Welcome to the 304th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. Apologies for the second late newsletter in a row, but it's now a very busy time, with preparation for the Critical Care Reviews Meeting and also writing the Critical Care Reviews Book 2018. There hasn't been much major research published that I came across over the past week, but there is an abundance of other material to read. The highlights of this week's newsletter are narrative reviews on severe hypoxemic respiratory failure, ARDS and diffuse alveolar damage and noninferiority trials; editorials on fluid therapy and suspected brain death, and commentaries on cytokine release syndrome and evaluating physical functioning in critical care.
In other news, after a successful survey on interventional study effect sizes leading to an interesting publication in Critical Care in June, Paul Young is again innovating with the use of social media and crowd sourcing in critical care research. He's inviting post-publication peer-review from the wider critical care community of a statistical analysis plan on a study evaluating knowledge translation in temperature management of patients following out-of-hospital cardiac arrest. If you have a few minutes, check out the study protocol, statistical analysis plan and announcement, and if you have any comments or suggestions, please contact Paul via email.
Finally, the Neurocritical Care Unit at Addenbrooke's Hospital in Cambridge, England, are recruiting consultants in Neurosciences and Trauma Critical Care. They are very flexible about the types of jobs they can offer and can accommodate a diverse range of interests including research, QI, and education - particularly social media education. You can view their promo video here.
- Abstract: Pavlov. Apneic oxygenation reduces the incidence of hypoxemia during emergency intubation: A systematic review and meta-analysis. Am J Emerg Med 2017;35(8):1184-1189
- Abstract: Sanfilippo. Tissue Doppler assessment of diastolic function and relationship with mortality in critically ill septic patients: a systematic review and meta-analysis. Br J Anaesth 2017;119(4):583–594
- Abstract: Rahouma. Does a balanced transfusion ratio of plasma to packed red blood cells improve outcomes in both trauma and surgical patients? A meta-analysis of randomized controlled trials and observational studies. Am J Surg 2017;epublished September 23rd
- Full Text: Fisher. The effect of regional citrate anti-coagulation on the coagulation system in critically ill patients receiving continuous renal replacement therapy for acute kidney injury - an observational cohort study. BMC Nephrol 2017;18(1):304
- Abstract: Tierney. Pulmonary ultrasound scoring system for intubated critically ill patients and its association with clinical metrics and mortality: A prospective cohort study. J Clin Ultrasound 2017;epublished October 6th
- Full Text: Lilly. Five-Year Trends of Critical Care Practice and Outcomes. Chest 2017;152(4):723–735
- Full Text: Yarnell. Association Between Immigrant Status and End-of-Life Care in Ontario, Canada. JAMA 2017;epublished October 2nd
- Abstract: Galvagno. Outcomes after concomitant traumatic brain injury and hemorrhagic shock: A secondary analysis from the Pragmatic, Randomized Optimal Platelets and Plasma Ratios trial. J Trauma Acute Care Surg 2017;83(4):668-674
- Radunovic. Mechanical ventilation for amyotrophic lateral sclerosis/motor neuron disease. Cochrane Database of Systematic Reviews 2017, Issue 10. Art. No.: CD004427
- Iro. Intravenous immunoglobulin for the treatment of childhood encephalitis. Cochrane Database of Systematic Reviews 2017, Issue 10. Art. No.: CD011367
- Zhang. Monitoring cerebral ischemia during cerebrovascular surgery. J Biomed Res 2017;31(4):279–282
- Li. Monitoring cerebral ischemia during carotid endarterectomy and stenting. J Biomed Res 2017;31(1):11–16
- Milinis. History of Aneurysmal Spontaneous Subarachnoid Hemorrhage. Stroke 2017;48:e280-e283
- Nagayama. Novel clinical features of nonconvulsive status epilepticus. F1000Research 2017, 6(F1000 Faculty Rev):1690
- Jonkman. Ketamine for pain. F1000Research 2017, 6(F1000 Faculty Rev):1711
- Öhman. Focused echocardiography and lung ultrasound protocol for guiding treatment in acute heart failure. ESC Heart Failure 2018;epublished September 28th
- Goyal. Extracorporeal Membrane Oxygenation in Cardiac Intensive Care Unit. J Card Crit Care 2017;01(01):10-14
- Ladha. Challenges in Multivalvular Heart Disease: Indian Scenario. J Card Crit Care 2017;01(01):015-020
- Hamadah. Bedside Ultrasound in the Diagnosis and Treatment of Children with Respiratory Difficulty Following Cardiac Surgery. J Clin Imaging Sci 2017;7:37
- Alvarez. Recent Advances in Understanding and Managing Cardiomyopathy. F1000Research 2017, 6(F1000 Faculty Rev):1659
- Bond. Recent advances in rhythm control for atrial fibrillation. F1000Research 2017, 6(F1000 Faculty Rev):1796
- Engberding. Acute Coronary Syndromes in the Elderly. F1000Research 2017, 6(F1000 Faculty Rev):1791
- Narendra. Update in Management of Severe Hypoxemic Respiratory Failure. Chest 2017;152(4):867–879
- Rios. What every intensivist should know about acute respiratory distress syndrome and diffuse alveolar damage. Rev Bras Ter Intensiva 2017;29(3):354-363
- Jin. Perioperative “remote” acute lung injury: recent update. J Biomed Res 2017;31(3):197–212
- Mason. Acute respiratory distress syndrome. Clin Med 2017;17:439-443
- Azadeh. The Role of Infection in Interstitial Lung Diseases. Chest 2017;152(4):842–852
- Loor. Bridging to lung transplantation with extracorporeal circulatory support: when or when not? J Thorac Dis 2017;9(9):3352-3361
- Hewlett. Foreign body aspiration in adult airways: therapeutic approach. J Thorac Dis 2017;9(9):3398-3409
- Lopes. Fluid overload in children undergoing mechanical ventilation. Rev Bras Ter Intensiva 2017;29(3):346-353
- Caminati. Severe idiopathic pulmonary fibrosis: what can be done? Eur Respir Rev 2017;26:170047
- Kondoh. Recent lessons learned in the management of acute exacerbation of idiopathic pulmonary fibrosis. Eur Respir Rev 2017;26:170050
- Ischaki. Nasal high flow therapy: a novel treatment rather than a more expensive oxygen device. Eur Respir Rev 2017;26:170028
- Calfee. Recent advances in the understanding and management of Klebsiella pneumoniae. F1000Research 2017, 6(F1000 Faculty Rev):1760
- Beales. Recent advances in the management of peptic ulcer bleeding. F1000Research 2017, 6(F1000 Faculty Rev):1763
- Gaião. Biomarkers of renal recovery after acute kidney injury. Rev Bras Ter Intensiva 2017;29(3):373-381
- Aramendi. Dysglycemia in the critically ill patient: current evidence and future perspectives. Rev Bras Ter Intensiva 2017;29(3):364-372
- Wada. Coagulofibrinolytic Changes in Patients with Post-cardiac Arrest Syndrome. Front Med 2017;4:156
- Wong. Antithrombotics in trauma: management strategies in the older patients. Journal of Blood Medicine 2017;8:165—174
- Tafur-Betancourt. From pharmacokinetics to pharmacodynamics – Are we ready for 3D software?. Colombian Journal of Anesthesiology 2017;epublished September 23rd
- Denault. Head to toe ultrasound: Current opinion on its role in hemodynamic instability, hypoxemia, oligoanuria and the patient with altered neurological status. Colombian Journal of Anesthesiology 2017;epublished September 22nd
- Cossu. Stem cells and regenerative medicine. Lancet 2017;epublished October 4th
- Mantero. Antibiotic therapy, supportive treatment and management of immunomodulation-inflammation response in community acquired pneumonia: review of recommendations. Multidisciplinary Respiratory Medicine 2017;12:26
- 2017 EACTS Guidelines on perioperative medication in adult cardiac surgery. European Journal of Cardio-Thoracic Surgery 2017;epublished October 6th
- The Society for Translational Medicine: clinical practice guidelines for mechanical ventilation management for patients undergoing lobectomy. J Thorac Dis 2017;9(9):3246-3254
- The Society for Translational Medicine: clinical practice guidelines for the postoperative management of chest tube for patients undergoing lobectomy. J Thorac Dis 2017;9(9):3255-3264
- Perner. Focus on fluid therapy. Intensive Care Med 2017;epublished October 5th
- Should Informed Consent Be Required for Apnea Testing in Patients With Suspected Brain Death? Chest 2017;152(4):702-706
- Ilia. Polymyxin B hemoperfusion in septic shock: nothing overmuch (Meden Agan)! J Thorac Dis 2017;9(9):2716-2719
- Pappalardo. Neurologic complications during V-V extracorporeal membrane oxygenation: still counting… J Thorac Dis 2017;9(9):2774-2776
- Li. Protecting lungs during spontaneous breathing: what can we do? J Thorac Dis 2017;9(9):2777-2781
- Hessler. ATHOS-3 and the knights of the round table—the search for the holy grail of vasopressors. J Thorac Dis 2017;9(9):2788-2791
- Tan. In sepsis, beyond adherence, timeliness matters. J Thorac Dis 2017;9(9):2808-2811
- Mehta. Sepsis and Septic Shock. J Card Crit Care TSS 2017;1:3–5
- Gödel. Understanding cytokine release syndrome. Intensive Care Med 2017;epublished September 27th
- Marston. The Critical Role of Biomedical Research in Pandemic Preparedness. JAMA 2017;epublished October 4th
- Abbasi. Could a New Method to Detect Coronary Inflammation Prevent Heart Attacks? JAMA 2017;epublished October 4th
- Mentzelopoulos. Research Integrity, Academic Promotion, and Attribution of Authorship and Nonauthor Contributions. JAMA 2017;318(13):1221-1222
- Parry. Evaluating physical functioning in critical care: considerations for clinical practice and research. Critical Care 2017;21:249
- Baumgartner. The ‘Ten Commandments’ in Valvular Heart Disease Guidelines. European Heart Journal 2017;38(36):2699
- Ozkan. ESC Clinical Practice Guidelines on the Management of Valvular Heart Disease-2017 Update. European Heart Journal 2017;38(36):2697–2698
- Jacobs. The life and work of Antonio Maria Valsalva (1666–1723) – Popping ears and tingling tongues. JICS 2017;epublished October 3rd
- Sud. Classic cases revisited – Death of a nurse and the anatomy of error. JICS 2017;epublished October 3rd
- Fahy. How will Brexit affect health and health services in the UK? Evaluating three possible scenarios. Lancet 2017;epublished September 28th
- Burns. Patient and Family Engagement in Designing and Implementing a Weaning Trial. Chest 2017;152(4):707–711
- Broman. Inter-hospital transports on extracorporeal membrane oxygenation in different health-care systems. J Thorac Dis 2017;9(9):3425-3429
- Mulvihill. Lung transplantation in the most critically-III: forging ahead. J Thorac Dis 2017;9(9):3430-3432
- Rady. Nonconsensual Determination of Neurologic (Brain) Death. Is It a Violation of Constitutional Rights? Chest 2017;152(4):903–904
- Walter. Vitamin C and Sepsis. Framing the Postpublication Discussion. Chest 2017;152(4):904–905
- Khoo. An unusual case of refractory status epilepticus in a young lady: anti-NMDA receptor encephalitis. Clin Med 2017;17:436-438
- Matsuo. Acute Esophageal Necrosis. N Engl J Med 2017;377:1378
- Nunes. When acrocyanosis in intensive care unit is not due to vasopressor support. Intensive Care Med 2017;epublished October 7th
- Chaddha. A 63-Year-Old Woman With Neurofibromatosis Type 1 and Pulmonary Hypertension With Worsening Hypoxemia. Chest 2017;152(4):e89–e93
- Famularo. A 58-Year-Old Woman With Pneumonia and Gram-Negative Diplococci. Chest 2017;152(4):e95-e97
It's now just 3 months until the Critical Care Reviews Meeting 2018, where the chief investigators for the best critical care trials of 2017 come to discuss their work and try to answer the question clinicians want to know - should I change my practice based on this trial? From Brisbane, Australia, Prof Bala Ventakesh will explore the ADRENAL trial, examining hydrocortisone in septic shock in the biggest sepsis trial ever undertaken. Working between Dublin and Melbourne, Prof Alistair Nichol will explain the findings of the TRANSFUSE trial, comparing transfusion of the freshest available blood with standard issued red cells. From Nantes, France, Dr Jean-Baptiste Lascarrou will consider the findings of the MACMAN trial, evaluating video laryngoscopy in the ICU. Dr Ashish Khanna, from the Cleveland Clinic, USA, will reflect on ATHOS-3 the first large clinical trial examining angiotensin II in septic shock. Prof Gavin Perkins, from Warwick in England, will discuss his multi-centre randomized controlled trial Breathe, evaluating the role of extubation to non-invasive ventilation in patients failing spontaneous breathing trials. Prof John Simpson, from Newcastle, England, will discuss the VAP-RAPID trial, evaluating the use of a biomarker-guided approach to exclude ventilator-associated pneumonia. The final trial added to the programme is the ART Trial. Prof Alexandre Biasi Cavalcanti (São Paulo) will explain this Brazilian investigation testing alveolar recruitment in ARDS.
We also have Prof Andrew Rhodes, from London, exploring the latest iteration of the Surviving Sepsis Campaign, published earlier this year and Dr Sophie Wallace (Perth, Australia), who will deliver the honorary John Hinds Trauma Lecture, entitled "Disaster on Everest - Trauma at the Top of the World"
We sold out #CCR17 and had to turn people away. At present we are way up on registrations compared to the same time-point in 2016. So, if you intend on coming, don't leave it too late to register. There is plenty of space still at present, but I expect the meeting will sell out well before it's date of Friday January 19th. Don't worry if you can't make it, as the talks will be recorded and put online for free viewing as usual. However, there is nothing like being there in person and having the opportunity to chat with these chief investigators. Numbers are strictly limited to ensure this remains a small, intimate meeting. It would be a shame to miss out......
The ANZICS/ACCCN Annual Scientific Meeting, which incorporates the annual Paediatric and Neonatal Intensive Care Conference, will be held at the Gold Coast Convention and Exhibition Centre, 11-13 October 2017. The Annual Scientific Meeting will be the preeminent critical care conference in Australasia for the calendar year and will be an important platform that will allow doctors, nurses and allied health practitioners to meaningfully connect and discuss new developments and research in the field of intensive and critical care.
The theme of the Meeting is “Thinking Outside the Flags” and will focus upon innovative and challenging advances that lie outside the safe zone of current practice, as well as the potential dangers that they may bring. A number of highly regarded international speakers will join our distinguished national and local speakers, experts in the field of intensive care medicine, nursing and allied health, promising delegates an exciting and challenging program.
Registration and the call for abstracts will open on 20 March 2017. For further information or to express your interest in attending, please visit http://intensivecareasm2017.com.au/.
#BMBTL17 is a conference on resuscitation that focuses on the skills and knowledge needed to bring your critically ill patients…back to life !
With cutting edge topics and a world class faculty, the conferences will be packed with clinical pearls and only the stuff that matters !
Ventilation, airway, EKGs, pediatric pearls, ultrasound and so much more…don’t miss this amazing conference ! It will be held on October 16th 2017 in downtown Montreal.
State-of-the-Art is back, for the 3rd year of its new format and an all-new venue in Liverpool for 2017. The futurism and innovation theme continues with novel topics including robotics, optical imaging of bacterial infection, new technology in patient recovery, and new device interventions in acute cardiology.
However, the focus on day-to-day care is not lost, and there are clinical updates in acute medicine, ARDS, mechanical ventilation, trauma, nutrition, rehabilitation, endocrine management in ICU, cancer patients in ICU, the difficult and altered airway, and much more. Pragmatic "how I treat..." sessions proved popular last year and will continue, along with meaningful debates on UK critical care, including the trend toward centralisation.
In addition, the trademark vibe of SOA will still be there with pop-up talks, panel debates, 'meet the expert' booths, new generation video e-posters, parent and infant facilities, two drinks evenings, and a new final night after-party. Registration and abstract submission is now open at http://soa.ics.ac.uk.
We are very pleased to announce the 6th International Fluid Academy Days (iFAD), which will take place on November 23-25th 2017 at the Hilton Hotel in Antwerp, Belgium. The iFAD is an innovative Critical Care Educational meeting in true SMACC spirit. This conference provides the highest quality of Critical Care education and is guaranteed to innovate and inspire. Recent advances in fluid management, and hemodynamic and organ function monitoring in the critical care setting will be reviewed in a comprehensive manner for intensivists, anaesthesiologists and emergency physicians as well as interested internists and surgeons.
The iFAD Faculty is the most provocative, engaging, motivating and inspiring group of international educational speakers and as organizing committee we want to ensure we have the participants, sponsors and endorsers to match. Together, we make iFAD stand apart from other Critical Care conferences.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board