Top Critical Care Nutritional Studies

  1. van Zanten. High-Protein Enteral Nutrition Enriched With Immune-Modulating Nutrients vs Standard High-Protein Enteral Nutrition and Nosocomial Infections in the ICU. A Randomized Clinical Trial (MetaPlus study). JAMA 2014;312(5):514-524
  2. Heyland. A Randomized Trial of Glutamine and Antioxidants in Critically Ill Patients (REDOXS study). N Engl J Med 2013;368:1489-1497
  3. Reignier. Effect of Not Monitoring Residual Gastric Volume on Risk of Ventilator-Associated Pneumonia in Adults Receiving Mechanical Ventilation and Early Enteral Feeding:  A Randomized Controlled Trial. JAMA 2013;309(3):249
  4. The National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Initial Trophic vs Full Enteral Feeding in Patients With Acute Lung Injury: The EDEN Randomized Trial. JAMA 2012;307(8):795-803
  5. Gramlich. Does enteral nutrition compared to parenteral nutrition result in better outcomes in critically ill adult patients? A systematic review of the literature. Nutrition 2004;20:843– 848.(from
  6. Casaer.  Early versus Late Parenteral Nutrition in Critically Ill Adults (EPaNIC study). NEJM 2011;365:506-517
  7. Rice. Enteral Omega-3 Fatty Acid, gamma-Linolenic Acid, and Antioxidant Supplementation in Acute Lung Injury. JAMA 2011;306(14):1574-1581 
  8. Andrews. Randomised trial of glutamine, selenium, or both, to supplement parenteral nutrition for critically ill patients. SIGNET study.  BMJ 2011; 342:d1542
  9. Angstwurm. Selenium in Intensive Care (SIC) study: Results of a prospective, randomized, placebo-controlled, multiple-center study in Patients with Severe systemic inflammatory response syndrome, sepsis and septic shock. Crit Care Med 2007, 35: 118-126.  (abstract)
  10. Déchelotte. L-alanyl-L-glutamine dipeptide-supplemented total parenteral nutrition reduces infectious complications and glucose intolerance in critically ill patients: the French controlled, randomized, double-blind, multicenter study. Crit Care Med 2006;34(3):598-604.(abstract)
  11. Doig. A Review of the True Methodological Quality of Nutritional Support Trials Conducted in the Critically Ill: Time for Improvement. Anesth Analg 2005;100:527–33