streptococcal disease, starting with a paper on disease manifestations and pathogenic mechanisms of Group A Streptococcus in tomorrow's Paper of the Day.

I haven't had time to finish the registration requirements for #CCR19. Hopefully, it will be ready to go on Wednesday!

Research

+ - Randomised Controlled Trials Click to collapse

• Abstract:  Ganesan. Airway Pressure Release Ventilation in Pediatric Acute Respiratory Distress Syndrome: a Randomized Controlled Trial. Am J Respir Crit Care Med 2018;epublished April 11th
• Full Text:  Welte. Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study). Intensive Care Med 2018;epublished April 9th
• Abstract:  Sarfati. Efficacy of early passive tilting in minimizing ICU-acquired weakness: A randomized controlled trial. J Crit Care 2018;epublished April 5th
• Abstract:  Mehra. Two-Year Outcomes with a Magnetically Levitated Cardiac Pump in Heart Failure. N Engl J Med 2018;378:1386-1395
• Abstract:  Lou. Prevention of upper gastrointestinal bleeding in critically ill Chinese patients: a randomized, double-blind study evaluating esomeprazole and cimetidine. Curr Med Res Opin 2018;11:1-19

+ - Systematic Reviews & Meta Analyses Click to collapse

• Abstract:  Zhou. Effect of levosimendan in patients with acute decompensated heart failure : A meta-analysis. Herz 2018;epublished April 10th
• Abstract:  Nassar Junior. Flexible Versus Restrictive Visiting Policies in ICUs: A Systematic Review and Meta-Analysis. Crit Care Med 2018;epublished April 10th
• Abstract:  Patel. Association between intra- and post-arrest hyperoxia on mortality in adults with cardiac arrest: a systematic review and meta-analysis. Resuscitation 2018;epublished April 10th
• Abstract:  Belletti. Vasopressors During Cardiopulmonary Resuscitation. A Network Meta-Analysis of Randomized Trials. Crit Care Med 2018;46(5):e443-e451
• Abstract:  Iankova. Efficacy and Safety of Procalcitonin Guidance in Patients With Suspected or Confirmed Sepsis: A Systematic Review and Meta-Analysis. Crit Care Med 2018;46(5):691–698
• Abstract:  Carson. Clinical Trials Evaluating Red Blood Cell Transfusion Thresholds: An Updated Systematic Review and with Additional Focus on Patients with Cardiovascular Disease. Am Heart J 2018;epublished February 8th

+ - Observational Studies Click to collapse

• Abstract:  McPhail. Incidence and Outcomes for Patients With Cirrhosis Admitted to the United Kingdom Critical Care Units. Crit Care Med 2018;46(5):705-712
• Abstract:  Gaasch. Cerebral Autoregulation in the Prediction of Delayed Cerebral Ischemia and Clinical Outcome in Poor-Grade Aneurysmal Subarachnoid Hemorrhage Patients. Crit Care Med 2018;46(5):774-780
• Full Text:  Yin. Karoshi, a new epidemic in Chinese medical practitioners. Intensive Care Med 2018;epublished March 20th
• Abstract:  Yoshida. Esophageal Manometry and Regional Transpulmonary Pressure in Lung Injury. Am J Respir Crit Care Med 2018;197(8):1018-1026
• Abstract:  McNeil. Novel Method for Noninvasive Sampling of the Distal Airspace in Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med 2018;197(8):1027-1035
• Abstract:  Viglianti. Late organ failures in patients with prolonged intensive care unit stays. J Crit Care 2018;epublished April 4th
• Full Text:  Grailey. The Faculty of Intensive Care Medicine Workforce Survey – What impacts on our working lives? JICS 2018;epublished April 3rd
• Full Text:  Madotto. Resolved versus confirmed ARDS after 24 h: insights from the LUNG SAFE study. Intensive Care Med 2018;epublished April 9th

+ - Protocols Click to collapse

• Reeder. Improving outcomes after pediatric cardiac arrest - the ICU-Resuscitation Project: study protocol for a randomized controlled trial. Trials 2018;19(1):213
• Dat. Continuous versus intermittent endotracheal cuff pressure control for the prevention of ventilator-associated respiratory infections in Vietnam: study protocol for a randomised controlled trial. Trials 2018;19(1):217

Guidelines

• British Thoracic Society Quality Standards for acute non-invasive ventilation in adults. BMJ Open Respir Res 2018;5(1):e000283
• Evaluation and Management of Right-Sided Heart Failure: A Scientific Statement From the American Heart Association. Circulation 2018;epublished April 12th
• European Society of Radiology (ESR) paper on the proper use of mobile devices in radiology. Insights into Imaging 2018;9(2):247–251
• Tardif. Management of Acute Coronary Syndromes. CJD 2018;42(Suppl 1):S190–S195

Review Articles

+ - Clinical Click to collapse

Circulatory

• Kobayashi. How to manage various arrhythmias and sudden cardiac death in the cardiovascular intensive care. Journal of Intensive Care 2018;6:23
• Murphy. Vascular CT and MRI: a practical guide to imaging protocols. Insights into Imaging 2018;9(2):215-236

Respiratory

• Alves. Antibiotic therapy in ventilator-associated tracheobronchitis: a literature review. Rev Bras Ter Intensiva 2018;30(1):80–85
• Plotnikow. Humidification and heating of inhaled gas in patients with artificial airway. A narrative review. Rev Bras Ter Intensiva 2018;30(1):86–97
• Sarkar. Pulmonary hypertension and cardiac anesthesia: Anesthesiologist's perspective. Ann Card Anaesth 2018;21:116-22
• Haaksma. Ultrasound imaging of the diaphragm: facts and future. A guide for the bedside clinician. Neth J Crit Care 2018;26(2):58-63

Gastrointestinal

• De Waele. What every intensivist should know about the management of peritonitis in the intensive care unit. Rev Bras Ter Intensiva 2018;30(1):9–14

Renal

• Pfortmueller. Serum chloride levels in critical illness—the hidden story. Intensive Care Medicine Experimental 2018;6:10
• Kardalas. Hypokalemia: a clinical update. Endocr Connect 2018;7(4):R135–R146
• Vecchio. Erythropoiesis stimulating agents and nephroprotection: is there any room for new trials? Nephrology Dialysis Transplantation 2018;32(2):211–214
• Massimo. Hypothermia and kidney: a focus on ischaemia–reperfusion injury. Nephrology Dialysis Transplantation 2018;32(2):241–247

Haematological

• Hayakawa. A summary of the Japan septic disseminated intravascular coagulation study. Acute Medicine & Surgery 2018;5(2):123-128
• Levy. Reversal agents for non-vitamin K antagonist oral anticoagulants. Nature Reviews Cardiology 2018;15:273–281

Sepsis

• Davies. Immune therapy in sepsis: Are we ready to try again? JICS 2018;epublished April 4th
• Mercier. Galactomannan, a Surrogate Marker for Outcome in Invasive Aspergillosis: Finally Coming of Age. Front Microbiol 2018;9:661
• Carla de Souza. From the International Pediatric Sepsis Conference 2005 to the Sepsis-3 Consensus. Rev Bras Ter Intensiva 2018;30(1):1–5

Trauma

• Ertl. Lower extremity traumatic amputations—brief review of reconstruction, wound and soft tissue management, alternatives to conventional practice. J Emerg Crit Care Med 2018;2:35

Perioperative

• Al-Ghamdi. Intraoperative fluid management: Past and future, where is the evidence? Saudi J Anaesth 2018;12(2):311–317
• Lyu. Past, present, and future of Emergency General Surgery in the USA. Acute Medicine & Surgery 2018;5(2):119-122

Miscellaneous

• Teixeira. Post-intensive care outpatient clinic: is it feasible and effective? A literature review. Rev Bras Ter Intensiva 2018;30(1):98–111
• Vergano. Clinical ethics: what the anesthesiologist and the intensivist need to know. Minerva Anestesiologica 2018;84(4):515-22

+ - Non-Clinical Click to collapse

• Rubulotta. Improving skills and education in intensive care medicine. J Emerg Crit Care Med 2018;2:36

+ - Pre-Clinical Click to collapse

• Sano. Promising novel therapy with hydrogen gas for emergency and critical care medicine. Acute Medicine & Surgery 2018;5(2):113-118

Editorials

• Weijs. Route, early or energy? … Protein improves protein balance in critically ill patients. Critical Care 2018;22:91
• Ray. Prone position ventilation in pregnancy: Concerns and evidence. J Obstet Anaesth Crit Care 2018;8:7-9
• Aronow. Antihypertensive drug therapy. Ann Transl Med 2018;6(7):123
• Williams. Can pancreatitis be treated by inhibiting Ca2+ signaling? Ann Transl Med 2018;6(7):124
• de Grooth. AKI biomarkers are poor discriminants for subsequent need for renal replacement therapy, but do not disqualify them yet. Intensive Care Med 2018;epublished April 12th
• Thelin. Monitoring Pathophysiology in the Injured Brain. Front Neurol 2018;9:193

Commentaries

• Gupta. Tranexamic acid: Beware of anaesthetic misadventures. J Obstet Anaesth Crit Care 2018;8:1-6
• Gilbert. Advancing towards precision medicine in ARDS. Lancet Respir Med 2018;epublished April 12th
• Harris. Divisions, New and Old — Conscience and Religious Freedom at HHS. N Engl J Med 2018; 378:1369-1371
• Cuk. Net Neutrality Repeal and the Potential Harm to Medical Education. JAMA 2018;epublished April 11th
• Moyé. Liberation From the P Value’s Tyranny. Circulation Research 2018;122:1046-1048
• Cox. Critical Evaluation of Data Requires Rigorous but Broadly Based Statistical Inference. Circulation Research 2018;122:1049-1051
• Khattar. Heparin: The Silver Bullet of Aneurysmal Subarachnoid Hemorrhage? Front Neurol 2018;9:97
• Zhang. Exploring heterogeneity in clinical trials with latent class analysis. Ann Transl Med 2018;6(7):119
• Zhang. Estimate risk difference and number needed to treat in survival analysis. Ann Transl Med 2018;6(7):120
• Zhang. Time-varying covariates and coefficients in Cox regression models. Ann Transl Med 2018;6(7):121
• Zhang. Subgroup identification in clinical trials: an overview of available methods and their implementations with R. Ann Transl Med 2018;6(7):122

Miscellaneous

+ - Correspondence Click to collapse

• Various. More on Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke. N Engl J Med 2018;378:1465-1466
• Legrand. Cardiac output and CVP monitoring… to guide fluid removal. Crit Care 2018;22:89

+ - Case Reports Click to collapse

• Elkoundi. Green urine in the operating room: the ‘Cloret Sign’. QJM 2018;111(4):265–266
• Vilela. A critical electrocardiographic pattern in the age of cardiac biomarkers. Ann Transl Med 2018;6(7):133
• Yu. Pneumocystis jiroveci pneumonia in patients with toxic epidermal necrolysis. J Emerg Crit Care Med 2018;2:37

+ - News Click to collapse

• Kwon. French Universities Cancel Subscriptions to Springer Journals. The Scientist 2018;epublished March 31st

Meetings

CCR19

Belfast, 18-19th January 2019

SMACC Sydney

Sydney, 26-29th March 2019

Women in ICM

London, February 6th

CCH Journal

Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive.  If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.

COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.

I hope you find these links useful.

Until next week

Rob

Supported by the Health Research Board