Welcome to the 269th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. The highlights of this week's edition are randomised controlled trials on a Pseudomonas vaccine in ventilated ICU patients and high-flow warm humidified oxygen for moderate bronchiolitis, as well as observational data on trends in ECPR survival from an international multicentre cohort study over 12-years, plus, from the CLASSIC trial, the effects of fluid restriction on measures of circulatory efficacy in adults with septic shock.
There are two series of narrative reviews, on surgical site infections and ischaemic stroke, with the latter being this week's Topic of the Week, starting with a general paper on acute ischemic stroke therapy in tomorrow's Paper of the Day.
If you only have time for one review article this week, try either this paper on echocardiography for patients undergoing extracorporeal cardiopulmonary resuscitation or this article on the impact of changes in intensive care organization on patient outcome and cost-effectiveness.
The not-for-profit Critical Care Reviews Book 2017, reviewing the biggest studies of the past year, was launched last week at #CCR17. It's freely available as a pdf download on the site. The book includes hyperlinks to all these main studies, as well as over 80 open access guidelines relevant to critical care. We're trying to track the downloads to assess the impact of the book, so please share the download link rather than the file directly. Many thanks to the REVIVE Charity of the Regional Intensive Care Unit of the Royal Victoria Hospital in Belfast for sponsoring the print run for the Critical Care Reviews Meeting.
- Full Text: Rello. A randomized placebo-controlled phase II study of a Pseudomonas vaccine in ventilated ICU patients. Critical Care 2017;21:22
- Abstract: Ahn. Transoesophageal echocardiographic evaluation of central venous catheter positioning using Peres’ formula or a radiological landmark-based approach: a prospective randomized single-centre study. Br J Anaesth 2017;118(2):215-222
- Abstract: Humphreys. Transnasal humidified rapid-insufflation ventilatory exchange (THRIVE) in children: a randomized controlled trial. Br J Anaesth 2017;118(2):232-238
- Abstract: Drake-Brockman. The effect of endotracheal tubes versus laryngeal mask airways on perioperative respiratory adverse events in infants: a randomised controlled trial. Lancet 2017;epublished January 17th
- Abstract: Park. Randomized clinical trial of preoperative skin antisepsis with chlorhexidine gluconate or povidone–iodine. Br J Surg 2017;104:e145–e150
- Abstract: Kepreotes. High-flow warm humidified oxygen versus standard low-flow nasal cannula oxygen for moderate bronchiolitis (HFWHO RCT): an open, phase 4, randomised controlled trial. Lancet 2017;epublished February 1st
- Full Text: Gögenur. The role of total cell-free DNA in predicting outcomes among trauma patients in the intensive care unit: a systematic review. Critical Care 2017;21:14
- Abstract: Jolly. Thrombus Aspiration in ST-Segment-Elevation Myocardial Infarction: An Individual Patient Meta-Analysis: Thrombectomy Trialists Collaboration. Circulation 2017;135(2):143-152
- Full Text: Liesching. Efficacy of High-Flow Nasal Cannula Therapy in Intensive Care Units: A Meta-Analysis of Physiological and Clinical Outcomes. J Intensive Care Med 2017;epublished January 23rd
- Abstract: Hjortrup. Effects of fluid restriction on measures of circulatory efficacy in adults with septic shock. Acta Anaesthesiologica Scandinavica 2017;epublished February 1st
- Full Text: Roberts. Tranexamic acid in bleeding trauma patients: an exploration of benefits and harms. Trials 2017;18:48
- Full Text: Salahuddin. Fluid overload is an independent risk factor for acute kidney injury in critically Ill patients: results of a cohort study. BMC Nephrol. 2017;18(1):45
- Abstract: Richardson. ECMO Cardio-Pulmonary Resuscitation (ECPR), trends in survival from an international multicentre cohort study over 12-years. Resuscitation 2017;112:34–40
- Abstract: Davis. Association of Delirium With Cognitive Decline in Late LifeA Neuropathologic Study of 3 Population-Based Cohort Studies. JAMA Psychiatry 2017;epublished January 18th
- Full Text: Ahn. Financial ties of principal investigators and randomized controlled trial outcomes: cross sectional study. BMJ 2017;356:i6770
- Nielsen. Targeted Hypothermia vs. Targeted Normothermia after Out-of-hospital Cardiac Arrest, a Randomised Clinical Trial (TTM2 Trial) (ht @DogICUma)
- Bouglé. Impact of the duration of antibiotics on clinical events in patients with Pseudomonas aeruginosa ventilator-associated pneumonia: study protocol for a randomized controlled study. Trials 2017;18:37
- Martinez. Prophylactic Melatonin for Delirium in Intensive Care (Pro-MEDIC): study protocol for a randomised controlled trial. Trials 2017;18:4
- Babi. Peri-Hemorrhagic Edema and Secondary Hematoma Expansion after Intracerebral Hemorrhage: From Benchwork to Practical Aspects. Front Neurol 2017;8:4
- Catanese. Acute Ischemic Stroke Therapy Overview. Circ Res 2017;120:541-558
- Hu. Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke. Circ Res 2017;120:449-471
- Barrett. Stroke Caused by Extracranial Disease. Circ Res 2017;120:496-501
- Kamel. Cardioembolic Stroke. Circ Res 2017;120:514-526
- Yaghi. Cryptogenic Stroke: Research and Practice. Circ Res 2017;120:527-540
- Tahsili-Fahadan. Heart–Brain Axis: Effects of Neurologic Injury on Cardiovascular Function. Circ Res 2017;120:559-572
- Zhang. Echocardiography for patients undergoing extracorporeal cardiopulmonary resuscitation: a primer for intensive care physicians. Journal of Intensive Care 2017;5:15
- Warnapura. Intravenous Fluid Therapy in Adults and Children. Sri Lankan Journal of Anaesthesiology 2017;25(1):3–7
- Kesavan. Humidified High-flow Nasal Cannula Oxygen Therapy in children. A narrative review. J Pediatr Crit Care 2016;3(4):29-34
- Sanaie. Nasogastric tube insertion in anesthetized patients: a comprehensive review. Anaesthesiology Intensive Therapy 2017;epublished January 11th
- Leguina-Ruzzi. Cardioprotective and anti-inflammatory effects of glutamine in parenteral nutrition. Neth J Crit Care 2017;25(1):6-8
- Stravitz. Thrombosis and coagulopathy in the liver transplant candidate and recipient. Clinical Liver Disease 2017;9:11–17
- Sager. Procalcitonin-guided diagnosis and antibiotic stewardship revisited. BMC Medicine 2017;15:15
- Ferreira. Misdirected Sympathy: The Role of Sympatholysis in Sepsis and Septic Shock. J Intensive Care Med 2017;epublished January 31st
- Wagar. Bioterrorism and the Role of the Clinical Microbiology Laboratory. Clin Microbiol Rev 2016;29(1):175–189
- Alverdy. The gut microbiome and the mechanism of surgical infection. Br J Surg 2017;104:e14–e23
- Ploegmakers. Alternatives to antibiotics for prevention of surgical infection. Br J Surg 2017;104:e24–e33
- Vincent. Update on surgical sepsis syndrome. Br J Surg 2017;104:e34–e40
- Mohamed. Vaccine development to prevent Staphylococcus aureus surgical-site infections. Br J Surg 2017;104:e41–e54
- Gillespie. Economic case for intraoperative interventions to prevent surgical-site infection. Br J Surg, 104: e55–e64
- Soop. Recent developments in the surgical management of complex intra-abdominal infection. Br J Surg 2017;104:e65–e74
- Percival. Importance of biofilm formation in surgical infection. Br J Surg 2017;104:e85–e94
- Cortegiani. Should we Administer Antifungal Drugs Before the Diagnosis of Invasive Fungal Infection in Non-Neutropenic Critically Ill Patients? Turk J Anaesthesiol Reanim 2016;44(6):276–278
- De Rosa. Appropriate Treatment of Invasive Candidiasis in ICU: Timing, Colonization Index, Candida Score & Biomarkers, Towards de-Escalation? Turk J Anaesthesiol Reanim 2016;44(6):279–282
- Hayakawa. Pathophysiology of trauma-induced coagulopathy: disseminated intravascular coagulation with the fibrinolytic phenotype. Journal of Intensive Care 2017;5:14
- Roy. Attempting to define and refine vasopressin use in septic shock: the VANISH trial. Ann Transl Med 2016;4(24):501
- Namas. From static to dynamic: a sepsis-specific dynamic model from clinical criteria in polytrauma patients. Ann Transl Med 2016;4(24):492
- Stiermaier. Clinical utility of novel biomarkers in acute myocardial infarction. Ann Transl Med 2016;4(24):491
- Kränkel. Early detection of myocardial infarction—microRNAs right at the time? Ann Transl Med 2016;4(24):502
- Marra. The evolving approach to sedation in ventilated patients: a real world perspective. Ann Transl Med 2016;4(24):494
- Barlas. Fatty acid-binding proteins as diagnostic and prognostic markers in pneumonia. Ann Transl Med 2016;4(24):495
- Vallabhajosyula. Ventilation in acute respiratory distress syndrome: importance of low-tidal volume. Ann Transl Med 2016;4(24):496
- Musuuza. Every other day bathing with chlorhexidine gluconate: what is the evidence? Ann Transl Med 2016;4(24):506
- Coady. SAMP-ending down sepsis. Ann Transl Med 2016;4(24): 509
- Landoni. Volatile anesthetics for lung protection: a bridge between operating rooms and intensive care units? Ann Transl Med 2016;4(24):514
- Müller. Forty years of intensive care medicine in the Netherlands – back to the future. Neth J Crit Care 2017;25(1):4-5
- Jorens. Ultrasound: a novel translational tool to study diaphragmatic dysfunction in critical illness. Ann Transl Med 2016;4(24):515
- McLymont. Scoring systems for the characterization of sepsis and associated outcomes. Ann Transl Med 2016;4(24):527
- Li. Finding ways to solve or prevent aminoglycoside-induced ototoxicity? Ann Transl Med 2016;4(24):533
- Klug. The role of circulating microRNAs in acute coronary syndromes: ready for prime time? Ann Transl Med 2016;4(24):537
- Radhakrishnan. Polytherapy as first-line in status epilepticus: should we change our practice? Ann Transl Med 2016;4(24):544
- Chávez-Moreno. Chlorhexidine bathing every other day still does the trick, but it may come at a cost. Ann Transl Med 2016;4(24):555
- Bakshi. Recurrent Laryngeal Papillomatosis. Mayo Clin Proc 2017;92(2):322
- Knapen. Pseudomonas aeruginosa meningitis after visiting a swimming pool: a complicated dive. Neth J Crit Care 2017;25(1):10-1
- van den Berg. A complicated case of Kingella kingae endocarditis and review of the literature. Neth J Crit Care 2017;25(1):12-4
There are just 5 months left unit Das SMACC and all tickets have now been sold for the main conference. If you are interested in attending the workshops, there are a very small number of tickets left for the Hardcore Intensive Care workshop being organised by Steve Mathieu and Sarah Yong. With a superb international faculty, this half-day event will address your burning critical care questions.
The Canadian Critical Care Conference (www.canadiancriticalcare.CA; @CriticalCareCa) is rather special. Not only a spectacular location (world famous Whistler, British Columbia, Canada) but also the world's finest downhill skiing, cross-country skiing, and mountain village location (did we mention it's in Whistler?). Located at the lovely Four Seasons Resort, we offer a meeting crammed with world renown speakers but in a more laid back, interactive, and reinvigorating setting that your typical medical conference. We cover all of the core science and latest research, but do not shy away from all those topics that make for a great, or not so great, patient care. This includes human factors, burnout and resilience, end-of-life care, multidisciplinary care, social media, organ donation, and the patient perspective. We are always kean to engage trainees and nurses, we offer world class precourses, and we ensure time to enjoy all that makes Whistler and Blackcomb so special. We have no desire to be the world's largest acute care conference. Rather we want to create something unique: an opportunity to learn; to interact, to have fun, and to leave more refreshed and engaged. Come and join us.
(Image from Chensiyuan via Wikipedia)
The Critical Care Symposium (CCS) was initiated to satisfy the purpose of creating a world-class environment for medical enrichment in the North of England, particularly in Manchester. It was envisioned as a common informal platform wherein professionals from the field of critical care could provide and enhance the knowledge of delegates on current practices and related fields of interest.
Now in its 14th year, the annual conference regularly has renowned speakers from around the world and attracts more than 400 delegates. And this year is no different. In recent years a parallel course on ultrasound has been conducted alongside the conference that provides ample hand-on experience over two days. This year will host the 7th Ultrasound in Acute Care. For more information please visit http://critcaresymposium.co.uk.
The ANZICS/ACCCN Annual Scientific Meeting, which incorporates the annual Paediatric and Neonatal Intensive Care Conference, will be held at the Gold Coast Convention and Exhibition Centre, 11-13 October 2017. The Annual Scientific Meeting will be the preeminent critical care conference in Australasia for the calendar year and will be an important platform that will allow doctors, nurses and allied health practitioners to meaningfully connect and discuss new developments and research in the field of intensive and critical care.
The theme of the Meeting is “Thinking Outside the Flags” and will focus upon innovative and challenging advances that lie outside the safe zone of current practice, as well as the potential dangers that they may bring. A number of highly regarded international speakers will join our distinguished national and local speakers, experts in the field of intensive care medicine, nursing and allied health, promising delegates an exciting and challenging program.
Registration and the call for abstracts will open on 20 March 2017. For further information or to express your interest in attending, please visit http://intensivecareasm2017.com.au/.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week