Newsletter 199 | October 4th 2015
Welcome to the 199th Critical Care Reviews Newsletter, bringing you the best critical care research published in the past week, plus a wide range of free full text review articles, guidelines, commentaries, editorials, study critiques, correspondence and case reports from hundreds of clinical and scientific journals.
The highlights of this week's newsletter are randomized controlled trials on apnoeic oxygenation, initiation of renal replacement therapy and fever control in traumatic brain injury, as well as review articles on echo in patients receiving ECMO, renal failure in cirrhosis, therapeutic hypothermia and emergency department thoracotomy. The first newsletter of the month contains recently made open access articles from the major critical care journals, with 32 papers included.
In the run up to the presentation and publication of the SPLIT, HEAT and VANISH trials at ESICM this week, each study will be the focus of the Topic of the Week over the next few weeks. All three studies are being discussed by their chief investigators at the Critical Care Reviews Meeting 2016, so it's a perfect time to look at these issues in greater detail. After looking at the SPLIT trial last week, tomorrow we turn to Anthony Gordon's VANISH trial, with the role of vasopressin and steroids in septic shock being the Topic of the Week, starting with a paper on endocrine dysfunction in sepsis in tomorrow's Paper of the Day.
Research
- Abstract: Semler. Randomized Trial of Apneic Oxygenation during Endotracheal Intubation of the Critically Ill (FELLOW Trial). Am J Respir Crit Care Med 2015 epublished October 1st
- Full Text: Wald. Comparison of standard and accelerated initiation of renal replacement therapy in acute kidney injury. Kidney Int 2015;88:897-904
- Abstract: Hifumi. Fever control management is preferable to mild therapeutic hypothermia in traumatic brain injury patients with Abbreviated Injury Scale 3-4: a multicenter, randomised controlled trial. J Neurotrauma 2015;September 28th
- Abstract: Gibelin. Acute respiratory distress syndrome mimickers lacking common risk factors of the Berlin definition. Intensive Care Med 2015;epublished September 25th
- Full Text: Slowinski. Safety and efficacy of regional citrate anticoagulation in continuous venovenous hemodialysis in the presence of liver failure: the Liver Citrate Anticoagulation Threshold (L-CAT) observational study. Critical Care 2015;19:349
- Abstract: Scicluna. A Molecular Biomarker to Diagnose Community-acquired Pneumonia on Intensive Care Unit Admission. Am J Respir Crit Care Med 2015;192(7):826-835
- Abstract: Helmerhorst. Associations of arterial carbon dioxide and arterial oxygen concentrations with hospital mortality after resuscitation from cardiac arrest. Critical Care 2015;19:348
- Abstract: Abdul-Aziz. Is prolonged infusion of piperacillin/tazobactam and meropenem in critically ill patients associated with improved pharmacokinetic/pharmacodynamic and patient outcomes? An observation from the Defining Antibiotic Levels in Intensive care unit patients (DALI) cohort. J Antimicrob Chemother 2015;epublished October 3rd
- Abstract: Roger. Impact of 30 mg/kg amikacin and 8 mg/kg gentamicin on serum concentrations in critically ill patients with severe sepsis. J Antimicrob Chemother 2015;epublished October 1st
- Abstract: Raghunathan. Association between Initial Fluid Choice and Subsequent In-hospital Mortality during the Resuscitation of Adults with Septic Shock. Anesthesiology 2015;epublished September 28th
- Abstract: Delbove. Impact of endotracheal intubation on septic shock outcome: A post hoc analysis of the SEPSISPAM trial. J Crit Care 2015;epublished September 1st
- Full Text: Ong. Cytomegalovirus reactivation and mortality in patients with acute respiratory distress syndrome. Intensive Care Med 2015;epublished September 28th
New
- Balain. Antimicrobial-impregnated central venous catheters for prevention of catheter-related bloodstream infection in newborn infants. Cochrane Database of Systematic Reviews 2015, Issue 9. Art. No.: CD011078
- Torres. Non-invasive positive pressure ventilation for prevention of complications after pulmonary resection in lung cancer patients. Cochrane Database of Systematic Reviews 2015, Issue 9. Art. No.: CD010355
Updated
Review Articles
Neurological
- Palaniswami. Mechanical Thrombectomy Is Now the Gold Standard for Acute Ischemic Stroke: Implications for Routine Clinical Practice. Intervent Neurol 2015;4:18-29
- Gao. Endovascular Treatment for Acute Ischemic Stroke: Updates and Future Implications. Intervent Neurol 2015;4:43-47
- Vallerand. Pain management strategies and lessons from the military: A narrative review. Pain Res Manag 2015;20(5):261-268
Circulatory
- Douflé. Echocardiography for adult patients supported with extracorporeal membrane oxygenation. Critical Care 2015;19:326
- Vamecq. Opioid Facilitation of β-Adrenergic Blockade: A New Pharmacological Condition? Pharmaceuticals 2015;8(4):664-674
Respiratory
- Perrin. Overcoming Barriers to Palliative Care Consultation. Crit Care Nurse 2015;35:44-52
- Walker. Tackling emerging infections: clinical and public health lessons from the West African Ebola virus disease outbreak, 2014–2015. Clin Med 2015;15:457-460
- Disayabutr. Interstitial lung diseases in the hospitalized patient. BMC Med 2015;13(1):245
Gastrointestinal
- Hossain. Acute oesophageal symptoms. Clin Med 2015;15:477-481
- Kurien. Acute upper gastrointestinal bleeding. Clin Med 2015;15:481-485
Hepatobiliary
- Blackmore. Acute liver failure. Clin Med 2015;15:468-472
- Milan. Analgesia after liver transplantation. World J Hepatol 2015;7(21):2331-2335
- Chen. Neurosurgical procedures in patients with liver cirrhosis: A review. World J Hepatol 2015;7(21):2352-7
Renal
Endocrine
Metabolic
- Mathiesen. Caring for Patients Treated With Therapeutic Hypothermia. Crit Care Nurse 2015;35:e1-e12
- Hunter. Targeted temperature management in emergency medicine: current perspectives. Open Access Emergency Medicine 2015;7:69—77
Sepsis
- Maurya. Hypoxic-Ischemic brain injury in an adult: Magnetic Resonance Imaging findings. Medical Journal Armed Forces India 2015;epublished September 24th
- Grobusch. Ebola virus disease: Basics the medical specialist should know. Neth J Crit Care 2015;22(4):6-14
Trauma
- Scott. Penetrating Injuries to the Lung and Heart: Resuscitation, Diagnosis, and Operative Indications. Curr Trauma Rep 2015;epublished September 23rd
- Codner. Emergency Department Thoracotomy: an Update. Curr Trauma Rep 2015;epublished September 22nd
- Bruns. Early and Persistent Hemothorax and Pneumothorax. Curr Trauma Rep 2015;epublished September 19th
Toxicology
Miscellaneous
American Journal of Respiratory & Critical Care Medicine
Review Articles
Guidelines & Position Statements
Chest
Review Articles
- Hurley. Ventilator-Associated Pneumonia Prevention Methods Using Topical Antibiotics: Herd Protection or Herd Peril? Chest 2014;146(4):890-898
- Miller. Brain Death and Islam: The Interface of Religion, Culture, History, Law, and Modern Medicine. Chest 2014;146(4):1092-1101Chest 2014;146(4):1092-1101
- Beitler. Preventing ARDS: Progress, Promise, and Pitfalls. Chest 2014;146(4):1102-1113
- Nikitovic. Anthracycline-Dependent Cardiotoxicity and Extracellular Matrix Remodeling. Chest 2014;146(4):1123-1130
Editorials
- Kollef. Ventilator-Associated Pneumonia Prevention: We Still Have a Long Way to Go! Chest 2014;146(4):873-874
- Sandrock. Care of the Critically Ill and Injured During Pandemics and Disasters: Groundbreaking Results from the Task Force on Mass Critical Care. Chest 2014;146(4):881-883
Case Reports
- Gores. Survival Following Investigational Treatment of Amanita Mushroom Poisoning: Thistle or Shamrock? Chest 2014;146(4):e126-e129
- Albores. A 40-Year-Old Woman With Multilobar Nodular Densities and Massive Hemoptysis. Chest 2014;146(4):e134-e137
Anesthesiology
Review Articles
- Grottke. Prothrombin Complex Concentrates in Trauma and Perioperative Bleeding. Anesthesiology 2015;122:923-931
- Lumb. Hypoxic Pulmonary Vasoconstriction: Physiology and Anesthetic Implications. Anesthesiology 2015;122:932-946
Editorials
- Wiener-Kronish. New Investigations of Core Competencies: Perioperative Mechanical Ventilation and Assessment of Lung Function. Anesthesiology 2015;122:723-724
- Brummet. Flipping the Paradigm: From Surgery-specific to Patient-driven Perioperative Analgesic. Anesthesiology 2015;122:731-733
Commentaries
- Wanderer. Unconventional Ventilation: High Frequency Oscillatory Ventillation & Adaptive Support. Anesthesiology 2015;122:A23Anesthesiology 2015;122:A23
- Barbara. Images in Anesthesiology: Bedside Lung Ultrasonography: A Tool for Rapid Assessment of Pneumothorax. Anesthesiology 2015;122:921Anesthesiology 2015;122:921
- Sáez. Patient–Ventilator Asynchrony during Anesthesia. Anesthesiology 2015;122:922
Anesthesia Analgesia
Review Articles
- Barbeito. The Society of Cardiovascular Anesthesiologists’ Initiative to Improve Quality and Safety in the Cardiovascular Operating Room. Anesth Analg 2014;119(4):777-783
- Klein. Controversies and Complications in the Perioperative Management of Transcatheter Aortic Valve Replacement. Anesth Analg 2014;119(4):784-798
British Journal of Anaesthesiology
Editorials
- Absalom. NAP5: the tip of the iceberg, or all we need to know? Br J Anaesth 2014;113(4):527-530
- Pryor. NAP5: intraoperative awareness detected, and undetected. Br J Anaesth 2014;113(4):530-533
- Hardman. Personal and medicolegal implications of awareness. Br J Anaesth 2014;113(4):533-534
- Myles. Generalizability of anaesthesia study populations. Br J Anaesth 2014;113(4):535-536
- Philips. Selective decontamination of the digestive tract: time to implement it in all UK intensive care units? Maybe not yet. Br J Anaesth 2014;113(4):537-539
Anaesthesia
Review Articles
Editorials
- Suntharalingam. Regionalisation of critical care: can we sustain an intensive care unit in every hospital? Anaesthesia 2014;69:1069–1073
- Kiernan. Quality of Life: changing the face of outcome measurements in critical care. Anaesthesia 2014;69:1073–1077
Medicina Intensiva
Review Articles
- Garnacho-Montero. Crystalloids and colloids in critical patient resuscitation. Med Intensiva 2015;39:303-15
- Escudero. Transcranial Doppler ultrasound in the diagnosis of brain death. Is it useful or does it delay the diagnosis. Med Intensiva 2015;39:244-50
- Manzanares. Hyponatremia in the neurocritical care patient: An approach based on current evidence. Med Intensiva 2015;39:234-43
Guidelines & Position Statements
Case Report
Editorials
- The PROPPR transfusion ratio in severe traumatic haemorrhage. Neth J Crit Care 2015;22(4):4-5
- Patry. Translational research in ARDS patients: new biological phenotypes. Intensive Care Med 2015;41:1986–1989
- Howell. ICUs after surgery, mortality, and the Will Rogers effect. Intensive Care Med 2015;41:1990-1992
- Schortgen. Defining renal recovery: pitfalls to be avoided. Intensive Care Med 2015;41:1993-1995
- Flaatten. The very old ICU patient: a never-ending story. Intensive Care Med 2015;41:1996-1998
- Laupland. Manipulating vital signs in septic shock: which one(s) and how? Intensive Care Med 2015;41:1999-2001
Commentaries
- Stocchetti. Fluid Choices in Brain Injury. ICU Management 2015;15(3)
- Meyfroidt. Sedation in Acute Brain Injury: Less is More? ICU Management 2015;15(3)
- Schröder. ICU-Related Dysphagia. ICU Management 2015;15(3)
- Cooper. Infections in the Immunosuppressed and Immunocompromised Patient. ICU Management 2015;15(3)
- Previgliano. Cognitive Impairment After Critical Illness: Prevention and Treatment. ICU Management 2015;15(3)
- Wilks. Clinical Benefits of Rapid Pathogen Testing with PCR/ESI-MS. ICU Management 2015;15(3)
- Wernerman. Nutrition Monitoring. ICU Management 2015;15(3)
- Presello. Critically Ill Diabetic Patients. ICU Management 2015;15(3)
- Sipmann. Heart-Lung Interactions from the Lung's Perspective. ICU Management 2015;15(3)
- Malbrain. Fluid Resuscitation in Burns. ICU Management 2015;15(3)
- Valley. The epidemiology of sepsis: questioning our understanding of the role of race. Critical Care 2015;19:347
- Juthani-Mehta. Antimicrobials at the End of Life. An Opportunity to Improve Palliative Care and Infection Management. JAMA 2015;epublished October 1st
Case Reports
- Landburg. New-onset type 1 diabetic ketoacidosis complicated by acute respiratory distress syndrome. Neth J Crit Care 2015;22(4):15-7
- Popal. Necrotising laryngitis and epiglottitis in a patient with methimazole-induced agranulocytosis. Neth J Crit Care 2015;22(4): 18-20
- Koekkoek. Electrical burns caused by a train-of-four monitor. Neth J Crit Care 2015;22(4):21-2
- Leus. An Acute Dystonic Reaction after Treatment with Metoclopramide. N Engl J Med 2015;373:e16
Meetings
Due to hugely successful previous events, the Critical Care Reviews Meeting 2016 has been moved to a brand new venue, the stunning, multi-million pound Titanic Centre, birthplace of RMS Titanic, As before, the meeting theme is to review the biggest studies of the previous year, with chief investigators present where possible to discuss their work in person. From Wellington, New Zealand, Dr Paul Young will talk on his studies SPLIT (saline versus plasmalyte) and HEAT (paracetamol for pyrexia control). Dr John Holcomb (Houston, USA) will review his mega trial PROPPR, evaluating blood product transfusion ratios in traumatic haemorrhage. Prof Tim Walsh (Edinburgh, Scotland) will review the ABLE study, including his ABLE UK component, evaluating age of transfused red cells, as well as RECOVER, a post-ICU rehab study. Similarly, Prof Danny McAuley (Belfast, Northern Ireland) will also review a post-ICU rehab study, the REVIVE trial. In addition, two of the most eminent intensivists in global critical care, Prof Jean-Louis Vincent (Brussels, Belgium) and Prof Luciano Gattinoni (Milan, Italy) will be on hand to discuss the significance of these findings. It won't be all study discussion, with other elements to the meeting, including the spectacularly popular "Informal Chat", taking place that evening.
If you haven't yet attended this modern, niche meeting, then put the date Friday January 29th in your diary. Both delegate and speaker feedback from previous meetings has been incredibly positive, allowing the event to grow and attract some of the biggest names in critical care. The Titanic Centre is just minutes from Belfast City Airport, with a hotel within 3 minutes walking distance, and is a 20 minute walk from the city centre, including the Cathedral Quarter, Belfast's cultural centre full of great restaurants and pubs. Further details regarding delegate rate accommodation should be available in the next week or two. Talks are given in the setting of the rebuilt famous staircase from the great ship, while both the "Informal Chat" session and dinner overlook the floodlit slipways where Titanic and Olympic were launched. With some exciting new innovations planned, this new meeting promises to delivery on its burgeoning reputation. The finalised programme won't be released until later this Autumn, but don't wait too long before registering, as numbers are capped to keep this an intimate event. It is as strong a one day programme as you could possibly find. If you think your colleagues would find this event interesting, please circulate this information - this is a not-for-profit event, run in association with the Northern Ireland Intensive Care Society.
Under the inspired guidance of meeting organiser Ganesh Suntharalingam, this year's State-of-the-Art Meeting promises an exciting programme in a new dynamic format. It aims to be the first major national society to fully embrace social media and free open access medical education, with an opening plenary session and a workshop, as well full integration of Twitter questions into sessions, live blogging, and open-access AV materials.
Take a look at the website or the flyer. The meeting is at London ExCeL, 20 minutes from the West End
The 4th SMACC Conference comes to Dublin next June. It's on in the spectatcular Dublin Convention Centre, on June 13th to 16th. Registration hasn't opened yet, but I'll keep you informed when it's due to open. Early registration is advised, as the event could book out within 24 hours.
CCH Journal
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Rob