Newsletter 195 | September 6th 2015
Welcome to the 195th Critical Care Reviews Newsletter, bringing you the best critical care research published in the past week, plus a wide range of free full text review articles, guidelines, commentaries, editorials, study critiques, correspondence and case reports from hundreds of clinical and scientific journals.
The highlights of this week's newsletter are randomized controlled trials comparing dopamine with adrenaline in paediatric septic shock, conservative with liberal oxygenation targets in mechanically ventilated patients, and a study investigating high-volume plasma exchange in patients with acute liver failure; an ESC guideline on management of acute coronary syndromes in patients presenting without persistent ST-segment elevation; plus review articles on hemodynamic support and therapy in septic shock, management and treatment of pulmonary embolism and lactic acidosis. The first newsletter of the month contains the latest articles recently made open access by the major critical care journals, with over 40 papers included.
This week's Topic of the Week is anaphylaxis, starting with an international consensus paper in tomorrow's Paper of the Day.
Research
- Abstract: Ventura. Double-Blind Prospective Randomized Controlled Trial of Dopamine Versus Epinephrine as First-Line Vasoactive Drugs in Pediatric Septic Shock. Crit Care Med 2015;epublished August 28th
- Abstract: Panwar. Conservative Versus Liberal Oxygenation Targets for Mechanically Ventilated Patients - a Pilot Multicenter Randomized Controlled Trial (CLOSE Study). Am J Respir Crit Care Med 2015;epublished September 3rd
- Abstract: Howe. Mechanical Ventilation Antioxidant Trial. Am J Crit Care 2015;24(5):440-5
- Abstract: Kim. The effect of magnesium sulphate on intubating condition for rapid-sequence intubation: a randomized controlled trial. J Clin Anaesth 2015;epublished August 24th
- Full Text: Valgimigli. Bivalirudin or Unfractionated Heparin in Acute Coronary Syndromes (MATRIX Study). N Engl J Med 2015;epublished September 1st
- Abstract: Larsen. High-volume plasma exchange in patients with acute liver failure: An open randomised controlled trial. J Hepatol 2015;epublished August 29th
- Full Text: Hill. Albumin Administration in Acute Ischemic Stroke: Safety Analysis of the ALIAS Part 2 Multicenter Trial. PLoS One 2015;10(9):e0131390
- Abstract: Cung. Cyclosporine before PCI in Patients with Acute Myocardial Infarction (CIRCUS Trial). N Engl J Med 2015;epublished August 30th
- Full Text: Ziff. Safety and efficacy of digoxin: systematic review and meta-analysis of observational and controlled trial data. BMJ 2015;351:h4451
- Abstract: Boutin. Red blood cell transfusion in patients with traumatic brain injury: a systematic review and meta-analysis. Transfusion Medicine Reviews 2015;epublished August 27th
- Abstract: Templin. Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy. N Engl J Med 2015;373:929-938
- Full Text: Lantigua. Subarachnoid hemorrhage: who dies, and why? Critical Care 2015;19:309
- Full Text: Hennings. Arterial waveform-analysis is of limited value in daily clinical practice in the intensive care unit. Dan Med J 2015;62(9)
- Abstract: Govindarajan. Outcomes of Daytime Procedures Performed by Attending Surgeons after Night Work. N Engl J Med 2015;373:845-853
- Abstract: Vincent. Rapid Diagnosis of Infection in the Critically Ill, a Multicenter Study of Molecular Detection in Bloodstream Infections, Pneumonia, and Sterile Site Infections. Crit Care Med 2015;epublished August 31st
- Abstract: Epker. An Observational Study on a Protocol for Withdrawal of Life-Sustaining Measures on Two Non-Academic Intensive Care Units in The Netherlands: Few Signs of Distress, No Suffering? J Pain Symptom Manage 2015;epublished August 31st
New
- Visvanathan. Parenteral fluid regimens for improving functional outcome in people with acute stroke. Cochrane Database of Systematic Reviews 2015, Issue 9. Art. No.: CD011138
- Martí-Carvajal. Prophylactic lidocaine for myocardial infarction. Cochrane Database of Systematic Reviews 2015, Issue 8. Art. No.: CD008553
Updated
- McInnes. Support surfaces for pressure ulcer prevention. Cochrane Database of Systematic Reviews 2015, Issue 9. Art. No.: CD001735
- Cirocchi. Non-operative management versus operative management in high-grade blunt hepatic injury. Cochrane Database of Systematic Reviews 2015, Issue 8. Art. No.: CD010989
- van der Hoeven. Preventive nebulization of mucolytic agents and bronchodilating drugs in invasively ventilated intensive care unit patients (NEBULAE): study protocol for a randomized controlled trial. Trials 2015;16(1):389
- dos Santos. Early rehabilitation using a passive cycle ergometer on muscle morphology in mechanically ventilated critically ill patients in the Intensive Care Unit (MoVe-ICU study): study protocol for a randomized controlled trial. Trials 2015;16:383
Review Articles
Neurological
- Gwyn. Management of Malignant Middle Cerebral Artery Infarction. EMJ Neurol 2015;3[1]:57-62
- Tomaszewski. Biomarkers of Brain Damage and Postoperative Cognitive Disorders in Orthopedic Patients: An Update. BioMed Research International 2015;2015:402959
Circulatory
- de Assuncao. How to choose the therapeutic goals to improve tissue perfusion in septic shock. Einstein (São Paulo) 2015;epublished August 21st
- Rocha. Current concepts on hemodynamic support and therapy in septic shock. Braz J Anesthesiol 2015;65(5):395-402
- Catréa. Perioperative morbidity and mortality in the first year of life: a systematic review (1997–2012). Braz J Anesthesiol 2015;65(5):384–394
- Jentzer. Myocardial Dysfunction and Shock after Cardiac Arrest. BioMed Research International 2015;2015:314796
- Horr. Troponin elevation after noncardiac surgery: Significance and management. CCJM 2015;82(9):595-602
- Lazzeri. Clinical significance of lactate in acute cardiac patients. World J Cardiol 2015;7(8):483-9
- Ali. Early repolarization syndrome: A cause of sudden cardiac death. World J Cardiol 2015;7(8):466-475
Respiratory
- Limbrey. Developments in the management and treatment of pulmonary embolism. Eur Respir Rev 2015;24:484-497
- Müller-Redetzky. Therapeutic strategies in pneumonia: going beyond antibiotics. Eur Respir Rev 2015;24:516-524
- Harari. Idiopathic pulmonary fibrosis: from clinical trials to real-life experiences. Eur Respir Rev 2015;24:420-427
- Vilela. Oral care and nosocomial pneumonia: a systematic review. Einstein (São Paulo) 2015;13(2)
Renal
Metabolic
Haematological
- Pischik. An update of clinical management of acute intermittent porphyria. The Application of Clinical Genetics 2015;8:201-214
- Weitz. Paroxysmal nocturnal hemoglobinuria: new concepts in pathophysiology and treatment. Orphan Drugs: Research and Reviews 2015;5:75-81
Sepsis
- Corrêa. Fluid therapy for septic shock resuscitation: which fluid should be used? Einstein (São Paulo) 2015;epublished August 21st
- da Silva. Strategies for appropriate antibiotic use in intensive care unit. Einstein (São Paulo) 2015;epublished June 30th
- Wortmann. Middle East respiratory syndrome: SARS redux? CCJM 2015;82(9):584-588
- Zumla. Middle East respiratory syndrome. Lancet 2015;386(9997):995-1007
- Camprubí-Rimblas. An Overview of Proteomics on Sepsis. Phys Chem Biophys 2015;5:4
Trauma
Miscellaneous
- Pearce. Randomised trials in context: practical problems and social aspects of evidence-based medicine and policy. Trials 2015;16:394
- Blencowe. Interventions in randomised controlled trials in surgery: issues to consider during trial design. Trials 2015;16:392
- Bullock. Technology in postgraduate medical education: a dynamic influence on learning? Postgrad Med J 2015;epublished September 4th
American Journal of Respiratory and Critical Care Medicine
Review Articles
- Ventetuolo. Extracorporeal Life Support in Critically Ill Adults. Am J Respir Crit Care Med 2014;190(5):497-508
- Cox. A Universal Decision Support System. Addressing the Decision-Making Needs of Patients, Families, and Clinicians in the Setting of Critical Illness. Am J Respir Crit Care Med 2014;190(4):366-373
Guideline
Editorial
Correspondence
Chest
Review Articles
- Shah. Mechanical Circulatory Support Devices in the ICU. Chest 2014;146(3):848-857
- Javaheri. Clinical Applications of Adaptive Servoventilation Devices: Part 2. Chest 2014;146(3):858-868
Editorial
Case Reports
- Catteeuw. A 54-Year-Old Man Referred With Nonresolving Pneumonia. Chest 2014;146(3):e92-e96
- Millington. Sudden Hypotension in a Medical Patient. Chest 2014;146(3):e78-e80
Correspondence
- Merceron. Palliative Vasoactive Therapy in Patients With Septic Shock. Chest 2014;146(3):e107-e108
- Nobre. Ultrasound in Suspected Pulmonary Embolism. Chest 2014;146(3):e109
- Thommi. Fibrinolytics in Parapneumonic Effusions/Empyemas. Chest 2014;146(3):e103-e104
Anesthesiology
Review Articles
Guidelines
Commentaries
Anesthesia & Analgesia
Review Articles
Commentaries
- Raghunathan. Intravenous Starches: Is Suspension the Best Solution? Anesth Analg 2014;119(3):731-736
- Irwin. Volume Therapy with Hydroxyethyl Starches: Are We Throwing the Anesthesia Baby Out with the Intensive Care Unit Bathwater? Anesth Analg 2014;119(3):737-739
- Kooij. Does Regional Analgesia for Major Surgery Improve Outcome? Focus on Epidural Analgesia. Anesth Analg 2014;119(3):740-744
Editorials
- Memtsoudis. Do Neuraxial Techniques Affect Perioperative Outcomes? The Story of Vantage Points and Number Games. Anesth Analg 2014;119(3):501-502
- Roizen. Vitamin D and Your Patients: Don’t Accept Wimpy. Anesth Analg 2014;119(3):503-505
- Beattie. The Growing Burden of Perioperative Heart Failure. Anesth Analg 2014;119(3):506-508
- Weiskopf. Hydroxyethyl Starches: A Tale of Two Contexts: The Problem of Knowledge. Anesth Analg 2014;119(3):509-513
- Cecconi. Goal-Directed Therapy: Time to Move on? Anesth Analg 2014;119(3):516-518
British Journal of Anaesthesia
Editorials
- Kelleher. Pendulum swings again: crystalloid or colloid fluid therapy? Br J Anaesth 2014;113(3):335-337
- Saugel. Are we ready for the age of non-invasive haemodynamic monitoring? Br J Anaesth 2014;113(3):340-343
- Tempe. Why do we not toe the line drawn by the National Institute for Clinical Excellence for internal jugular vein cannulation? Br J Anaesth 2014;113(3):344-345
Review Articles
BJA Education
Review Articles
- Nowicki. Anaesthesia for major spinal surgery. Contin Educ Anaesth Crit Care Pain 2014;14(4):147-152
- Sharma. Paracetamol: mechanisms and updates. Contin Educ Anaesth Crit Care Pain 2014;14(4):153-158
- Clegg. Strategies for handling the aftermath of intraoperative death. Contin Educ Anaesth Crit Care Pain 2014;14(4):159-162
- Williams. Rhabdomyolysis. Contin Educ Anaesth Crit Care Pain 2014;14(4):163-166
- Tameem. Whiplash injury. Contin Educ Anaesth Crit Care Pain 2014;14(4):167-170
- Robinson. Aspiration under anaesthesia: risk assessment and decision-making. Contin Educ Anaesth Crit Care Pain 2014;14(4):171-175
- Simpson. Use of ultrasound in chronic pain medicine—Part 2: Musculoskeletal and peripheral nerve applications. Contin Educ Anaesth Crit Care Pain 2014;14(4):176-184
- Kumar. Ultrasound-guided brachial plexus blocks. Contin Educ Anaesth Crit Care Pain 2014;14(4):185-191
Anaesthesia
Review Articles
Editorials
Guidelines
- Galiè. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Circulation 2015;epublished August 29th
- Adler. 2015 ESC Guidelines for the diagnosis and management of pericardial diseases. Circulation 2015;epublished August 29th
- Roffi. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Circulation 2015;epublished August 29th
- Priori. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Circulation 2015;epublished August 29th
- Habib. 2015 ESC Guidelines for the management of infective endocarditis. Circulation 2015;epublished August 29th
- Jain. Guidelines for the Management of a Pregnant Trauma Patient. J Obstet Gynaecol Can 2015;37(6):553–571
Editorials
- Levy. Early goal-directed therapy: Sorting through confusion. Lung India 2015;32:435-6
- Esteves. Can residual paralysis be avoided?: A critical appraisal of the use of sugammadex. European Journal of Anaesthesiology 2015;32(10):663–665
- Kant. MERS may not be SARS; but India is still vulnerable. Indian J Med Res 2015;142:103-5
Commentaries
- Hadanny. Oxygen - a limiting factor for brain recovery. Critical Care 2015;19:307
- Dhooria. "Early goal-directed therapy" versus "Early" and "goal-directed" therapy for severe sepsis and septic shock: Time to rationalize. Lung India 2015;32:521-3
- Ronco. Italian AKI Guidelines: The Best of the KDIGO and ADQI Results. Blood Purif 2015;40:I-III
- Weingart. Future of ED Sepsis Care May be Out of Our Hands — Unless We Agitate. Emergency Medicine News 2015;37(9):31–32
Correspondence
- Freebaim. Systemic Inflammatory Response Syndrome Criteria for Severe Sepsis. N Engl J Med 2015;373:879-881
- Various. Corticosteroid therapy for pneumonia. Lancet 2015;386(9997):953-5
Meetings
Due to hugely successful previous events, the meeting has moved to a brand new venue, the stunning, multi-million pound Titanic Centre, birthplace of RMS Titanic, From Wellington, New Zealand, Dr Paul Young will talk on his studies SPLIT (saline versus plasmalyte) and HEAT (paracetamol for pyrexia control). Dr John Holcomb (Houston, USA) will review his mega trial PROPPR, evaluating blood product transfusion ratios in traumatic haemorrhage. Prof Tim Walsh (Edinburgh, Scotland) will review the ABLE study, including his ABLE UK component, evaluating age of transfused red cells, as well as RECOVER, a post-ICU rehab study. A late edition to the programme, Dr Anthony Gordon (London, England), will review his VANISH study, a multi-centre randomized controlled trial comparing vasopressin with noradrenaline, with or without hydrocortisone, for first-line vasopressor support in septic shock. In addition, two of the most eminent intensivists in global critical care, Prof Jean-Louis Vincent (Brussels, Belgium) and Prof Luciano Gattinoni (Milan, Italy) will be on hand to discuss the significance of these findings. It won't be all study discussion, with other elements to the meeting, including the spectacularly popular "Informal Chat", taking place that evening.
If you haven't yet attended this modern, niche meeting, then put the date Friday January 29th in your diary. Both delegate and speaker feedback from previous meetings has been incredibly positive, allowing the event to grow and attract some of the biggest names in critical care. The Titanic Centre is just minutes from Belfast City Airport, with a hotel within 3 minutes walking distance, and is a 20 minute walk from the city centre, including the Cathedral Quarter, Belfast's cultural centre full of great restaurants and pubs. Further details regarding delegate rate accommodation should be available in the next week or two. Talks are given in the setting of the rebuilt famous staircase from the great ship, while both the "Informal Chat" session and dinner overlook the floodlit slipways where Titanic and Olympic were launched. With some exciting new innovations planned, this new meeting promises to delivery on its burgeoning reputation. The programme is all but finalised, so don't wait too long before registering, as numbers are capped to keep this an intimate event. It is as strong a one day programme as you could possibly find. If you think your colleagues would find this event interesting, please circulate this information - this is a not-for-profit event, run in association with the Northern Ireland Intensive Care Society. Accommodation has been secured at special rates for the meeting at 3*, 4* and 5* hotels - I should be able to add the details to the website next week.
Under the inspired guidance of meeting organiser Ganesh Suntharalingam, this year's State-of-the-Art Meeting promises an exciting programme in a new dynamic format. It aims to be the first major national society to fully embrace social media and free open access medical education, with an opening plenary session and a workshop, as well full integration of Twitter questions into sessions, live blogging, and open-access AV materials.
Take a look at the website or the flyer. The meeting is at London ExCeL, 20 minutes from the West End
CCH Journal
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Rob