Welcome to the 228th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. The highlights of this week's newsletter are the randomised controlled HICORES Trial, guidelines on prevention of ventilator-associated pneumonia, hypothermia-related transfusion complications in trauma and pain, sedation, withdrawal and delirium assessment in critically ill infants and children. If you only have time to read one article this week, try either this paper on Ebola virus disease: the UK critical care perspective or this article on designing phase 3 sepsis trials.
This week's Topic of the Week is from a series in Transfusion, on haemostatic resuscitation in traumatic haemorrhage, starting with a paper on where now for transfusion: the evolution of a paradigm and its logical progression in tomorrow's Paper of the Day.
The inaugural John Hinds Trauma Lecture, delivered by Dr Brian Burns at the Critical Care Reviews Meeting 2016 was released this week and is available below. Registration has opened for #CCR17, so if you want to see the second in this annual series, just sign up for next year's meeting on Friday January 27th at the Titanic Centre in Belfast. The faculty is pretty impressive already. If you want a print copy of the Critical Care Reviews Book 2016, summarising, critiquing and discussing the biggest studies of last year, a small number are still available, at below cost price. The pdf is available as a free download.
The Inaugural John Hinds Trauma Lecture
Dr Brian Burns (Sydney): Trauma Care - Back to the Future
- Abstract: Park. High-Dose Versus Conventional-Dose Continuous Venovenous Hemodiafiltration and Patient and Kidney Survival and Cytokine Removal in Sepsis-Associated Acute Kidney Injury: A Randomized Controlled Trial (HICORES Trial). Am J Kidney Dis 2016;epublished April 12th
- Abstract: Beygui. Early Aldosterone Blockade in Acute Myocardial Infarction. The ALBATROSS Randomized Clinical Trial. J Am Coll Cardiol 2016;67(16):1917-1927
- Abstract: Kim. Video laryngoscopy vs. direct laryngoscopy: which should be chosen for endotracheal intubation during cardiopulmonary resuscitation?: A prospective randomized controlled study of experienced intubators. Resuscitation 2016;epublished April 16th
- Full Text: Crossingham. Comparing cardiac output monitors and defining agreement: A systematic review and meta-analysis. JICS 2016;epublished April 20th
- Full Text: Spreadborough. A systematic review and meta-analysis of perioperative oral decontamination in patients undergoing major elective surgery. Perioperative Medicine 2016;5:6
- Full Text: Hu. Protection of remote ischemic preconditioning against acute kidney injury: a systematic review and meta-analysis. Critical Care 2016;20:111
- Full Text: Glas. Nebulized heparin for patients under mechanical ventilation: an individual patient data meta-analysis. Ann Intensive Care 2016;6(1):33
- Abstract: Cherpanath. Predicting Fluid Responsiveness by Passive Leg Raising: A Systematic Review and Meta-Analysis of 23 Clinical Trials. Crit Care Med 2016;44(5):981–991
- Abstract: Goyal. Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet 2016;387(10029):1723–1731
- Abstract: Scolletta. Comparison Between Doppler-Echocardiography and Uncalibrated Pulse Contour Method for Cardiac Output Measurement: A Multicenter Observational Study. Crit Care Med 2016;epublished April 19th
- Abstract: Berning. A Novel Picture Guide to Improve Spiritual Care and Reduce Anxiety in Mechanically Ventilated Intensive Care Unit Adults. Annals ATS 2016;epublished April 20th
- Abstract: Costantini. Current management of hemorrhage from severe pelvic fractures: Results of an American Association for the Surgery of Trauma multi-institutional trial. Journal of Trauma and Acute Care Surgery 2016;80(5):717–725
- Abstract: Parnia. Cerebral Oximetry During Cardiac Arrest: A Multicenter Study of Neurologic Outcomes and Survival. Crit Care Med 2016;epublished April 11th
- Abstract: Acharya. Ventricular Assist Device in Acute Myocardial Infarction. J Am Coll Cardiol 2016;67(16):1871-1880
- Full Text: Westhall. Standardized EEG interpretation accurately predicts prognosis after cardiac arrest. Neurology 2016;86:1482-1490
- Abstract: Rudinská. Intra-thoracic injuries associated with cardiopulmonary resuscitation – Frequent and serious. Resuscitation 2016;epublished April 16th
- Abstract: Morelli. Heart rate reduction with esmolol is associated with improved arterial elastance in patients with septic shock: a prospective observational study. Intensive Care Med 2016;epublished April 21st
- Abstract: Paul. Delayed awakening after cardiac arrest: prevalence and risk factors in the Parisian registry. Intensive Care Med 2016;epublished April 20th
- Abstract: Peñuelas . Prediction and Outcome of Intensive Care Unit-Acquired Paresis. J Intensive Care Med 2016;epublished April 13th
- Vincent. Comfort and patient-centred care without excessive sedation: the eCASH concept. Intensive Care Med 2016;epublished April 13th
- Duncan. Neurological complications in obstetric regional anesthetic practice. J Obstet Anaesth Crit Care 2016;6:3-10
- Ñáñez-Varona. Restoring microcirculation in anesthesia: Impact, usefulness and controversies. Rev Colomb Anestesiol 2016;epublished April 3rd
- Rostagno. Aortic Stenosis and Non-Cardiac Surgery. Journal of Cardiology and Therapy 2016;3(2):508-512
- van Heerebeek. Understanding heart failure with preserved ejection fraction: where are we today? Netherlands Heart Journal 2016;24(4):227-236
- Meijers. Biomarkers in heart failure with preserved ejection fraction. Netherlands Heart Journal 2016;24(4):252-258
- Schellekens. Strategies to optimize respiratory muscle function in ICU patients. Critical Care 2016;20:103
- Bassetti. Characteristics of an ideal nebulized antibiotic for the treatment of pneumonia in the intubated patient. Annals of Intensive Care 2016;6:35
- Kokosi. Rare idiopathic interstitial pneumonias: LIP and PPFE and rare histologic patterns of interstitial pneumonias: AFOP and BPIP. Respirology 2016;21:600–614
- Yoshida. Findings from two large randomized controlled trials on renal replacement therapy in acute kidney injury. Renal Replacement Therapy 2016;2:13
- Martin. Ebola virus disease: the UK critical care perspective. Br J Anaesth 2016;116(5):590-596
- Gonzalez-Ruiz. Daptomycin: an evidence-based review of its role in the treatment of Gram-positive infections. Infection and Drug Resistance 2016;9:47-58
- Sônego. Paradoxical roles of the neutrophil in sepsis: protective and deleterious. Front Immunol 2016;7:155
- Peeling. Reimagining the Future of the Diagnosis of Viral Infections. J Infect Dis 2016;epublished March 16th
Series on Traumatic Haemorrhage from Transfusion
- Moore. Rationale for the selective administration of tranexamic acid to inhibit fibrinolysis in the severely injured patient. Transfusion 2016;56:S110–S114
- Roberts. Fibrinolytic shutdown: fascinating theory but randomized controlled trial data are needed. Transfusion 2016;56:S115–S118
- Doughty. A proposed field emergency donor panel questionnaire and triage tool. Transfusion 2016;56:S119–S127
- Pusateri. Dried plasma: state of the science and recent developments. Transfusion 2016;56:S128–S139
- Milford. Comprehensive review of platelet storage methods for use in the treatment of active hemorrhage. Transfusion 2016;56:S140–S148
- Yonge. The pragmatic randomized optimal platelet and plasma ratios trial: what does it mean for remote damage control resuscitation?. Transfusion 2016;56:S149–S156
- Maegele. Coagulation factor concentrate-based therapy for remote damage control resuscitation (RDCR): a reasonable alternative?. Transfusion 2016;56:S157–S165
- Bjerkvig. “Blood failure” time to view blood as an organ: how oxygen debt contributes to blood failure and its implications for remote damage control resuscitation. Transfusion 2016;56:S182–S189
- Spinella. Whole blood for hemostatic resuscitation of major bleeding. Transfusion 2016;56:S190–S202
- Rappold. Surgical adjuncts to noncompressible torso hemorrhage as tools for patient blood management. Transfusion 2016;56:S203–S207
- Doughty. Mass casualty events: blood transfusion emergency preparedness across the continuum of care. Transfusion 2016;56:S208–S216
- Stubbs. The state of the science of whole blood: lessons learned at Mayo Clinic. Transfusion 2016;56:S173–S181
- Woolley. NATO Blood Panel perspectives on changes to military prehospital resuscitation policies: current and future practice. Transfusion 2016;56:S217–S223
- Farrugia. Where now for transfusion: the evolution of a paradigm and its logical progression. Transfusion 2016;56:S224–S232
- Hellyer. The Intensive Care Society recommended bundle of interventions for the prevention of ventilator-associated pneumonia. JICS 2016;epublished April 20th
- Perlman. A recommended early goal-directed management guideline for the prevention of hypothermia-related transfusion, morbidity, and mortality in severely injured trauma patients. Crit Care 2016;20(1):107
- Harris. Clinical recommendations for pain, sedation, withdrawal and delirium assessment in critically ill infants and children: an ESPNIC position statement for healthcare professionals. Intensive Care Med 2016;epublished April 15th
- Barlam. Implementing an Antibiotic Stewardship Program: Guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. Clin Infect Dis 2016;epublished April 13th
- Dimopoulos. In 2035, will all bacteria be multiresistant? Yes. Intensive Care Med 2016;epublished April 18th
- Laupland. In 2035, will all bacteria be multidrug resistant? We are not sure. Intensive Care Med 2016;epublished April 18th
- Barbier. In 2035, will all bacteria be multidrug-resistant? No. Intensive Care Med 2016;epublished April 18th
- Blot. Evidence in the eye of the beholder: about probiotics and VAP prevention. Intensive Care Med 2016;epublished April 20th
- Stapleton. Does increased ICU strain prompt clinicians to communicate with families about end-of-life issues earlier? Intensive Care Med 2016;epublished April 13th
- Muslem. Kinking, thrombosis and need for re-operation in a patient with a left ventricular assist device. Intensive Care Med 2016;epublished April 7th
- Weigel. Fatal calyceal-venous fistula. Intensive Care Med 2016;epublished April 15th
- Marjanovic. Esophagogastric Bypass in Motion. N Engl J Med 2016;374:e20
The Irish Critical Care-Clinical Trials Group (ICC-CTG) host a two hour meeting in conjunction with the Intensive Care Society of Ireland Annual Meeting in the AVIVA Stadium on Saturday June 11th and two Clinical Research Foundation Workshops on Sunday June 12th & Monday June 13th. A distinguished international panel of guests will be present to demonstrate how a CTG functions and what each unit needs to know. In addition, this meeting provides the opportunity to network and keep up to speed with the ICC-CTG's current and future trials portfolio.
A networking dinner will be hosted on Monday 13th June in Sophie's Restaurant at The Dean Hotel. These meetings will be immediately before SMACC Dub and may also be of interest to those visiting Dublin. The registration fee is €50 and includes lunch & refreshments throughout the day. Book before 1st May to avail of the Early Bird option of €30 (limited availability).
Please contact Louise at email@example.com to register for the meeting and meal.
The Summer Scientific Meeting of the Intensive Care Society is on Saturday June 11th at the Aviva Stadium, the home of Irish Rugby and Soccer. The theme is toxicology and features several of the SMACC faculty who will be in town that weekend. Registration hasn't yet opened, but the meeting programme is available here.
The 13th Annual Critical Care Symposium is on April 28th and 29th in Manchester Town Hall, England. This meeting aims to bring together world renowned speakers for a conference outside London and to provide a conducive environment allowing informal discussion. Most importantly, this event provides good quality education covering various topics in Intensive Care at an affordable price.
The 9th UK Critical Care Research Forum is being held on 23rd – 24th June 2016 at the Sage Gateshead, with over 20 research proposals as well as sessions on adaptive trial design, international collaborations in critical care trials and patient-centred research. There is also a Forum dinner at the Baltic Centre for Contemporary Art. Registration is now open.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week