Critical Care Reviews Newsletter
December 18th 2011
Welcome to the Critical Care Reviews Newsletter. Every week some of the more important research publications in critical care are highlighted. These studies are added to the News section of the website on a daily basis, as publication occurs. If you do not wish to receive the newsletter please use the unsubscribe option below. If you would like this newsletter to contain other information please let me know.
Saturday December 17th 2011
There are a couple of interesting RCTs in January's issue of Critical Care Medicine.
Payen and colleagues report a randomized controlled trial in 97 subjects comparing the effects of hydrocortisone supplementation versus placebo post single-induction dose of etomidate. Although the requirement for noradrenaline was reduced at 6 hours in the hydrocortisone group, no intergroup differences were found regarding the duration of mechanical ventilation, intensive care unit length of stay, or 28-day mortality.
Acute Lung Injury -Therapy
A double-blind, placebo-controlled randomized trial in 130 patients with acute lung injury of 3 days duration failed to demonstrate an effect from human recombinant granulocyte-macrophage colony stimulating factor on ventilator-free days, organ failure-free days or 28 day mortality.
Thursday December 15th 2011
Red Cell Transfusion
Although not a critical care study, The FOCUS study, reported in this week's New England Journal of Medicine further informs the field of transfusion triggers. 2016 patients aged 50 years or older and post hip fracture surgery, with either a history of or risk factors for cardiovascular disease, were randomly assigned to a liberal transfusion strategy (a hemoglobin threshold of 10 g per deciliter) or restrictive transfusion strategy (symptoms of anemia or at physician discretion for a hemoglobin level of <8 g per deciliter). A median of 2 units of red cells were transfused in the liberal-strategy group and none in the restrictive-strategy group. No effect was seen on mortality, ability to walk across a room unassisted, the development of acute coronary syndromes or other complication.
I hope you find these brief summaries useful.
Until next week