Major Studies on Goal-Directed Therapy
- Jansen. Early Lactate-Guided Therapy in ICU Patients: A Multicenter, Open-Label, Randomized, Controlled Trial. Am. J. Respir. Crit. Care Med. 2010;182: 752-761
- Gattinoni. A trial of goal-oriented hemodynamic therapy in critically ill patients. SvO2 Collaborative Group. N Engl J Med 1995;333:1025-1032
- Hayes. Elevation of systemic oxygen delivery in the treatment of critically ill patients. N Engl J Med 1994, 330:1717-1722.
- Jones. Lactate Clearance vs Central Venous Oxygen Saturation as Goals of Early Sepsis Therapy. JAMA. 2010;303(8):739-746.
- Sevransky. Hemodynamic goals in randomized clinical trials in patients with sepsis: a systematic review of the literature. Critical Care 2007, 11:R67
- Rivers. Early goal directed therapy in the treatment of severe sepsis and septic shock. N Eng J Med 2001;345:1368-77.