Welcome to the 279th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. It's a small newsletter this week, whose highlights are the TRUE-AHF trial, examining ularitide in acute heart failure, an individual patient level meta analysis evaluating tidal volumes used in three large ARDS randomized control trials and an observational study investigating early predictors of poor outcome after out-of-hospital cardiac arrest.
If you missed it last week, registration has opened for #CCR18, on Friday January 19th in Titanic, Belfast. As ever, the aim is to have the chief investigators for the biggest trials of the year discuss their work. Next year's meeting is already shaping up to be another fantastic event. From Brisbane, we have Prof Bala Ventakesh, CI for the largest sepsis study ever performed, the ADRENAL trial, investigating steroids in septic shock. Alistair Nichol, who divides his time between Melbourne and Dublin, will discuss TRANSFUSE, the latest trial examining age of transfused red cells in the critically ill. Jean-Baptiste Lascarrou, from Nantes, will present his MACMAN trial, comparing direct laryngoscopy with video laryngoscopy in the ICU, which is sure to generate much discussion. Several other chief investigators will be added to the programme during the year as further trials either near completion or are published. If you're not sure what the meeting is about, check out either the talks from previous years or the promotional movie. If you want to stay up-to-date with advances in critical care in 2017, this is the meeting for you.
- Full Text: Packer. Effect of Ularitide on Cardiovascular Mortality in Acute Heart Failure (TRUE-AHF). N Engl J Med 2017;epublished April 12th
- Abstract: Vargas. Intermittent noninvasive ventilation after extubation in patients with chronic respiratory disorders: a multicenter randomized controlled trial (VHYPER). Intensive Care Med 2017;epublished April 9th
- Full Text: Hoedemaker. Early Invasive Versus Selective Strategy for Non–ST-Segment Elevation Acute Coronary Syndrome. The ICTUS Trial. JACC 2017;69(15):1883–93
- Abstract: Guinot. Monitoring dynamic arterial elastance as a means of decreasing the duration of norepinephrine treatment in vasoplegic syndrome following cardiac surgery: a prospective, randomized trial. Intensive Care Med 2017;43(5):643-651
- Abstract: Poole. Individual patient data analysis of tidal volumes used in three large randomized control trials involving patients with acute respiratory distress syndrome. Br J Anaesth 2017;118(4):570-575
- Full Text: Wang. The efficacy and safety of tigecycline for the treatment of bloodstream infections: a systematic review and meta-analysis. Annals of Clinical Microbiology and Antimicrobials 2017;16:24
- Abstract: Bhattacharjee. Levosimendan does not provide mortality benefit over dobutamine in adult patients with septic shock: A meta-analysis of randomized controlled trials. J Crit Care 2017;39:67–72
- Abstract: Taccone. Extracorporeal CO2 removal (ECCO2R) in critically ill patients: a systematic review. Minerva Anestesiologica 2017;epublished April 11th
- Abstract: Martinell. Early predictors of poor outcome after out-of-hospital cardiac arrest. Critical Care 2017;21:96
- Abstract: Gustafsson. Apnoeic oxygenation in adults under general anaesthesia using Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) – a physiological study. Br J Anaesth 2017;118(4):610-617
- Abstract: Andrews. Mortality Risk Stratification After Traumatic Brain Injury and Hazard of Death With Titrated Hypothermia in the Eurotherm3235Trial. Crit Care Med 2017;45(5):883–890
- Full Text: Su. Measuring (1,3)-β-D-glucan in tracheal aspirate, bronchoalveolar lavage fluid, and serum for detection of suspected Candida pneumonia in immunocompromised and critically ill patients: a prospective observational study. BMC Infect Dis 2017;17(1):252
- Mypinder. Clinical pathophysiology of hypoxic ischemic brain injury after cardiac arrest: a “two-hit” model. Critical Care 2017;21:90
- Kwak. Postdural puncture headache. Korean J Anesthesiol 2017;70(2):136-143
- Kwon. Intraoperative management of critical arrhythmia. Korean J Anesthesiol 2017;70(2):120-126
- Rehm. State of the art in fluid and volume therapy. Anaesthesist 2017;epublished April 10th
- Tjong. Permanent Leadless Cardiac Pacemaker Therapy. A Comprehensive Review. Circulation 2017;135:1458-1470
- Subramaniam. Prosthesis-patient mismatch - what cardiac anesthesiologists need to know?. Ann Card Anaesth 2017;20:234-42
- Chakravarthy. Modifying risks to improve outcome in cardiac surgery: An anesthesiologist's perspective. Ann Card Anaesth 2017;20:226-33
- Apostolakis. Myocardial revascularization without extracorporeal circulation; Why hasn't it convinced yet?. Ann Card Anaesth 2017;20:219-25
- Amin. Recent insight into potential acute respiratory distress syndrome. Saudi Med J 2017;38(4):344-349
- Mok. Airway Problems in Neonates—A Review of the Current Investigation and Management Strategies. Front Pediatr 2017;5:60
- Hoeper. Pulmonary Hypertension. Dtsch Arztebl Int 2017;114(5):73-84
- Gómez. Nutritional Support of the Critically Ill Pediatric Patient: Foundations and Controversies. Clinical Medicine Insights: Trauma and Intensive Medicine 2017;8:1-7
- Clark. The future of critical care: renal support in 2027. Critical Care 2017;21:92
- Yoshida. Atypical hemolytic uremic syndrome. Renal Replacement Therapy 2017;3:5
- Polat. Sepsis and Septic Shock: Current Treatment Strategies and New Approaches. Eurasian J Med 2017; 49:53-58
- Kroschinsky. New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management. Critical Care 2017;21:89
- Levy. Antibiotics in Sepsis: The New Frontier. Crit Care Med 2017;45(5):907-908
- Stowell. The Decision to Transfuse: One Size Might Not Fit All. Critical Care Med 2017;45(5):908-910
- Marik. Glucocorticosteroids as Adjunctive Therapy for Acute Respiratory Distress Syndrome and Sepsis? Yes, But Not as Monotherapy. Crit Care Med 2017;45(5):910-911
- Komorowski. Will Artificial Intelligence Contribute to Overuse in Healthcare? Crit Care Med 2017;45(5):912–913
- Han. Brain and lung: dangerous crosstalk. Korean J Anesthesiol 2017;70(2):116-117
- Kapoor. Online virtual world of resources and the cardiac anaesthesiologist. Ann Card Anaesth 2017;20:125-6
- Dondorp. What’s wrong in the control of antimicrobial resistance in critically ill patients from low- and middle-income countries? Intensive Care Med 2017;epublished April 13th
- Roberts. What’s new in pharmacokinetics of antimicrobials in AKI and RRT? Intensive Care Med 2017;epublished April 6th
- Lyon. The Lung Microbiome: Key to Respiratory Ills? JAMA 2017;epublished April 12th
- Meduri. Prolonged glucocorticoid treatment in acute respiratory distress syndrome. Lancet 2017;389(10078):1516
- Mac Sweeney. Prolonged glucocorticoid treatment in acute respiratory distress syndrome – Authors' reply. Lancet 2017;389(10078):1516-1517
- Open Access Pre-Print Version: Mac Sweeney. Acute respiratory distress syndrome. Lancet 2016;388:2416–2430
- Kassis. Recruitment maneuvers: using transpulmonary pressure to help Goldilocks. Intensive Care Med 2017;epublished April 6th
- Alter. Feasibility and safety of whole-body vibration therapy in intensive care patients. Critical Care 2017;21:91
There are just 5 months left unit Das SMACC and all tickets have now been sold for the main conference. If you are interested in attending the workshops, there are a very small number of tickets left for the Hardcore Intensive Care workshop being organised by Steve Mathieu and Sarah Yong. With a superb international faculty, this half-day event will address your burning critical care questions.
(Image from Chensiyuan via Wikipedia)
The Critical Care Symposium (CCS) was initiated to satisfy the purpose of creating a world-class environment for medical enrichment in the North of England, particularly in Manchester. It was envisioned as a common informal platform wherein professionals from the field of critical care could provide and enhance the knowledge of delegates on current practices and related fields of interest.
Now in its 14th year, the annual conference regularly has renowned speakers from around the world and attracts more than 400 delegates. And this year is no different. In recent years a parallel course on ultrasound has been conducted alongside the conference that provides ample hand-on experience over two days. This year will host the 7th Ultrasound in Acute Care. For more information please visit http://critcaresymposium.co.uk.
The ANZICS/ACCCN Annual Scientific Meeting, which incorporates the annual Paediatric and Neonatal Intensive Care Conference, will be held at the Gold Coast Convention and Exhibition Centre, 11-13 October 2017. The Annual Scientific Meeting will be the preeminent critical care conference in Australasia for the calendar year and will be an important platform that will allow doctors, nurses and allied health practitioners to meaningfully connect and discuss new developments and research in the field of intensive and critical care.
The theme of the Meeting is “Thinking Outside the Flags” and will focus upon innovative and challenging advances that lie outside the safe zone of current practice, as well as the potential dangers that they may bring. A number of highly regarded international speakers will join our distinguished national and local speakers, experts in the field of intensive care medicine, nursing and allied health, promising delegates an exciting and challenging program.
Registration and the call for abstracts will open on 20 March 2017. For further information or to express your interest in attending, please visit http://intensivecareasm2017.com.au/.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week