Newsletter 133 / June 22nd 2014



Welcome to the abbreviated 133rd Critical Care Reviews Newsletter. I'm presently travelling with limited internet access, so this is another small newsletter. Accordingly, there are no study summaries. Normal service will resume next week.

In news this week, do-not-attempt-resuscitation orders are judged on in English Courts. This week's research studies include randomized controlled trials on long-term sedation, coagulopathy correction prior to interventions, a long term follow-up to 6S and helmet-CPAP for pneumonia; interventional studies on rehabilitation post-ICU and post-cardiac arrest debriefing; meta analyses on thrombolysis for pulmonary embolism, chlorhexidine-impregnated dressing for the prevention of catheter-related bloodstream infections, venothromboembolism prophylaxis post-surgery and glycaemic control in sepsis; and observational studies on  long-term outcomes after severe hypoxaemic respiratory failure, hydrocortisone therapy in septic shock, rescue bedside laparotomy, red cell transfusion in trauma and cardiac arrest outcomes. This week's guidelines address pulmonary hypertension, paediatric intestinal failure, contrast-induced nephropathy, the effects of non-coumarin anticoagulants on tests of haemostasis, and firearm injuries and deaths in the USA.

Editorials look at carbapenemase gram negative bacteria and post-cardiac arrest management. Commentaries focus on post graduate education and academic medical centres. There is one correspondence of note, on the nutrition paper in the New England Journal of Medicine Critical Care series, all 10 current articles of which can be accessed in the clinical review articles section. Two non-clinical reviews discuss propensity analysis and the frailties of evidence-based medicine.

The New England Journal of Medicine Critical Care series is the standout choice for our topic of the week in This Week's Papers, starting with a paper on severe sepsis and septic shock in tomorrow's Paper of the Day.