Prof Mervyn Singer explains how he manages antibiotics at #CCR17
Welcome to the 276th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. This week's edition is packed full of the major trials presented at Brussels a few days ago, as well as 10 papers from the Annual Update in Intensive Care and Emergency Medicine, seven of which form this week's Topic of the Week, starting with a paper on anemia and blood transfusion in the critically ill patient with cardiovascular disease in tomorrow's Paper of the Day. The 10th talk from #CCR17 was released this morning - Prof Mervyn Singer discusses "How I Manage...Antibiotics". For those interested in attending #CCR18, registration opens in 2 weeks.
While on the conference theme, registration for two other critical care meetings has recently opened, as well as more tickets becoming available for SMACC:
- Joint Meeting of the Intensive Care Society of Ireland / Northern Ireland Intensive Care Society (Belfast, June 9/10)
- Intensive Care Society State-of-the-Art Meeitng (Liverpool, December 4 to 6th)
- SMACC (Berlin, June 26th to 29th)
- Full Text: Landoni. Levosimendan for Hemodynamic Support after Cardiac Surgery (CHEETAH Study). N Engl J Med 2017;epublished March 21st
- Full Text: Leme. Effect of Intensive vs Moderate Alveolar Recruitment Strategies Added to Lung-Protective Ventilation on Postoperative Pulmonary Complications. A Randomized Clinical Trial. JAMA 2017;epublished March 21st
- Full Text: Yu Kawazoe. Effect of Dexmedetomidine on Mortality and Ventilator-Free Days in Patients Requiring Mechanical Ventilation With Sepsis. A Randomized Clinical Trial (DESIRE Trial). JAMA 2017;epublished March 21st
- Full Text: Hess. Safety and efficacy of multipotent adult progenitor cells in acute ischaemic stroke (MASTERS): a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Neurology 2017;epublished March 17th
- Full Text: The PRISM Investigators. Early, Goal-Directed Therapy for Septic Shock — A Patient-Level Meta-Analysis. N Engl J Med 2017;epublished March 21st
- Full Text: Schoenfelder. Effects of continuous and intermittent renal replacement therapies among adult patients with acute kidney injury. GMS Health Technol Assess 2017;epublished March 1st
- Full Text: Feng. The effect of early versus late initiation of renal replacement therapy in patients with acute kidney injury: A meta-analysis with trial sequential analysis of randomized controlled trials. PLoS One 2017;12(3):e0174158
- Full Text: Zimmermann. Systemic Immunomodulating Therapies for Stevens-Johnson Syndrome and Toxic Epidermal NecrolysisA Systematic Review and Meta-analysis. JAMA Dermatol 2017;epublished March 22nd
- Full Text: Vail. Association Between US Norepinephrine Shortage and Mortality Among Patients With Septic Shock. JAMA 2017;epublished March 21st
- Abstract: Konstantinides. Impact of Thrombolytic Therapy on the Long-Term Outcome of Intermediate-Risk Pulmonary Embolism. JACC 2017;69(12):1536-1544
- Abstract: Russell. The Septic Shock 3.0 Definition and Trials: A Vasopressin and Septic Shock Trial Experience. Crit Care Med 2017;epublished March 22nd
- Hummel. Prophylactic levosimendan for the prevention of low cardiac output syndrome and mortality in paediatric patients undergoing surgery for congenital heart disease. Cochrane Database of Systematic Reviews 2017, Issue 3. Art. No.: CD011312
- Menting. Ischaemic preconditioning for the reduction of renal ischaemia reperfusion injury. Cochrane Database of Systematic Reviews 2017, Issue 3. Art. No.: CD010777
- Nelson. Antibiotic treatment for Clostridium difficile-associated diarrhoea in adults. Cochrane Database of Systematic Reviews 2017, Issue 3. Art. No.: CD004610
- Semler. Balanced crystalloids versus saline in the intensive care unit: study protocol for a cluster-randomized, multiple-crossover trial (SMART Trial). Trials 2017;18(1):129
- Le Guen. Frailty Related to Anesthesia guided by the Index “bispectraL” (FRAIL) study: study protocol for a randomized controlled trial. Trials 2017;18:127
- O'Toole. Supplemental Perioperative Oxygen to Reduce Surgical Site Infection After High-Energy Fracture Surgery (OXYGEN Study). Journal of Orthopaedic Trauma 2017;31:S25–S31
- Mahmood. Management strategies for severe aortic stenosis and coronary artery disease in the transcatheter aortic valve implantation era. Continuing Cardiology Education 2017;3(1)
- Brown. Antiplatelet therapy in acute coronary syndrome. Continuing Cardiology Education 2017;3(1):11–21
- Thomas. Ventricular arrhythmias in acute coronary syndromes—mechanisms and management. Continuing Cardiology Education 2017;3(1)22–29
- Brown. A review of the current management of acute and chronic heart failure in the context of ischemic heart disease. Continuing Cardiology Education 2017;3(1)30–36
- Borne. Implantable Cardioverter-Defibrillators for Secondary Prevention of Sudden Cardiac Death: A Review. Journal of the American Heart Association 2017;epublished March 3rd
- Chavez. Editor’s Choice- Inside the cold heart: A review of therapeutic hypothermia cardioprotection. European Heart Journal: Acute Cardiovascular Care 2017;6(2):130–141
- Amat-Santosa. Current and Future Percutaneous Strategies for the Treatment of Acute and Chronic Heart Failure. Rev Esp Cardiol. 2017;epublished March 20th
- Ng. Clinical use of venovenous extracorporeal membrane oxygenation. Hong Kong Med J 2017;epublished March 17th
- Sorrentino. Combined totally mini-invasive approach in necrotizing pancreatitis: a case report and systematic literature review. World Journal of Emergency Surgery 2017;12:16
- Kullak-Ublick. Drug-induced liver injury: recent advances in diagnosis and risk assessment. Gut 2017;epublished March 23rd
- Makris. Acute Kidney Injury: Definition, Pathophysiology and Clinical Phenotypes. Clin Biochem Rev 2016;37(2):85-98
- Makris. Acute Kidney Injury: Diagnostic Approaches and Controversies. Clin Biochem Rev 2016;37(4):153–175
- Hamrahian. Evaluation and management of adrenal insufficiency in critically ill patients. Disease state review. Endocr Pract 2017;epublished March 23rd
- Richards. Focused Assessment with Sonography in Trauma (FAST) in 2017: What Radiologists Can Learn. Radiology 2017;283(1):30-48
- Moeller. Clinical Interpretation of Urine Drug Tests. What Clinicians Need to Know About Urine Drug Screens. Mayo Clin Proc. 2017;epublished March 18thMayo Clin Proc. 2017;epublished March 18th
- Docherty. Anemia and blood transfusion in the critically ill patient with cardiovascular disease. Critical Care 2017;21:61
- Myatra. Use of ‘tidal volume challenge’ to improve the reliability of pulse pressure variation. Critical Care 2017;21:60
- Dzierba. Medicating patients during extracorporeal membrane oxygenation: the evidence is building. Critical Care 2017;21:66
- Jonkman. Novel insights in ICU-acquired respiratory muscle dysfunction: implications for clinical care. Critical Care 2017;21:64
- Tagami. Antiarrhythmic drugs for out-of-hospital cardiac arrest with refractory ventricular fibrillation. Critical Care 2017;21:59
- Cruz. Anti-inflammatory properties of anesthetic agents. Critical Care 2017;21:67
- Heming. Neuroanatomy of sepsis-associated encephalopathy. Critical Care 2017;21:65
- De Jong. Mechanical ventilation in obese ICU patients: from intubation to extubation. Critical Care 2017;21:63
- Hernandez. High-flow nasal cannula support therapy: new insights and improving performance. Critical Care 2017;21:62
- DePorre. Facing the ongoing challenge of the febrile young infant. Critical Care 2017;21:68
- Gerritsen. New developments in the provision of family-centered care in the intensive care unit. Intensive Care Med 2017;43:550
- Nolan. In this patient in refractory cardiac arrest should I continue CPR for longer than 30 min and, if so, how? Intensive Care Med 2016;epublished March 16th
- Halpern. ICU design in 2050: looking into the crystal ball! Intensive Care Med 2017;epublished March 17th
- Gattinoni. Intensive care medicine in 2050: ventilator-induced lung injury. Intensive Care Med 2017;epublished March 22nd
- Bell. Understanding renal recovery. Intensive Care Med 2017;epublished March 23rd
- Pickkers. What’s new in the extracorporeal treatment of sepsis? Intensive Care Med 2017;epublished March 17th
- Heneghan. Why clinical trial outcomes fail to translate into benefits for patients. Trials 2017;18:122
- Kirch. Addressing the Physician Shortage. The Peril of Ignoring Demography. JAMA 2017;epublished March 20th
- Bertagnolli. Advantages of a Truly Open-Access Data-Sharing Model. N Engl J Med 2017;376:1178-1181
- Muller. Kathryn. N Engl J Med 2017;376:1101-1103
- Hill. Breaking the Stigma — A Physician’s Perspective on Self-Care and Recovery. N Engl J Med 2017; 376:1103-1105
- Samet. The Trump Administration and the Environment — Heed the Science. N Engl J Med 2017; 376:1182-1188
There are just 5 months left unit Das SMACC and all tickets have now been sold for the main conference. If you are interested in attending the workshops, there are a very small number of tickets left for the Hardcore Intensive Care workshop being organised by Steve Mathieu and Sarah Yong. With a superb international faculty, this half-day event will address your burning critical care questions.
(Image from Chensiyuan via Wikipedia)
The Critical Care Symposium (CCS) was initiated to satisfy the purpose of creating a world-class environment for medical enrichment in the North of England, particularly in Manchester. It was envisioned as a common informal platform wherein professionals from the field of critical care could provide and enhance the knowledge of delegates on current practices and related fields of interest.
Now in its 14th year, the annual conference regularly has renowned speakers from around the world and attracts more than 400 delegates. And this year is no different. In recent years a parallel course on ultrasound has been conducted alongside the conference that provides ample hand-on experience over two days. This year will host the 7th Ultrasound in Acute Care. For more information please visit http://critcaresymposium.co.uk.
The ANZICS/ACCCN Annual Scientific Meeting, which incorporates the annual Paediatric and Neonatal Intensive Care Conference, will be held at the Gold Coast Convention and Exhibition Centre, 11-13 October 2017. The Annual Scientific Meeting will be the preeminent critical care conference in Australasia for the calendar year and will be an important platform that will allow doctors, nurses and allied health practitioners to meaningfully connect and discuss new developments and research in the field of intensive and critical care.
The theme of the Meeting is “Thinking Outside the Flags” and will focus upon innovative and challenging advances that lie outside the safe zone of current practice, as well as the potential dangers that they may bring. A number of highly regarded international speakers will join our distinguished national and local speakers, experts in the field of intensive care medicine, nursing and allied health, promising delegates an exciting and challenging program.
Registration and the call for abstracts will open on 20 March 2017. For further information or to express your interest in attending, please visit http://intensivecareasm2017.com.au/.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week