Welcome to the 281st Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. It's a small newsletter this week packed with great trials, guidelines and reviews.
The highlight of this edition is the WOMAN randomised controlled trial, evaluating tranexamic acid in post partum haemorrhage. Also of interest are RCTs comparing coagulation factor concentrates with fresh frozen plasma for trauma-induced coagulopathy and antiviral therapy for the prevention of cytomegalovirus reactivation in immunocompetent critically ill patients. In addition, there are interesting guidelines on echocardiography and lung ultrasonography for acute heart failure and palliative sedation, as well as narrative reviews on stress cardiomyopathy in the critically ill, chronic critical illness and renal replacement therapy. If you only have time for one review article this week, try this paper on vitamin B1 in critically ill patients.
- Full Text: WOMAN Trial Collaborators. Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial. Lancet 2017;epublished April 26th
- Abstract: Innerhofer. Reversal of trauma-induced coagulopathy using first-line coagulation factor concentrates or fresh frozen plasma (RETIC): a single-centre, parallel-group, open-label, randomised trial. Lancet Haematology 2017;epublished April 27th
- Abstract: Cowley. Safety and Efficacy of Antiviral Therapy for Prevention of Cytomegalovirus Reactivation in Immunocompetent Critically Ill Patients: A Randomized Clinical Trial. JAMA Intern Med 2017;epublished April 24th
- Abstract: Suominen. Stress-Dose Corticosteroid Versus Placebo in Neonatal Cardiac Operations: A Randomized Controlled Trial. Ann Thorac Surg 2017;epublished April 20th
- Full Text: Blattner. Acute bag-valve breathing maneuvers plus manual chest compression is safe during stable septic shock: a randomized clinical trial. Rev Bras Ter Intensiva 2017;29(1):14-22
- Full Text: Taniguchi. Applicability of respiratory variations in stroke volume and its surrogates for dynamic fluid responsiveness prediction in critically ill patients: a systematic review of the prevalence of required conditions. Rev Bras Ter Intensiva 2017;29(1):70-76
- Full Text: Borges. Expiratory rib cage compression in mechanically ventilated adults: systematic review with meta-analysis. Rev Bras Ter Intensiva 2017;29(1):96-104
- Abstract: VISION Study Investigators. Association of Postoperative High-Sensitivity Troponin Levels With Myocardial Injury and 30-Day Mortality Among Patients Undergoing Noncardiac Surgery. JAMA 2017;317(16):1642-1651
- Abstract: Balakumar. Both Positive and Negative Fluid Balance May Be Associated With Reduced Long-Term Survival in the Critically Ill. Crit Care Med 2017;epublished April 21st
- Abstract: Zhang. Comparison of the clinical characteristics and prognosis of primary versus secondary acute gastrointestinal injury in critically ill patients. J Intensive Care 2017;5:26
- Abstract: Shiraishi. Effectiveness of early administration of tranexamic acid in patients with severe trauma. Br J Surg 2017;104(6):710-717
- Abstract: Kahan. Critical care admission following elective surgery was not associated with survival benefit: prospective analysis of data from 27 countries. Intensive Care Med 2017;epublished April 25th
- Abstract: Bos. Identification and validation of distinct biological phenotypes in patients with acute respiratory distress syndrome by cluster analysis. Thorax 2017;epublished April 27th
- Abstract: Kamdar. Joblessness and Lost Earnings After ARDS in a 1-Year National Multicenter Study. Am J Respir Crit Care Med 2017;epublished April 27th
- Elgueta. Ultrasonography for neuraxial blocks: a review of the evidence. Minerva Anestesiologica 2017;83(5):512-23
- Chockalingama. Stress cardiomyopathy of the critically ill: Spectrum of secondary, global, probable and subclinical forms. Indian Heart Journal 2017;epublished April 19th
- Mishra. Management algorithms for acute ST elevation myocardial infarction in less industrialized world. Indian Heart Journal 2017;69(Supplement 1):S98–S103
- Shah. Pharmacological and Non-pharmacological Treatment for Decompensated Heart Failure: What Is New?. Curr Heart Fail Rep 2017;epublished April 18thfor Decompensated Heart Failure: What Is New?. Curr Heart Fail Rep 2017;epublished April 18th
- Franchi. Echocardiography to guide fluid therapy in critically ill patients: check the heart and take a quick look at the lungs. J Thorac Dis 2017;9(3):477–481
- Confalonieri. Acute respiratory distress syndrome. European Respiratory Review 2017;26:160116
- Tomassetti. Diffuse parenchymal lung disease. European Respiratory Review 2017;26:170004
- Fontela. Variable mechanical ventilation. Rev Bras Ter Intensiva 2017;29(1):77-86
- Hobson. Perioperative Acute Kidney Injury Risk Factors and Predictive Strategies. Crit Care Clinics 2017;33(2):379–396
- Fogarty. Hyponatraemia in Hospitalised Adults: a Guide for the Junior Doctor. Ulster Medical Journal 2017;epublished April 28th
- Bagshaw. Current state of the art for renal replacement therapy in critically ill patients with acute kidney injury. Intensive Care Med 2017;epublished March 13th
- Collie. Vitamin B1 in critically ill patients: needs and challenges. Clin Chem Lab Med 2017;epublished April 22nd
- Price. Expert consensus document: Echocardiography and lung ultrasonography for the assessment and management of acute heart failure. Nature Reviews Cardiology 2017;epublished April 27th
- Orsi. Palliative sedation: the position statement of the Italian National Committee for Bioethics. Minerva Anestesiologica 2017;83(5):524-8
- Chow. Role of Biomarkers for the Prevention, Assessment, and Management of Heart Failure. A Scientific Statement From the American Heart Association. Circulation. 2017;135:00–00
- Cardiological Society of India: Position statement for the management of ST elevation myocardial infarction in India. Indain Heart Journal 2017;69(Suppl 1):S63–S97
- Akshay. Barriers to a career in intensive care medicine. JICS 2017;18(2):91-92
- Harris. Effective commercial/industry-led research delivery in UK critical care. JICS 2017;18(2):93–95
- Shaw. Presumed consent to organ donation and the family overrule. JICS 2017;18(2):96-97
- McMahon. Have biomarkers failed in acute kidney injury? No. Intensive Care Med 2017;epublished April 24th
- Prowle. Have biomarkers failed in acute kidney injury? We are not sure. Intensive Care Med 2017;epublished April 24th
- Anonymous. A hundred days: what is to show for it? Lancet 2017;389(10080):1669
- Voisin. Tracheoscopic ventilation tube: a new step towards safer tracheostomy? J Clin Monit Comput 2017;31(3):503–505
- Cruz. β-blockers in septic shock: are we there yet? Rev Bras Ter Intensiva 2017;29(1):1-3
- Carneiro. Dear Sepsis-3, we are sorry to say that we don't like you. Rev Bras Ter Intensiva 2017;29(1):4-8
- La Calle. Seeking to humanize intensive care. Rev Bras Ter Intensiva 2017;29(1):9-13
- Matias. Ultrasound-guided central venous catheterization – “Syringe-Free” approach. Rev Bras Anestesiol 2017;67(3):314-317Bras Anestesiol 2017;67(3):314-317
- Abbasi. A Day in the Life: NICU Medical Director Tends to Opioid-Addicted Infants. JAMA 2017;epublished April 27th
- Bierer. Data Authorship as an Incentive to Data Sharing. N Engl J Med 2017;376:1684-1687
- Hunter. Preventive Medicine for the Planet and Its Peoples. N Engl J Med 2017;376:1605-1607
- Rosenbaum. Resisting the Suppression of Science. N Engl J Med 2017;376:1607-1609
- Reisman. Board Review and the Middle-Aged Doctor. N Engl J Med 2017;376:1612-1613
- Various. Hypothermia after In-Hospital Cardiac Arrest in Children. N Engl J Med 2017;376:1695-1697
- de Denus. Spironolactone Metabolites in TOPCAT — New Insights into Regional Variation. N Engl J Med 2017;376:1690-1692
- Jaffal. Is hyperoxaemia a risk factor for ICU-acquired pneumonia? Lancet Respir Med 2017;5(5):e16
- Shortgen. Is hyperoxaemia a risk factor for ICU-acquired pneumonia? – Authors' reply. Lancet Respir Med 2017;5(5):e17
There are just 5 months left unit Das SMACC and all tickets have now been sold for the main conference. If you are interested in attending the workshops, there are a very small number of tickets left for the Hardcore Intensive Care workshop being organised by Steve Mathieu and Sarah Yong. With a superb international faculty, this half-day event will address your burning critical care questions.
The ANZICS/ACCCN Annual Scientific Meeting, which incorporates the annual Paediatric and Neonatal Intensive Care Conference, will be held at the Gold Coast Convention and Exhibition Centre, 11-13 October 2017. The Annual Scientific Meeting will be the preeminent critical care conference in Australasia for the calendar year and will be an important platform that will allow doctors, nurses and allied health practitioners to meaningfully connect and discuss new developments and research in the field of intensive and critical care.
The theme of the Meeting is “Thinking Outside the Flags” and will focus upon innovative and challenging advances that lie outside the safe zone of current practice, as well as the potential dangers that they may bring. A number of highly regarded international speakers will join our distinguished national and local speakers, experts in the field of intensive care medicine, nursing and allied health, promising delegates an exciting and challenging program.
Registration and the call for abstracts will open on 20 March 2017. For further information or to express your interest in attending, please visit http://intensivecareasm2017.com.au/.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week