Newsletter 202 | October 25th 2015
Welcome to the 202nd Critical Care Reviews Newsletter, bringing you the best critical care research published in the past week, plus a wide range of free full text review articles, guidelines, commentaries, editorials, study critiques, correspondence and case reports from hundreds of clinical and scientific journals.
The highlights of this week's newsletter are randomized controlled trials on combined ECCO2R and RRT for ARDS with AKI and fever control in traumatic brain injury; observational studies on fluid balance in acute kidney injury and the prognostic significance of bradycardia in survivors of out-of-hospital cardiac arrest; guidelines on PCI for STEMI, infective endocarditis and post-cardiac arrest care; commentaries on the care of migrants; a very public rebuke from the editor-in-chief of the BMJ to the British Secretary of State for Health for the continued deliberate misuse of observational data for political gain, plus review articles on decompressive craniectomy, hypervolaemia and fluid resuscitation in burns.
If you only have time for one paper this week, try this one from my colleagues in the Royal Victoria Hospital in Belfast, proposing a potential role for aspirin in the management of ARDS and providing the rationale for the phase II randomized controlled STAR study.
This week's Topic of the Week is Pelvic Trauma, starting with a paper on angioembolization in tomorrow's Paper of the Day.
SMACC DUBLIN
If you haven't yet heard, registration for SMACC Dublin opens in just two days time. The exact countdown is available on the SMACC website, but as a guide, registration opens at 21:00 Irish time on Tuesday night.
Research
- Full Text: Allardet-Servent. Safety and Efficacy of Combined Extracorporeal CO2 Removal and Renal Replacement Therapy in Patients With Acute Respiratory Distress Syndrome and Acute Kidney Injury: The Pulmonary and Renal Support in Acute Respiratory Distress Syndrome Study. Critical Care Med 2015;epublished October 20th
- Full Text: Garner. The Head Injury Retrieval Trial (HIRT): a single-centre randomised controlled trial of physician prehospital management of severe blunt head injury compared with management by paramedics only. Emerg Med J 2015;32:869-875
- Abstract: Kuan. Emergency Department Management of Sepsis Patients: A Randomized, Goal-Oriented, Noninvasive Sepsis Trial. Annals of Emergency Medicine 2015;epublished October 13th
- Abstract: Toru. Fever Control Management Is Preferable to Mild Therapeutic Hypothermia in Traumatic Brain Injury Patients with Abbreviated Injury Scale 3–4: A Multi-Center, Randomized Controlled Trial (B-HYPO Study) Group in Japan. Journal of Neurotrauma 2015;epublished October 20th
- Full Text: Kubica. Morphine delays and attenuates ticagrelor exposure and action in patients with myocardial infarction: the randomized, double-blind, placebo-controlled IMPRESSION trial. Eur Heart J 2015;epublished October 21st
- Abstract: Wan. Efficacy and Safety of Corticosteroids for Community-Acquired Pneumonia: A Systematic Review and Meta-Analysis. Chest 2015;epublished October 22nd
- Full Text: Zeng. Progesterone for Acute Traumatic Brain Injury: A Systematic Review of Randomized Controlled Trials. PLoS ONE 10(10): e0140624
- Full Text: Hole. Music as an aid for postoperative recovery in adults: a systematic review and meta-analysis. Lancet 2015;386(10004)1659-1671Lancet 2015;386(10004)1659-1671
- Abstract: Bai. Citrate versus heparin anticoagulation for continuous renal replacement therapy: an updated meta-analysis of RCTs. Intensive Care Med 2015;epublished October 19th
- Full Text: Wang. Fluid balance and mortality in critically ill patients with acute kidney injury: a multicenter prospective epidemiological study. Critical Care 2015;19:371
- Abstract: Thomsen. Bradycardia During Targeted Temperature Management: An Early Marker of Lower Mortality and Favorable Neurologic Outcome in Comatose Out-of-Hospital Cardiac Arrest Patients. Crit Care Med 2015;epublished October 14th
- Abstract: Klompas. Associations between different sedatives and ventilator-associated events, length-of-stay, and mortality in mechanically ventilated patients. Chest 2015;epublished October 22nd
- Full Text: Mao. Decompressive craniectomy for severe traumatic brain injury patients with fixed dilated pupils. Therapeutics and Clinical Risk Management 2015;11:1627-1633
- Full Text: Sawhney. Acute kidney injury—how does automated detection perform? Nephrol Dial Transplant 2015;30:1853-1861
- Full Text: Yergens. Assessing the association between occupancy and outcome in critically Ill hospitalized patients with sepsis. BMC Emergency Medicine 2015;15:31
- Full Text Le Bel. Diagnostic accuracy of C-reactive protein and procalcitonin in suspected community-acquired pneumonia adults visiting emergency department and having a systematic thoracic CT scan. Critical Care 2015;19:366
- Abstract: Campbell. Validation and analysis of prognostic scoring systems for critically ill patients with cirrhosis admitted to ICU. Critical Care 2015;19:364
- Abstract: Lei. Glial fibrillary acidic protein as a biomarker in severe traumatic brain injury patients: a prospective cohort study. Critical Care 2015;19:362
- Abstract: Beitler. Volume Delivered During Recruitment Maneuver Predicts Lung Stress in Acute Respiratory Distress Syndrome. Crit Care Med 2015;epublished October 15th
- Abstract: Kangelaris. Timing of Intubation and Clinical Outcomes in Adults With Acute Respiratory Distress Syndrome. Crit Care Med 2015;epublished October 15th
- Abstract: Costa. The Association Between Daytime Intensivist Physician Staffing and Mortality in the Context of Other ICU Organizational Practices: A Multicenter Cohort Study. Critical Care Med 2015;43(11):2275–2282
Review Articles
Neurological
- Mezue. Decompressive craniectomy in the management of traumatic brain injury: a review of current practice. Open Access Surgery 2015;8:73-83
- Pani. Reversal agents in anaesthesia and critical care. Indian J Anaesth 2015;59:664-9
- Chang. Ether in the developing world: rethinking an abandoned agent. BMC Anesthesiology 2015;15:149
- Georgiou. The Impact of Pain Assessment on Critically Ill Patients’ Outcomes: A Systematic Review. BioMed Research International 2015;2015:503830
Circulatory
- Hahn. Must hypervolaemia be avoided? A critique of the evidence. Anaesthesiology Intensive Therapy 2015;47(5):XXX–XXX
- Peeters. An overview on fluid resuscitation and resuscitation endpoints in burns: Past, present and future. Part 1 — historical background, resuscitation fluid and adjunctive treatment. Anaesthesiology Intensive Therapy 2015;47(5):XXX–XXX
- Peeters. An overview on fluid resuscitation and resuscitation endpoints in burns: Past, present and future. Part 2 — avoiding complications by using the right endpoints with a new personalized protocolized approach. Anaesthesiology Intensive Therapy 2015;47(5):XXX–XXX
- Chia. A practical approach to perioperative management of cardiac implantable electronic devices. Singapore Med J 2015; 56(10): 538-541
- Silva. Acute management of unstable angina and non-ST segment elevation myocardial infarction. Einstein (São Paulo) 2015;13(3):454-461
Respiratory
- Toner. Aspirin as a potential treatment in sepsis or acute respiratory distress syndrome. Critical Care 2015;19:374
- Boey. Electrocardiographic findings in pulmonary embolism. Singapore Med J 2015;56(10):533-537
- Fitzgerald. Techniques for single lung ventilation in infants and children. Anaesthesia Tutorial of the Week 322;epublished October 23rd
Nutrition
Hepatobiliary
- Russ. Acute Kidney Injury in Patients with Cirrhosis. Journal of Clinical and Translational Hepatology 2015;3:195–2042015;3:195–204
- Sabol. Thrombotic Venous Diseases of the Liver. Journal of Clinical and Translational Hepatology 2015;3:189-194
- Khouryx. Drug Induced Liver Injury: Review with a Focus on Genetic Factors, Tissue Diagnosis, and Treatment Options. Journal of Clinical and Translational Hepatology 2015;2:99-108
- Dugum. Diagnosis and Management of Alcoholic Liver Disease. Journal of Clinical and Translational Hepatology 2015;2:109-116
- Montgomery. Acute Hepatic Porphyria. Journal of Clinical and Translational Hepatology 2015;1:17-26
- Liberal. Update on Autoimmune Hepatitis. Journal of Clinical and Translational Hepatology 2015;1:42-52
- Moy. An Update to Hepatobiliary Stents. Journal of Clinical and Translational Hepatology 2015;1:67-77
- Zhang. The management of perioperative nutrition in patients with end stage liver disease undergoing liver transplantation. Hepatobiliary Surg Nutr 2015;4(5):336-344
Renal
- Kellum. Can decision support systems work for acute kidney injury? Nephrol Dial Transplant 2015;30:1786-1789
- Oliveira. Dengue-associated acute kidney injury. Clin Kidney J 2015;epublished October 16th
Haematological
- Arora. New Anticoagulants and Emerging Trends in Regional Anesthesia. Anesthesiology News 2015;41:105
- Fragasso. Oral direct thrombin inhibition: a double-edged sword? Heart, Lung and Vessels 2015;7(3):191-197
Sepsis
- Miceli. Isavuconazole: A New Broad-Spectrum Triazole Antifungal Agent. Clin Infect Dis 2015;61:1558-1565
- Verweij. Azole resistance in Aspergillus fumigatus: can we retain the clinical use of mold-active antifungal azoles? Clin Infect Dis 2015;epublished October 20th
Trauma
- Trueger. The Altmetric Score: A New Measure for Article-Level Dissemination and Impact. Ann Intern Med 2015;66(5):549-553
- Bullock. Technology in postgraduate medical education: a dynamic influence on learning? Postgrad Med J 2015;91:646-650
- Bhaskar. Innovative studies, eloquent peer reviewing and cultured editing: Academic desires and tangible dreams of an editor. Indian J Anaesth 2015;59:627-9
Guidelines
- 2015 ACC/AHA/SCAI Focused Update on Primary Percutaneous Coronary Intervention for Patients With ST-Elevation Myocardial Infarction: An Update of the 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention and the 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction. Circulation 2015;epublished October 21st
- Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications. A Scientific Statement for Healthcare Professionals From the American Heart Association. Circulation 2015;132:00-00
- Nolan. European Resuscitation Council and European Society of Intensive Care Medicine 2015 guidelines for post-resuscitation care. Intensive Care Med 2015;epublished October 13th
- Pereira. WSES position paper on vascular emergency surgery. World Journal of Emergency Surgery 2015;10:49
Editorials
- Skrobik. Chasing the elusive notion of delirium causality. Intensive Care Med 2015;epublished October 16th
- Torres. Hospitalized patients at risk of dying: an Intensive Care Medicine call for papers. Intensive Care Med 2015;epublished October 22nd
- Marini. Does high-pressure, high-frequency oscillation shake the foundations of lung protection? Intensive Care Med 2015;epublished October 23rd
Commentaries
- Gostin. Forced Migration: The Human Face of a Health Crisis. JAMA 2015;epublished October 22nd
- Poulakou. Critically ill migrants with infection: diagnostic considerations for intensive care physicians in Europe. Intensive Care Med 2015;epublished October 13th
- Tsiodras. Irregular migrants: a critical care or a public health emergency. Intensive Care Med 2015;epublished October 14th
- Ding. Apparently Recovering Breath Function in Brain Death. Chin Med J 2015;128:2969-71
- Owyang. Are Balanced Crystalloids the Preferred Resuscitation Fluid for Severe Sepsis and Septic Shock? Ann Intern Med 2015;66(5):523–525
- Milliner. Are Steroids Effective for Severe Chronic Obstructive Pulmonary Disease Requiring Intensive Care? Ann Emerg Med 2015;66(5):544-545
- West. Can Computed Tomography–Assessed Right-Sided Ventricular Dysfunction Predict Mortality in Hemodynamically Stable Pulmonary Embolism? Ann Emerg Med 2015;66(5):546-548
Meetings
Due to hugely successful previous events, the Critical Care Reviews Meeting 2016 has been moved to a brand new venue, the stunning, multi-million pound Titanic Centre, birthplace of RMS Titanic, As before, the meeting theme is to review the biggest studies of the previous year, with chief investigators present where possible to discuss their work in person. From Wellington, New Zealand, Dr Paul Young will talk on his studies SPLIT (saline versus plasmalyte) and HEAT (paracetamol for pyrexia control). Dr John Holcomb (Houston, USA) will review his mega trial PROPPR, evaluating blood product transfusion ratios in traumatic haemorrhage. Dr Anthony Gordon (London, England), will review his VANISH study, a multi-centre randomized controlled trial comparing vasopressin with noradrenaline, with or without hydrocortisone, for first-line vasopressor support in septic shock. Prof Tim Walsh (Edinburgh, Scotland) will review the ABLE study, including his ABLE UK component, evaluating age of transfused red cells, as well as RECOVER, a post-ICU rehab study. In addition, two of the most eminent intensivists in global critical care, Prof Jean-Louis Vincent (Brussels, Belgium) and Prof Luciano Gattinoni (Milan, Italy) will be on hand to discuss the significance of these findings. A new feature for the meeting is the John Hinds' Trauma Lecture, with Dr Brian Burns (Sydney HEMS, Australia) travelling across the world to deliver the inaugural presentation. It won't be all study discussion, with other elements to the meeting, including the spectacularly popular "Informal Chat", taking place that evening.
If you haven't yet attended this modern, niche meeting, then put the date Friday January 29th in your diary. Both delegate and speaker feedback from previous meetings has been incredibly positive, allowing the event to grow and attract some of the biggest names in critical care. The Titanic Centre is just minutes from Belfast City Airport, with a hotel within 3 minutes walking distance, and is a 20 minute walk from the city centre, including the Cathedral Quarter, Belfast's cultural centre full of great restaurants and pubs. Further details regarding delegate rate accommodation should be available in the next week or two. Talks are given in the setting of the rebuilt famous staircase from the great ship, while both the "Informal Chat" session and dinner overlook the floodlit slipways where Titanic and Olympic were launched. With some exciting new innovations planned, this new meeting promises to delivery on its burgeoning reputation. The finalised programme won't be released until later this Autumn, but don't wait too long before registering, as numbers are capped to keep this an intimate event. It is as strong a one day programme as you could possibly find. If you think your colleagues would find this event interesting, please circulate this information - this is a not-for-profit event, run in association with the Northern Ireland Intensive Care Society.
The next SMACC Conference is on June 13th to 16th, in Dublin, Ireland. Registration opens at 21:00 October 27th Irish time and early registration is highly advised, as the event could book out within 24 hours. With its informal manner and flat hierarchy, this event delivers on its promise to provide top class critical care education in a fun, modern way. Speakers are deliberately chosen for their ability to present and convey information, rather than their academic or social media status, marking this as the field leader in medical conferencing. On a related note, the first presentations from SMACC Chicago are now online also at Intensive Care Network.
This year's State-of-the-Art Meeting promises an exciting programme in a new dynamic format. It aims to be the first major national society to fully embrace social media and free open access medical education, with an opening plenary session and a workshop, as well full integration of Twitter questions into sessions, live blogging, and open-access AV materials.
Take a look at the website or the flyer. The meeting is at London ExCeL, 20 minutes from the West End.
CCH Journal
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Rob