Welcome to the 252nd Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
With the annual ESICM Congress, it's been a busy week for critical care. The major studies presented and published at Milan have been included in a midweek supplemental newsletter and last weekend's newsletter. Three of the biggest trials will be presented at #CCR17, with the rest being discussed on the day and included in the Critical Care Reviews Book 2017. There is still lots of research to look through this week, as well as a large number of guidelines and position statements, reviews, editorials, commentaries, and study critiques. If you only have time for one review paper, try this one on early liberal fluid therapy for sepsis patients is not harmful: hydrophobia is unwarranted but drink responsibly, which is interesting given this week's presentation of the CLASSIC trial.
With ESICM out of the way, the big news this week is the announcement that the programme for Das SMACC will be released this Wednesday (October 12th), with registration opening two weeks later on Wednesday October 26th. The format is changing, with a single stream of only the best speakers taking to the stage in the Berlin Tempodrom. As with last year, there will be a simultaneous worldwide ticket release at 08:00 Sydney time, with the bulk of the tickets going on sale initially, followed by two smaller releases over the following months. Based on previous levels of demand, tickets will go in just a few hours. Watch the countdown clock on the SMACC website.
- Abstract: Sandroni. The rate of brain death and organ donation in patients resuscitated from cardiac arrest: a systematic review and meta-analysis. Intensive Care Med 2016;epublished October 3rd
- Full Text: Park. Pharmacological and Mechanical Thromboprophylaxis in Critically Ill Patients: a Network Meta-Analysis of 12 Trials. J Korean Med Sci 2016;31(11):1828-1837
- Abstract: Barile. Acute Normovolemic Hemodilution Reduces Allogeneic Red Blood Cell Transfusion in Cardiac Surgery: A Systematic Review and Meta-analysis of Randomized Trials. Anaesth Analg 2016;epublished September 23rd
- Full Text: Ripollésa. Intraoperative goal directed hemodynamic therapy in noncardiac surgery: a systematic review and meta-analysis. Rev Bras Anestesiol 2016;66(5):513-528
- Abstract: Serpa Neto. Epidemiological characteristics, practice of ventilation, and clinical outcome in patients at risk of acute respiratory distress syndrome in intensive care units from 16 countries (PRoVENT): an international, multicentre, prospective study. Lancet Respir Med 2016;epublished October 4th
- Full Text: Beitland. Urine biomarkers give early prediction of acute kidney injury and outcome after out-of-hospital cardiac arrest. Critical Care 2016;20:314
- Full Text: Suetrong. Hyperchloremia and moderate increase in serum chloride are associated with acute kidney injury in severe sepsis and septic shock patients. Critical Care 2016;20:315
- Full Text: Kawano. Augmented renal clearance in Japanese intensive care unit patients: a prospective study. Journal of Intensive Care 2016;4:62
- Abstract: Sarosiek. Association Between Inferior Vena Cava Filter Insertion in Trauma Patients and In-Hospital and Overall Mortality. JAMA Surg 2016;epublished September 28th
- Abstract: Duan. Noninvasive ventilation for avoidance of reintubation in patients with various cough strength. Critical Care 2016;20:316
- Full Text: Donati. Near-infrared spectroscopy for assessing tissue oxygenation and microvascular reactivity in critically ill patients: a prospective observational study. Critical Care 2016;20:311
- Fayad. Intensity of continuous renal replacement therapy for acute kidney injury. Cochrane Database of Systematic Reviews 2016, Issue 10. Art. No.: CD010613
- Liu. Gamma aminobutyric acid (GABA) receptor agonists for acute stroke. Cochrane Database of Systematic Reviews 2016, Issue 10. Art. No.: CD009622
- Jordan. Factors that impact on the use of mechanical ventilation weaning protocols in critically ill adults and children: a qualitative evidence-synthesis. Cochrane Database of Systematic Reviews 2016, Issue 10. Art. No.: CD011812
- Taylor. Design and implementation of the AIRWAYS-2 trial: A multi-centre cluster randomised controlled trial of the clinical and cost effectiveness of the i-gel supraglottic airway device versus tracheal intubation in the initial airway management of out of hospital cardiac arrest. Resuscitation 2016;epublished September 30th
- Muscedere. Prevention of nosocomial infections in critically ill patients with lactoferrin (PREVAIL study): study protocol for a randomized controlled trial. Trials 2016;17:474
- Saadoun. Spinal cord injury: is monitoring from the injury site the future? Critical Care 2016;20:308
- Dodds. Sarcopenia and frailty: new challenges for clinical practice. Clin Med 2016;16:455-458
- Arora. Perioperative transesophageal echocardiography: State of the art 2016. Ann Card Anaesth 2016;19:576-9
- Patris. The formation of bronchocutaneous fistulae due to retained epicardial pacing wires: A literature review. Ann Card Anaesth 2016;19:683-6
- Ortega-Loubon. Cardiac surgery-associated acute kidney injury. Ann Card Anaesth 2016;19:687-98
- Kapoor. Global end-diastolic volume an emerging preload marker vis-a-vis other markers - Have we reached our goal?. Ann Card Anaesth 2016;19:699-704
- Tawil. Differential diagnosis and clinical management of diastolic heart failure: current best practice. Research Reports in Clinical Cardiology 2016;7:117—135
- Okwuosa. The ABCs of managing systolic heart failure: Past, present, and future. CCJM 2016;83(10):753-765
- Eun. Nonatherosclerotic limb ischemia: Prompt evaluation and diagnosis. CCJM 2016;83(10):741-751
- Rahat. Role of prophylactic coronary revascularisation in improving cardiovascular outcomes during non-cardiac surgery: A narrative review. Netherlands Heart Journal 2016;24(10):563–570
- Singh. Antithrombotic Approaches in Acute Coronary Syndromes: Optimizing Benefit vs Bleeding Risks. Mayo Clin Proc 2016;91(10):1413–1447
- Dietrich. Ultrasound-guided central vascular interventions, comments on the European Federation of Societies for Ultrasound in Medicine and Biology guidelines on interventional ultrasound. J Thorac Dis 2016;8(9):E851-E868
- Banfi. Veno-arterial extracorporeal membrane oxygenation: an overview of different cannulation techniques. J Thorac Dis 2016;8(9):E875-E885
- Xu. Atrial fibrillation: review of current treatment strategies. J Thorac Dis 2016;8(9):E886-E900
- Zhang. High-flow nasal cannula therapy for adult patients. J Int Med Res 2016;epublished October 2nd
- Dhanani. Fundamentals of aerosol therapy in critical care. Critical Care 2016;20:269
- Thomas. Haemophagocytic lymphohistiocytosis: an elusive syndrome. Clin Med 2016;16:432-436
- Asakura. Proposal for new diagnostic criteria for DIC from the Japanese Society on Thrombosis and Hemostasis. Thrombosis Journal 2016;14:42
- Jaehne. Early Liberal Fluid Therapy for Sepsis Patients Is Not Harmful: Hydrophobia Is Unwarranted but Drink Responsibly. Crit Care Med 2016;epublished October 4th
- Prina. New aspects in the management of pneumonia. Critical Care 2016;20:267
- Cohn. Update in perioperative cardiac medicine. CCJM 2016 Oct;83(10):723-730
- Singh. Strategies for blood conservation in pediatric cardiac surgery. Ann Card Anaesth 2016;19:705-16
- Chakraborty. Ultrasound-guided truncal blocks: A new frontier in regional anaesthesia. Indian J Anaesth 2016;60:703-11
- Møller. Scandinavian SSAI clinical practice guideline on choice of first-line vasopressor for patients with acute circulatory failure. Acta Anaesthesiologica Scandinavia 2016;60(10):1347–1366
- Silva. Brazilian Consensus on perioperative hemodynamic therapy goal guided in patients undergoing noncardiac surgery: fluid management strategy – produced by the São Paulo State Society of Anesthesiology (Sociedade de Anestesiologia do Estado de São Paulo – SAESP). Rev Bras Anestesiol 2016;epublished October 1st
- Morin. Refractory septic shock in children: a European Society of Paediatric and Neonatal Intensive Care definition. Intensive Care Med 2016;epublished October 5th
- Lee. Optimal nutrition therapy in paediatric critical care in the Asia - Pacific and Middle East: a consensus. Asia Pac J Clin Nutr 2016;25(4):676-696
- St-Onge. Experts Consensus Recommendations for the Management of Calcium Channel Blocker Poisoning in Adults. Crit Care Med 2016;epublished October 3rd
- Zhang. The Society for Translational Medicine: clinical practice guidelines for diagnosis and early identification of sepsis in the hospital. J Thorac Dis 2016;8(9):2654-2665
- Amin. The Intensive care unit specialist: Report from the Task Force of World Federation of Societies of Intensive and Critical Care Medicine. J Crit Care 2016;35:223-228
- Kim. Sugammadex: watch out for new side effects. Korean J Anesthesiol 2016;69(5):427-428
- Rudiger. Decatecholaminisation during sepsis. Critical Care 2016;20:309
- Mehta. Long-term physical morbidity in ARDS survivors. Intensive Care Med 2016;epublished October 5th
- Paiva. Treatment of severe MRSA infections: current practice and further development. Intensive Care Med 2016;epublished October 4th
- Vincent. What patient data should be collected in this randomized controlled trial in sepsis? Intensive Care Med 2016;epublished October 4th
- Vincent. Intensive care medicine in 2050: the future of ICU treatments. Intensive Care Med 2016;epublished October 4th
- Arora. Recent trends on hemodynamic monitoring in cardiac surgery. Ann Card Anaesth 2016;19:580-3
- Umesh. Melatonin - marvel in the making?. Indian J Anaesth 2016;60:701-2
- Cholley. Ventriculo-arterial coupling: the comeback? J Thorac Dis 2016;8(9):2287-2289
- Qian. Fine-tuning treatment for patients with ST-elevation myocardial infarction. J Thorac Dis 2016;8(9):2296-2300
- Persico. Veno-arterial extracorporeal membrane oxygenation for acute myocardial infarction-associated cardiogenic shock: can we predict survival before decision of implantation? J Thorac Dis 2016;8(9):2331-2333
- Ahn. Translation from the data of clinical trials to precision medicine: limitation of the current risk score for predicting coronary thrombosis and major bleeding. J Thorac Dis 2016;8(9):2376-2378
- Gibney. Continous renal replacement therapy and intermittent hemodialysis in acute kidney injury: equivalent or complementary? J Thorac Dis 2016;8(9):2397-2399
- Tucci. Noninvasive ventilation for acute respiratory distress syndrome: the importance of ventilator settings. J Thorac Dis 2016;8(9):E982-E986
- Honore. Adjuvant vitamin C treatment in sepsis—how many oranges a day keep (vasopressor-dependent) septic shock away? J Thorac Dis 2016;8(9):E993-E995
- Vincent. Quick sequential organ failure assessment: big databases vs. intelligent doctors. J Thorac Dis 2016;8(9):E996-E998
- Knauert. Dexmedetomidine for hyperactive delirium: worth further study. J Thorac Dis 2016;8(9):E999-E1002
- Kim. Beta-blockers in patients with septic shock: plenty of promise, but no hard evidence yet. J Thorac Dis 2016;8(9):E1041-E1043
- Lange. Statins for delirium in ICU patients: a negative trial but a positive step. J Thorac Dis 2016;8(9):E1063-E1066
- Neylon. Antiplatelet agents in out of hospital cardiac arrest survivors—does an impaired biological response increase stent thrombosis risk? J Thorac Dis 2016;8(9):E1090-E1092
- Mazzeffi. Pharmacotherapy in acute respiratory distress syndrome—the long and winding road. J Thorac Dis 2016;8(9):2337-2339
- Meersch. Timing of renal replacement therapy in acute kidney injury—an issue of importance? J Thorac Dis 2016;8(9):2301-2304
- Moerer. Non-invasive mechanical ventilation in hypoxemic respiratory failure: Just a matter of the interface? J Thorac Dis 2016;8(9):2348-2352
- Paratz. Dealing with the critical care aftermath: where to from here? J Thorac Dis 2016;8(9):2400-2402
- Romagnoli. The good receipt for the kidneys: salty…but not too much. J Thorac Dis 2016;8(9):2403-2406
- Bielopolski. Conservatism strikes back: later is better than earlier dialysis for acute kidney injury. J Thorac Dis 2016;8(9):2415-2419
- Chen. High-flow nasal cannula in postextubation management. J Thorac Dis 2016;8(9):E1013-E1016
- Dhooria. The quest for the optimal blood pressure in septic shock. J Thorac Dis 2016;8(9):E1019-E1022
- Busani. Dexmedetomidine for agitated delirium in intensive care unit intubated patients. J Thorac Dis 2016;8(9):E1072-E1074
Once again the Critical Care Reviews Meeting will be discussing the biggest studies of the previous year with their chief investigators, asking the question "should we implement the results of this trial into our dialy practice?". We also have the John Hinds Trauma Lecture, delivered this year by Prof Donat Spahn (Zurich), lead for the new European Trauma Guideline, published a few months ago. Paul Marik thinks he has discovered "The Cure for Sepsis", while John Myburgh will explain the ins and outs of research methodology in the "Path to Truth". In addition, there is the very popular "How I Manage....." series of short talks from our speakers on conditions they are experts in, the "Year in Review" and the now famous "Informal Chat" in the bar after the main event.
Don't forget to register for dinner also, where the menu is based on an original menu from the only sailing the Titanic made. Registration for both the meeting and meal is available on the meeting webpage. The Critical Care Reviews Meeting is a not-for-profit event.
Following last year's massively successful event, the UK Intensive Care Society's State-of-the-Art Meeting is starting its build-up to 2016. The ICS completely changed its game in 2015, and relaunched SOA as a new beacon for forward-looking clinical content, open-access education, and medical social media. In keeping with the times, the podcasts and other materials from last year's meeting have been made open access.
This year the programme is looking even better, with topics ranging from the futuristic (space medicine, Formula 1 applied technology, Google Deepmind, and AI) through to the human, practical, and controversial (look out for the clinical scenarios, controversies, and the "From Ivory Tower to Desert Island" session). Speakers include Peter Brindley, Kevin Fong, Jack Iwashyna, Kath Maitland, Louise Rose, Mervyn Singer, and Jean-Louis Vincent among many others. It runs from Mon 5th - Wed 7th Dec, and I hope I'll see you there. Keep an eye on http://soa.ics.ac.uk for programme and registration, and meanwhile enjoy the comprehensive FOAM from last year.
(Image from Chensiyuan via Wikipedia)
This adult and paediatric ICM meeting is jointly organized by the Society of Intensive Care Medicine (SICM), Singapore and the Australia-New Zealand Intensive Care Society (ANZICS) and is scheduled for 20-24 April 2017 in Suntec Convention Centre, Singapore. It has grown from its humble beginnings in a small hospital venue to become one of the best ICM conference in the Asia-Pacific region. Past editions featured prominent speakers such as Jean Louis Vincent, Daniel De Backer, John J Marini, Rinaldo Bellomo amongst many others, and in this edition the list of distinguished international panel of speakers, program schedule and planned workshops look more impressive than ever. Beside the obvious educational benefits, this conference is also a great opportunity to experience the unique Singaporean culture, enjoy its famed gastronomy and visit its attractions.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week