Welcome to the 293rd Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. The highlights of this week's newsletter are randomised controlled trials examining simvastatin in the prevention and treatment of delirium in critically ill patients and low-dose furosemide in critically ill patients with early acute kidney injury; an observtional study on veno-venous extracorporeal CO2 removal for acute hypercapnic respiratory failure, reviews on hyperventilation therapy for control of posttraumatic intracranial hypertension, pediatric sepsis and antiseizure medications in the ICU; commentaries on dying with uncertainty and questions about timing and mandates in sepsis. There has also been a reanalysis of the CHEST Trial, which, unsurprisingly, gave the same results as the original analysis. If you only have time for one review article this week, try this one on cardiocerebral and cardiopulmonary resuscitation.
This week's Topic of the Week is cerebral oedema, starting with a paper on the the pathophysiology of brain oedema and intracranial hypertension in tomorrow's Paper of the Day.
In conference news, FemInEM.org is excited to bring you their first ever, in person conference, FIX2017! The FemInEM Idea Exchange is all about education, inspiration and motivation. Their world renowned faculty will speak from their hearts and minds, providing the substance and spark for you to change the world. They will meet, greet and motivate each other, pushing the limits of your previous selves. You won't want to miss it!
- Abstract: Page. Evaluation of early administration of simvastatin in the prevention and treatment of delirium in critically ill patients undergoing mechanical ventilation (MoDUS): a randomised, double-blind, placebo-controlled trial. Lancet Respir Med 2017;epublished July 19th
- Abstract: Bagshaw. The effect of low-dose furosemide in critically ill patients with early acute kidney injury: A pilot randomized blinded controlled trial (the SPARK study). J Crit Care 2017;epublished July 12th
- Abstract: Stocker. Procalcitonin-guided decision making for duration of antibiotic therapy in neonates with suspected early-onset sepsis: a multicentre, randomised controlled trial (NeoPIns). Lancet 2017;epublished July 12th
- Full Text: Belenguer-Muncharaz. Non-invasive ventilation versus invasive mechanical ventilation in patients with hypoxemic acute respiratory failure in an Intensive Care Unit. A randomized controlled study. Minerva Pneumologica 2017;56(1):1-10
- Full Text: Silva. Effectiveness of Apneic Oxygenation During Intubation: A Systematic Review and Meta-analysis. Ann Emerg Med 2017;epublished July 14th
- Abstract: de Oliveira. Accuracy of C - Reactive protein as a bacterial infection marker in critically immunosuppressed patients: A systematic review and meta-analysis. J Crit Care 2017;epublished July 15th
- Abstract: Wu. Efficacy of corticosteroid treatment for severe community-acquired pneumonia: A meta-analysis. Am J Emerg Med 2017;epublished July 14th
- Abstract: Patkova. Energy, Protein, Carbohydrate, and Lipid Intakes and Their Effects on Morbidity and Mortality in Critically Ill Adult Patients: A Systematic Review. Adv Nutr 2017;8(4):624-634
- Abstract: Putzu. Blood purification with continuous veno-venous hemofiltration in patients with sepsis or ARDS: a systematic review and meta-analysis. Minerva Anestesiologica 2017;83(8):867-77
- Full Text: Gewandter. Interpretation of CIs in clinical trials with non-significant results: systematic review and recommendations. BMJ Open 2017;7:e017288
- Full Text: Khorsandi. Extra-corporeal membrane oxygenation for refractory cardiogenic shock after adult cardiac surgery: a systematic review and meta-analysis. J Cardiothorac Surg. 2017;12: 55
- Abstract: Pfeiffer. Auditory discrimination improvement predicts awakening of postanoxic comatose patients treated with targeted temperature management at 36°C. Resuscitation 2017;epublished July 13th
- Abstract: Hilty. Low flow veno-venous extracorporeal CO2 removal for acute hypercapnic respiratory failure. Minerva Anestesiologica 2017;83(8):812-23
- Full Text: Neumeier. Prolonged acute care and post-acute care admission and recovery of physical function in survivors of acute respiratory failure: a secondary analysis of a randomized controlled trial. Critical Care 2017;21:190
- Full Text: Eronia. Bedside selection of positive end-expiratory pressure by electrical impedance tomography in hypoxemic patients: a feasibility study. Annals of Intensive Care 2017;7:76
- Godoy. Hyperventilation Therapy for Control of Posttraumatic Intracranial Hypertension. Front Neurol 2017;8:250
- Orinx. Recent antiseizure medications in the Intensive Care Unit. Minerva Anestesiologica 2017;83(8):878-87
- Calviello. Cerebral autoregulation monitoring in acute traumatic brain injury: what’s the evidence? Minerva Anestesiologica 2017 August;83(8):844-57
- Ewy. Cardiocerebral and cardiopulmonary resuscitation – 2017 update. Acute Med Surg 2017;4:227–234
- Batul. Recent advances in the management of ventricular tachyarrhythmias. F1000Research 2017, 6(F1000 Faculty Rev):1027
- Goyal. Coronary CT angiography in acute chest pain. F1000Research 2017, 6(F1000 Faculty Rev):1125
- Gimbel. Management of elderly patients with a non-ST-segment-elevation acute coronary syndrome. Neth Heart J 2017;25:409–415
- Narendra. Update in Management of Severe Hypoxemic Respiratory Failure. Chest 2017;epublished ahead of print
- Ittrich. The Diagnosis and Treatment of Hemoptysis. Dtsch Arztebl Int 2017;114(21):371-81
- Millington. Better with Ultrasound: Pleural Procedures in Critically Ill Patients. Chest 2017;epublished July 20th
- Toda. AKI after pediatric cardiac surgery for congenital heart diseases–recent developments in diagnostic criteria and early diagnosis by biomarkers. Journal of Intensive Care 2017;5:49
- Panahi. The role of magnesium sulfate in the intensive care unit. EXCLI J 2017;16:464–482
- Prandoni. Optimal duration of anticoagulation in patients with unprovoked venous thromboembolism: the impact of novel anticoagulants. International Angiology 2017;36(5):395-401
- Weitz. Recent advances in the treatment of venous thromboembolism in the era of the direct oral anticoagulants. F1000Research 2017, 6(F1000 Faculty Rev):985
- Moreno . Using beta-lactam antibiotics in patients with a history of beta-lactam allergy: current concepts. Pol Arch Intern Med 2017;epublished July 19th
- Kawasaki. Update on pediatric sepsis: a review. Journal of Intensive Care 2017;5:47
- Polverino. Multidrug-resistant pathogens in respiratory diseases. Minerva Pneumologica 2017;56(1):33-46
- Mansfield. Emerging Tick-Borne Viruses in the Twenty-First Century. Front Cell Infect Microbiol 2017;7:298
- Nakao. A review of the history of the origin of triage from a disaster medicine perspective. Acute Med Surg 2017;epublished July 14th
- Zhang. Ten Basic Principles about Critical Ultrasonography: Critical Care Practitioners Need to Know. Chin Med J (Engl) 2017;130(13):1610–1614
- Takazawa. Drug-induced anaphylaxis in the emergency room. Acute Med Surg 2017;4:235–245
- Nishimura. Current status of pediatric transplantation in Japan. Journal of Intensive Care 2017;5:48
- Dellinger. The Aging Physician and the Medical Profession. A Review. JAMA Surg 2017;epublished July 19th
- Schwarze. Managing Uncertainty — Harnessing the Power of Scenario Planning. N Engl J Med 2017;377:206-208
- Drazen. Certain about Dying with Uncertainty. N Engl J Med 2017;377:208-209
- Abbasi. In Treating Sepsis, Questions About Timing and Mandates. JAMA 2017;epublished July 19th
- Alam. Trauma care: Finding a better way. PLoS Med 2017;14(7):e1002350
- Lockey. Research questions in pre-hospital trauma care. PLoS Med 2017;14(7):e1002345
- Rawal. Post-intensive Care Syndrome: an Overview. J Transl Int Med. 2017 Jun 30;5(2):90-92
- Benders. Central pontine myelinolysis: Case report and short overview. Neth J Crit Care 2017;25(4):129-132
- Vos. Survival of a formalin intoxication: a case report. Neth J Crit Care July 2017;25(4):133-136
- de Wilde. Cerebral blood flow velocity during chest compressions in cardiac arrest. Neth J Crit Care 2017;25(4):137-139
- Houterman. Leptospirosis: today a rare occurrence, in the future more prevalent? Neth J Crit Care 2017;25(4):140-141
- Hannivoort. Do you harvest what you sow? Neth J Crit Care 2017;25(4):128
- Patel. Reanalysis of the Crystalloid versus Hydroxyethyl Starch Trial (CHEST). N Engl J Med 2017;377:298-300
- Abidi. The clinical picture of severe leptospirosis in critically ill patients. Intensive Care Med 2017;epublished June 30th
- Gaudry. Optimal timing of renal replacement therapy in patients with acute kidney injury in the context of sepsis. Intensive Care Med 2017;epublished July 12th
It's now just 6 months until the Critical Care Reviews Meeting 2018, where the chief investigators for the best critical care trials of 2017 come to discuss their work and try to answer the question clinicians want to know - should I change my practice based on this trial? From Brisbane, Australia, Prof Bala Ventakesh will explore the ADRENAL trial, examining hydrocortisone in septic shock in the biggest sepsis trial ever undertaken. Split between Dublin and Melbourne, Prof Alistair Nichol will explain the findings of the TRANSFUSE trial, comparing transfusion of the freshest available blood with standard issued red cells. From Nantes, France, Dr Jean-Baptiste Lascarrou will consider the findings of the MACMAN trial, evaluating video laryngoscopy in the ICU. Dr Ashish Khanna, from the Cleveland Clinic, USA, will reflect on ATHOS-3, the first large clinical trial examining angiotensin II in septic shock. We also have Prof Andrew Rhodes, from London, exploring the latest iteration of the Surviving Sepsis Campaign, published earlier this year. There are still additional speakers to add to the programme, so the meeting will continue to grow and get better and better.
We sold out #CCR17 and had to turn people away. At present we are way up on registrations compared to the same time-point in 2016. So, if you intend on coming, don't leave it too late to register. There is plenty of space still at present, but I expect the meeting will sell out well before it's date of Friday January 19th. Don't worry if you can't make it, as the talks will be recorded and put online for free viewing as usual. However, there is nothing like being there in person and having the opportunity to chat with these chief investigators. Numbers are strictly limited to ensure this remains a small, intimate meeting. It would be a shame to miss out......
The ANZICS/ACCCN Annual Scientific Meeting, which incorporates the annual Paediatric and Neonatal Intensive Care Conference, will be held at the Gold Coast Convention and Exhibition Centre, 11-13 October 2017. The Annual Scientific Meeting will be the preeminent critical care conference in Australasia for the calendar year and will be an important platform that will allow doctors, nurses and allied health practitioners to meaningfully connect and discuss new developments and research in the field of intensive and critical care.
The theme of the Meeting is “Thinking Outside the Flags” and will focus upon innovative and challenging advances that lie outside the safe zone of current practice, as well as the potential dangers that they may bring. A number of highly regarded international speakers will join our distinguished national and local speakers, experts in the field of intensive care medicine, nursing and allied health, promising delegates an exciting and challenging program.
Registration and the call for abstracts will open on 20 March 2017. For further information or to express your interest in attending, please visit http://intensivecareasm2017.com.au/.
#BMBTL17 is a conference on resuscitation that focuses on the skills and knowledge needed to bring your critically ill patients…back to life !
With cutting edge topics and a world class faculty, the conferences will be packed with clinical pearls and only the stuff that matters !
Ventilation, airway, EKGs, pediatric pearls, ultrasound and so much more…don’t miss this amazing conference ! It will be held on October 16th 2017 in downtown Montreal.
FemInEM.org is excited to bring you our first ever, in person conference, FIX2017! The FemInEM Idea Exchange is all about education, inspiration and motivation. Our world renowned faculty will speak from their hearts and minds, providing the substance and spark for you to change the world. We will meet, greet and motivate each other, pushing the limits of our previous selves. You won't want to miss it - October 4th to 6th, NYC.
State-of-the-Art is back, for the 3rd year of its new format and an all-new venue in Liverpool for 2017. The futurism and innovation theme continues with novel topics including robotics, optical imaging of bacterial infection, new technology in patient recovery, and new device interventions in acute cardiology.
However, the focus on day-to-day care is not lost, and there are clinical updates in acute medicine, ARDS, mechanical ventilation, trauma, nutrition, rehabilitation, endocrine management in ICU, cancer patients in ICU, the difficult and altered airway, and much more. Pragmatic "how I treat..." sessions proved popular last year and will continue, along with meaningful debates on UK critical care, including the trend toward centralisation.
In addition, the trademark vibe of SOA will still be there with pop-up talks, panel debates, 'meet the expert' booths, new generation video e-posters, parent and infant facilities, two drinks evenings, and a new final night after-party. Registration and abstract submission is now open at http://soa.ics.ac.uk.
We are very pleased to announce the 6th International Fluid Academy Days (iFAD), which will take place on November 23-25th 2017 at the Hilton Hotel in Antwerp, Belgium. The iFAD is an innovative Critical Care Educational meeting in true SMACC spirit. This conference provides the highest quality of Critical Care education and is guaranteed to innovate and inspire. Recent advances in fluid management, and hemodynamic and organ function monitoring in the critical care setting will be reviewed in a comprehensive manner for intensivists, anaesthesiologists and emergency physicians as well as interested internists and surgeons.
The iFAD Faculty is the most provocative, engaging, motivating and inspiring group of international educational speakers and as organizing committee we want to ensure we have the participants, sponsors and endorsers to match. Together, we make iFAD stand apart from other Critical Care conferences.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board