Major Studies on the use of

Anti-Fibrinolytics in Trauma

Tranexamic Acid

  1. Morrison. Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study. Arch Surg 2012;147(2):113-119  (abstract)      
  2. Morrison. Association of Cryoprecipitate and Tranexamic Acid With Improved Survival Following Wartime Injury. Findings From the MATTERs II Study. Arch Surg 2012; epublished November 19th  (abstract)
  3. CRASH-2 trial collaborators. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 2010;376:23-32