Not a bad Christmas present this year....
Welcome to the 315th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. This week we bring you our biggest news yet - Critical Care Reviews Meeting 2018 will host the ANZICS CTG / The George Institute for Global Health ADRENAL trial results in Belfast on January 19th. In addition to discussing the best trials of the year with their chief investigators, and hearing editorials from a select group of internationally renowned trialists, we will also have an entire session dedicated to this landmark trial investigating steroids in septic shock.
After the chief investigator Prof Bala Venkatesh presents the results of ADRENAL, Prof Kathy Rowan will deliver a 15 minute editorial, followed by a 30 minute panel discussion, including three ADRENAL investigators, Prof Karin Amrein, an endocrinologist/intensivist/trialist and Prof Anthony Gordon, who also looked at steroids in sepsis as part of his VANISH trial. Prof Venkatesh will complete the session with a talk dicussing the administration of the ADRENAL trial, including the various issues they faced. If you can't make it, don't worry as the entire ADRENAL session will be live streamed for free, starting at 9am GMT. All the other talks will be recorded and released later for free viewing as usual. The programme is now online also. The meeting still has some availability, so don't wait if you intend on registering. It will sell out quite soon.
In other news, the US FDA has this week surprisingly approved angiotensin II for use in vasodilatory shock. We're lucky enough to have the first author on the recent ATHOS-3 trial, Dr Ashish Khanna, speak at #CCR18 and no doubt discuss this latest announcement.
Contiinuing our build up to #CCR18, this week's Topic of the Week is the ART trial, investigating recruitment manoeuvres and titrated PEEP in ARDS, starting with the ART paper in tomorrow's Paper of the Day.
- Full Text: Bath. Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial. Lancet 2017;epublished December 20th
- Abstract: Torres. Ceftazidime-avibactam versus meropenem in nosocomial pneumonia, including ventilator-associated pneumonia (REPROVE): a randomised, double-blind, phase 3 non-inferiority trial. Lancet 2017;epublished December 15th
- Full Text: Yasuda. Comparison of the efficacy of three topical antiseptic solutions for the prevention of catheter colonization: a multicenter randomized controlled study. Critical Care 2017;21:320
- Full Text: Jung. Antimicrobials for the treatment of drug-resistant Acinetobacter baumannii pneumonia in critically ill patients: a systemic review and Bayesian network meta-analysis. Critical Care 2017;21:319
- Full Text: Veitz-Keenan. Oral care with chlorhexidine seems effective for reducing the incidence of ventilator-associated pneumonia. Evidence-Based Dentistry 2017;18:113–114
- Abstract: Coudroy. Early Identification of Acute Respiratory Distress Disorder in the Absence of Positive Pressure Ventilation: Implications for Revision of the Berlin Criteria for Acute Respiratory Distress Syndrome. Crit Care Med 2017;epublished December 21st
- Full Text: Sjoding. Inter-observer reliability of the Berlin ARDS definition and strategies to improve the reliability of ARDS diagnosis. Chest 2017;epublished December 14th
- Abstract: McNeil. Novel Method for Non-invasive Sampling of the Distal Airspace in Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med 2017;epublished December 18th
- Full Text: Shin. Initial blood pH during cardiopulmonary resuscitation in out-of-hospital cardiac arrest patients: a multicenter observational registry-based study. Critical Care 2017;21:322
- Full Text: Hundeshagen. Co-administration of vancomycin and piperacillin-tazobactam is associated with increased renal dysfunction in adult and pediatric burn patients.
Critical Care 2017;21:318
- Full Text: Kerbert. Copeptin in acute decompensation of liver cirrhosis: relationship with acute-on-chronic liver failure and short-term survival. Critical Care 2017;21:321
- Full Text: Wuister. Characteristics of critically ill influenza patients in an intensive care unit in the Netherlands. Neth J Crit Care 2017;25(6):205-10
- Kijpaisalratana. Hyperacute Simultaneous Cardiocerebral Infarction: Rescuing the Brain or the Heart First? Front Neurol 2017;8:664
- Xu. Remote Diffusion-Weighted Imaging Lesions in Intracerebral Hemorrhage: Characteristics, Mechanisms, Outcomes, and Therapeutic Implications. Front Neurol 2017;8:678
- Figaji. Anatomical and Physiological Differences between Children and Adults Relevant to Traumatic Brain Injury and the Implications for Clinical Assessment and Care. Front Neurol 2017;8:685
- Kenny. Predicting the Haemodynamic Response to Prone Positioning: A Novel and Simultaneous Analysis of the Guyton and Rahn Diagrams. Critical Care Horizons 2017:1-7
- Kasaoka. Evolved role of the cardiovascular intensive care unit (CICU). Journal of Intensive Care 2017;5:72
- Horn. Towards improved outcome after cardiac arrest: new studies coming up. Neth J Crit Care 2017;25(6):22-26
- Liu. Pediatric acute respiratory distress syndrome - current views. Experimental and Therapeutic Medicine 2017;epublished November 29thxperimental and Therapeutic Medicine 2017;epublished November 29th
- Woods. Current and emerging evidence for immunomodulatory therapy in community-acquired pneumonia. Ann Res Hosp 2017;1:33
- Gréve. Seasonal respiratory viruses in adult ICU patients. Neth J Crit Care 2017;25(6):198-204
- Jeph. Novel use of interventional radiology in trauma. J Emerg Crit Care Med 2017;1:40
- Cragun. Interventional and operative procedures in complex and poly-trauma. J Emerg Crit Care Med 2017;1:42
Annals of Translational Medicine - Series on ICU Ethics
- Moutel. Anticipating the role of the intensive care unit in healthcare and life trajectories. Ann Transl Med 2017;5(Suppl 4):S37
- Rigaud. Ethical aspects of admission or non-admission to the intensive care unit. Ann Transl Med 2017;5(Suppl 4):S38
- Meunier-Beillard. Intersecting vulnerabilities in professionals and patients in intensive care. Ann Transl Med 2017;5(Suppl 4):S39
- Quenot. What are the ethical issues in relation to the role of the family in intensive care? Ann Transl Med 2017;5(Suppl 4):S40
- Ecarnot. Ethical challenges involved in obtaining consent for research from patients hospitalized in the intensive care unit. Ann Transl Med 2017;5(Suppl 4):S41
- Rigaud. What are the ethical aspects surrounding intensive care unit admission in patients with cancer? Ann Transl Med 2017;5(Suppl 4):S42
- Quenot. What are the ethical aspects surrounding the collegial decisional process in limiting and withdrawing treatment in intensive care? Ann Transl Med 2017;5(Suppl 4):S43
- Lesieur. A few realistic questions raised by organ retrieval in the intensive care unit. Ann Transl Med 2017;5(Suppl 4):S44
- Meunier-Beillard. Can qualitative research play a role in answering ethical questions in intensive care? Ann Transl Med 2017;5(Suppl 4):S45
- Quenot. What are the ethical questions raised by the integration of intensive care into advance care planning? Ann Transl Med 2017;5(Suppl 4):S46
- Quenot. What are the ethical dimensions in the profession of intensive care specialist? Ann Transl Med 2017;5(Suppl 4):S47
- Anonymous. Artificial intelligence in health care: within touching distance. Lancet 2017;390(10114):2739
- Verghese. What This Computer Needs Is a Physician. Humanism and Artificial Intelligence. JAMA 2017;epublished December 20th
- Babi. Spontaneous Intracerebral Hemorrhage: Should We Operate? Front Neurol 2017;8:645
- Ouwehand. Is massive transfusion with a high FFP:RBC ratio of any benefit when applied in a non-traumatic setting? Neth J Crit Care 2017;25(6):218-9
- Mohta. Recruitment and titrated positive end-expiratory pressure in acute respiratory distress—have we reached the ceiling? J Emerg Crit Care Med 2017;1:41
- Steenvoorden. Necessary additional steps in ultrasound guided central venous catheter placement: getting to the heart of the matter. Critical Care 2017;21:307
- Shrestha. The forgotten value of the clinical examination to individualize and guide fluid resuscitation in patients with sepsis. Critical Care 2017;21:306
- Zaworski. Lithium: one drug, five complications. Journal of Intensive Care 2017;5:70
- Gietler. Coma and haemodynamic instability in the context of trauma. Neth J Crit Care 2017;25(6):210-14
- Henderson. Caught between a rock and a hard place: a patient with aortic valve stenosis and phaeochromocytoma. Neth J Crit Care 2017;25(6):215-217
- Hamoen. Cerebral fat embolism. Neth J Crit Care 2017;25(6):220-221
It's now less than a month until the Critical Care Reviews Meeting 2018, where the chief investigators for the best critical care trials of 2017 come to discuss their work and try to answer the question clinicians want to know - should I change my practice based on this trial? From Brisbane, Australia, Prof Bala Venkatesh will explore the ADRENAL trial, examining hydrocortisone in septic shock in the biggest sepsis trial ever undertaken. Working between Dublin and Melbourne, Prof Alistair Nichol will explain the findings of the TRANSFUSE trial, comparing transfusion of the freshest available blood with standard issued red cells. From Nantes, France, Dr Jean-Baptiste Lascarrou will consider the findings of the MACMAN trial, evaluating video laryngoscopy in the ICU. Dr Ashish Khanna, from the Cleveland Clinic, USA, will reflect on ATHOS-3 the first large clinical trial examining angiotensin II in vasodilatory shock. Prof Gavin Perkins, from Warwick in England, will discuss his multi-centre randomized controlled trial BREATHE, evaluating the role of extubation to non-invasive ventilation in patients failing spontaneous breathing trials. Prof John Simpson, from Newcastle, England, will discuss the VAP-RAPID trial, evaluating the use of a biomarker-guided approach to exclude ventilator-associated pneumonia. The final trial added to the programme is the ART trial, investigating alveolar recruitment in ARDS, to be presented by Prof Alexandre Cavalcanti (São Paulo, Brazil).
We also have Prof Andrew Rhodes, from London, exploring the latest iteration of the Surviving Sepsis Campaign, published earlier this year and Dr Sophie Wallace (Perth, Australia), who will deliver the honorary John Hinds Trauma Lecture, entitled "Disaster on Everest - Trauma at the Top of the World". A new addition to the Critical Care Reviews Meeting format is an incredible editorial team of Prof Kathy Rowan (London), Prof Karin Amrein (Graz), Prof Anders Perner (Copenhagen) and Prof Simon Finfer (Sydney). These noted trialists will provide expert analysis on the major trials being presented.
We sold out #CCR17 and had to turn people away. At present we are way up on registrations compared to the same time-point in 2016. So, if you intend on coming, don't leave it too late to register. There is plenty of space still at present, but I expect the meeting will sell out well before it's date of Friday January 19th. Don't worry if you can't make it, as the talks will be recorded and put online for free viewing as usual. However, there is nothing like being there in person and having the opportunity to chat with these chief investigators. Numbers are strictly limited to ensure this remains a small, intimate meeting. It would be a shame to miss out......especially as we will be hosting the ADRENAL trial results. If you can't make it, don't worry, as in addition to our usual recording and later release of all talks, this year we will be live streaming the ADRENAL session!
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
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