Major Studies on Stroke


  1. Brott. Early Hemorrhage Growth in Patients With Intracerebral Hemorrhage. Stroke. 1997;28:1-5



Blood Pressure Control

  1. He. Effects of Immediate Blood Pressure Reduction on Death and Major Disability in Patients With Acute Ischemic Stroke. The CATIS Randomized Clinical Trial. JAMA 2014;311(5):479-489
  2. Anderson. Rapid Blood-Pressure Lowering in Patients with Acute Intracerebral Hemorrhage (INTERACT 2). N Eng J Med 2013;368:2355-2365  

Recombinant Factor 7

  1. Mayer. Efficacy and Safety of Recombinant Activated Factor VII for Acute Intracerebral Hemorrhage. N Engl J Med 2008; 358:2127-213


  1. Ginsberg. High-dose albumin treatment for acute ischaemic stroke (ALIAS) part 2: a randomised, double-blind, phase 3, placebo-controlled trial. Lancet Neurology 2013;epublished September 27th


Clot Evacuation

  1. Medelow. Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial.  Lancet 2005;365:387 - 397  (abstract)

Decompressive Craniectomy

  1. Jüttler. Hemicraniectomy in Older Patients with Extensive Middle-Cerebral-Artery Stroke (Destiny II). N Engl J Med 2014;370:1091-1100
  2. Vahedi. Early decompressive surgery in malignant infarction of the middle cerebral artery: a pooled analysis of three randomised controlled trials. Lancet Neurol 2007;6(3):215–22.
  3. Jüttler. Decompressive Surgery for the Treatment of Malignant Infarction of the Middle Cerebral Artery (DESTINY). A Randomized, Controlled Trial. Stroke 2007;38:2518
  4. Vahedi. Sequential-Design, Multicenter, Randomized, Controlled Trial of Early Decompressive Craniectomy in Malignant Middle Cerebral Artery Infarction (DECIMAL Trial). Stroke. 2007;38:2506


  1. Berkhemer. A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke (MR CLEAN Trial). N Engl J Med 2014;epublished December 17th