Welcome to the 181st Critical Care Reviews Newsletter, bringing you the best critical care research published in the past week, plus a wide range of free full text review articles, guidelines, commentaries, editorials, study critiques, correspondence and case reports from hundreds of clinical and scientific journals.
The highlight of this week's newsletter is the three major RCTs ( (STOP-IT, PermiT, & FLORALI) presented at the American Thoracic Society Meeting in Denver last weekend. If you only have time for one review article this week, check out this paper on tranexamic acid: a clinical review. With less than a month to go, the countdown to SMACC Chicago has begun in earest, so I'm beginning a focus on the topic of my talks - fluid management. As such, this week's Topic of the Week is blood volume monitoring, starting with a general paper in tomorrow's Paper of the Day.
- Full Text: Sawyer. Trial of Short-Course Antimicrobial Therapy for Intraabdominal Infection (STOP-IT trial). N Engl J Med 2015; 372:1996-2005
- Full Text: Arabi. Permissive Underfeeding or Standard Enteral Feeding in Critically Ill Adults (PermiT Trial). N Engl J Med 2015;epublished May 20th
- Full Text: Frat. High-Flow Oxygen through Nasal Cannula in Acute Hypoxemic Respiratory Failure (FLORALI study). N Eng J Med 2015;epublished May 17th
- Full Text: Stéphan. High-Flow Nasal Oxygen vs Noninvasive Positive Airway Pressure in Hypoxemic Patients After Cardiothoracic Surgery: A Randomized Clinical Trial. JAMA 2015;epublished May 17th
- Abstract: Stub. Air Versus Oxygen in ST-Segment Elevation Myocardial Infarction (AVOID Study). Circulation 2015;epublished May 22nd
- Abstract: Rusconi. Early goal-directed therapy vs usual care in the treatment of severe sepsis and septic shock: a systematic review and meta-analysis. Intern Emerg Med 2015;epublished May 16th
- Abstract: Su. Intra-aortic balloon pump may grant no benefit to improve the mortality of patients with acute myocardial infarction in short and long term: an updated meta-analysis. J Pediatr Gastroenterol Nutr 2015;94(19):1-7
- Abstract: Hew. The diagnostic accuracy of chest ultrasound for CT-detected radiographic consolidation in hospitalised adults with acute respiratory failure: a systematic review. BMJ Open 2015;5(5):e007838
- Abstract: Lim. Levosimendan Reduces Mortality in Adults with Left Ventricular Dysfunction Undergoing Cardiac Surgery: A Systematic Review and Meta-analysis. J Card Surg 2015;epublished May 19th
- Full Text: Goldaracena. Live Donor Liver Transplantation: A Valid Alternative for Critically Ill Patients Suffering From Acute Liver Failure. American Journal of Transplantation 2015;15:1591–1597
- Abstract: Barnard. Rapid sequence induction of anaesthesia via the intraosseous route: a prospective observational study. Emerg Med J 2015;32:449-452
- Abstract: Parke. A Randomised feasibility study to assess a novel strategy to rationalise fluid in patients after cardiac surgery. Br J Anaesth 2015;epublished May 19th
- Abstract: Curry. Early cryoprecipitate for major haemorrhage in trauma: a randomised controlled feasibility trial. Br J Anaesth 2015;epublished May 19th
- Abstract: Gillies. Perioperative myocardial injury in patients receiving cardiac output-guided haemodynamic therapy: a substudy of the OPTIMISE Trial. Br J Anaesth 2015;epublished May 21st
- Abstract: Dumas. Outcomes in Critically Ill Patients with Systemic Rheumatic Disease: a multicenter study. Chest 2015 May 21st
- Abstract: Sekiguchi. Critical Care Ultrasonography Differentiates ARDS, Pulmonary Edema, and Other Causes in the Early Course of Acute Hypoxemic Respiratory Failure. Chest 2015;epublished May 21st
- Dumville. Alginate dressings for treating pressure ulcers. Cochrane Database of Systematic Reviews 2015, Issue 5. Art. No.: CD011277
- Dumville. Negative pressure wound therapy for treating pressure ulcers. Cochrane Database of Systematic Reviews 2015, Issue 5. Art. No.: CD011334
- Castellanos. Endoscopic injection of cyanoacrylate glue versus other endoscopic procedures for acute bleeding gastric varices in people with portal hypertension. Cochrane Database of Systematic Reviews 2015, Issue 5. Art. No.: CD010180
- Nistor. Haemodiafiltration, haemofiltration and haemodialysis for end-stage kidney disease. Cochrane Database of Systematic Reviews 2015, Issue 5. Art. No.: CD006258
- Su. Adenosine and verapamil for no-reflow during primary percutaneous coronary intervention in people with acute myocardial infarction. Cochrane Database of Systematic Reviews 2015, Issue 5. Art. No.: CD009503
- Robinson. Intravenous immunoglobulin for presumed viral myocarditis in children and adults. Cochrane Database of Systematic Reviews 2015, Issue 5. Art. No.: CD004370
- Casarin. Evaluating early administration of the hydroxymethylglutaryl-CoA reductase inhibitor simvastatin in the prevention and treatment of delirium in critically ill ventilated patients (MoDUS trial): study protocol for a randomized controlled trial. Trials 2015;16:218
- Keijzers. What is the effect of a formalised trauma tertiary survey procedure on missed injury rates in multi-trauma patients? Study protocol for a randomised controlled trial. Trials 2015;16:215
- Canney. Posterior Reversible Encephalopathy Syndrome in End-Stage Kidney Disease: Not Strictly Posterior or Reversible. Am J Nephrol 2015;41:177-182
Series from Stroke: Understanding and Applying the Endovascular Trials
- Fisher. Dawning of a New Era for Acute Stroke Therapy. Stroke 2015;46:1438-1439
- Pierot. Interventionalist Perspective on the New Endovascular Trials. Stroke 2015;46:1440-1446
- Grotta. Stroke Neurologist’s Perspective on the New Endovascular Trials. Stroke 2015;46:1447-1452
- Menon. Role of Imaging in Current Acute Ischemic Stroke Workflow for Endovascular Therapy. Stroke 2015;46:1453-1461
- Smith. Endovascular Clot Retrieval Therapy: Implications for the Organization of Stroke Systems of Care in North America. Stroke 2015;46:1462-1467
- Tatlisumak. Implication of the Recent Positive Endovascular Intervention Trials for Organizing Acute Stroke Care: European Perspective. Stroke 2015;46:1468-1473
- Toyoda. Acute Reperfusion Therapy and Stroke Care in Asia After Successful Endovascular Trials. Stroke 2015;46:1474-1481
- Lawson. Percutaneous Ventricular Assist Devices and ECMO in the Management of Acute Decompensated Heart Failure. Clin Med Insights Cardiol 2015;9(Suppl 1):41–48
- Kovács. Diastolic Function in Heart Failure. Clin Med Insights Cardiol 2015;9(Suppl 1):49–55
- Kerkhof. Characterizing Heart Failure in the Ventricular Volume Domain. Clin Med Insights Cardiol 2015;9(Suppl 1):11–31
- Liu. “Reverse McConnell’s Sign”: Interpreting Interventricular Hemodynamic Dependency and Guiding the Management of Acute Heart Failure during Takotsubo Cardiomyopathy. Clin Med Insights Cardiol 2015;9(Suppl 1):33–40
- Westaby. NICE guidelines for acute heart failure: long on pills, short on pumps. Br J Cardiol 2015;22:(2)
- Dasbiswas. Overview of Reteplase, A Novel Thrombolytic Agent in Indian Context. Cardiol Pharmacol 2015;4:2
- Patel. Complications of Continuous-Flow Mechanical Circulatory Support Devices. Clinical Medicine Insights: Cardiology 2015:Suppl 2:15-21
- Patel. Reversible Cardiomyopathies. Clinical Medicine Insights: Cardiology 2015:Suppl. 2:7-14
- Alansari. Use of ultrasound guidance to improve the safety of percutaneous dilatational tracheostomy: a literature review. Critical Care 2015;19:229
- Gibbs. Pulmonary hypertension in UK clinical practice: an update. Br J Cardiol 2015;22(suppl 1):S2–S15
- Hagberg. Current Concepts In the Management of The Difficult Airway. Anesthesiology News 2015;12(1):1-28
- De Waele. How to deal with an open abdomen? Anaesthesiology Intensive Therapy 2015;epublished April 5th
- Malbrain. Intra-abdominal hypertension and abdominal compartment syndrome in burns, obesity, pregnancy, and general medicine. Anaesthesiology Intensive Therapy 2015;epublished May 4th
- De Waele. Intra-abdominal hypertension and abdominal compartment syndrome in pancreatitis, paediatrics, and trauma. Anaesthesiology Intensive Therapy 2015;epublished May 7th
- Sugrue. A user’s guide to intra-abdominal pressure measurement. Anaesthesiology Intensive Therapy 2015;epublished May 7th
- Malbrain. What every ICU clinician needs to know about the cardiovascular effects caused by abdominal hypertension. Anaesthesiology Intensive Therapy 2015;epublished May 11th
- Blaser. Abdominal signs and symptoms in intensive care patients. Anaesthesiology Intensive Therapy 2015;epublished May 4th
- Starczewska. Perioperative bleeding in patients undergoing liver transplantation. Anaesthesiology Intensive Therapy 2015;epublished April 2nd
- Wani. Extrahepatic portal vein obstruction and portal vein thrombosis in special situations: Need for a new classification. Saudi J Gastroenterol 2015;21:129-38
- Rowaiye. The kidneys and ANCA-associated vasculitis: from pathogenesis to diagnosis. Clin Kidney J 2015;8: 343-350
- Ng. Tranexamic acid: a clinical review. Anaesthesiology Intensive Therapy 2015;epublished March 17th
- Pollack. Coagulation assessment with the new generation of oral anticoagulants. Emerg Med J 2015;epublished May 18th
- Leppäniemi. Management of abdominal sepsis — a paradigm shift? Anaesthesiology Intensive Therapy 2015;epublished May 7th
- Shah. Reversing resistance: The next generation antibacterials. Indian J Pharmacol 2015;47:248-55
- Zheng. Experimental treatments for mitochondrial dysfunction in sepsis: A narrative review. J Res Med Sci. 2015;20(2):185–195
- Hung. Clinical impact of Clostridium difficile colonization. Journal of Microbiology, Immunology and Infection 2015;48(3):241-248
- Wong. Ebola virus disease in nonendemic countries. Journal of the Formosan Medical Association 2015;114(5):384e398
- Hoskote. Peri-operative kidney injury and long-term chronic kidney disease following orthotopic heart transplantation in children. Pediatr Nephrol 2015;30:905–918
- Juurlink. Extracorporeal Treatment for Salicylate Poisoning: Systematic Review and Recommendations From the EXTRIP Workgroup. Ann Emerg Med 2015;epublished May 8th
- Gewitz. Revision of the Jones Criteria for the Diagnosis of Acute Rheumatic Fever in the Era of Doppler Echocardiography: A Scientific Statement From the American Heart Association. Circulation 2015;131:1806-1818
- Fonarow. Workplace Wellness Recognition for Optimizing Workplace Health: A Presidential Advisory From the American Heart Association. Circulation 2015;131:e480-e497
- Mebazaa. Recommendations on pre-hospital and early hospital management of acute heart failure: a consensus paper from the Heart Failure Association of the European Society of Cardiology, the European Society of Emergency Medicine and the Society of Academic Emergency Medicine – short version. European Heart Journal 2015;epublished May 21st
- Russell. Early goal-directed therapy: from discovery through enthusiasm to equipoise? Intensive Care Med 2015;epublished May 22nd
- Joannidis. Feeding the kidneys in AKI: no appetite for a change in practice. Intensive Care Med 2015;epublished May 22nd
- Chant. Do we need a pharmacist in the ICU? Intensive Care Med 2015;epublished May 21st
- Sprung. Variability in forgoing life-sustaining treatments: reasons and recommendations. Intensive Care Med 2015;epublished May 19th
Due to hugely successful previous events, the Critical Care Reviews Meeting 2016 has been moved to a brand new venue, the stunning, multi-million pound Titanic Centre, birthplace of RMS Titanic, As before, the meeting theme is to review the biggest studies of the previous year, with chief investigators present where possible to discuss their work in person. From Wellington, New Zealand, Dr Paul Young will talk on his studies SPLIT (saline versus plasmalyte) and HEAT (paracetamol for pyrexia control). Dr John Holcomb (Houston, USA) will review his mega trial PROPPR, evaluating blood product transfusion ratios in traumatic haemorrhage. Prof Tim Walsh (Edinburgh, Scotland) will review the ABLE study, including his ABLE UK component, evaluating age of transfused red cells, as well as RECOVER, a post-ICU rehab study. Similarly, Prof Danny McAuley (Belfast, Northern Ireland) will also review a post-ICU rehab study, the REVIVE trial. In addition, two of the most eminent intensivists in global critical care, Prof Jean-Louis Vincent (Brussels, Belgium) and Prof Luciano Gattinoni (Milan, Italy) will be on hand to discuss the significance of these findings. It won't be all study discussion, with other elements to the meeting, including the spectacularly popular "Informal Chat", taking place that evening.
If you haven't yet attended this modern, niche meeting, then put the date Friday January 29th in your diary. Both delegate and speaker feedback from previous meetings has been incredibly positive, allowing the event to grow and attract some of the biggest names in critical care. The Titanic Centre is just minutes from Belfast City Airport, with a hotel within 3 minutes walking distance, and is a 20 minute walk from the city centre, including the Cathedral Quarter, Belfast's cultural centre full of great restaurants and pubs. Further details regarding delegate rate accommodation should be available in the next week or two. Talks are given in the setting of the rebuilt famous staircase from the great ship, while both the "Informal Chat" session and dinner overlook the floodlit slipways where Titanic and Olympic were launched. With some exciting new innovations planned, this new meeting promises to delivery on its burgeoning reputation. The finalised programme won't be released until later this Autumn, but don't wait too long before registering, as numbers are capped to keep this an intimate event. It is as strong a one day programme as you could possibly find. If you think your colleagues would find this event interesting, please circulate this information - this is a not-for-profit event, run in association with the Northern Ireland Intensive Care Society.
There are just weeks to one of the biggest, and definitely the best, critical care conference in the world. The next SMACC Conference is on June 23rd to 26th, in Chicago, USA. With its informal manner and flat hierarchy, this event delivers on its promise to provide top class critical care education in a fun, modern way. Speakers are deliberately chosen for their ability to present and convey information, rather than their academic or social media status, marking this as the field leader in medical conferencing. With an emphasis on TED-like presentation styles, minimal slides and maximal social media involvement, this is the future of medical meetings. In addition to numerous world-leading academics, many active in the altruistic social media world of FOAM are there to contribute, including helping deliver a massive set of workshops the day before the main meeting begins. In the main programme, I'll be giving a talk on kicking perioperative goals, and also debating Prof Paul Marik on the usefulness, or not, of predicting fluid responsiveness. I hope to see you there - I'll need all the support I'll can get!
This year's State-of-the-Art Meeting promises an exciting programme in a new dynamic format. With strong social media input, and fresh ideas from those successfully delivering free educational content through various FOAM websites and events, this conference will be very different to before. Covering every CPD requirement, and attracting the most eminent researchers from the UK and beyond, the State-of-the-Art meeting remains the biggest critical care conference in the UK. I'll be on the debate trail again, taking on two world experts in respiratory failure, Dr Eddy Fan and Prof Luciano Gattinoni.
The ICSI host a superb three day ESICM meeting at Dubin Castle on June 11th to 13th, focusing on every aspect of respiratory critical care. From mechanical ventilation to ARDS to heart-lung interactions, this event is ideal for anyone interested in updating their knowledge in this field, under the guidance of some of the leading names in the area.
After almost a year of preparation, the first issue of the new genuine open access critical care journal, Critical Care Horizons is nearing publication. This is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have something interesting to say, and can say it in an engaging manner, please get in touch.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week