Top Critical Care Circulatory Studies

  1. Finfer. A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med 2004;350(22):2247-56
  2. Myburgh. Hydroxyethyl Starch or Saline for Fluid Resuscitation in Intensive Care (CHEST study). NEJM 2012; epublished ahead of print
  3. Bernard. Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia. N Engl J Med 2002; 346:557-563
  4. The Hypothermia after Cardiac Arrest Study Group. Mild Therapeutic Hypothermia to Improve the Neurologic Outcome after Cardiac Arrest. N Engl J Med 2002; 346:549-556
  5. Harvey. Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised controlled trial. Lancet 2006;366:472 - 477(abstract)
  6. Maitland. Mortality after Fluid Bolus in African Children with Severe Infection (FEAST Trial). N Engl J Med 2011.(Paediatric Study)
  7. Annane. Norepinephrine plus dobutamine versus epinephrine alone for management of septic shock: A randomised trial. Lancet 2007; 370:676-684. (abstract)
  8. The National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Pulmonary-Artery versus Central Venous Catheter to Guide Treatment of Acute Lung Injury. N Engl J Med 2006;354:2213-24
  9. Richard. Early use of the pulmonary artery catheter and outcomes in patients with shock and acute respiratory distress syndrome: A randomized controlled trial. JAMA 2003; 290: 2713–2720
  10. Jansen. Early Lactate-Guided Therapy in ICU Patients: A Multicenter, Open-Label, Randomized, Controlled Trial. Am. J. Respir. Crit. Care Med. 2010;182: 752-761
  11. Gattinoni. A trial of goal-oriented hemodynamic therapy in critically ill patients. SvO2 Collaborative Group. N Engl J Med 1995;333:1025-1032
  12. Hayes. Elevation of systemic oxygen delivery in the treatment of critically ill patients. N Engl J Med 1994, 330:1717-1722.
  13. Jones. Lactate Clearance vs Central Venous Oxygen Saturation as Goals of Early Sepsis Therapy. JAMA. 2010;303(8):739-746.
  14. Rivers. Early goal directed therapy in the treatment of severe sepsis and septic shock. N Eng J Med 2001;345:1368-77.
  15. Sevransky. Hemodynamic goals in randomized clinical trials in patients with sepsis: a systematic review of the literature. Critical Care 2007, 11:R67
  16. Kilgannon. Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA 2010;303:2165–2171.
  17. Follath. Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (the LIDO study): a randomised double-blind trial. Lancet 2002;360:196-202  (abstract)
  18. Nieminen. Randomized study on safety and effectiveness of levosimendan in patients with left ventricular failure after an acute myocardial infarction (RUSSLAN). European Heart Journal 2002;23:1422-32.
  19. Pitt. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 2003;348:1309-1321
  20. Pitt. The effect of spironolactone on mortality and morbidity in patients with severe heart failure (RALE study). N Engl J Med 1999; 341(10):709-717
  21. Copeland. Cardiac Replacement with a Total Artificial Heart as a Bridge to Transplantation. N Engl J Med 2004;351:859-67
  22. Slaughter. Advanced heart failure treated with continuous-flow left ventricular assist device. N Engl J Med 2009;361(23):2241-51.
  23. Rose. Long-term mechanical left ventricular assistance for end-stage heart failure. N Engl J Med 2001;345:1435-43.