Due to hugely successful previous events, the Critical Care Reviews Meeting 2016 has been moved to a brand new venue, the stunning, multi-million pound Titanic Centre, birthplace of RMS Titanic,  As before, the meeting theme is to review the biggest studies of the previous year, with chief investigators present where possible to discuss their work in person. From Wellington, New Zealand, Dr Paul Young will talk on his studies SPLIT (saline versus plasmalyte) and HEAT (paracetamol for pyrexia control). Dr John Holcomb (Houston, USA) will review his mega trial PROPPR, evaluating blood product transfusion ratios in traumatic haemorrhage. Prof Tim Walsh (Edinburgh, Scotland) will review the ABLE study, including his ABLE UK component, evaluating age of transfused red cells, as well as RECOVER, a post-ICU rehab study. Similarly, Prof Danny McAuley (Belfast, Northern Ireland) will also review a post-ICU rehab study, the REVIVE trial. In addition, two of the most eminent intensivists in global critical care, Prof Jean-Louis Vincent (Brussels, Belgium) and Prof Luciano Gattinoni (Milan, Italy) will be on hand to discuss the significance of these findings. It won't be all study discussion, with other elements to the meeting, including the spectacularly popular "Informal Chat", taking place that evening.

If you haven't yet attended this modern, niche meeting, then put the date Friday January 29th in your diary. Both delegate and speaker feedback from previous meetings has been incredibly positive, allowing the event to grow and attract some of the biggest names in critical care. The Titanic Centre is just minutes from Belfast City Airport, with a hotel within 3 minutes walking distance, and is a 20 minute walk from the city centre, including the Cathedral Quarter, Belfast's cultural centre full of great restaurants and pubs. Further details regarding delegate rate accommodation should be available in the next week or two. Talks are given in the setting of the rebuilt famous staircase from the great ship, while both the "Informal Chat" session and dinner overlook the floodlit slipways where Titanic and Olympic were launched. With some exciting new innovations planned, this new meeting promises to delivery on its burgeoning reputation. The finalised programme won't be released until later this Autumn, but don't wait too long before registering, as numbers are capped to keep this an intimate event. It is as strong a one day programme as you could possibly find. If you think your colleagues would find this event interesting, please circulate this information - this is a not-for-profit event, run in association with the Northern Ireland Intensive Care Society.

There are just 8 weeks to one of the biggest, and definitely the best, critical care conference in the world. The next SMACC Conference is on June 23rd to 26th, in Chicago, USA. With its informal manner and flat hierarchy, this event delivers on its promise to provide top class critical care education in a fun, modern way. Speakers are deliberately chosen for their ability to present and convey information, rather than their academic or social media status, marking this as the field leader in medical conferencing. With an emphasis on TED-like presentation styles, minimal slides and maximal social media involvement, this is the future of medical meetings. In addition to numerous world-leading academics, many active in the altruistic social media world of FOAM are there to contribute, including helping deliver a massive set of workshops the day before the main meeting begins.  Just like the Critical Care Reviews Meeting, this is a not-for-profit event, run by a team interested in sharing knowledge in a fun, modern way. It's a conference like no other. I hope to see you there.

This year's State-of-the-Art Meeting promises an exciting programme in a new dynamic format. With strong social media input, and fresh ideas from those successfully delivering free educational content through various FOAM websites and events, this conference will be very different to before. Covering every CPD requirement, and attracting the most eminent researchers from the UK and beyond, the State-of-the-Art meeting remains the biggest critical care conference in the UK.

The ICSI host a superb three day ESICM meeting at Dubin Castle on June 11th to 13th, focusing on every aspect of respiratory critical care. From mechanical ventilation to ARDS to heart-lung interactions, this event is ideal for anyone interested in updating their knowledge in this field, under the guidance of some of the leading names in the area.

• Abstract:  Mismetti. Effect of a Retrievable Inferior Vena Cava Filter Plus Anticoagulation vs Anticoagulation Alone on Risk of Recurrent Pulmonary Embolism:  A Randomized Clinical Trial. JAMA 2015;313(16):1627
• Full Text:  Glun. A randomised study in healthy volunteers to investigate the safety, tolerability and pharmacokinetics of idarucizumab, a specific antidote to dabigatran. Thromb Haemost 2015;113(5):943-951

• Abstract:  Rittayamai. Pressure-Controlled versus Volume-Controlled Ventilation in Acute Respiratory Failure: A Physiology-Based Narrative and Systematic Review. Chest 2015;epublished April 30th
• Abstract:  Corredor. The role of point-of-care platelet function testing in predicting postoperative bleeding following cardiac surgery: a systematic review and meta-analysis. Anaesthesia 2015;epublished April 27th
• Abstract:  Nguyen. The volume-outcome relationship in critical care: a systematic review and meta-analysis. Chest 2015;epublished April 30th
• Abstract:  Marti. Systemic thrombolytic therapy for acute pulmonary embolism: a systematic review and meta-analysis. Eur Heart J 2015;36(10):605–614

• Full Text:  de Groot. The association between time to antibiotics and relevant clinical outcomes in emergency department patients with various stages of sepsis: a prospective multi-center study. Critical Care 2015;19:194
• Full Text:  Balzer. Early deep sedation is associated with decreased in-hospital and 2-years follow-up survival. Critical Care 2015;19:197
• Abstract:  Betjemann. Trends in Status Epilepticus—Related Hospitalizations and MortalityRedefined in US Practice Over Time. JAMA Neurol 2015;epublished April 27th
• Abstract:  Park. Culprit or multivessel revascularisation in ST-elevation myocardial infarction with cardiogenic shock. Heart 2015;epublished April 8th
• Abstract:  Dragancea. Neurological prognostication after cardiac arrest and targeted temperature management 33 °C versus 36 °C: Results from a randomized controlled clinical trial. Resuscitation 2015;epublished April 25th
• Full Text:  Póvoa. Clinical impact of stress dose steroids in patients with septic shock: insights from the PROWESS-Shock trial. Critical Care 2015;19:193
• Full Text:  Lai. Functional outcome of prolonged refractory status epilepticus. Critical Care 2015;19:199
• Abstract:  Kentish-Barnes. Complicated grief after death of a relative in the intensive care unit. Eur Respir J 2015 45:1341-1352
• Full Text:  Póvoa. Clinical impact of stress dose steroids in patients with septic shock: insights from the PROWESS-Shock trial. Crit Care 2015;28;19(1):193
• Abstract:  Willig. Whole-genome sequencing for identification of Mendelian disorders in critically ill infants: a retrospective analysis of diagnostic and clinical findings. Lancet Respir Med 2015;epublished April 27th

• Brunskill. Red blood cell transfusion for people undergoing hip fracture surgery. Cochrane Database of Systematic Reviews 2015, Issue 4. Art. No.: CD009699

Updated

• Liu. Pharmacological treatment for pain in Guillain-Barré syndrome. Cochrane Database of Systematic Reviews 2015, Issue 4. Art. No.: CD009950

• Gaudry. Comparison of two strategies for initiating renal replacement therapy in the intensive care unit: study protocol for a randomized controlled trial (AKIKI). Trials 2015;16:170
• Brown. A randomized trial of continuous versus interrupted chest compressions in out-of-hospital cardiac arrest: Rationale for and design of the Resuscitation Outcomes Consortium Continuous Chest Compressions (ROC) Trial. AHJ 2015;169(3):334–341.e5
• Ferrando. Rationale and study design for an individualized perioperative open lung ventilatory strategy (iPROVE): study protocol for a randomized controlled trial. Trials 2015;16:193 
• Smischney. Ketamine/propofol admixture (ketofol) at induction in the critically ill against etomidate (KEEP PACE trial): study protocol for a randomized controlled trial. Trials 2015;16:177
• Eastwood. A pilot feasibility, safety and biological efficacy multicentre trial of therapeutic. Trials 2015;16:135

• Stafford-Smith. Acute kidney injury after cardiac and non-cardiac surgery: are there more similarities than differences? Can J Anesth 2015;epublished April 23rd

• Dogra. Myths about Publishing in an Open Access Journal. J Clin Imaging Sci 2015;5:26

• Yealy. Recognizing and managing sepsis: what needs to be done? BMC Medicine 2015;13:98
• Ashley. The Precision Medicine Initiative:  A New National Effort. JAMA 2015;epublished April 30th
• Liu. Current Clinical Research of Acute Kidney Injury in China. Chin Med J 2015;128:1268-71
• Schork. Personalized medicine: Time for one-person trials. Nature 2015;520:609-611

• Leek. Statistics: P values are just the tip of the iceberg. Nature 2015;520:612
• Blumenthal. Measuring Vital Signs. An IOM Report on Core Metrics for Health and Health Care Progress. JAMA 2015;epublished April 28th

Neurological

• Bernat. Observations on Ethical Issues in the Neuro-ICU. Neuro Crit Care 2015;epublished April 18th
• King. Promoting sleep in critically ill patients. Nursing Critical Care 2015;10(3):37–43

Circulatory

• McLarty. Mechanical Circulatory Support and the Role of LVADs in Heart Failure Therapy. Clinical Medicine Insights: Cardiology 2015:Suppl 2:1-5
• Westerhof. Bridging cardiovascular physics, physiology, and clinical practice: Karel H. Wesseling, pioneer of continuous noninvasive hemodynamic monitoring. Am J Physiol Heart Circ Physiol 2015;308(3): H153–H156.

Respiratory

• Janz. The role of red blood cells and cell-free hemoglobin in the pathogenesis of ARDS. Journal of Intensive Care 2015;3:20

Gastrointestinal

• Kowlgi. D-Lactic Acidosis: An Underrecognized Complication of Short Bowel Syndrome. Gastroenterology Research and Practice 2015;(2015):476215

Hepatobiliary

• Bernal. Acute liver failure: A curable disease by 2024? Journal of Hepatology 2015;62:S112–S120
• Arroyo. Acute-on-chronic liver failure: A new syndrome that will re-classify cirrhosis. Journal of Hepatology 2015;62:S131–S143
• Byrne. NAFLD: A multisystem disease. Journal of Hepatology 2015;62:S47–S64
• Bosch. Evolution in the understanding of the pathophysiological basis of portal hypertension: How changes in paradigm are leading to successful new treatments. Journal of Hepatology 2015;62:S121–S130
• Tapper. Refining the Ammonia Hypothesis. A Physiology-Driven Approach to the Treatment of Hepatic Encephalopathy. Mayo Clinic Proc 2015;90(5):646-658

Renal

• Nayak. Myoglobinuria and Acute Kidney Injury. J Integr Nephrol Androl 2015;2:50-4
• Pôncio. The long-term outcome after acute kidney injury: a narrative review. J Bras Nefrol 2015;37(1):115-120
• Roberts. Urine Dipstick Testing: Everything You Need to Know. Emergency Medicine News 2015;37(5):14–17

Haematological

• Faraoni. Updates in the perioperative and emergency management of non-vitamin K antagonist oral anticoagulants. Critical Care 2015;19:203
• Greinacher. Reversal of anticoagulants: an overview of current developments. Thromb Haemost 2015;113(5):931-942
• Roubinian. Transfusion-associated circulatory overload (TACO): prevention, management, and patient outcomes. International Journal of Clinical Transfusion Medicine 2015;3:17-28

Sepsis

• Matthaiou. How to treat fungal infections in ICU patients. BMC Infectious Diseases 2015;15:205
• Molus. Ebola–critical care considerations. Anaesthesia Tutorial of the Week 2015;epublished April 16th
• Osterholm. Transmission of Ebola Viruses: What We Know and What We Do Not Know. mBio 2015;6:e00137-15
• Helal. Immunomodulation in critically ill septic patients. Menoufia Med J 2015;28:259-65
• Schuetz. Can biomarkers help us to better diagnose and manage sepsis? Diagnosis 2015;2(2):81–87
• Erdem. New global viral threats. Saudi Med J 2015;36(4):393–398

Toxicology

• Wieland. Psychoactive bath salts: An emerging crisis. Nursing Critical Care 2015;10(3):22–27

Obstetrics

• Pavord. How I treat postpartum hemorrhage.  Blood 2015;125(18)

Miscellaneous

• Jutel. Digitizing diagnosis: a review of mobile applications in the diagnostic process. Diagnosis 2015;2(2):89-96
• Zwaan. The challenges in defining and measuring diagnostic error. Diagnosis 2015;2(2):97-103
• Martin. Overdiagnosis and overtreatment over time. Diagnosis 2015;2(2):105-109
• Liebovitz. Next steps for electronic health records to improve the diagnostic process. Diagnosis 2015;2(2):111–116

• Pène. Insights and limits of translational research in critical care medicine. Annals of Intensive Care 2015;5:8

American Journal of Respiratory and Critical Care Medicine

Review Articles

• Blackwood. How Outcomes Are Defined in Clinical Trials of Mechanically Ventilated Adults and Children. Am J Respir Crit Care Med 2015;189(8):886-893 
• Reves. Update in Tuberculosis and Nontuberculous Mycobacterial Infections 2013. Am J Respir Crit Care Med 2015;189(8):894-898 

Editorials

• Needham. Understanding and Improving Clinical Trial Outcome Measures in Acute Respiratory Failure. Am J Respir Crit Care Med 2015;189(8):875-877 
• Bagshaw. Novel Biomarkers to Anticipate Acute Kidney Injury. Getting Ahead of the Curve. Am J Respir Crit Care Med 2015;189(8):879-882  
• Wunderink. Ventilator-associated Complications, Ventilator-associated Pneumonia, and Newton’s Third Law of Mechanics. Am J Respir Crit Care Med 2015;189(8):882-883  
• Abroug. What Is the Right Dose of Systemic Corticosteroids for Intensive Care Unit Patients with Chronic Obstructive Pulmonary Disease Exacerbations?. A Question in Search of a Definitive Answer. Am J Respir Crit Care Med 2015;189(8):1014-1016 
• Kellum. Acute Kidney Injury: Still Deadly 10 Years Later. Am J Respir Crit Care Med 2015;189(8):1016-1017 

Correspondence

• Contentin. Heterogeneity in the Definition of Mechanical Ventilation Duration and Ventilator-Free Days. Am J Respir Crit Care Med 2015;189(8):998-1002
• Antioxidants in the Intensive Care Unit. Am J Respir Crit Care Med 2015;189(8):1007-1008   Fisher  |   Jain
• Bates. Specialty Status of Intensive Care Medicine in Ireland. Am J Respir Crit Care Med 2015;189(8):1149  

Chest

Review Articles 

• Desai. Nutrition in the ICU: An Evidence-Based Approach. Chest 2014;145(5):1148-1157
• Edrich. A Postoperative Patient Decompensates During Transfer From an Outside Hospital. Chest 2014;145(5):e14-e16
• Brusselle. Inflammasomes in Respiratory Disease: From Bench to Bedside. Chest 2014;145(5):1121-1133 

Editorials

• Mathis. Thromboembolism in Ultrasound: Killing Three Birds With One Stone. Chest 2014;145(5):931-932 
• Curtis. Our Responsibility for Training Physicians to Understand the Effect Patient Death Has on Them: The Role of the Intensivist. Chest 2014;145(5):932-934

Anesthesiology

Editorials

• Augoustides. Vasopressin: The Perioperative Gift that Keeps on Giving. Anesthesiology 2014;121:914-915

Review Articles

• Vetter. Perioperative Management of the Patient with a Coronary Artery Stent. Anesthesiology 2014;121
• Monsel. Cell-based Therapy for Acute Organ Injury: Preclinical Evidence and Ongoing Clinical Trials Using Mesenchymal Stem Cells. Anesthesiology 2014;121:1099-1121

Anesthesia & Analgesia

Review Articles

• Kain. The Perioperative Surgical Home as a Future Perioperative Practice Model. Anesth Analg 2014;118(5):1126-1130
• Vetter. The Perioperative Surgical Home: How Anesthesiology Can Collaboratively Achieve and Leverage the Triple Aim in Health Care. Anesth Analg 2014;118(5):1131-1136 

Editorial

• Butterworth. The Anesthesiologist-Directed Perioperative Surgical Home: A Great Idea That Will Succeed Only if It Is Embraced by Hospital Administrators and Surgeons. Anesth Analg 2014;118(5):896-897
• Crosby. Cognitive Outcome of Surgery: Is There No Place Like Home? Anesth Analg 2014;118(5):898-900
• Cannesson. Enhanced Recovery after Surgery Versus Perioperative Surgical Home: Is It All in the Name? Anesth Analg 2014;118(5):901-902
• Leslie. Sedation Depth and Mortality: A Large Randomized Trial Is Required. Anesthesia & Analgesia. Anesth Analg 2014;118(5):903-905
• Mannion. Bispectral Index, Sedation, Spinal Anesthesia and Mortality: Time to Put the Jigsaw Puzzle Together? Anesth Analg 2014;118(5):906-908
• Sear. Perioperative Renin-Angiotensin Blockade: To Continue or Discontinue, That Is the Question! Anesth Analg 2014;118(5):909-911

British Journal of Anaesthesia

Editorials

• Brindley. Adult cardiopulmonary resuscitation: ‘who’ rather than ‘how’. Br J Anaesth 2014;112(5):777-779
• Tanaka. Looking into the future of platelet transfusion in the presence of P2Y12 inhibitors. Br J Anaesth 2014;112(5):780-784
• Kozek-Langenecker. Fibrinogen concentrate: clinical reality and cautious Cochrane recommendation. Br J Anaesth 2014;112(5):784-787
• Servin. Surrogate measures, do they really describe anaesthetic state? Br J Anaesth 2014;112(5):787-790
• Sanders. ‘For now we see through a glass, darkly’: the anaesthesia syndrome. Br J Anaesth 2014;112(5):790-793

Review Articles

• Reusz. Needle-related ultrasound artifacts and their importance in anaesthetic practice. Br J Anaesth 2014;112(5):794-802
• Mazzeo. Brain–heart crosstalk: the many faces of stress-related cardiomyopathy syndromes in anaesthesia and intensive care. Br J Anaesth 2014;112(5):803-815
• Price. Initial assessment and management of pain: a pathway for care developed by the British Pain Society. Br J Anaesth 2014;112(5):816-823

Anaesthesia

Editorials

• Stroud. A defence of the NICE guidelines on intravenous fluids. Anaesthesia 2014;69:416–419

Review Articles

• Biccard. Cardiac biomarkers in the prediction of risk in the non-cardiac surgery setting. Anaesthesia 2014;69:484–493
• Staikou. A narrative review of peri-operative management of patients with thalassaemia. Anaesthesia 2014;69:494–510

Medicina Intensiva

Review Articles

• Díaz-Miguel. Temporary internal pacing. Med Intensiva 2014;38:575-9
• Alberdi. Epidemiology of severe trauma. Med Intensiva 2014;38:580-8
• Vera. Quality indicators on the use of antimicrobials in critically ill patients. Med Intensiva 2014;38:567-74

Anaesthesia and Intensive Care

Review Articles

• Reynolds. Copper removal strategies for Wilson’s disease crisis in the ICU. Anaesth Intensive Care 2014;42:253-257     (free registration required)
• Ramaswamykanive. Intravenous infusion of sterile water for the treatment of hypernatraemia. Anaesth Intensive Care 2014;42:258-262     (free registration required)

Commentary

• Shekar. Extracorporeal respiratory support: breaking conventions? Anaesth Intensive Care 2014;42:175-177     (free registration required)

Correspondence

• Tiruvoipati. Management of severe hypercapnia post cardiac arrest with extracorporeal carbon dioxide removal. Anaesth Intensive Care 2014;42:248-252(free registration required)