Top Critical Care Respiratory Studies

  1. The Acute Respiratory Distress Syndrome Network. Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome. N Engl J Med 2000; 342:1301-1308
  2. Determann. Ventilation with lower tidal volumes as compared with conventional tidal volumes for patients without acute lung injury: a preventive randomized controlled trial. Crit Care. 2010;14(1):R1.Papazian. Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med 2010;363:1107-1116 
  3. Drakulovic. Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial. Lancet 1999;354(9193):1851–1858
  4. Peek. Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial. Lancet 2009; 374: 1351-63.  (abstract)
  5. Noah. Referral to an Extracorporeal Membrane Oxygenation Center and Mortality Among Patients With Severe 2009 Influenza A(H1N1). JAMA 2011;306(15):1659-1668
  6. Australia and New Zealand Extracorporeal Membrane Oxygenation (ANZ ECMO) Influenza Investigators. Extracorporeal membrane oxygenation for 2009 influenza A(H1N1) acute respiratory distress syndrome. JAMA 2009; 302:1888-95.
  7. Wiedemann. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med. 2006; 354:2564-75
  8. Frat. High-Flow Oxygen through Nasal Cannula in Acute Hypoxemic Respiratory Failure (FLORALI study). N Eng J Med 2015;epublished May 17th
  9. Meduri. Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial. Chest 2007; 131:954-63.
  10. Taccone. Prone Positioning in Patients With Moderate and Severe Acute Respiratory Distress Syndrome. A Randomized Controlled Trial. JAMA. 2009;302(18):1977-1984
  11. Mancebo. A multicentre trial of prolonged prone ventilation in severe acute respiratory distress syndrome.  Am J Respir Crit Care Med. 2006;173:-1233-1239
  12. Adhikari. Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis. BMJ 2007; 334 : 779
  13. Wheeler. Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury. N Engl J Med. 2006; 354:2213-24.
  14. The National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Initial Trophic vs Full Enteral Feeding in Patients With Acute Lung Injury: The EDEN Randomized Trial. JAMA Published online February 5, 2012.
  15. Rice. Enteral Omega-3 Fatty Acid, γ-Linolenic Acid, and Antioxidant Supplementation in Acute Lung Injury. JAMA 2011;306(14):1574-1581
  16. Villar. The ALIEN study: incidence and outcome of acute respiratory distress syndrome in the era of lung protective ventilation. Intensive Care Med 2011;37(12):1932-1941 (abstract)(Erratum)
  17. Terragni. Tidal hyperinflation during low tidal volume ventilation in acute respiratory distress syndrome. Am J Respir Crit Care Med 2007;175:160–166
  18. Jabre. Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial. Lancet 2009;374(9686):293-300(abstract)
  19. Sørensen. Rapid sequence induction and intubation with rocuronium–sugammadex compared with succinylcholine: a randomized trial. Br J Anaesth 2012;108(4):682-689  (full text late 2012)
  20. Terragni. Early vs late tracheotomy for prevention of pneumonia in mechanically ventilated adult ICU patients. JAMA 2010;303:1483–1489.
  21. Rumbak. A prospective, randomized, study comparing early percutaneous dilational tracheotomy to prolonged translaryngeal intubation (delayed tracheotomy) in critically ill medical patients. Crit Care Med 2004;32:1689–1694. (abstract)
  22. Delaney. Percutaneous dilatational tracheostomy versus surgical tracheostomy in critically ill patients: a systematic review andmeta-analysis. Critical Care 2006, 10:R55
  23. Esteban. Noninvasive Positive-Pressure Ventilation for Respiratory Failure after Extubation.N Engl J Med 2004; 350:2452-2460
  24. Esteban. A comparison of four methods of weaning patients from mechanical ventilation. Spanish Lung Failure Collaborative Group.N Engl J Med. 1995 Feb 9;332(6):345-50.
  25. Slutsky AS. Lung Injury Caused by Mechanical Ventilation. Chest. 1999 Jul 1;116(suppl 1):9S -15S.
  26. Levine. Rapid disuse atrophy of Diaphragm fibres in mechanically ventilated humans. N Engl J Med 2008;358(13):1327-1335
  27. Gattinoni. Lung Recruitment in Patients with the Acute Respiratory Distress Syndrome. N Engl J Med 2006;354:1775-86
  28. Hudson. Clinical risks for development of ARDS. Am J Respir Crit Care Med 1995;151:293-301
  29. Herridge. Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med. 2011;364(14):1293-304 
  30. Eichacker. Meta-analysis of ALI and ARDS trials testing low tidal volumes. Am J Respir Crit Care Med 2002;166:1510-4
  31. The ARDS Definition Task Force. Acute Respiratory Distress Syndrome. The Berlin Definition. JAMA 2012; epublished ahead of print
  32. Bernard. The American European consensus conference on ARDS: definitions mechanisms, relevant outcomes and clinical trial coordination, Am J Respir Crit Care Med 1994; 149:818–24.(abstract)
  33. Ferguson. Development of a clinical definition for acute respiratory distress syndrome using the Delphi technique. J Crit Care 2005; 20:147–154(pubmed abstract)  
  34. Murray. An expanded definition of the adult respiratory distress syndrome. Am Rev Respir Dis 1988;138(3):720-3  (not available)
  35. Ferguson. Acute respiratory distress syndrome: underrecognition by clinicians and diagnostic accuracy of three clinical definitions. Crit Care Med 2005;33(10):2228-34 (pubmed abstract)
  36. Meade. Agreement between Alternative Classifications of Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med 2001;163:490–493
  37. Rubenfeld. Incidence and outcomes from acute lung injury. N Engl J Med 2005; 353:1685-1693
  38. Herridge MS, Cheung AM, Tansey CM, et al. One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med. 2003; 348:683-93.
  39. Herridge. Functional Disability 5 Years after Acute Respiratory Distress Syndrome. N Engl J Med 2011; 364:1293-1304
  40. Gattinoni. Acute respiratory distress syndrome caused by pulmonary and extrapulmonary disease. Different syndromes?. Am J Respir Crit Care Med 1998; 158:3-11.
  41. Stapleton. Causes and timing of death in patients with ARDS. Chest 2005;128:525-532
  42. Meade. Interobserver variation in interpreting chest radiographs for the diagnosis of acute respiratory distress syndrome. Am J Respir Crit Care Med 2000; 161:85–90
  43. Rubenfeld. Interobserver variability in applying a radiographic definition for ARDS. Chest 1999;116:1347-1353
  44. Esteban. Comparison of clinical criteria for the acute respiratory distress syndrome with autopsy findings. Ann Intern Med 2004;141:440-445.
  45. Villar. The ALIEN study: incidence and outcome of acute respiratory distress syndrome in the era of lung protective ventilation. Intensive Care Med 2011; epub ahead of print.(Erratum)
  46. Terragni. Tidal hyperinflation during low tidal volume ventilation in acute respiratory distress syndrome. Am J Respir Crit Care Med 2007;175:160–166
  47. Villar. A high positive end-expiratory pressure, low tidal volume ventilatory strategy improves outcome in persistent acute respiratory distress syndrome: a randomized, controlled trial. Crit Care Med 2006; 34:1311-1318.   (abstract)
  48. The Acute Respiratory Distress Syndrome Network. Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome. N Engl J Med 2000; 342:1301-1308
  49. Brower. Prospective, randomized, controlled clinical trial comparing traditional versus reduced tidal volume ventilation in acute respiratory distress syndrome patients. Crit Care Med 1999;27:1492-1498.   (abstract)
  50. Stewart. Evaluation of a ventilation strategy to prevent barotrauma in patients at high risk for acute respiratory distress syndrome. Pressure- and Volume-Limited Ventilation Strategy Group. N Engl J Med 1998;338:355-361.
  51. Amato. Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med 1998; 338:347-354.
  52. Brochard. Tidal volume reduction for prevention of ventilator-induced lung injury in acute respiratory distress syndrome. The Multicenter Trial Group on Tidal Volume Reduction in ARDS. Am J Respir Crit Care Med 1998; 158:1831-1838.
  53. Wolthuis. Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injury. Anesthesiology 2008 Jan;108(1):46-54.
  54. Mercat. Positive End-Expiratory Pressure Setting in Adults With Acute Lung Injury and Acute Respiratory Distress Syndrome. JAMA. 2008;299(6):646-655.
  55. Meade. Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: A randomized controlled trial. JAMA 2008; 299:637-645.
  56. The National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Higher versus Lower Positive End-Expiratory Pressures in Patients with the Acute Respiratory Distress Syndrome. N Engl J Med 2004;351:327-36.
  57. Putensen. Meta-analysis: Ventilation Strategies and Outcomes of the Acute Respiratory Distress Syndrome and Acute Lung Injury. Ann Intern Med. 2009;151:566-57(abstract)
  58. Fan. Recruitment Maneuvers for Acute Lung Injury: A Systematic Review. Am J Respir Crit Care Med 2008;178:1156–1163
  59. Gattinoni. Lung Recruitment in Patients with the Acute Respiratory Distress Syndrome. N Engl J Med 2006;354:1775-86.
  60. Povoa. Evaluation of a recruitment maneuver with positive inspiratory pressure and high PEEP in patients with severe ARDS. Acta Anaesthesiol Scand 2004;48:287-293.
  61. Brower. Effects of recruitment maneuvers in patients with acute lung injury and acute respiratory distress syndrome ventilated with high positive end-expiratory pressure. Crit Care Med 2003;31:2592-2597.   (abstract)
  62. Halter. Positive end-expiratory pressure after a recruitment maneuver prevents both alveolar collapse and recruitment/derecruitment. Am J Respir Crit Care Med 2003;167:1620-1626(Video)
  63. Villagra. Recruitment maneuvers during lung protective ventilation in acute respiratory distress syndrome. Am J Respir Crit Care Med 2002;165:165-170.
  64. Gattinoni. Prone positioning improves survival in severe ARDS: a pathophysiologic review and individual patient meta-analysis. Minerva Anestesiologica 2010 June;76(6):448-54
  65. Taccone. Prone Positioning in Patients With Moderate and Severe Acute Respiratory Distress Syndrome. A Randomized Controlled Trial. JAMA. 2009;302(18):1977-1984
  66. Fernandez. Prone positioning in acute respiratory distress syndrome: a multicentre, randomized clinical trial. Intensive Care Med. 2008;34:1487-1491  (abstract)
  67. Mancebo. A multicentre trial of prolonged prone ventilation in severe acute respiratory distress syndrome.  Am J Respir Crit Care Med. 2006;173:-1233-1239
  68. Voggenreiter. Prone Positioning Improves Oxygenation in Post-Traumatic Lung Injury-A Prospective Randomized Trial. J Trauma. 2005;59:333-341(abstract)
  69. Guerin. Effects of Systematic Prone Positioning in Hypoxemic Acute Respiratory Failure: A Randomized Controlled Trial. JAMA. 2004;292(19):2379-2387
  70. Gattinoni. Effect of prone positioning on the survival of patients with acute respiratory failure. N Engl J Med 2001;345:568-73
  71. Sud. High frequency oscillation in patients with acute lung injury and acute respiratory distress syndrome (ARDS): systematic review and meta-analysis. BMJ 2010;340:c2327
  72. Derdak. High-frequency oscillatory ventilation for acute respiratory distress syndrome in adults (MOAT Study). Am J Respir Crit Care Med 2002; 166: 801–8
  73. Kacmarek. Partial Liquid Ventilation in Adult Patients with Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2006 Sep 1;174(5):615
  74. Wiedemann. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med. 2006; 354:2564-75
  75. Wheeler. Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury. N Engl J Med. 2006; 354:2213-24.
  76. Papazian. Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med 2010;363:1107-1116
  77. Adhikari. Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis. BMJ 2007; 334 : 779
  78. Smith. Effect of intravenous β-2 agonist treatment on clinical outcomes in acute respiratory distress syndrome (BALTI-2): a multicentre, randomised controlled trial. Lancet epub ahead of print December 12 2011(full text version)
  79. NHLBI ARDSnet. Randomized, Placebo-controlled Clinical Trial of an Aerosolized ?2-Agonist for Treatment of Acute Lung Injury. Am J Resp Crit Care Med 2011;184:561-568  (CAT Review - JICS 2012)   (Critique - Critical Care 2012)
  80. Perkins. The Beta-Agonist Lung Injury Trial (BALTI): A Randomized Placebo-controlled Clinical Trial.  Am J Respir Crit Care Med 2006;173:281–287
  81. Meduri GU, Golden E, Freire AX, et al. Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial. Chest 2007; 131:954-63.
  82. Steinberg KP, Hudson LD, Goodman RB, et al. Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. N Engl J Med 2006; 354:1671-84.
  83. Liu. Randomized Clinical Trial of Activated Protein C for the Treatment of Acute Lung Injury. Am J Respir Crit Care Med 2008;178(6):618-623
  84. Spragg. Recombinant Surfactant Protein C–based Surfactant for Patients with Severe Direct Lung Injury. American Journal of Respiratory and Critical Care Medicine 2011;183(8):1055 –1061
  85. Kesecioglu. Exogenous Natural Surfactant for Treatment of Acute Lung Injury and the Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med 2009;180(10):989–994
  86. Spragg. Effect of Recombinant Surfactant Protein C–Based Surfactant on the Acute Respiratory Distress Syndrome. N Engl J Med 2004;351(9):884–92
  87. Spragg. Treatment of Acute Respiratory Distress Syndrome with Recombinant Surfactant Protein C Surfactant. Am J Respir Crit Care Med 2003;167(11):1562–6
  88. Anzueto. Aerosolized surfactant in adults with sepsis-induced acute respiratory distress syndrome. Exosurf Acute Respiratory Distress Syndrome Sepsis Study Group. N Engl J Med 1996;334:1417–1421
  89. Davidson. Exogenous pulmonary surfactant for the treatment of adult patients with acute respiratory distress syndrome: results of a meta-analysis. Critical Care 2006;10:R41
  90. Noah. Referral to an Extracorporeal Membrane Oxygenation Center and Mortality Among Patients With Severe 2009 Influenza A(H1N1). JAMA 2011;306(15):1659-1668
  91. Peek. Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial. Lancet 2009; 374: 1351-63.  (abstract)
  92. Australia and New Zealand Extracorporeal Membrane Oxygenation (ANZ ECMO) Influenza Investigators. Extracorporeal membrane oxygenation for 2009 influenza A(H1N1) acute respiratory distress syndrome. JAMA 2009; 302:1888-95.
  93. Morris. Randomized clinical trial of pressure-controlled inverse ratio ventilation and extracorporeal CO2 removal for adult respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 1994;149(2):295-305.
  94. Zapol. Extracorporeal Membrane Oxygenation in Severe Acute Respiratory Failure A Randomized Prospective Study. JAMA 1979;242:2193-2196
  95. The National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Initial Trophic vs Full Enteral Feeding in Patients With Acute Lung Injury: The EDEN Randomized Trial. JAMA Published online February 5, 2012.
    1. Editorial:Griffths. Nutrition for Critically Ill Patients: How Much Is Enough? JAMA. Published online February 5, 2012
  96. Rice. Enteral Omega-3 Fatty Acid, γ-Linolenic Acid, and Antioxidant Supplementation in Acute Lung Injury. JAMA 2011;306(14):1574-1581
  97. Stapleton. A phase II randomized placebo-controlled trial of omega-3 fatty acids for the treatment of acute lung injury. Crit Care Med. 2011;39(7):1655-62

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