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CCR Book 2017

Summarising, critiquing and putting in context the best critical care trials of 2016

We also provide one page summaries of the "best of the rest" trials, as well as a collection of the best free critical care guidelines

Included Trials

RESCUEicp Trial

Decompressive craniectomy for TBI-related intracranial hypertension

ALPS Trial

Antiarrthymic therapy in shockable out-of-hospital cardiac arrest


Liberal vs conservative oxygenation in the ICU


Early vs late parenteral nutrition in critically ill children


Timing of initiation of renal replacement therapy in acute kidney injury

Included Trials

Iron supplementation in ICU


IRONMAN tested whether the early administration of intravenous iron in critically ill patients with anaemia reduces allogeneic red blood cell transfusion during hospital stay.

Levosimendan in sepsis


LeoPARDs tested whether levosimendan, in comparison with placebo, reduces the severity of organ dysfunction in adults with sepsis.

Vasopressin in septic shock


The VANISH trial compared the effects of early vasopressin with noradrenaline on kidney failure in patients with septic shock.


The CLASSIC trial investigated the effects of restricting volumes of resuscitation fluid in adults with septic shock after initial management.

Book Authors

Dr Dominic Trainor

After completing an intercalated degree in Medical Genetics, Dominic graduated with honours from The Queen’s University of Belfast in 2002. He undertook a Fellowship at The Alfred Hospital, Melbourne, from 2013-2014, where he was awarded "Registrar of the Year". Special interests include end of life care and focused intensive care echocardiography. He is currently clinical lead for organ donation in The Royal Victoria Hospital, Belfast.

Dr Chris Gowers

Chris Gowers is a Consultant in ICM and Anaesthesia in the Ulster Hospital, Belfast. He qualifed from Nottingham University in 1997 and trained in Engand, Australia and Northern Ireland. He is currently the hospital’s FICM tutor and has interests in teaching, cycling and end-of-life care.

Dr Peter McGuigan

Peter McGuigan is a consultant in ICM & anaesthesia in the Royal Victoria Hospital, Belfast. He attended Queen’s University Belfast and trained in Northern Ireland. He subsequently undertook a fellowship in the Royal Melbourne Hospital, Australia where he developed an interest in clinical governance. His main clinical interests are in post cardiac arrest care and anaesthesia for head and neck surgery.

Dr Chris Nutt

Chris is an intensivist & anaesthetist in the Royal Victoria Hospital, Belfast. He graduated from Queen’s University Belfast in 2001 and began training in Anaesthesia and Intensive Care in 2003. He has a strong research interest, publishing on pre operative risk assessment & has collaborated on several major international trials.

Dr Rob Mac Sweeney

Rob is an intensivist in the Regional Intensive Care Unit at the Royal Victoria Hospital, Belfast. He attended medical school at University College Dublin, undertook a PhD at Queen’s University Belfast and completed his anaesthetic and ICM training in Northern Ireland. He started Critical Care Reviews in 2009.

Included Trials

Pan Scan in Severe Trauma

REACT-2 Trial

Daily Round Checklists & Goal Setting


Empirical antifungal therapy in ICU


Hypothemia in status epilepticus


Acetazolamide in ventilated COPD patients


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