Welcome to the 299th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. It's another packed issue with numerous articles of every variety. The highlights are the DETO2X–SWEDEHEART trial investigating supplemental oxygen in acute myocardial infarction, the protocol for the ADRENAL trial, an ERS/ATS guideline on noninvasive ventilation for acute respiratory failure, as well as narrative reviews on aneurysmal subarachnoid haemorrhage, the right ventricle in ARDS and high FIO2. There are also excellent editorials on co-enrolment for the TAME and TTM-2 trials and to co-enrol or not to co-enrol: that is the question, commentaries on esophageal pressure manometry, rehabilitation and mobilisation in the ICU and a statement from The College of Intensive Care Medicine of Australia and New Zealand on supporting global collaboration and respect , plus a report of the presented, but unpublished (as far as I can find at present), CAAM RCT comparing bag-mask ventilation with endotracheal intubation in out-of-hospital cardiac arrest.
This week's Topic of the Week is the second part of a selection of ARDS review articles from the Annals of Translational Medicine, starting with a paper on prone positioning in tomorrow's Paper of the Day.
- Full Text: Hofmann. Oxygen Therapy in Suspected Acute Myocardial Infarction (DETO2X–SWEDEHEART). N Engl J Med 2017;epublished August 28th
- Full Text: Ridker. Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease. N Engl J Med 2017;epublished August 27th
- Full Text: Litton. Quality sleep using earplugs in the intensive care unit: the QUIET pilot randomised controlled trial. Crit Care Resus 2017;19(2):128-133
- Abstract: Stöckl. Continuous versus intermittent neuromuscular blockade in patients during targeted temperature management after resuscitation from cardiac arrest - A randomized, double blinded, double dummy, clinical trial. Resuscitation 2017;epublished August 28th
- Abstract: El-Kersh. Enteral nutrition as stress ulcer prophylaxis in critically ill patients: A randomized controlled exploratory study. J Crit Care 2017;epublished August 26th
- Full Text: Pu. Efficacy and Safety of a Pharmaco-Invasive Strategy With Half-Dose Alteplase Versus Primary Angioplasty in ST-Segment-Elevation Myocardial Infarction: EARLY-MYO Trial (Early Routine Catheterization After Alteplase Fibrinolysis Versus Primary PCI in Acute ST-Segment-Elevation Myocardial Infarction). Circulation 2017;epublished August 27th
- Abstract: Weinberg. Effects of intraoperative and early postoperative normal saline or Plasma-Lyte 148® on hyperkalaemia in deceased donor renal transplantation: a double-blind randomized trial. Br J Anaesth 2017;epublished August 30th
- Abstract: de la Gala. Postoperative pulmonary complications, pulmonary and systemic inflammatory responses after lung resection surgery with prolonged one-lung ventilation. Randomized controlled trial comparing intravenous and inhalational anaesthesia. Br J Anaesth 2017;epublished August 30th
- Abstract: Göcze. Biomarker-guided Intervention to Prevent Acute Kidney Injury After Major Surgery: The Prospective Randomized BigpAK Study. Ann Surg 2017;epublished August 29th
- Full Text: Davies. Protein delivery and clinical outcomes in the critically ill: a systematic review and meta-analysis. Crit Care Resus 2017;19(2):117-127
- Full Text: Serpa Neto. Balanced versus isotonic saline resuscitation-a systematic review and meta-analysis of randomized controlled trials in operation rooms and intensive care units. Ann Transl Med 2017;(16):323
- Abstract: Lewis. Videolaryngoscopy versus direct laryngoscopy for adult patients requiring tracheal intubation: a Cochrane Systematic Review. Br J Anaesth 2017;epublished August 30th
- Abstract: Walkey. Low Tidal Volume versus Non-Volume-Limited Strategies for Patients with Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis. Ann Am Thorac Soc 2017;epublished August 28th
- Abstract: Tsivgoulis. Noninvasive Ventilatory Correction in Patients With Acute Ischemic Stroke: A Systematic Review and Meta-Analysis. Stroke 2017;48(8):2285-2288
- Abstract: Duyx. Scientific citations favor positive results: a systematic review and meta-analysis. Journal of Clinical Epidemiology 2017;88:92-101
- Abstract: Dupont. Antifungal Prevention of Systemic Candidiasis in Immunocompetent ICU Adults: Systematic Review and Meta-Analysis of Clinical Trials. Crit Care Med 2017;epublished August 28th
- Abstract: van de Weerdt. Central venous catheter placement in coagulopathic patients: risk factors and incidence of bleeding complications. Transfusion 2017;epublished August 30th
- Abstract: Chowdhury. Antiarrhythmics in Cardiac Arrest: A Systematic Review and Meta-Analysis. Heart Lung Circ 2017;epublished August 22nd
- Abstract: Jolley. Relationship between Race and the Effect of Fluids on Long-term Mortality after Acute Respiratory Distress Syndrome. Secondary Analysis of the National Heart, Lung, and Blood Institute Fluid and Catheter Treatment Trial. Annals ATS 2017;14(9):1443–1449
- Abstract: Haas. Descriptive analysis of extracorporeal cardiopulmonary resuscitation following out-of-hospital cardiac arrest—An ELSO registry study. Resuscitation 2017;119:56–62
- Abstract: Moseby-Knappe. Head computed tomography for prognostication of poor outcome in comatose patients after cardiac arrest and targeted temperature management. Resuscitation 2017;119:89–94
- Abstract: Huis in 't Veld. Ultrasound use during cardiopulmonary resuscitation is associated with delays in chest compressions. Resuscitation 2017;119:95–98
- Abstract: Biais. Mini-fluid Challenge of 100 ml of Crystalloid Predicts Fluid Responsiveness in the Operating Room. Anesthesiology 2017;127(3):450-456
- Abstract: Perneger. The distribution of P-values in medical research articles suggested selective reporting associated with statistical significance. Volume Journal of Clinical Epidemiology 2017;87:70-77
- Abstract: Stelfox. A multi-center prospective cohort study of patient transfers from the intensive care unit to the hospital ward. Intensive Care Med 2017;epublished August 29th
- Abstract: Faguer. Heparin-Free Prolonged Intermittent Hemodialysis Using Calcium-Free Citrate Dialysate in Critically Ill Patients. Crit Care Med 2017;epublished August 28th
- Full Text: Bennett. Functional Outcome After Intracranial Pressure Monitoring for Children With Severe Traumatic Brain Injury. JAMA Pediatr 2017;epublished August 28th
- Abstract: Fisher. Balanced haemostasis with both hypo- and hyper-coagulable features in critically ill patients with acute-on-chronic-liver failure. J Crit Care 2017;43:54-60
- Billot. Statistical analysis plan for the Adjunctive Corticosteroid Treatment in Critically Ill Patients with Septic Shock (ADRENAL) trial. Crit Care Resus 2017;19(2):183-191
- Macdonald. REstricted Fluid REsuscitation in Sepsis-associated Hypotension (REFRESH): study protocol for a pilot randomised controlled trial. Trials 2017;18:399
- Zampieri. Study protocol for the Balanced Solution versus Saline in Intensive Care Study (BaSICS): a factorial randomised trial. Crit Care Resus 2017;19(2):175-182
- Huang. Design and rationale of the Procalcitonin Antibiotic Consensus Trial (ProACT), a multicenter randomized trial of procalcitonin antibiotic guidance in lower respiratory tract infection. BMC Emergency Medicine 2017;17:25
- Da Collina. Oral hygiene in intensive care unit patients with photodynamic therapy: study protocol for randomised controlled trial. Trials 2017;18:385
- Udy. Critical care management of aneurysmal subarachnoid haemorrhage in Australia and New Zealand: what are we doing, and where to from here? Crit Care Resus 2017;19(2):103-109
- Liu. Sepsis-Induced Cardiomyopathy: Mechanisms and Treatments. Front Immunol 2017;8:1021
- Zochios. The Right Ventricle in ARDS. Chest 2017;152(1):181-193
- Rymer. Failure to Launch : Targeting Inflammation in Acute Coronary Syndromes. J Am Coll Cardiol Basic Trans Science 2017;2:484
- Saugel. Ultrasound-guided central venous catheter placement: a structured review and recommendations for clinical practice. Critical Care 2017;21:225
- Miller. Computed Tomography Angiographic Assessment of Acute Chest Pain. Journal of Thoracic Imaging 2017;32(3):137–150
- Latson. Imaging of the Postsurgical Thoracic Aorta: A State-of-the-Art Review. Journal of Thoracic Imaging 2017;32(1):1–25
- Martin. Pathophysiology, diagnosis and treatment of tachycardiomyopathy. Heart 2017;epublished August 30th
- Siddiqui. Three decades of transtracheal oxygen therapy: A review of the associated complications with an illustrative case presentation. Lung India 2017;34:448-51
- Akca. WHO Needs High FIO2? Turk J Anaesthesiol Reanim 2017; 45: 181-92
- Evans. Pancreatitis: Preventing catastrophic haemorrhage. World J Gastroenterol 2017;23(30):5460-5468
- Alexopoulou. Bacterial translocation markers in liver cirrhosis. Ann Gastroenterol 2017;30(5):486-497
- Jaswani. MicroRNAs involvement in renal pathophysiology: A bird's eye view. Indian J Nephrol 2017;27:337-41
- Pyropoulos. New paradigms in venous thromboprophylaxis of medically ill patients. Thromb Haemost 2017;117:1662–1670
- Zuidgeesta. Series: Pragmatic trials and real world evidence: Paper 1. Introduction. Journal of Clinical Epidemiology 2017;88:7-13
- Worsley. Series: Pragmatic trials and real world evidence: Paper 2. Setting, sites, and investigator selection. Journal of Clinical Epidemiology 2017;88:14-20
- Streetera. Adjusting for unmeasured confounding in nonrandomized longitudinal studies: a methodological review. Journal of Clinical Epidemiology 2017;88:23-34
- Rucker. Flipped classroom model for learning evidence-based medicine. Advances in Medical Education and Practice 2017;8:619—625
- Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure. European Respiratory Journal 2017;50(2):1602426
- Brueton. Best practice guidance for the use of strategies to improve retention in randomized trials developed from two consensus workshops. Journal of Clinical Epidemiology 2017;88:122-132
- Teboul. Intensive care medicine in 2050: vasopressors in sepsis. Intensive Care Med 2017;epublished August 31st
- Parry. Implementing early physical rehabilitation and mobilisation in the ICU: institutional, clinician, and patient considerations. Intensive Care Med 2017;epublished August 25th
- Yoshida. Ten tips to facilitate understanding and clinical use of esophageal pressure manometry. Intensive Care Med 2017;epublished August 25th
- Beerenahally. No free bed with ventilator: experience of a public health specialist. Indian Journal of Medical Ethics 2017;2(1):56-57
- Reade. Considerations for co-enrolment in randomised controlled effectiveness trials in critical care: the SPICE-8 co-enrolment guidelines. Crit Care Resus 2017;19(2):110-11
- Bevan. The College of Intensive Care Medicine of Australia and New Zealand supports global collaboration and respect. Crit Care Resus 2017;19(2):115-116
It's now just 4 months until the Critical Care Reviews Meeting 2018, where the chief investigators for the best critical care trials of 2017 come to discuss their work and try to answer the question clinicians want to know - should I change my practice based on this trial? From Brisbane, Australia, Prof Bala Ventakesh will explore the ADRENAL trial, examining hydrocortisone in septic shock in the biggest sepsis trial ever undertaken. Working between Dublin and Melbourne, Prof Alistair Nichol will explain the findings of the TRANSFUSE trial, comparing transfusion of the freshest available blood with standard issued red cells. From Nantes, France, Dr Jean-Baptiste Lascarrou will consider the findings of the MACMAN trial, evaluating video laryngoscopy in the ICU. Dr Ashish Khanna, from the Cleveland Clinic, USA, will reflect on ATHOS-3 the first large clinical trial examining angiotensin II in septic shock. Prof Gavin Perkins, from Warwick in England, will discuss his multi-centre randomized controlled trial Breathe, evaluating the role of extubation to non-invasive ventilation in patients failing spontaneous breathing trials. Prof John Simpson, from Newcastle, England, will discuss the VAP-RAPID trial, evaluating the use of a biomarker-guided approach to exclude ventilator-associated pneumonia. We also have Prof Andrew Rhodes from London, exploring the latest iteration of the Surviving Sepsis Campaign, published earlier this year, and Dr Sophie Wallace (Perth, Australia), who will deliver the honorary John Hinds Trauma Lecture, entitled "Disaster on Everest - Trauma at the Top of the World".
There is still an announcement or two to come, so watch this space!
We sold out #CCR17 and had to turn people away. At present we are way up on registrations compared to the same time-point in 2016. So, if you intend on coming, don't leave it too late to register. There is plenty of space still at present, but I expect the meeting will sell out well before it's date of Friday January 19th. Don't worry if you can't make it, as the talks will be recorded and put online for free viewing as usual. However, there is nothing like being there in person and having the opportunity to chat with these chief investigators. Numbers are strictly limited to ensure this remains a small, intimate meeting. It would be a shame to miss out......
The ANZICS/ACCCN Annual Scientific Meeting, which incorporates the annual Paediatric and Neonatal Intensive Care Conference, will be held at the Gold Coast Convention and Exhibition Centre, 11-13 October 2017. The Annual Scientific Meeting will be the preeminent critical care conference in Australasia for the calendar year and will be an important platform that will allow doctors, nurses and allied health practitioners to meaningfully connect and discuss new developments and research in the field of intensive and critical care.
The theme of the Meeting is “Thinking Outside the Flags” and will focus upon innovative and challenging advances that lie outside the safe zone of current practice, as well as the potential dangers that they may bring. A number of highly regarded international speakers will join our distinguished national and local speakers, experts in the field of intensive care medicine, nursing and allied health, promising delegates an exciting and challenging program.
Registration and the call for abstracts will open on 20 March 2017. For further information or to express your interest in attending, please visit http://intensivecareasm2017.com.au/.
#BMBTL17 is a conference on resuscitation that focuses on the skills and knowledge needed to bring your critically ill patients…back to life !
With cutting edge topics and a world class faculty, the conferences will be packed with clinical pearls and only the stuff that matters !
Ventilation, airway, EKGs, pediatric pearls, ultrasound and so much more…don’t miss this amazing conference ! It will be held on October 16th 2017 in downtown Montreal.
FemInEM.org is excited to bring you our first ever, in person conference, FIX2017! The FemInEM Idea Exchange is all about education, inspiration and motivation. Our world renowned faculty will speak from their hearts and minds, providing the substance and spark for you to change the world. We will meet, greet and motivate each other, pushing the limits of our previous selves. You won't want to miss it - October 4th to 6th, NYC.
State-of-the-Art is back, for the 3rd year of its new format and an all-new venue in Liverpool for 2017. The futurism and innovation theme continues with novel topics including robotics, optical imaging of bacterial infection, new technology in patient recovery, and new device interventions in acute cardiology.
However, the focus on day-to-day care is not lost, and there are clinical updates in acute medicine, ARDS, mechanical ventilation, trauma, nutrition, rehabilitation, endocrine management in ICU, cancer patients in ICU, the difficult and altered airway, and much more. Pragmatic "how I treat..." sessions proved popular last year and will continue, along with meaningful debates on UK critical care, including the trend toward centralisation.
In addition, the trademark vibe of SOA will still be there with pop-up talks, panel debates, 'meet the expert' booths, new generation video e-posters, parent and infant facilities, two drinks evenings, and a new final night after-party. Registration and abstract submission is now open at http://soa.ics.ac.uk.
We are very pleased to announce the 6th International Fluid Academy Days (iFAD), which will take place on November 23-25th 2017 at the Hilton Hotel in Antwerp, Belgium. The iFAD is an innovative Critical Care Educational meeting in true SMACC spirit. This conference provides the highest quality of Critical Care education and is guaranteed to innovate and inspire. Recent advances in fluid management, and hemodynamic and organ function monitoring in the critical care setting will be reviewed in a comprehensive manner for intensivists, anaesthesiologists and emergency physicians as well as interested internists and surgeons.
The iFAD Faculty is the most provocative, engaging, motivating and inspiring group of international educational speakers and as organizing committee we want to ensure we have the participants, sponsors and endorsers to match. Together, we make iFAD stand apart from other Critical Care conferences.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board