Top Sepsis Studies

  1. Sprung. Hydrocortisone Therapy for Patients with Septic Shock. N Engl J Med 2008;358:111-124
  2. Rivers. Early goal directed therapy in the treatment of severe sepsis and septic shock. N Eng J Med 2001;345:1368-77.
  3. Chastre. Comparison of 8 vs. 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial. JAMA. 2003;290:2588-2598.
  4. Vincent. International Study of the Prevalence and Outcomes of Infection in Intensive Care Units. JAMA. 2009;302(21):2323-2329
  5. Martin. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003, 348:1546-1554.
  6. Vincent. The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of Infection in Intensive Care (EPIC) Study. EPIC International Advisory Committee. JAMA 1995;274(8):639-644.  (abstract)
  7. Kumar. Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock. Chest 2009; 136(5):1237-1248.
  8. Kumar. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006; 34(6): 1589-1596.  (abstract) (appraisal : Brindley CJA 2006; 53(11): 1157–1160 )
  9. Bouadma. Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomized controlled trial. Lancet. 2010;375:463-474.
  10. Ranieri. Drotrecogin Alfa (Activated) in Adults with Septic Shock ( PROWESS-SHOCK Study). N Engl J Med 2012;366:2055-206 (abstract)
  11. Micek. A randomized controlled trial of an antibiotic discontinuation policy for clinically suspected ventilator-associated pneumonia. Chest. 2004;125:1791-1799
  12. Stephens. Randomized, double-blind, placebo-controlled trial of granulocyte colony-stimulating factor in patients with septic shock. Crit Care Med. 2008 Feb;36(2):448-54.
  13. COIITSS Study Investigators. Corticosteroid treatment and intensive insulin therapy for septic shock in adults: a randomized controlled trial. JAMA. 2010 Jan 27;303(4):341-8.
  14. Annane. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002;288:862-871
  15. Annane. Corticosteroids in the Treatment of Severe Sepsis and Septic Shock in Adults. JAMA 2009;301(22):2362-2375
  16. Dhainaut. Extended drotrecogin alfa (activated) treatment in patients with prolonged septic shock. Intensive Care Medicine 2009;35(7):1187–95. (abstract)
  17. Nadel. Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomized controlled trial (RESOLVE) . Lancet 2007;369:836-43 (abstract)
  18. Edward. Drotrecogin Alfa (Activated) for Adults with Severe Sepsis and a Low Risk of Death (ADDRESS). N Engl J Med 2005;353:1332-41 
  19. Bernard. Efficacy and safety of recombinant human activated protein C for severe sepsis (PROWESS). N Engl J Med 2001;344:699-709
  20. Bernard. Safety and dose relationship of recombinant human activated protein C for coagulopathy in severe sepsis. Crit Care Med 2001;29(11):2051–9.  (abstract)
  21. Walkey. Linezolid versus Glycopeptide Antibiotics for the Treatment of Suspected Methicillin-Resistant Staphylococcus Aureus Nosocomial Pneumonia: A Meta-Analysis of Randomized Controlled Trials. ePublished ahead of print 23/09/2010
  22. Bo. Granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) for sepsis: a meta-analysis. Critical Care 2011;15(1):R58