Welcome to the 297th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. The highlights of this week's issue are a randomised controlled trial investigating selepressin in septic shock; an observational trial examining electrical impedance tomography for PEEP; guidelines on the management of acute mesenteric ischemia and the role of the open abdomen in non-trauma patients; as well as clincal reviews on the intensive care medicine research agenda for airways, invasive and noninvasive mechanical ventilation & oncological patients in the ICU; a non-clinical review on Bayesian anaysis; and commentaries on saying goodbye to lectures in medical school and the Nuremberg Code. If you only have time to read one paper this week, try either this clarion call on medical education in the era of alternative facts or creating social media portfolios for academic promotion and tenure - I wonder what the traditional university-affiliated academics think of this?
There are now 5 months to the Critical Care Reviews Meeting 2018 being held in Titanic, Belfast, on Friday, January 19th. The latest addition to the programme is Dr Sophie Wallace (Perth, Australia), who will deliver the honorary John Hinds Trauma Lecture, entitled "Disaster on Everest - Trauma at the Top of the World". Hopefully the programme will be complete at the start of September, but so far we have chief investigators for some of the most interesting critical care trials of the year. The meeting is proving ever more popular so don't delay registering or you might just miss out.
- Full Text: Russell. Selepressin, a novel selective vasopressin V1A agonist, is an effective substitute for norepinephrine in a phase IIa randomized, placebo-controlled trial in septic shock patients. Critical Care 2017;21:213
- Full Text: Nourmohammadi. Effect of fat-based versus carbohydrate-based enteral feeding on glycemic control in critically ill patients: A randomized clinical trial. Indian J Crit Care Med 2017;21:500-5
- Abstract: Stens. The added value of cardiac index and pulse pressure variation monitoring to mean arterial pressure-guided volume therapy in moderate-risk abdominal surgery (COGUIDE): a pragmatic multicentre randomised controlled trial. Anaesthesia 2017;72:1078–1087
- Abstract: Shroyer. Five-Year Outcomes after On-Pump and Off-Pump Coronary-Artery Bypass. N Engl J Med 2017;377:623-632
- Abstract: Zakhary.The Utility of High-Fidelity Simulation for Training Critical Care Fellows in the Management of Extracorporeal Membrane Oxygenation Emergencies: A Randomized Controlled Trial. Crit Care Med 2017;45(8):1367-1373
- Abstract: Panigrahi. A randomized synbiotic trial to prevent sepsis among infants in rural India. Nature 2017;epublished August 16th
- Abstract: Bendavid. Prevention of Exposure Keratopathy in Critically Ill Patients: A Single-Center, Randomized, Pilot Trial Comparing Ocular Lubrication With Bandage Contact Lenses and Punctal Plugs. Crit Care Med 2017;epublished August 17th
- Full Text: Mesotten. Software-guided versus nurse-directed blood glucose control in critically ill patients: the LOGIC-2 multicenter randomized controlled clinical trial. Critical Care 2017;21:212
- Full Text: Koziarz. Optic nerve sheath diameter sonography for the diagnosis of increased intracranial pressure: a systematic review and meta-analysis protocol. BMJ Open 2017;7(8):e016194
- Abstract: Elmi-Sarabi. Aerosolized Vasodilators for the Treatment of Pulmonary Hypertension in Cardiac Surgical Patients: A Systematic Review and Meta-analysis. Anesth Analg 2017;125(2):393-402
- Abstract: Franchineau. Bedside Contribution of Electrical Impedance Tomography to Setting Positive End-Expiratory Pressure for Extracorporeal Membrane Oxygenation–treated Patients with Severe Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med 2017;196(4):447–457
- Abstract: van Vught. The Host Response in Patients with Sepsis Developing Intensive Care Unit–acquired Secondary Infections. Am J Respir Crit Care Med 2017;196(4):458–470
- Abstract: van de Veerdonk. Influenza-associated Aspergillosis in Critically Ill Patients. Am J Respir Crit Care Med 2017;196(4):524–527
- Abstract: Docherty. Early troponin I in critical illness and its association with hospital mortality: a cohort study. Critical Care 2017;21:216
- Full Text: Cillóniz. Time to blood culture positivity as a predictor of clinical outcomes and severity in adults with bacteremic pneumococcal pneumonia. PLoS One 2017;12(8):e0182436
- Abstract: Shankar-Hari. Epidemiology of sepsis and septic shock in critical care units: comparison between sepsis-2 and sepsis-3 populations using a national critical care database. British Journal of Anaesthesia 2017;epublished August 16th
- Ruszkai. Effects of intraoperative PEEP optimization on postoperative pulmonary complications and the inflammatory response: study protocol for a randomized controlled trial. Trials 2017;18:375
- Warner. Point-of-care washing of allogeneic red blood cells for the prevention of transfusion-related respiratory complications (WAR-PRC): a protocol for a multicenter randomised clinical trial in patients undergoing cardiac surgery. BMJ Open 2017;7:e016398
- Makinde. The Role of Microglia in the Etiology and Evolution of Chronic Traumatic Encephalopathy. Shock 2017;48(3):276-283
- Jaber. The intensive care medicine research agenda for airways, invasive and noninvasive mechanical ventilation. Intensive Care Med 2017;epublished August 7th
- Sharma. Extraglottic airway devices: technology update. Medical Devices: Evidence and Research 2017;10:189-205
- Speck. Plasma and bronchoalveolar lavage samples in acute lung allograft rejection: the potential role of cytokines as diagnostic markers. Respiratory Research 2017;18:151
- Grassi. Noninvasive mechanical ventilation in early acute respiratory distress syndrome. Pol Arch Intern Med 2017;epublished August 17th
- Rahaman. Mathematics of ventilator-induced lung injury. Indian J Crit Care Med 2017;21:521-4
- Vilz. Ileus in Adults: Pathogenesis, Investigation and Treatment. Dtsch Arztebl Int 2017;114(29-30):508-18
- Zawadzka. Thermoregulation disorders of central origin - how to diagnose and treat. Anaesthesiol Intensive Ther 2017;49(3):227-234
- Ali. New-onset acute thrombocytopenia in hospitalized patients: pathophysiology and diagnostic approach. J Community Hosp Intern Med Perspect 2017;7(3):157–167
- Hassoun. Incidence, prevalence, and management of MRSA bacteremia across patient populations—a review of recent developments in MRSA management and treatment. Critical Care 2017;21:211
- Biskup. Oncological patients in the intensive care unit: prognosis, decision-making, therapies and end-of-life care. Swiss Med Wkly 2017;147:w14481
- Lightner. Perioperative use of immunosuppressive medications in patients with Crohn's disease in the new "biological era". Gastroenterology Report 2017;5(3):165–177
- Rahman. Medical identification or alert jewellery: an opportunity to save lives or an unreliable hindrance?. Anaesthesia 2017;72:1139–1145
- Hahn. Angioedema—an interdisciplinary emergency. Dtsch Arztebl Int 2017;114(29-30):489-96
- Bittl. Bayesian Analysis: A Practical Approach to Interpret Clinical Trials and Create Clinical Practice Guidelines. Circ Cardiovasc Qual Outcomes 2017;10:e003563
- Cabrera. More Than Likes and Tweets: Creating Social Media Portfolios for Academic Promotion and Tenure. Journal of Graduate Medical Education 2017;9(4):421-425
- Bala. Acute mesenteric ischemia: guidelines of the World Society of Emergency Surgery. World Journal of Emergency Surgery 2017;12:38
- Coccolini. The role of open abdomen in non-trauma patient: WSES Consensus Paper. World J Emerg Surg 2017;12:39
- Eschenhagen. Cardiomyocyte Regeneration. A Consensus Statement. Circulation 2017;136:680-686
- Wenzel. Medical Education in the Era of Alternative Facts. N Engl J Med 2017;377:607-609
- Schwartzstein. Saying Goodbye to Lectures in Medical School — Paradigm Shift or Passing Fad? N Engl J Med 2017;377:605-607
- Mimouni. Opinion: We Need a Replacement for Beall’s List. Scientist 2017;epublished August 15th
- Machado. Sepsis 3 from the perspective of clinicians and quality improvement initiatives. J Crit Care 2017;40:315-317
- Wellbery. Signs. N Engl J Med 2017;377:609-611
- Moreno. The Nuremberg Code 70 Years Later. JAMA 2017;epublished August 17th
- Shrestha. Point-of-care ultrasonography: a practical step in the path to precision in critical care. Critical Care 2017;21:215
- Nedel. A simple and fast ultrasonographic method of detecting enteral feeding tube placement in mechanically ventilated, critically ill patients. Journal of Intensive Care 2017;5:55
It's now just 5 months until the Critical Care Reviews Meeting 2018, where the chief investigators for the best critical care trials of 2017 come to discuss their work and try to answer the question clinicians want to know - should I change my practice based on this trial? From Brisbane, Australia, Prof Bala Ventakesh will explore the ADRENAL trial, examining hydrocortisone in septic shock in the biggest sepsis trial ever undertaken. Split between Dublin and Melbourne, Prof Alistair Nichol will explain the findings of the TRANSFUSE trial, comparing transfusion of the freshest available blood with standard issued red cells. From Nantes, France, Dr Jean-Baptiste Lascarrou will consider the findings of the MACMAN trial, evaluating video laryngoscopy in the ICU. Dr Ashish Khanna, from the Cleveland Clinic, USA, will reflect on ATHOS-3, the first large clinical trial examining angiotensin II in septic shock. We also have Prof Andrew Rhodes, from London, exploring the latest iteration of the Surviving Sepsis Campaign, published earlier this year. There are still additional speakers to add to the programme, so the meeting will continue to grow and get better and better.
We sold out #CCR17 and had to turn people away. At present we are way up on registrations compared to the same time-point in 2016. So, if you intend on coming, don't leave it too late to register. There is plenty of space still at present, but I expect the meeting will sell out well before it's date of Friday January 19th. Don't worry if you can't make it, as the talks will be recorded and put online for free viewing as usual. However, there is nothing like being there in person and having the opportunity to chat with these chief investigators. Numbers are strictly limited to ensure this remains a small, intimate meeting. It would be a shame to miss out......
The ANZICS/ACCCN Annual Scientific Meeting, which incorporates the annual Paediatric and Neonatal Intensive Care Conference, will be held at the Gold Coast Convention and Exhibition Centre, 11-13 October 2017. The Annual Scientific Meeting will be the preeminent critical care conference in Australasia for the calendar year and will be an important platform that will allow doctors, nurses and allied health practitioners to meaningfully connect and discuss new developments and research in the field of intensive and critical care.
The theme of the Meeting is “Thinking Outside the Flags” and will focus upon innovative and challenging advances that lie outside the safe zone of current practice, as well as the potential dangers that they may bring. A number of highly regarded international speakers will join our distinguished national and local speakers, experts in the field of intensive care medicine, nursing and allied health, promising delegates an exciting and challenging program.
Registration and the call for abstracts will open on 20 March 2017. For further information or to express your interest in attending, please visit http://intensivecareasm2017.com.au/.
#BMBTL17 is a conference on resuscitation that focuses on the skills and knowledge needed to bring your critically ill patients…back to life !
With cutting edge topics and a world class faculty, the conferences will be packed with clinical pearls and only the stuff that matters !
Ventilation, airway, EKGs, pediatric pearls, ultrasound and so much more…don’t miss this amazing conference ! It will be held on October 16th 2017 in downtown Montreal.
FemInEM.org is excited to bring you our first ever, in person conference, FIX2017! The FemInEM Idea Exchange is all about education, inspiration and motivation. Our world renowned faculty will speak from their hearts and minds, providing the substance and spark for you to change the world. We will meet, greet and motivate each other, pushing the limits of our previous selves. You won't want to miss it - October 4th to 6th, NYC.
State-of-the-Art is back, for the 3rd year of its new format and an all-new venue in Liverpool for 2017. The futurism and innovation theme continues with novel topics including robotics, optical imaging of bacterial infection, new technology in patient recovery, and new device interventions in acute cardiology.
However, the focus on day-to-day care is not lost, and there are clinical updates in acute medicine, ARDS, mechanical ventilation, trauma, nutrition, rehabilitation, endocrine management in ICU, cancer patients in ICU, the difficult and altered airway, and much more. Pragmatic "how I treat..." sessions proved popular last year and will continue, along with meaningful debates on UK critical care, including the trend toward centralisation.
In addition, the trademark vibe of SOA will still be there with pop-up talks, panel debates, 'meet the expert' booths, new generation video e-posters, parent and infant facilities, two drinks evenings, and a new final night after-party. Registration and abstract submission is now open at http://soa.ics.ac.uk.
We are very pleased to announce the 6th International Fluid Academy Days (iFAD), which will take place on November 23-25th 2017 at the Hilton Hotel in Antwerp, Belgium. The iFAD is an innovative Critical Care Educational meeting in true SMACC spirit. This conference provides the highest quality of Critical Care education and is guaranteed to innovate and inspire. Recent advances in fluid management, and hemodynamic and organ function monitoring in the critical care setting will be reviewed in a comprehensive manner for intensivists, anaesthesiologists and emergency physicians as well as interested internists and surgeons.
The iFAD Faculty is the most provocative, engaging, motivating and inspiring group of international educational speakers and as organizing committee we want to ensure we have the participants, sponsors and endorsers to match. Together, we make iFAD stand apart from other Critical Care conferences.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board