Welcome to the 298th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. The highlights of this week's edition are the GRAIL trial, investigating ganciclovir in CMV-seropositive critically ill patients; several new circulatory guidelines from the European Society of Cardiology; and a fantastic series of papers from Annals of Translational Medicine, marking the 50th anniversary of the landmark description of ARDS by Ashbaugh and colleagues, from which 7 papers form this week's Topic of the Week, starting with a favourite topic of mine - the definition and epidemiology of ARDS in tomorrow's Paper of the Day. If you only have time to read one review article this week, try this one on thoracic ultrasound.
As the Critical Care Reviews Meeting moves closer, we can announce our latest trial and speaker. Prof John Simpson, from Newcastle, England, will discuss the VAP-RAPID trial, evaluating the use of a biomarker-guided approach to exclude ventilator-associated pneumonia.
- Abstract: Limaye. Effect of Ganciclovir on IL-6 Levels Among Cytomegalovirus-Seropositive Adults With Critical Illness. A Randomized Clinical Trial. JAMA 2017;318(8):731-740
- Abstract: Felker. Effect of Natriuretic Peptide–Guided Therapy on Hospitalization or Cardiovascular Mortality in High-Risk Patients With Heart Failure and Reduced Ejection Fraction. A Randomized Clinical Trial. JAMA 2017;318(8):713-720
- Abstract: Hajjej. Effects of Levosimendan on Cellular Metabolic Alterations in Patients With Septic Shock: A Randomized Controlled Pilot Study. Shock 2017;48(3):307-312
- Abstract: Human. A Randomized Trial of Brief Versus Extended Seizure Prophylaxis After Aneurysmal Subarachnoid Hemorrhage. Neurocrit Care 2017;epublished August 22nd
- Full Text: Xu. Comparison of Space Glucose Control and Routine Glucose Management Protocol for Glycemic Control in Critically Ill Patients: A Prospective, Randomized Clinical Study. Chin Med J (Engl) 2017;130(17):2041-2049
- Abstract: Koch. A Randomized Clinical Trial of Red Blood Cell Transfusion Triggers in Cardiac Surgery. Ann Thorac Surg 2017;epublished August 16th
- Full Text: Erlinge. Bivalirudin versus Heparin Monotherapy in Myocardial Infarction (VALIDATE-SWEDEHEART). N Engl J Med 2017;epublished August 27th
- Full Text: Komiya. A systematic review of diagnostic methods to differentiate acute lung injury/acute respiratory distress syndrome from cardiogenic pulmonary edema. Critical Care 2017;21:228
- Abstract: Pavasini. Extracorporeal Circulatory Support in Acute Coronary Syndromes: A Systematic Review and Meta-Analysis. Crit Care Med 2017;epublished August 24th
- Abstract: Machado. The epidemiology of sepsis in Brazilian intensive care units (the Sepsis PREvalence Assessment Database, SPREAD): an observational study. Lancet Infect Dis 2017;epublished August 17th
- Abstract: Zakharkina. The dynamics of the pulmonary microbiome during mechanical ventilation in the intensive care unit and the association with occurrence of pneumonia. Thorax 2017;72:803-810Thorax 2017;72:803-810
- Abstract: DesPrez. Oxygenation saturation index predicts clinical outcomes in ARDS. Chest 2017;epublished August 16th
- Full Text: Nedel. A simple and fast ultrasonographic method of detecting enteral feeding tube placement in mechanically ventilated, critically ill patients. J Intensive Care 2017;5:55
- Full Text: Vallejo. Current clinical nutrition practices in critically ill patients in Latin America: a multinational observational study. Critical Care 2017;21:227
- Mesgarpour. Harms of off-label erythropoiesis-stimulating agents for critically ill people. Cochrane Database of Systematic Reviews 2017, Issue 8. Art. No.: CD010969
- Feinberg. Drug-eluting stents versus bare-metal stents for acute coronary syndrome. Cochrane Database of Systematic Reviews 2017, Issue 8. Art. No.: CD012481
- Fuhrer. Optimizing Cardiac Out-Put to Increase Cerebral Penumbral Perfusion in Large Middle Cerebral Artery Ischemic Lesion—OPTIMAL Study. Front Neurol 2017;8:402
- Kriege. Evaluation of the McGrath MAC and Macintosh laryngoscope for tracheal intubation in 2000 patients undergoing general anaesthesia: the randomised multicentre EMMA trial study protocol. BMJ Open 2017;7:e016907
- Thom. Therapeutic Potential of Intravenous Immunoglobulin in Acute Brain Injury. Front Immunol 2017;31;8:875
- Iordanova. Alterations in Cerebral Blood Flow after Resuscitation from Cardiac Arrest. Front Pediatr 2017;5:174
- Medaglia. Functional Neuroimaging in Traumatic Brain Injury: From Nodes to Networks. Front Neurol 2017;8:407
- Shao. Epinephrine in Out-of-hospital Cardiac Arrest: Helpful or Harmful?. Chin Med J 2017;130:2112-6
- De Jong. Vascular complications following intra-aortic balloon pump implantation: an updated review. Perfusion 2017;epublished August 17th
- Gawinecka. Acute aortic dissection: pathogenesis, risk factors and diagnosis. Swiss Med Wkly. 2017;147:w14489
- Rezoagli. Definition and epidemiology of acute respiratory distress syndrome. Ann Transl Med 2017;5(14):282
- García-Laorden. Biomarkers for the acute respiratory distress syndrome: how to make the diagnosis more precise. Ann Transl Med 2017;5(14):283
- Larsson. Monitoring of lung function in acute respiratory distress syndrome. Ann Transl Med 2017;5(14):284
- Grieco. Transpulmonary pressure: importance and limits. Ann Transl Med 2017;5(14):285
- Tonetti. Driving pressure and mechanical power: new targets for VILI prevention. Ann Transl Med 2017;5(14):286
- Umbrello. Tidal volume in acute respiratory distress syndrome: how best to select it. Ann Transl Med 2017;5(14):287
- Gattinoni. Positive end-expiratory pressure: how to set it at the individual level. Ann Transl Med 2017;5(14):288
- Guérin. Prone positioning acute respiratory distress syndrome patients. Ann Transl Med 2017;5(14):289
- Constantin. Recruitment maneuvers in acute respiratory distress syndrome. Ann Transl Med 2017;5(14):290
- Bourenne. Sedation and neuromuscular blocking agents in acute respiratory distress syndrome. Ann Transl Med 2017;5(14):291
- Mauri. Spontaneous breathing: a double-edged sword to handle with care. Ann Transl Med 2017;5(14):292
- Artigas. Inhalation therapies in acute respiratory distress syndrome. Ann Transl Med 2017;5(14):293
- Ball. Lung imaging: how to get better look inside the lung. Ann Transl Med 2017;5(14):294
- Repessé. Right heart function during acute respiratory distress syndrome. Ann Transl Med 2017;5(14):295
- Parekh. Extracorporeal techniques in acute respiratory distress syndrome. Ann Transl Med 2017;5(14):296
- Frat. High-flow nasal oxygen therapy and noninvasive ventilation in the management of acute hypoxemic respiratory failure. Ann Transl Med 2017;5(14):297
- Tane. Ex Vivo Lung Perfusion. Chest 2017;151(6):1220–1228
- Raju. Chest CT Signs in Pulmonary Disease. A Pictorial Review. Chest 2017;151(6):1356-1374
- Corcoran. State of the art thoracic ultrasound: intervention and therapeutics. Thorax 2017;72:840-849
- Slain. The use of high-flow nasal cannula in the pediatric emergency department. J Pediatr (Rio J) 2017;epublished August 14th
- Xu. Biomarkers for patients with trauma associated acute respiratory distress syndrome. Military Medical Research 2017;4:25
- Turton. Role of 3D Echocardiography in Cardiac Surgery: Strengths and Limitations. Curr Anesthesiol Rep 2017;7:291–298
- Vazquez-Sandoval. Critically ill patients and gut motility: Are we addressing it? World J Gastrointest Pharmacol Ther 2017;8(3):174-179
- Bear. The role of nutritional support in the physical and functional recovery of critically ill patients: a narrative review. Critical Care 2017;21:226
- ESC Joint Working Groups on Cardiovascular Surgery and the Cellular Biology of the Heart Position Paper: Peri-operative myocardial injury and infarction in patients undergoing coronary artery bypass graft surgery. European Heart Journal 2017;38(31):2392–2411
- 2017 ESC/EACTS Guidelines for the management of valvular heart disease: The Task Force for the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). European Heart Journal 2017;epublished August 26th
- 2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS): Document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries. European Heart Journal 2017;epublished August 26th
- Questions and answers on diagnosis and management of patients with Peripheral Arterial Diseases: a companion document of the 2017 ESC Guidelines for the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS): Endorsed by: the European Stroke Organisation (ESO). European Heart Journal 2017;epublished August 26thEuropean Heart Journal 2017;epublished August 26th
- 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS: The Task Force for dual antiplatelet therapy in coronary artery disease of the European Society of Cardiology (ESC) and of the European Association for Cardio-Thoracic Surgery (EACTS). European Heart Journal 2017;epublished August 26th European Heart Journal 2017;epublished August 26th
- Case-based implementation of the 2017 ESC Focused Update on Dual Antiplatelet Therapy in Coronary Artery Disease†: The Task Force for the Management of Dual Antiplatelet Therapy in Coronary Artery Disease of the European Society of Cardiology (ESC) and of the European Association for Cardio-Thoracic Surgery (EACTS). European Heart Journal 2017;epublished August 26th
- Guidelines for the Institutional Implementation of Developmental Neuroprotective Care in the Neonatal Intensive Care Unit. Part A: Background and Rationale. A Joint Position Statement From the CANN, CAPWHN, NANN, and COINN. Can J Nurs Res 2017;49(2):46-62
- Guidelines for the Institutional Implementation of Developmental Neuroprotective Care in the NICU. Part B: Recommendations and Justification. A Joint Position Statement From the CANN, CAPWHN, NANN, and COINN. Can J Nurs Res 2017;49(2):63-74
- Splenic trauma: WSES classification and guidelines for adult and pediatric patients. World Journal of Emergency Surgery 2017;12:40
It's now just 6 months until the Critical Care Reviews Meeting 2018, where the chief investigators for the best critical care trials of 2017 come to discuss their work and try to answer the question clinicians want to know - should I change my practice based on this trial? From Brisbane, Australia, Prof Bala Ventakesh will explore the ADRENAL trial, examining hydrocortisone in septic shock in the biggest sepsis trial ever undertaken. Split between Dublin and Melbourne, Prof Alistair Nichol will explain the findings of the TRANSFUSE trial, comparing transfusion of the freshest available blood with standard issued red cells. From Nantes, France, Dr Jean-Baptiste Lascarrou will consider the findings of the MACMAN trial, evaluating video laryngoscopy in the ICU. Dr Ashish Khanna, from the Cleveland Clinic, USA, will reflect on ATHOS-3, the first large clinical trial examining angiotensin II in septic shock. We also have Prof Andrew Rhodes, from London, exploring the latest iteration of the Surviving Sepsis Campaign, published earlier this year. There are still additional speakers to add to the programme, so the meeting will continue to grow and get better and better.
We sold out #CCR17 and had to turn people away. At present we are way up on registrations compared to the same time-point in 2016. So, if you intend on coming, don't leave it too late to register. There is plenty of space still at present, but I expect the meeting will sell out well before it's date of Friday January 19th. Don't worry if you can't make it, as the talks will be recorded and put online for free viewing as usual. However, there is nothing like being there in person and having the opportunity to chat with these chief investigators. Numbers are strictly limited to ensure this remains a small, intimate meeting. It would be a shame to miss out......
The ANZICS/ACCCN Annual Scientific Meeting, which incorporates the annual Paediatric and Neonatal Intensive Care Conference, will be held at the Gold Coast Convention and Exhibition Centre, 11-13 October 2017. The Annual Scientific Meeting will be the preeminent critical care conference in Australasia for the calendar year and will be an important platform that will allow doctors, nurses and allied health practitioners to meaningfully connect and discuss new developments and research in the field of intensive and critical care.
The theme of the Meeting is “Thinking Outside the Flags” and will focus upon innovative and challenging advances that lie outside the safe zone of current practice, as well as the potential dangers that they may bring. A number of highly regarded international speakers will join our distinguished national and local speakers, experts in the field of intensive care medicine, nursing and allied health, promising delegates an exciting and challenging program.
Registration and the call for abstracts will open on 20 March 2017. For further information or to express your interest in attending, please visit http://intensivecareasm2017.com.au/.
#BMBTL17 is a conference on resuscitation that focuses on the skills and knowledge needed to bring your critically ill patients…back to life !
With cutting edge topics and a world class faculty, the conferences will be packed with clinical pearls and only the stuff that matters !
Ventilation, airway, EKGs, pediatric pearls, ultrasound and so much more…don’t miss this amazing conference ! It will be held on October 16th 2017 in downtown Montreal.
FemInEM.org is excited to bring you our first ever, in person conference, FIX2017! The FemInEM Idea Exchange is all about education, inspiration and motivation. Our world renowned faculty will speak from their hearts and minds, providing the substance and spark for you to change the world. We will meet, greet and motivate each other, pushing the limits of our previous selves. You won't want to miss it - October 4th to 6th, NYC.
State-of-the-Art is back, for the 3rd year of its new format and an all-new venue in Liverpool for 2017. The futurism and innovation theme continues with novel topics including robotics, optical imaging of bacterial infection, new technology in patient recovery, and new device interventions in acute cardiology.
However, the focus on day-to-day care is not lost, and there are clinical updates in acute medicine, ARDS, mechanical ventilation, trauma, nutrition, rehabilitation, endocrine management in ICU, cancer patients in ICU, the difficult and altered airway, and much more. Pragmatic "how I treat..." sessions proved popular last year and will continue, along with meaningful debates on UK critical care, including the trend toward centralisation.
In addition, the trademark vibe of SOA will still be there with pop-up talks, panel debates, 'meet the expert' booths, new generation video e-posters, parent and infant facilities, two drinks evenings, and a new final night after-party. Registration and abstract submission is now open at http://soa.ics.ac.uk.
We are very pleased to announce the 6th International Fluid Academy Days (iFAD), which will take place on November 23-25th 2017 at the Hilton Hotel in Antwerp, Belgium. The iFAD is an innovative Critical Care Educational meeting in true SMACC spirit. This conference provides the highest quality of Critical Care education and is guaranteed to innovate and inspire. Recent advances in fluid management, and hemodynamic and organ function monitoring in the critical care setting will be reviewed in a comprehensive manner for intensivists, anaesthesiologists and emergency physicians as well as interested internists and surgeons.
The iFAD Faculty is the most provocative, engaging, motivating and inspiring group of international educational speakers and as organizing committee we want to ensure we have the participants, sponsors and endorsers to match. Together, we make iFAD stand apart from other Critical Care conferences.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board