• Full Text:  Thwaites. Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet 2017;epublished December 14th
  
  • Editorial: Holland. Rifampicin for Staphylococcus aureus bacteraemia: give it ARREST. Lancet 2017;epublished December 14th
• Abstract:  Stienen. NT-proBNP-Guided Therapy in Acute Decompensated Heart Failure: The PRIMA II Randomized Controlled Trial. Circulation 2017;epublished December 14th
• Abstract: Torres. Ceftazidime-avibactam versus meropenem in nosocomial pneumonia, including ventilator-associated pneumonia (REPROVE): a randomised, double-blind, phase 3 non-inferiority trial. Lancet Infectious Dis 2017;epublished December 15th
• Abstract:  Duez. Neuron-specific enolase and S-100b in prolonged targeted temperature management after cardiac arrest: A randomised study. Resuscitation 2018;122:79–86
• Full Text:  van der Kooi. Prevention of hospital infections by intervention and training (PROHIBIT): results of a pan-European cluster-randomized multicentre study to reduce central venous catheter-related bloodstream infections. Intensive Care Med 2017;epublished December 16th

• Abstract:  Kalra. Targeted Temperature Management After Cardiac Arrest: Systematic Review and Meta-analyses. Anesth Analg 2017;epublished December 11th
• Abstract:  Stephens. Practice Patterns and Outcomes Associated With Early Sedation Depth in Mechanically Ventilated Patients: A Systematic Review and Meta-Analysis. Crit Care Med 2017;epublished December 8th
• Full Text:  Póvoa. Effect of antibiotics administered via the respiratory tract in the prevention of ventilator-associated pneumonia: A systematic review and meta-analysis. J Crit Care 2018;43:240–245
• Full Textt:  Huang. High-flow oxygen therapy in immunocompromised patients with acute respiratory failure: A review and meta-analysis. J Crit Care 2018;43:300–305
• Full Text:  Su. Positive end-expiratory pressure selection based on best respiratory system compliance or collapse/hyperdistension curves in patients with acute respiratory distress syndrome: lack of correlation with alveolar recruitment. Intensive Care Med 2017;epublished December 13th

• Full Text:  Carr. Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes. Critical Care 2017;21:300
• Abstract:  Iuliano. Estimates of global seasonal influenza-associated respiratory mortality: a modelling study. Lancet 2017;epublished December 13th
• Full Text:  Fisher. Balanced haemostasis with both hypo- and hyper-coagulable features in critically ill patients with acute-on-chronic-liver failure. J Crit Care 2018;43:54–60
• Abstract:  van den Berg. Diaphragm Atrophy and Weakness in the Absence of Mitochondrial Dysfunction in the Critically Ill. Am J Respir Crit Care Med 2017;196(12):1544–1558
• Abstract:  Sottile. An Observational Study of the Efficacy of Cisatracurium Compared to Vecuronium in Patients with or at Risk for ARDS. Am J Respir Crit Care Med 2017;epublished December 14th
• Full Text:  Su. Positive end-expiratory pressure selection based on best respiratory system compliance or collapse/hyperdistension curves in patients with acute respiratory distress syndrome: lack of correlation with alveolar recruitment. Intensive Care Med 2017;epublished December 13th
• Abstract:  An Observational Veneto research on Ventilator Associated Pneumonia (OVeRVAP): attributable mortality and cumulative incidence of ventilator-associated pneumonia. Minerva Anestesiol 2017;epublished December 13th
• Abstract:  Torbic. Body Mass's Impact on Response to Fixed-Dose Vasopressin in Patients with Septic Shock. Shock 2017;epublished December 13th
• Full Text:  Gergelé. Mountain ultra-marathon finishers exhibit marked immune alterations similar to those of severe trauma patients. Intensive Care Med 2017;epublished December 7th

• Stern. Corticosteroids for pneumonia. Cochrane Database of Systematic Reviews 2017, Issue 12. Art. No.: CD007720
• Feinberg. Thrombolysis for acute upper extremity deep vein thrombosis. Cochrane Database of Systematic Reviews 2017, Issue 12. Art. No.: CD012175

• Lee. Low tidal volume mechanical ventilation against no ventilation during cardiopulmonary bypass heart surgery (MECANO): study protocol for a randomized controlled trial. Trials 2017;18:582
• Åsberg. Timing of oral anticoagulant therapy in acute ischemic stroke with atrial fibrillation: study protocol for a registry-based randomised controlled trial. Trials 2017;18:581
• Winkel. Statistical analysis plan for the EuroHYP-1 trial: European multicentre, randomised, phase III clinical trial of the therapeutic hypothermia plus best medical treatment versus best medical treatment alone for acute ischaemic stroke. Trials 2017;18:573
• Kahn. Decreasing Delirium through Music (DDM) in critically ill, mechanically ventilated patients in the intensive care unit: study protocol for a pilot randomized controlled trial. Trials 2017;18:574
• Yan. Prophylactic penehyclidine inhalation for prevention of postoperative pulmonary complications in high-risk patients: study protocol of a randomized controlled trial. Trials 2017;18:571

Neurological

• Tasbihgou. Accidental awareness during general anaesthesia – a narrative review. Anaesthesia 2018;73:112–122
• Arts. Korsakoff’s syndrome: a critical review. Neuropsychiatr Dis Treat 2017;13:2875–2890

Circulatory

• Moir. A narrative review of long-term central venous access devices for the intensivist. JICS 2017;epublished December 12th
• Cortesi. Cardiorenal Syndrome, Hemodynamics, and Noninvasive Evaluation. Clinical Medicine Insights: Therapeutics 2017;9:1–8
• Kotecha. Cardiorenal syndrome in sepsis: A narrative review. J Crit Care 2018;43:122–127
• Doenst. The Opportunities and Limitations of Minimally Invasive Cardiac Surgery. Dtsch Arztebl Int 2017;114(46):777-784
• Milazzo. Extracorporeal ultrafiltration for acute heart failure: patient selection and perspectives. Vascular Health and Risk Management 2017;13:449—456
• Tissot. Basics of Functional Echocardiography in Children and Neonates. Front Pediatr 2017;5:235

Respiratory

• Ashworthth. Clinical management of pressure control ventilation: An algorithmic method of patient ventilatory management to address “forgotten but important variables”. J Crit Care 2018;43:169–182
• Cook. Strategies for the prevention of airway complications – a narrative review. Anaesthesia 2018;73:93–111

Hepatobiliary

•  Zhao. Current management of refractory ascites in patients with cirrhosis. Journal of International Medical Research 2017;epublished December 6th

Endocrine

• Egi. Glycemic control in acute illness. Korean J Anesthesiol 2017;70(6):591-595
• Pontes. Evaluation and perioperative management of patients with diabetes mellitus. A challenge for the anesthesiologist. Rev Bras Anestesiol 2018;68(1):75-86

Haematological

• ten Cate. Practical guidance on the use of laboratory testing in the management of bleeding in patients receiving direct oral anticoagulants. Vascular Health and Risk Management 2017;13:457—467
• Mathias. Pediatric Thermal Burns and Treatment: A Review of Progress and Future Prospects. Medicines 2017;4:91
• Tarango. Pediatric Thrombolysis: A Practical Approach. Front Pediatr 2017;5:260

Sepsis

• Bar-Or. Overcoming the Warburg Effect: Is it the key to survival in sepsis? J Crit Care 2018;43:197–201
• Beloborodova. Metabolomic findings in sepsis as a damage of host-microbial metabolism integration. J Crit Care 2018;43:246–255
• Teng. Vitamin C: The next step in sepsis management? J Crit Care 2018;43:230–234

Trauma

• Phillips. Chest trauma: “Damage Control” Begins in the emergency room. J Cardiothorac Trauma 2017;2:3-9

Miscellaneous

• James. Decision-making in intensive care medicine – A review. JICS 2017;epublished December 12th
• Shetty. The brain-dead donor: An anaesthesiologist's perspective. Indian J Anaesth 2017;61:952-6
  • Editorial:  Pandit. Brain death and organ donation in India. Indian J Anaesth 2017;61:949-51

• In. Introduction of a pilot study. Korean J Anesthesiol 2017;70(6):601-605

• Giwa. The promise of organ and tissue preservation to transform medicine. Nat Biotechnol 2017;35(6):530–542

It's now just 4 weeks until the Critical Care Reviews Meeting 2018, where the chief investigators for the best critical care trials of 2017 come to discuss their work and try to answer the question clinicians want to know - should I change my practice based on this trial? From Brisbane, Australia, Prof Bala Ventakesh will explore the ADRENAL trial, examining hydrocortisone in septic shock in the biggest sepsis trial ever undertaken. Working between Dublin and Melbourne, Prof Alistair Nichol will explain the findings of the TRANSFUSE trial, comparing transfusion of the freshest available blood with standard issued red cells. From Nantes, France, Dr Jean-Baptiste Lascarrou will consider the findings of the MACMAN trial, evaluating video laryngoscopy in the ICU. Dr Ashish Khanna, from the Cleveland Clinic, USA, will reflect on ATHOS-3 the first large clinical trial examining angiotensin II in septic shock. Prof Gavin Perkins, from Warwick in England, will discuss his multi-centre randomized controlled trial Breathe, evaluating the role of extubation to non-invasive ventilation in patients failing spontaneous breathing trials. Prof John Simpson, from Newcastle, England, will discuss the VAP-RAPID trial, evaluating the use of a biomarker-guided approach to exclude ventilator-associated pneumonia. The final trial added to the programme is the ART Trial. Prof Alexandre Biasi Cavalcanti (São Paulo) will explain this Brazilian investigation testing alveolar recruitment in ARDS.

We also have Prof Andrew Rhodes, from London, exploring the latest iteration of the Surviving Sepsis Campaign, published earlier this year and Dr Sophie Wallace (Perth, Australia), who will deliver the honorary John Hinds Trauma Lecture, entitled "Disaster on Everest - Trauma at the Top of the World"

We sold out #CCR17 and had to turn people away. At present we are way up on registrations compared to the same time-point in 2016. So, if you intend on coming, don't leave it too late to register. There is plenty of space still at present, but I expect the meeting will sell out well before it's date of Friday January 19th. Don't worry if you can't make it, as the talks will be recorded and put online for free viewing as usual. However, there is nothing like being there in person and having the opportunity to chat with these chief investigators. Numbers are strictly limited to ensure this remains a small, intimate meeting. It would be a shame to miss out......