Newsletter 158 / December 14th 2014



Welcome to the 158th Critical Care Reviews Newsletter, bringing you the best critical care research published in the past week, plus a wide range of free full text review articles, guidelines, commentaries, editorials, study critiques, correspondence and case reports from hundreds of clinical and scientific journals. It's a small newsletter this week, with its highlights being a randomized controlled trial comparing liberal with restrictive red cell transfusion, a meta analysis evaluating albumin as a resuscitation fluid in sepsis, an observational study investigating apnoeic oxygenation during tracheal intubation, plus review articles on massive transfusion and intracranial haemorrhage. If you only have time to read one paper, try this one on "current controversies in the support of sepsis.".

This week's Topic of the Week is pacemakers and internal cardioverter-defibrillators, starting with a paper on transvenous pacing in tomorrow's Paper of the Day.


Review Articles:  Clinical


Upcoming Meetings

Critical Care Reviews Meeting 2015

It's now less than seven weeks until the Critical Care Reviews Meeting 2015, discussing the hottest trial of 2014. Studies being reviewed include the mechanical chest compression device studies CIRC and LINC; ALBIOS, investigating albumin in sepsis; TRISS, evaluating red cell transfusion thresholds in septic shock; OPTIMISE, looking at perioperative goal-directed haemodynamic therapy; SEPSISPAM, examining blood pressure targets in septic shock, PEITHO, exploring fibrinolysis in intermediate-risk PE, and a comparison of cerebral perfusion pressure-targeted therapy versus intracranial pressure-targeted therapy for raised intracranial pressure in paediatric CNS Infections. Chief investigators for three of the major RCTs presented at the Hot Topics Session of the European Society of Intensive Care Medicine meeting in Barcelona in October are present to discuss their work (CALORIES, HARP 2, VITdAL-ICU), as is the chief investigator for TTM. 2014 is the year of the early goal-directed sepsis therapy studies, and the chief investigator for ProMISe will be on hand to discuss the results of ProCESS & ARISE, as well as give an insight into the yet to finish UK sepsis study ProMISe. If this wasn't enough, there are also review talks from world experts on early mobilisation, ECMO, airway management, sepsis and neuroprognostication post cardiac arrest. Regardless if you're a believer in, or skeptic of, evidence-based medicine, you'll be amazed by the discussion on this recent paper exposing the fragility of the science we base our practice on.

The programme is available and online registration is open. With a global array of speakers, including the chief investigators for some of the biggest studies of the past 12 months, this is one of the most contemporary meetings around. Register early and don't miss out. Please feel free to contact me if you're thinking about making the trip - it would be great to hear from you.

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Critical Care Horizons

Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. A call for papers has been issued, so if you have something interesting to say, and can say it in an engaging manner, please get in touch. The first issue will be released on January 1st 2015.

COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.

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Randomized Controlled Trials

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Meta Analyses

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Observational Studies

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Study Critiques

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I hope you find these links useful.

Until next week



Other:  Study Critiques  |  Editorials  |  Commentaries  |  Case Reports 
Review Articles:  Clinical