Welcome to the 282nd Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. It's been a great week for critical care publications, with Gonzalo Hernandez's latest HFNO trial released, as well as other RCTs on stress ulcer prophylaxis, inhaled nitric oxide to treat acute pulmonary embolism and an educational intervention for anti-infectious measures. There are also excellent observational studies on bystander efforts in out-of-hospital cardiac arrest, emergency transfusion of patients with unknown blood type with O positive red blood cells, and the latest from Kath Maitland's group, the AFIRM trial, evaluating myocardial and haemodynamic responses to two fluid regimens in African children with severe malnutrition and hypovolaemic shock. In addition, there are guidelines on severe perioperative bleeding and the prevention of surgical site infection, plus an entire open access issue from JAMA on "conflict of interest".
Based on a number of recent excellent articles in Intensive Care Medicine, this week's Topic of the Week is acute kidney injury, starting with a paper on fluid management in acute kidney injury in tomorrow's Paper of the Day.
The latest speaker confirmed for the Critical Care Reviews Meeting 2018 is Prof Andrew Rhodes from London, co-chair of this year's iteration of the Surviving Sepsis Campaign. Registration is open. Critical Care Reviews is a not-for-profit organisation.
- Full Text: Hernandez. High-flow nasal cannula to prevent postextubation respiratory failure in high-risk non-hypercapnic patients: a randomized multicenter trial. Annals of Intensive Care 2017;7:47
- Abstract: Alhazzani. Withholding Pantoprazole for Stress Ulcer Prophylaxis in Critically Ill Patients: A Pilot Randomized Clinical Trial and Meta-Analysis. Crit Care Med 2017;epublished April 27th
- Abstract: Kline. Randomized trial of inhaled nitric oxide to treat acute pulmonary embolism: The iNOPE trial. Am Heart J 2017;186:100-110
- Abstract: Bloos. Effect of a multifaceted educational intervention for anti-infectious measures on sepsis mortality: a cluster randomized trial. Intensive Care Med 2017;epublished May 2nd
- Abstract: Zatloukal. Comparison of absolute fluid restriction versus relative volume redistribution strategy in low central venous pressure anesthesia in liver resection surgery: a randomized controlled trial. Minerva Anestesiologica 2017;epublished April 19th
- Abstract: Xu. Noninvasive Ventilation in Acute Hypoxemic Nonhypercapnic Respiratory Failure: A Systematic Review and Meta-Analysis. Crit Care Med 2017;epublished April 22nd
- Abstract: Costa. Identifying barriers to delivering the ABCDE bundle to minimize adverse outcomes for mechanically ventilated patients: A systematic review. Chest 2017;epublished April
- Abstract: Chang. Effects of Polymyxin B Hemoperfusion on Mortality in Patients With Severe Sepsis and Septic Shock: A Systemic Review, Meta-Analysis Update, and Disease Severity Subgroup Meta-Analysis. Crit Care Med 2017;epublished April 25th
- Abstract: Holyoak. Intubation using apnoeic oxygenation to prevent desaturation: A systematic review and meta-analysis. J Crit Care 2017;epublished April 29th
- Abstract: Nydahl. Safety of Patient Mobilization and Rehabilitation in the Intensive Care Unit. Systematic Review with Meta-Analysis. Annals ATS 2017;14(5):766–777
- Abstract: An. Effect of anesthesia methods on postoperative major adverse cardiac events and mortality after non-cardiac surgeries: a systematic review and meta-analysis. Minerva Anestesiologica 2017;epublished April 11th
- Abstract: Taccone. Extracorporeal CO2 removal (ECCO2R) in critically ill patients: a systematic review. Minerva Anestesiologica 2017;epublished April 11th
- Full Text: Obonyo. Myocardial and haemodynamic responses to two fluid regimens in African children with severe malnutrition and hypovolaemic shock (AFRIM study). Crit Care. 2017; 21: 103. Published online 2017 May 3rd
- Abstract: Kragholm. Bystander Efforts and 1-Year Outcomes in Out-of-Hospital Cardiac Arrest. N Engl J Med 2017;376:1737-1747
- Abstract: Dangers. Extracorporeal Membrane Oxygenation for Acute Decompensated Heart Failure. Crit Care Med 2017;epublished May 3rd
- Abstract: Selleng. Emergency transfusion of patients with unknown blood type with blood group O Rhesus D positive red blood cell concentrates: a prospective, single-centre, observational study. Lancet Haematology 2017;4(5):e218–e224
- Abstract: Orwelius. Hopelessness: Independent associations with health-related quality of life and short-term mortality after critical illness: A prospective, multicentre trial. J Crit Care 2017;epublished April 27th
- Abstract: Moskowitz. Thiamine as a Renal Protective Agent in Septic Shock. A Secondary Analysis of a Randomized, Double-Blind, Placebo-controlled Trial. Annals ATS 2017;14(5):737–741
- Benstoem. Remote ischaemic preconditioning for coronary artery bypass grafting (with or without valve surgery). Cochrane Database of Systematic Reviews 2017, Issue 5. Art. No.: CD011719
- Bravo. Complete versus culprit-only revascularisation in ST elevation myocardial infarction with multi-vessel disease. Cochrane Database of Systematic Reviews 2017, Issue 5. Art. No.: CD011986
- Bluth. Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): study protocol for a randomized controlled trial. Trials 2017;18:202
- Ostadal. Extra corporeal membrane oxygenation in the therapy of cardiogenic shock (ECMO-CS): rationale and design of the multicenter randomized trial. Eur J Heart Fail 2017;19:124–127
- Latronico. The ICM research agenda on intensive care unit-acquired weakness. Intensive Care Med 2017;epublished March 13th
- Herrup. Characteristics of postintensive care syndrome in survivors of pediatric critical illness: A systematic review. World J Crit Care Med 2017;6(2):124-134
- Sorokin. Choosing the appropriate configuration and cannulation strategies for extracorporeal membrane oxygenation: the potential dynamic process of organ support and importance of hybrid modes. Eur J Heart Fail 2017;19:75–83
- Meani. Modalities and Effects of Left Ventricle Unloading on Extracorporeal Life support: a Review of the Current Literature. Eur J Heart Fail 2017;19:84–91
- Di Nardo. Reversed differential cyanosis during veno-arterial extracorporeal membrane oxygenation in infants: the reevaluation of an old phenomenon. Eur J Heart Fail 2017;19:117–119
- Roeleveld. What is new in pediatric ECMO? 2016, a year in review. Eur J Heart Fail 2017;19:92–96
- Dikmen. Perioperative hyperoxia: perhaps a malady in disguise. Romanian Journal of Anaesthesia and Intensive Care 2017;24(1):53-56
- Perner. Fluid management in acute kidney injury. Intensive Care Med 2017;epublished May 3rd
- Forni. Renal recovery after acute kidney injury. Intensive Care Med 2017;epublished May 2nd
- Darmon. Diagnostic work-up and specific causes of acute kidney injury. Intensive Care Med 2017;epublished April 28th
- Bellomo. Acute kidney injury in the ICU: from injury to recovery: reports from the 5th Paris International Conference. Annals of Intensive Care 2017;7:49
- Del Rio. Neuroendocrine stress response: implications for cardiac surgery-associated acute kidney injury. Romanian Journal of Anaesthesia and Intensive Care 2017;24(1):57-63
- Timsit. Appropriate endpoints for evaluation of new antibiotic therapies for severe infections: a perspective from COMBACTE’s STAT-Net. Intensive Care Med 2017;epublished May 2nd
- Kozek-Langenecker. Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology: First update 2016. European Journal of Anaesthesiology 2017;34(6):332–395
- Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017. JAMA Surg 2017;epublished May 3rd
- de Prost. Therapeutic targets in necrotizing soft tissue infections. Intensive Care Med 2017;epublished May 4th
- Makdisi. How to establish a successful destination therapy ventricular assist device program. J Thorac Dis 2017;9(4):932-935
- Marik. SIRS, qSOFA and new sepsis definition. J Thorac Dis 2017;9(4):943-945
- Lazzeri. Fluid responsiveness raises many questions—echocardiography may be the answer. J Thorac Dis 2017;9(4):946-949
- Nuding. IABP plus ECMO—Is one and one more than two? J Thorac Dis 2017;9(4):961-964
- Hou. qSOFA—welcome to the sepsis alphabet soup. J Thorac Dis 2017;9(4):965-968
- Chiumello. ARDS onset time and prognosis: is it a turtle and rabbit race? J Thorac Dis 2017;9(4):973-975
- Chong. The end of the road for early tracheal intubation in cardiac arrest? J Thorac Dis 2017;9(4):976-978
- Baron. Clinical guidelines: How can we improve adherence and implementation? European Journal of Anaesthesiology 2017;34(6):329–331
- Liu. The ten barriers for translation of animal data on AKI to the clinical setting. Intensive Care Med 2017;epublished April 27th
- Makris. Ten ineffective interventions to prevent ventilator-associated pneumoniaDemosthenes. Intensive Care Med 2017;epublished May 3rd
- Forni. Blood pressure deficits in acute kidney injury: not all about the mean arterial pressure? Crit Care 2017;21:102
- Fineberg. Conflict of Interest. Why Does It Matter? JAMA 2017;317(17):1717-1718
- Lo. Payments to Physicians. Does the Amount of Money Make a Difference? JAMA 2017;317(17):1719-1720
- McCoy. Why There Are No “Potential” Conflicts of Interest. JAMA 2017;317(17):1721-1722
- Bero. Addressing Bias and Conflict of Interest Among Biomedical Researchers. JAMA 2017;317(17):1723-1724
- Lichter. Conflict of Interest and the Integrity of the Medical Profession. JAMA 2017;317(17):1725-1726
- McKinney Jr. Strategies for Addressing a Broader Definition of Conflicts of Interest. JAMA 2017;317(17):1727-1728
- Pizzo. Role of Leaders in Fostering Meaningful Collaborations Between Academic Medical Centers and Industry While Also Managing Individual and Institutional Conflicts of Interest. JAMA. 2017;317(17):1729-1730
- Flier. Conflict of Interest Among Medical School Faculty. Achieving a Coherent and Objective Approach. JAMA 2017;317(17):1731-1732
- Wayne. Teaching Medical Students About Conflicts of Interest. JAMA 2017;317(17):1733-1734
- Galea. Funding, Institutional Conflicts of Interest, and Schools of Public HealthRealities and Solutions. JAMA 2017;317(17):1735-1736
- Nissen. Conflicts of Interest and Professional Medical AssociationsProgress and Remaining Challenges. JAMA 2017;317(17):1737-1738
- Barnes. Financial Conflicts of Interest in Continuing Medical EducationImplications and Accountability. JAMA 2017;317(17):1741-1742
- Armstrong. Challenges and Opportunities in Disclosing Financial Interests to Patients. JAMA 2017;317(17):1743-1744
- Larkin. Business Model–Related Conflict of Interests in Medicine. Problems and Potential Solutions. JAMA 2017;317(17):1745-1746
- Zuger. What Do Patients Think About Physicians’ Conflicts of Interest?Watching Transparency Evolve. JAMA 2017;317(17):1747-1748
- Ornstein. Public Disclosure of Payments to Physicians From Industry. JAMA 2017;317(17):1749-1750
- Waldstreicher. Managing Conflicts of Interest in Industry-Sponsored Clinical ResearchMore Physician Engagement Is Required. JAMA 2017;317(17):1751-1752
- Steinbrook. Physicians, Industry Payments for Food and Beverages, and Drug Prescribing. JAMA 2017;317(17):1753-1754
- Mozaffarian. Conflict of Interest and the Role of the Food Industry in Nutrition Research. JAMA 2017;317(17):1755-1756
- Easley. Medical Journals, Publishers, and Conflict of Interest. JAMA 2017;317(17):1759-1760
- Thornton. Conflict of Interest and Legal Issues for Investigators and Authors. JAMA 2017;317(17):1761-1762
There are just 5 months left unit Das SMACC and all tickets have now been sold for the main conference. If you are interested in attending the workshops, there are a very small number of tickets left for the Hardcore Intensive Care workshop being organised by Steve Mathieu and Sarah Yong. With a superb international faculty, this half-day event will address your burning critical care questions.
The ANZICS/ACCCN Annual Scientific Meeting, which incorporates the annual Paediatric and Neonatal Intensive Care Conference, will be held at the Gold Coast Convention and Exhibition Centre, 11-13 October 2017. The Annual Scientific Meeting will be the preeminent critical care conference in Australasia for the calendar year and will be an important platform that will allow doctors, nurses and allied health practitioners to meaningfully connect and discuss new developments and research in the field of intensive and critical care.
The theme of the Meeting is “Thinking Outside the Flags” and will focus upon innovative and challenging advances that lie outside the safe zone of current practice, as well as the potential dangers that they may bring. A number of highly regarded international speakers will join our distinguished national and local speakers, experts in the field of intensive care medicine, nursing and allied health, promising delegates an exciting and challenging program.
Registration and the call for abstracts will open on 20 March 2017. For further information or to express your interest in attending, please visit http://intensivecareasm2017.com.au/.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week