Welcome to the 310th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. It's a relatively short newsletter this week, partly because I'm travelling and am time limited. The highlights of this week's issue are narratve reviews on airway management in trauma, ischaemic stroke care and critical care echocardiography; commentaries on ICU sedation and fluid administration in the critically ill patient; a guideline on sonography in hypotension and cardiac arrest, and an editorial debate on whether "social media has created emergency medicine celebrities who now influence practice more than published evidence".
Continuing our theme of focusing on the main papers to be presented and discussed at #CCR18, this week's Topic of the Week is the TRANSFUSE Trial, investigating the age of transfused red cells in the critically ill, and starting with the trial itself in tomorrow's Paper of the Day. I'll finalise the Topic of the Week in the morning.
- Full Text: Payne. Cefepime-induced neurotoxicity: a systematic review. Critical Care 2017;21:276
- Abstract: Yao. Decompressive craniectomy for spontaneous intracerebral hemorrhage: a systematic review and meta-analysis. World Neurosurgery 2017;epublished November 9th
- Abstract: Alali. Beta-blockers and Traumatic Brain Injury: A Systematic Review, Meta-analysis, and Eastern Association for the Surgery of Trauma Guideline. Annals of Surgery 2017;266(6):952–961
- Abstract: Galloway. The Effect of ICU Out-of-Hours Admission on Mortality: A Systematic Review and Meta-Analysis. Crit Care Med 2017;epublished November 11th
- Abstract: Kawano-Dourado. Low- Versus High-Chloride Content Intravenous Solutions for Critically Ill and Perioperative Adult Patients: A Systematic Review and Meta-analysis. Anesth Analg 2017;epublished November 14th
- Abstract: James. Derivation and External Validation of Prediction Models for Advanced Chronic Kidney Disease Following Acute Kidney Injury. JAMA 2017;318(18):1787-1797
- Abstract: Viña. Results and functional outcomes of acute ischemic stroke patients who underwent mechanical thrombectomy admitted to intensive care unit. Med Intensiva 2017;epublished November 11th
- Abstract: Henninger. "Don't lose hope early": Hemorrhagic diffuse axonal injury on head CT is not associated with poor outcome in moderate-severe TBI patients. J Trauma Acute Care Surg 2017;November 14th
Bellingan. Comparison of the efficacy and safety of FP-1201-lyo (intravenously administered recombinant human interferon beta-1a) and placebo in the treatment of patients with moderate or severe acute respiratory distress syndrome: study protocol for a randomized controlled trial. Trials 2017;18(1):536
- Select International Federation for Emergency Medicine Consensus Statement: Sonography in hypotension and cardiac arrest (SHoC): An international consensus on the use of point of care ultrasound for undifferentiated hypotension and during cardiac arrest. CJEM 2017;19(6):459-470
- Filipescu. Perioperative Patient Blood Management Programme. Multidisciplinary recommendations from the Patient Blood Management Initiative Group. Rom J Anaesth Intensive Care 2017;24(2):139-157
- Godier. Use of factor concentrates for the management of perioperative bleeding: guidance from the SSC of the ISTH. J Thromb Haemost 2017;epublished November 2nd
- Ulndreaj. Promising neuroprotective strategies for traumatic spinal cord injury with a focus on the differential effects among anatomical levels of injury. F1000Research 2017, 6(F1000 Faculty Rev):1907
- Evans. Revolution in acute ischaemic stroke care: a practical guide to mechanical thrombectomy. Practical Neurology 2017;17:252-265
- Gomez. Recent advances in the management of transient ischemic attacks. F1000Research 2017, 6(F1000 Faculty Rev):1893
- Helbok. Clinical Use of Cerebral Microdialysis in Patients with Aneurysmal Subarachnoid Hemorrhage—State of the Art. Front Neurol 2017;8:565
- Orde. Pearls and pitfalls in comprehensive critical care echocardiography. Critical Care 2017;21:279
- Csepe. Advancements in mechanical circulatory support for patients in acute and chronic heart failure. J Thorac Dis 2017;9(10):4070-4083
- Baedorf Kassis. Esophageal pressure: research or clinical tool? Med Klin Intensivmed Notfmed 2017;epublished November 13th
- Cressoni. Does high PEEP prevent alveolar cycling? Med Klin Intensivmed Notfmed 2017;epublished November 13th
- Cruz. Role of the extracellular matrix in the genesis of ventilator-induced lung injury. Med Klin Intensivmed Notfmed 2017;epublished November 13th
- Morrison. Pathophysiology and classification of primary graft dysfunction after lung transplantation. J Thorac Dis 2017;9(10):4084-4097
- Neunert. Management of newly diagnosed immune thrombocytopenia: can we change outcomes? Blood Advances 2017;1:2295-2301
- Gong. Early fluid loading for septic patients: any safety limit needed? Chinese Journal of Traumatology 2017;epublished November 8th
- Fischer. Ebola virus disease: an update on post-exposure prophylaxis. Lancet Infect Disease 2017;epublished November 15th
- Mackenzie. An isolated elevation in blood urea level is not ‘uraemia’ and not an indication for renal replacement therapy in the ICU. Critical Care 2017;21:275
- Coppens. Management of submassive pulmonary embolism. Neth J Crit Care 2017;25(5):156-8
- Dellinger. From Barcelona to New York: 15 years of transition of sepsis performance improvement. J Thorac Dis 2017;9(10):3453-3455
- Bernard. Clinical prediction models: a fashion or a necessity in medicine? J Thorac Dis 2017;9(10):3456-3457
- Shander. Rethinking the role of postoperative critical care in an inequitable world. J Thorac Dis 2017;9(10):3493-3497
- Cameron. #SocialMedia – Social media has created emergency medicine celebrities who now in fluence practice more than published evidence. CJEM 2017;19(6):471-474
- Mehta. Ten tips for ICU sedation. Intensive Care Med 2017;epublished November 18th
- Reuter. The dark sides of fluid administration in the critically ill patient. Intensive Care Med 2017;epublished November 11th
- Mehta. Central venous stenosis: What should a nephrologist know?. Indian J Nephrol 2017;27:427-9
- Touw. When to start renal-replacement therapy in critically ill patients? Neth J Crit Care 2017;25(5):183-4
- Colombo. Light in the dark: 18F-FDG PET/CT in Staphylococcus aureus bacteremia of unknown origin. Intensive Care Med 2017;epublished November 13th
- Oostwoud.A severe community-acquired pneumonia during pregnancy. Neth J Crit Care 2017;25(5):178-182
- IJmkers. An unexpected cause of in-hospital cardiac arrest. Neth J Crit Care 2017;25(5):176-7
- de Pont. Treating pulmonary embolism in the intensive care unit: are the guidelines helpful? Neth J Crit Care 2017;25(5):172-5
- van den Brink. Successful use of plain subcostal transthoracic echocardiography in VV-ECMO cannula repositioning. Neth J Crit Care 2017;25(5):186-7
- Diehl. Pump head thrombosis in extracorporeal membrane oxygenation (ECMO). Intensive Care Med 2017;epublished November 7th
- Waskowski. Cardiopulmonary resuscitation and intrathoracic renal ectopy. Intensive Care Med 2017;epublished November
- Singer. The lessons learned from the EAT ICU study. Intensive Care Med 2017;epublished November 7th
- Antonucci. Angiotensin II in vasodilatory shock: lights and shadows. Critical Care 2017;21:277
- Cherel. Does a 1-h rest after a successful spontaneous breathing trial really improve extubation outcome? Intensive Care Med 2017;epublished November 9th
It's now just 2 months until the Critical Care Reviews Meeting 2018, where the chief investigators for the best critical care trials of 2017 come to discuss their work and try to answer the question clinicians want to know - should I change my practice based on this trial? From Brisbane, Australia, Prof Bala Ventakesh will explore the ADRENAL trial, examining hydrocortisone in septic shock in the biggest sepsis trial ever undertaken. Working between Dublin and Melbourne, Prof Alistair Nichol will explain the findings of the TRANSFUSE trial, comparing transfusion of the freshest available blood with standard issued red cells. From Nantes, France, Dr Jean-Baptiste Lascarrou will consider the findings of the MACMAN trial, evaluating video laryngoscopy in the ICU. Dr Ashish Khanna, from the Cleveland Clinic, USA, will reflect on ATHOS-3 the first large clinical trial examining angiotensin II in septic shock. Prof Gavin Perkins, from Warwick in England, will discuss his multi-centre randomized controlled trial Breathe, evaluating the role of extubation to non-invasive ventilation in patients failing spontaneous breathing trials. Prof John Simpson, from Newcastle, England, will discuss the VAP-RAPID trial, evaluating the use of a biomarker-guided approach to exclude ventilator-associated pneumonia. The final trial added to the programme is the ART Trial. Prof Alexandre Biasi Cavalcanti (São Paulo) will explain this Brazilian investigation testing alveolar recruitment in ARDS.
We also have Prof Andrew Rhodes, from London, exploring the latest iteration of the Surviving Sepsis Campaign, published earlier this year and Dr Sophie Wallace (Perth, Australia), who will deliver the honorary John Hinds Trauma Lecture, entitled "Disaster on Everest - Trauma at the Top of the World"
We sold out #CCR17 and had to turn people away. At present we are way up on registrations compared to the same time-point in 2016. So, if you intend on coming, don't leave it too late to register. There is plenty of space still at present, but I expect the meeting will sell out well before it's date of Friday January 19th. Don't worry if you can't make it, as the talks will be recorded and put online for free viewing as usual. However, there is nothing like being there in person and having the opportunity to chat with these chief investigators. Numbers are strictly limited to ensure this remains a small, intimate meeting. It would be a shame to miss out......
State-of-the-Art is back, for the 3rd year of its new format and an all-new venue in Liverpool for 2017. The futurism and innovation theme continues with novel topics including robotics, optical imaging of bacterial infection, new technology in patient recovery, and new device interventions in acute cardiology.
However, the focus on day-to-day care is not lost, and there are clinical updates in acute medicine, ARDS, mechanical ventilation, trauma, nutrition, rehabilitation, endocrine management in ICU, cancer patients in ICU, the difficult and altered airway, and much more. Pragmatic "how I treat..." sessions proved popular last year and will continue, along with meaningful debates on UK critical care, including the trend toward centralisation.
In addition, the trademark vibe of SOA will still be there with pop-up talks, panel debates, 'meet the expert' booths, new generation video e-posters, parent and infant facilities, two drinks evenings, and a new final night after-party. Registration and abstract submission is now open at http://soa.ics.ac.uk.
We are very pleased to announce the 6th International Fluid Academy Days (iFAD), which will take place on November 23-25th 2017 at the Hilton Hotel in Antwerp, Belgium. The iFAD is an innovative Critical Care Educational meeting in true SMACC spirit. This conference provides the highest quality of Critical Care education and is guaranteed to innovate and inspire. Recent advances in fluid management, and hemodynamic and organ function monitoring in the critical care setting will be reviewed in a comprehensive manner for intensivists, anaesthesiologists and emergency physicians as well as interested internists and surgeons.
The iFAD Faculty is the most provocative, engaging, motivating and inspiring group of international educational speakers and as organizing committee we want to ensure we have the participants, sponsors and endorsers to match. Together, we make iFAD stand apart from other Critical Care conferences.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board