Welcome to the 312th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. The highlights of this week's issue are randomised controlled trials investigating prehospital antibiotics for sepsis & reducing discomfort in critically ill patients; narrative reviews on blood pressure management in acute intracerebral hemorrhage, non-invasive cardiac output monitoring, managing persistent hypoxemia & ventilator-associated pneumonia; as well as commentaries on 10 false beliefs in adult critical care nephrology, medical preprints and five ways to fix statistics.
Continuing our theme of focusing on the main papers to be presented and discussed at #CCR18, this week's Topic of the Week is the BREATHE trial, investigating non-invasive ventilation post extubation in patients who fail a spontaneous breathing trial, and starting with the ACCP/ATS guideline on liberation from mechanical ventilation in tomorrow's Paper of the Day.
There are just 6 weeks to Critical Care Reviews Meeting 2018, where we discuss some of the most interesting critical care trials of 2017 with their chief investigators and other expert international trialists. Tickets are selling strongly so don't wait too long and miss out. If you're lucky enough to be going to the UK Intensive Care Society State-of-the-Art Meeting tomorrow in Liverpool, have a great time at what has become a world class critical care conference.
- Abstract: Alam. Prehospital antibiotics in the ambulance for sepsis: a multicentre, open label, randomised trial (PHANTASi Trial). Lancet Respir Med 2017;epublished November 28th
- Abstract: Kalfon. A tailored multicomponent program to reduce discomfort in critically ill patients: a cluster-randomized controlled trial (IPREA Study). Intensive Care Med 2017;epublished November 27th
- Abstract: Kao. Effect of Oral Capsule– vs Colonoscopy-Delivered Fecal Microbiota Transplantation on Recurrent Clostridium difficile InfectionA Randomized Clinical Trial. JAMA 2017;318(20):1985-1993
- Abstract: Spadaro. The effects of storage of red blood cells on the development of postoperative infections after noncardiac surgery. Transfusion 2017;57(11):2727-2737
- Abstract: Yao. Timing of surgery for aneurysmal subarachnoid hemorrhage: A systematic review and meta-analysis. Int J Surg 2017;epublished November 24th
- Abstract: Binks. Apnoeic oxygenation during intubation in the intensive care unit: A systematic review and meta-analysis. Heart Lung 2017;46(6):452-457
- Abstract: Ng. Effect of nicotine replacement therapy on mortality, delirium, and duration of therapy in critically ill smokers: a systematic review and meta-analysis. Anaesth Intensive Care 2017;45(5):556-561
- Full Text: Blanchard. The effectiveness of prehospital hypertonic saline for hypotensive trauma patients: a systematic review and meta-analysis. BMC Emergency Medicine 2017;17:35
- Abstract: Du. Antiplatelet Therapy for Critically Ill Patients: A Pairwise and Bayesian Network Meta-Analysis. Shock 2017;epublished November 15th
- Abstract: Putzu. Perioperative levosimendan in cardiac surgery: A systematic review with meta-analysis and trial sequential analysis. International Journal of Cardiology 2017;251:22-31
- Abstract: Kahn. Chemical venous thromboembolism prophylaxis in neurosurgical patients: an updated systematic review and meta-analysis. J Neurosurg 2017;epublished December 1st
- Abstract: da Hora Passos. Agitated Saline Bubble−Enhanced Ultrasound for Assessing Appropriate Position of Hemodialysis Central Venous Catheter in Critically Ill Patients. Kidney International Reports 2017;2(5):952–956
- Full Text: Klingele. Long-term continuous renal replacement therapy and anticoagulation with citrate in critically ill patients with severe liver dysfunction. Critical Care 2017;21:294
- Full Text: Peperstraete. Low flow extracorporeal CO2 removal in ARDS patients: a prospective short-term crossover pilot study. BMC Anesthesiol 2017;17(1):155
- Abstract: Pincus. Association Between Wait Time and 30-Day Mortality in Adults Undergoing Hip Fracture Surgery. JAMA 2017;318(20):1994-2003
- Abstract: Duan. Management of Acute Respiratory Distress Syndrome and Refractory Hypoxemia. A Multicenter Observational Study. Annals ATS 2017;14(12):1818–1826
- Abstract: Dixon. Continuous Infusion of Low-Dose Iohexol Measures Changing Glomerular Filtration Rate in Critically Ill Patients. Crit Care Med 2017;epublished November 30th
- Abstract: Stravitz. Bleeding Complications in Acute Liver Failure. Hepatology 2017;epublished December 1st
- Carteron. Cerebral Microdialysis Monitoring to Improve Individualized Neurointensive Care Therapy: An Update of Recent Clinical Data. Front Neurol 2017;8:601
- Tsitsopoulos. Current Opportunities for Clinical Monitoring of Axonal Pathology in Traumatic Brain Injury. Front Neurol 2017;8:599
- Pulvers. If Time Is Brain Where Is the Improvement in Prehospital Time after Stroke? Front Neurol 2017;8:617
- Helbok. Clinical Use of Cerebral Microdialysis in Patients with Aneurysmal Subarachnoid Hemorrhage—State of the Art. Front Neurol 2017;8:565
- Chu. Evolution of blood pressure management in acute intracerebral hemorrhage. F1000Research 2017, 6(F1000 Faculty Rev):2035
- Wardhan. Recent advances in acute pain management: understanding the mechanisms of acute pain, the prescription of opioids, and the role of multimodal pain therapy. F1000Research 2017, 6(F1000 Faculty Rev):2065
- Naccache. Minimally conscious state or cortically mediated state? Brain 2017;epublished December 1st
- Nguyen. Non-Invasive Monitoring of Cardiac Output in Critical Care Medicine. Front Med 2017;4:200
- Donato. Protecting the heart from ischemia/reperfusion injury: an update on remote ischemic preconditioning and postconditioning. Current Opinion in Cardiology 2017;32(6):784-790
- Villar. Managing Persistent Hypoxemia: what is new? F1000Res 2017;6:1993
- Alencar. Patients with uninjured lungs may also benefit from lung-protective ventilator settings. F1000Research 2017, 6(F1000 Faculty Rev):2040
- Scelfo. Recent advances in managing idiopathic pulmonary fibrosis. F1000Research 2017, 6(F1000 Faculty Rev):2052
- Timsit. Update on ventilator-associated pneumonia. F1000Research 2017, 6(F1000 Faculty Rev):2061
- Chen. Novel Therapies for Acute Kidney Injury. Kidney International Reports 2017;2(5):785-799
- Wang. Cardiac surgery-associated acute kidney injury: risk factors, pathophysiology and treatment. Nature Reviews Nephrology 2017;13:697–711
- Gacto-Sanchez. Surgical treatment and management of the severely burn patient: Review and update. Med Intensiva 2017;41:356-64
- Dewitte. Blood platelets and sepsis pathophysiology: A new therapeutic prospect in critical ill patients? Ann Intensive Care 2017;7(1):115
- Delabranche. Immunohaemostasis: a new view on haemostasis during sepsis. Annals of Intensive Care 2017;7:117
- Brunel. Multidrug resistant (or antimicrobial-resistant) pathogens - alternatives to new antibiotics? Swiss Med Wkly 2017;147:w14553
- Stenglova. Continuous Non-Invasive Arterial Pressure Assessment during Surgery to Improve Outcome. Front Med 2017;4:202
- Trueger. Medical Journals in the Age of Ubiquitous Social Media. J Am Coll Radiol 2017;epublished November 6th
- Chan. Social Media and the 21st-Century Scholar: How You Can Harness Social Media to Amplify Your Career. J Am Coll Radiol 2017;epublished November 15th
- Seidel. Radiologists and Social Media: Do Not Forget About Facebook. J Am Coll Radiol 2017;epublished November 11th
- Bigham. Going Viral and Interacting with the Press. J Am Coll Radiol 2017;epublished November 10th
- Kotsenas. The Strategic Imperative for the Use of Social Media in Health Care. J Am Coll Radiol 2017;epublished November 9th
- Retrouvey. Women in Radiology: Creating a Global Mentorship Network Through Social Media. J Am Coll Radiol 2017;epublished November 9th
- Kotsenas. The Social Media DNA of Mayo Clinic—and Health Care. J Am Coll Radiol 2017;epublished November 8th
- Cabrera. Social Media Scholarship and Alternative Metrics for Academic Promotion and Tenure. J Am Coll Radiol 2017;epublished November 6th
- Wadhwa. #TwittIR: Understanding and Establishing a Twitter Ecosystem for Interventional Radiologists and Their Practices. J Am Coll Radiol 2017;epublished November 6th
- Trueger. Impact of a Physician-Led Social Media Sharing Program on a Medical Journal’s Web Traffic. J Am Coll Radiol 2017;epublished November 6th
- Hawkins. Exploring Social Media in Health Care: Beyond Its Pervasiveness. J Am Coll Radiol 2017;epublished November 6th
- Trueger. Medical Journals in the Age of Ubiquitous Social Media. J Am Coll Radiol 2017;epublished November 6th
- Wald. Mayo Clinic Care Network: A Collaborative Health Care Model. J Am Coll Radiol 2017;epublished November 6th
- Roland. Social Media, Health Policy, and Knowledge Translation. J Am Coll Radiol 2017;epublished November 6th
- Johnson. Facebook Live: A Free Real-Time Interactive Information Platform. J Am Coll Radiol 2017;epublished November 6th
- Ranginwala. Use of Social Media in Radiology Education. J Am Coll Radiol 2017;epublished November 1st
- Ricci. The 10 false beliefs in adult critical care nephrology. Intensive Care Med 2017;epublished December 1stDecember 1st
- Devaux. What’s new in prognostication after cardiac arrest: microRNAs? Intensive Care Med 2017;epublished November 20th
- Martin‑Loeches. Intensive care medicine in 2050: nanotechnology. Emerging technologies and approaches and their impact on critical care. Intensive Care Med 2017;epublished November 24th
- Burry. Physical restraint: time to let go. Intensive Care Med 2017;epublished November 23rd
- Desai. Understanding the role of host immune responses in invasive candidiasis. Intensive Care Med 2017;epublished November 23rd
- Nicklas. Non-Invasive Hemodynamic Monitoring for Hemodynamic Management in Perioperative Medicine. Front Med 2017;4:209
- Maslove. Medical Preprints—A Debate Worth Having. JAMA 2017;epublished November 30th
- Furqan. Challenges in the implementation of strategies to increase communication and enhance patient and family centered care in the ICU. Med Intensiva 2017;41:365-7
- Paules. Chasing Seasonal Influenza — The Need for a Universal Influenza Vaccine. N Eng J Med 2017;epublished November 29th
- Leek. Five ways to fix statistics. Nature 2017;551:557-559
It's now just 6 weeks until the Critical Care Reviews Meeting 2018, where the chief investigators for the best critical care trials of 2017 come to discuss their work and try to answer the question clinicians want to know - should I change my practice based on this trial? From Brisbane, Australia, Prof Bala Ventakesh will explore the ADRENAL trial, examining hydrocortisone in septic shock in the biggest sepsis trial ever undertaken. Working between Dublin and Melbourne, Prof Alistair Nichol will explain the findings of the TRANSFUSE trial, comparing transfusion of the freshest available blood with standard issued red cells. From Nantes, France, Dr Jean-Baptiste Lascarrou will consider the findings of the MACMAN trial, evaluating video laryngoscopy in the ICU. Dr Ashish Khanna, from the Cleveland Clinic, USA, will reflect on ATHOS-3 the first large clinical trial examining angiotensin II in septic shock. Prof Gavin Perkins, from Warwick in England, will discuss his multi-centre randomized controlled trial Breathe, evaluating the role of extubation to non-invasive ventilation in patients failing spontaneous breathing trials. Prof John Simpson, from Newcastle, England, will discuss the VAP-RAPID trial, evaluating the use of a biomarker-guided approach to exclude ventilator-associated pneumonia. The final trial added to the programme is the ART Trial. Prof Alexandre Biasi Cavalcanti (São Paulo) will explain this Brazilian investigation testing alveolar recruitment in ARDS.
We also have Prof Andrew Rhodes, from London, exploring the latest iteration of the Surviving Sepsis Campaign, published earlier this year and Dr Sophie Wallace (Perth, Australia), who will deliver the honorary John Hinds Trauma Lecture, entitled "Disaster on Everest - Trauma at the Top of the World"
We sold out #CCR17 and had to turn people away. At present we are way up on registrations compared to the same time-point in 2016. So, if you intend on coming, don't leave it too late to register. There is plenty of space still at present, but I expect the meeting will sell out well before it's date of Friday January 19th. Don't worry if you can't make it, as the talks will be recorded and put online for free viewing as usual. However, there is nothing like being there in person and having the opportunity to chat with these chief investigators. Numbers are strictly limited to ensure this remains a small, intimate meeting. It would be a shame to miss out......
Fancy attending a leading intensive care medicine conference with worldwide experts in one of Asia Pacific’s most vibrant countries? At SG ANZICS 2018 in Singapore, you can meet renowned experts from all parts of the world at their plenary sessions, breakfast and lunch symposia and interactive conference sessions. Choose from our 10 preconference critical care workshops on offer and also showcase your poster to make an impression on international attendees.
SG ANZICS is an annual intensive care meeting jointly organized by the Society of Intensive Care Medicine (SICM), Singapore and the Australia-New Zealand Intensive Care Society (ANZICS). In 2017, we had 1200 attendees from more than 35 different countries. We are also proud to announce that we have awarded 30 Education Grants to low and lower-middle income countries and affirm our commitment to improve critical care in developing Asia-Pacific countries.
Our 5th meeting is scheduled for 17-21 May 2018 in Suntec Convention Centre. It promises to be better than ever! Timothy Buchman, Hayley Gershengorn, Anthony Gordon, Michael Pinsky, David Pilcher and Francesca Rubulotta are among a list of illustrious speakers confirmed for the conference. Do keep your dates free and block your calendars. Visit http://sg-anzics.com to find out more!
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board