Welcome to the 255th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. The highlights of this week's issue are randomised controlled trials evaluating the age of transfused red cells, tranexamic acid in coronary-artery surgery and sedation vs general anesthesia for stroke thrombectomy, reviews on lung ultrasound, nutrition in critical illness and hypoxic hepatitis, plus editorials on acute circulatory failure, transfusion, bleeding and thrombosis, and sepsis.
In other news, the University of Cambridge Master of Studies in Intensive Care Medicine is available again. This is a two year combined clinical and academic training scheme in Cambridge for aspiring tertiary centre intensive care medicine consultants. It comprises a one-year Postgraduate Certificate course, a two-year Master of Studies (MSt) and a two year course on Healthcare Education Leadership and Management. This Clinical Medicine Programme will enhance the specialist training of senior intensivists in training and broaden their understanding of healthcare education, research, leadership and management. Applicantions and further information are available here.
- Full Text: Heddle. Effect of Short-Term vs. Long-Term Blood Storage on Mortality after Transfusion. N Engl J Med 2016;epublished October 24th
- Full Text: Myles. Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery (ATACAS). N Engl J Med 2016;epublished October 23rd
- Full Text: Schönenberger. Effect of Conscious Sedation vs General Anesthesia on Early Neurological Improvement Among Patients With Ischemic Stroke Undergoing Endovascular Thrombectomy. A Randomized Clinical Trial. JAMA 2016;epublished October 26th
- Abstract: Picker. A Randomized Trial of Palliative Care Discussions Linked to an Automated Early Warning System Alert. Crit Care Med 2016;epublished October 20th
- Abstract: Grant. Dexmedetomidine Use in Critically Ill Children With Acute Respiratory Failure. (RESTORE Study). Pediatr Crit Care Med 2016;epublished September 20th
- Abstract: Pavlovic. Impact of early haemodynamic goal-directed therapy in patients undergoing emergency surgery: an open prospective, randomised trial. J Clin Monit Comput 2016;30(1):87-99
- Abstract: Pinciroli. Endotracheal Tubes Cleaned With a Novel Mechanism for Secretion Removal: A Randomized Controlled Clinical Study. Respir Care 2016;61:1431-1439
- Abstract: Coccolini. Early goal-directed treatment versus standard care in management of early septic shock: Meta-analysis of randomized trials. J Trauma Acute Care Surg 2016;81(5):971-978
- Full Text: Song. The Role of Targeted Temperature Management in Adult Patients Resuscitated from Nonshockable Cardiac Arrests: An Updated Systematic Review and Meta-Analysis. BioMed Research International 2016;2016:2350974
- Full Text: Fan. Does ventilator-associated event surveillance detect ventilator-associated pneumonia in intensive care units? A systematic review and meta-analysis. Critical Care 2016;20:338
- Full Text: Manzanares. High-dose intravenous selenium does not improve clinical outcomes in the critically ill: a systematic review and meta-analysis. Critical Care 2016;20:356
- Full Text: Mao. Subglottic secretion suction for preventing ventilator-associated pneumonia: an updated meta-analysis and trial sequential analysis. Critical Care 2016;20:353
- Full Text: Nagendran. Very large treatment effects in randomised trials as an empirical marker to indicate whether subsequent trials are necessary: meta-epidemiological assessment;BMJ 2016;355:i5432
- Full Text: Álvarez-Lerma. Delay in diagnosis of influenza A (H1N1)pdm09 virus infection in critically ill patients and impact on clinical outcome. Critical Care 2016;20:337
- Full Text: Blassmann. Cerebrospinal fluid penetration of meropenem in neurocritical care patients with proven or suspected ventriculitis: a prospective observational study. Critical Care 2016;20:343
- Full Text: Wilsterman. Short-term effects of neuromuscular blockade on global and regional lung mechanics, oxygenation and ventilation in pediatric acute hypoxemic respiratory failure. Ann Intensive Care 2016;6(1):103
- Full Text: Mahul. Spontaneous breathing trial and post-extubation work of breathing in morbidly obese critically ill patients. Crit Care 2016;20(1):346
- Hua. Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia. Cochrane Database of Systematic Reviews 2016, Issue 10. Art. No.: CD008367
- Arthur. Antibiotics for ventilator-associated pneumonia. Cochrane Database of Systematic Reviews 2016, Issue 10. Art. No.: CD004267
- Messina. Anaesthetic interventions for prevention of awareness during surgery. Cochrane Database of Systematic Reviews 2016, Issue 10. Art. No.: CD007272
- Widimsky. Catheter-based interventions for acute ischaemic stroke. Eur Heart J 2016;37:3081-3089
- Guan. Targeting Secondary Hematoma Expansion in Spontaneous Intracerebral Hemorrhage – State of the Art. Front Neurol 2016;7:187
- Stankiewicz-Rudnicki. Neuromuscular blockade in the elderly. Anaesthesiol Intensive Ther 2016;48(4):257-260
- Billington. Adult Status Epilepticus: A Review of the Prehospital and Emergency Department Management. J Clin Med. 2016;5(9):74
- Maas. Traumatic brain injury: Changing concepts and approaches. Chin J Traumatol 2016;19(1):3–6
- Kuiper. The vulnerable microcirculation in the critically ill pediatric patient. Critical Care 2016;20:352
- Wang. Lung ultrasound: a promising tool to monitor ventilator-associated pneumonia in critically ill patients. Critical Care 2016;20:320
- Putz. Jet Ventilation during Rigid Bronchoscopy in Adults: A Focused Review. BioMed Research International 2016;2016:4234861
- Klein. Closure of the Open Abdomen: a Practical Approach. Curr Trauma Rep 2016;epublished October 11th
- Maloney. Intra-Operative Damage Control Maneuvers to Reduce Abdominal Compartment Syndrome. Curr Trauma Rep 2016;epublished October 11th
- Khasawneh. Optimum Methods for Keeping the Abdomen Open. Curr Trauma Rep 2016;epublished October 3rd
- Van der Cruyssen. Splenic artery embolization: technically feasible but not necessarily advantageous. World J Emerg Surg 2016;11(1):47
- Hoffer. Nutrition in critical illness: a current conundrum. F1000Research 2016;5(F1000 Faculty Rev):2531
- Wilson. Nutrition: A Primary Therapy in Pediatric Acute Respiratory Distress Syndrome. Front Pediatr 2016;4:108
- Moradi. Artificial Blood Substitutes: First Steps on the Long Route to Clinical Utility. Clinical Medicine Insights: Blood Disorders 2016;9:33-41
- Lipinska-Gediga. Sepsis and septic shock-is a microcirculation a main player? Anaesthesiol Intensive Ther 2016;48(4):261-265
- Culligan. Advances in the Microbiome: Applications to Clostridium difficile Infection. J Clin Med 2016;5(9):83
- Russo. Pediatric Combat Trauma. Curr Trauma Rep 2016;epublished October 1st
- Weber. Clearing the Pediatric Cervical Spine. Curr Trauma Rep 2016;epublished September 19th
- Yu. Treatment strategy for hepatic trauma. Chin J Traumatol 2016;19(3):168-71
- Wang. Damage of vascular endothelial barrier induced by explosive blast and its clinical significance. Chin J Traumatol 2016;19(3):125–128
- Liu. Relationship between trauma-induced coagulopathy and progressive hemorrhagic injury in patients with traumatic brain injury. Chin J Traumatol 2016;19(3):172–175
- Zagory. Planning for the Pediatric Patient During a Disaster. Curr Trauma Rep 2016;epublished October 13th
- Duran. Current Concepts in the Medical Management of the Pediatric Burn Patient. Curr Trauma Rep 2016;epublished September 17th
- Blanco. Common pitfalls in point-of-care ultrasound: a practical guide for emergency and critical care physicians. Critical Ultrasound Journal 2016;8:15
- Bonne. Changes in Organ Physiology in the Aging Adult. Curr Trauma Rep 2016;epublished October 24th
- Williams. Special Considerations for the Treatment of Pain from Torture and War. Curr Anesthesiol Rep 2016;epublished October 25th
- Galvagno. Pain management for blunt thoracic trauma: A joint practice management guideline from the Eastern Association for the Surgery of Trauma and Trauma Anesthesiology Society. Journal of Trauma and Acute Care Surgery 2016; 81(5):936–951
- Coccolini. WSES classification and guidelines for liver trauma. World J Emerg Surg 2016;11:50
- Major. Surviving critical illness: what is next? An expert consensus statement on physical rehabilitation after hospital discharge. Critical Care 2016;20:354
- Bakker. Focus on acute circulatory failure. Intensive Care Med 2016;epublished October 21st
- Azoulay. Focus on transfusion, bleeding and thrombosis. Intensive Care Med 2016;epublished October 25th
- Timsit. Sepsis: find me, manage me, and stop me! Intensive Care Med 2016;epublished October 24th
- Saugel. Cardiac output monitoring: less invasiveness, less accuracy? J Clin Monit Comput 2016;30(6):753-755
- Viale. The venous–arterial partial pressure of carbon dioxide as a new monitoring of circulatory disorder: no so simple. J Clin Monit Comput 2016;30(6):757-760
- Chaïbi. Not all β-lactams are equal regarding neurotoxicity. Critical Care 2016;20:350
- Dive. Benefit of prokinetics during enteral nutrition: still searching for a piece of evidence. Crit Care 2016;20(1):341
- Cortegiani. Should we continue to use prediction tools to identify patients at risk of Candida spp. infection? If yes, why? Critical Care 2016;20:351
- Martindale. Management of severe traumatic brain injury and acute respiratory distress syndrome using pumped extracorporeal carbon dioxide removal device. JICS 2016;epublished October 25th
Once again the Critical Care Reviews Meeting will be discussing the biggest studies of the previous year with their chief investigators, asking the question "should we implement the results of this trial into our dialy practice?". We also have the John Hinds Trauma Lecture, delivered this year by Prof Donat Spahn (Zurich), lead for the new European Trauma Guideline, published a few months ago. Paul Marik thinks he has discovered "The Cure for Sepsis", while John Myburgh will explain the ins and outs of research methodology in the "Path to Truth". In addition, there is the very popular "How I Manage....." series of short talks from our speakers on conditions they are experts in, the "Year in Review" and the now famous "Informal Chat" in the bar after the main event.
Don't forget to register for dinner also, where the menu is based on an original menu from the only sailing the Titanic made. Registration for both the meeting and meal is available on the meeting webpage. The Critical Care Reviews Meeting is a not-for-profit event.
Following last year's massively successful event, the UK Intensive Care Society's State-of-the-Art Meeting is starting its build-up to 2016. The ICS completely changed its game in 2015, and relaunched SOA as a new beacon for forward-looking clinical content, open-access education, and medical social media. In keeping with the times, the podcasts and other materials from last year's meeting have been made open access.
This year the programme is looking even better, with topics ranging from the futuristic (space medicine, Formula 1 applied technology, Google Deepmind, and AI) through to the human, practical, and controversial (look out for the clinical scenarios, controversies, and the "From Ivory Tower to Desert Island" session). Speakers include Peter Brindley, Kevin Fong, Jack Iwashyna, Kath Maitland, Louise Rose, Mervyn Singer, and Jean-Louis Vincent among many others. It runs from Mon 5th - Wed 7th Dec, and I hope I'll see you there. Keep an eye on http://soa.ics.ac.uk for programme and registration, and meanwhile enjoy the comprehensive FOAM from last year.
The first release of tickets for Das SMACC sold out in just 2.5 hours this week. The next opportunity will be on Wednesday December 7th (depending on where you are in the world). If you haven't yet checked out the programme and workshops, then have a look on the SMACC website. The Hardcore Intensive Care workshop being organised by Steve Mathieu and Sarah Yong will cover all your critical care questions.
(Image from Chensiyuan via Wikipedia)
This adult and paediatric ICM meeting is jointly organized by the Society of Intensive Care Medicine (SICM), Singapore and the Australia-New Zealand Intensive Care Society (ANZICS) and is scheduled for 20-24 April 2017 in Suntec Convention Centre, Singapore. It has grown from its humble beginnings in a small hospital venue to become one of the best ICM conference in the Asia-Pacific region. Past editions featured prominent speakers such as Jean Louis Vincent, Daniel De Backer, John J Marini, Rinaldo Bellomo amongst many others, and in this edition the list of distinguished international panel of speakers, program schedule and planned workshops look more impressive than ever. Beside the obvious educational benefits, this conference is also a great opportunity to experience the unique Singaporean culture, enjoy its famed gastronomy and visit its attractions.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week